eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| non-functioning pituitary adenoma | ||||
| Disease ID | 1685 |
|---|---|
| Disease | non-functioning pituitary adenoma |
| Definition | A type of pituitary adenoma that is of unknown cellular origin and that lacks immunocytochemical or fine structural markers. Null cell adenomas are not associated with hormone excess. [DDD:spark] |
| Synonym | clinically silent pituitary adenoma functionless adenoma of pituitary functionless adenoma of pituitary gland functionless adenoma of the pituitary functionless adenoma of the pituitary gland functionless pituitary adenoma functionless pituitary adenoma (disorder) functionless pituitary gland adenoma hormonally silent pituitary adenoma non-functional pituitary adenoma non-functioning adenoma of pituitary non-functioning adenoma of pituitary gland non-functioning adenoma of the pituitary non-functioning adenoma of the pituitary gland non-functioning neoplasm of pituitary non-functioning neoplasm of pituitary gland non-functioning neoplasm of the pituitary non-functioning neoplasm of the pituitary gland non-functioning pituitary gland adenoma non-functioning pituitary gland neoplasm non-functioning pituitary gland tumor non-functioning pituitary neoplasm non-functioning pituitary tumor non-functioning pituitary tumour non-functioning tumor of pituitary non-functioning tumor of pituitary gland non-functioning tumor of the pituitary non-functioning tumor of the pituitary gland non-secretory adenoma of pituitary non-secretory adenoma of pituitary gland non-secretory adenoma of the pituitary non-secretory adenoma of the pituitary gland non-secretory pituitary adenoma non-secretory pituitary gland adenoma nonfunctioning pituitary adenoma nonfunctioning pituitary tumor nonfunctioning pituitary tumors null cell pituitary adenoma pituitary adenoma, nonfunctioning pituitary null cell adenoma pituitary tumor, nonfunctioning silent pituitary adenoma |
| Orphanet | |
| DOID | |
| UMLS | C0338078 |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:16) C0001430 | adenoma | 1 C0001206 | acromegaly | 1 C0034013 | precocious puberty | 1 C0032000 | pituitary adenoma | 1 C1527390 | intracranial tumors | 1 C0014236 | endophthalmitis | 1 C0221406 | cushing disease | 1 C0242343 | panhypopituitarism | 1 C0456909 | blindness | 1 C0032001 | pituitary apoplexy | 1 C1527390 | intracranial tumor | 1 C0003857 | arteriovenous malformation | 1 C0020514 | hyperprolactinemia | 1 C0020514 | hyperprolactinaemia | 1 C0020635 | hypopituitarism | 1 C0036202 | sarcoidosis | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 1685 |
|---|---|
| Disease | non-functioning pituitary adenoma |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:57) HP:0000044 | Hypogonadotrophic hypogonadism HP:0002050 | Macroorchidism, postpubertal HP:0000863 | Central diabetes insipidus HP:0008202 | Prolactin deficiency HP:0002920 | Decreased circulating ACTH level HP:0002013 | Vomiting HP:0100639 | Erectile abnormalities HP:0011748 | Adrenocorticotropic hormone deficiency HP:0012378 | Fatigue HP:0000873 | Diabetes insipidus HP:0007942 | Internal ophthalmoplegia HP:0011804 | Abnormality of muscle physiology HP:0000824 | Growth hormone deficiency HP:0001117 | Sudden loss of visual acuity HP:0008993 | Increased intraabdominal fat HP:0000508 | Ptosis HP:0000135 | Hypogonadism HP:0000618 | Blindness HP:0040075 | Hypopituitarism HP:0030521 | Bitemporal hemianopia HP:0000837 | Increased circulating gonadotropin level HP:0000134 | Female hypogonadism HP:0002017 | Nausea and vomiting HP:0000871 | Panhypopituitarism HP:0002615 | Hypotension HP:0006897 | Cranial nerve VI palsy HP:0003335 | Low gonadotropins (secondary hypogonadism) HP:0000140 | Abnormality of the menstrual cycle HP:0000858 | Menstrual irregularities HP:0007011 | Fourth cranial nerve palsy HP:0012246 | Oculomotor nerve palsy HP:0001250 | Seizures HP:0011357 | Abnormality of hair density HP:0000026 | Male hypogonadism HP:0011735 | Adrenocorticotropin deficient adrenal insufficiency HP:0003388 | Easy fatigability HP:0000868 | Decreased fertility in females HP:0000846 | Adrenal insufficiency HP:0010972 | Anemia of inadequate production HP:0030517 | Heteronymous hemianopia HP:0000651 | Diplopia HP:0000529 | Progressive visual loss HP:0000830 | Anterior hypopituitarism HP:0000802 | Impotence HP:0000053 | Macroorchidism HP:0012377 | Hemianopsia HP:0002321 | Vertigo HP:0030018 | Decreased female libido HP:0030088 | Increased serum testosterone level HP:0012503 | Abnormality of the pituitary gland HP:0006824 | Cranial nerve paralysis HP:0012041 | Decreased fertility in males HP:0000980 | Pallor HP:0002315 | Headache HP:0008240 | Secondary growth hormone deficiency HP:0008245 | Pituitary hypothyroidism HP:0011734 | Central adrenal insufficiency |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:14) HP:0002664 | Neoplasia | 3 HP:0000870 | Hyperprolactinemia | 2 HP:0000871 | Panhypopituitarism | 1 HP:0010513 | Pituitary calcification | 1 HP:0100026 | Arteriovenous malformation | 1 HP:0000845 | Acromegalic growth | 1 HP:0000618 | Blindness | 1 HP:0000826 | Precocious puberty | 1 HP:0030062 | Craniopharyngioma | 1 HP:0040075 | Hypopituitarism | 1 HP:0012721 | Venous malformations | 1 HP:0002893 | Pituitary adenoma | 1 HP:0012199 | Cluster headache | 1 HP:0002315 | Headaches | 1 |
| Disease ID | 1685 |
|---|---|
| Disease | non-functioning pituitary adenoma |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:3) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:1) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
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| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:12) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0002920 | Decreased circulating ACTH level | MP:0011549 | increased urine corticosterone level | an increased amount of corticosterone in the urine compared to the normal state |
| HP:0010972 | Anemia of inadequate production | MP:0010178 | increased number of Howell-Jolly bodies | abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in |
| HP:0000529 | Progressive visual loss | MP:0010749 | absent visual evoked potential | absence of a characteristic electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; absence may indicate blindness |
| HP:0000830 | Anterior hypopituitarism | MP:0003348 | hypopituitarism | reduction or cessation of secretion of one or more hormones from the anterior pituitary gland; this may result from ablation, tumors, infarction, or other trauma |
| HP:0000837 | Increased circulating gonadotropin level | MP:0011533 | increased urine major urinary protein level | increased amount in the urine of a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine |
| HP:0000140 | Abnormality of the menstrual cycle | MP:0004499 | increased incidence of tumors by chemical induction | higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens |
| HP:0006824 | Cranial nerve paralysis | MP:0006303 | abnormal retinal nerve fiber layer morphology | any structural anomaly of the layer of the retina formed by expansion of the fibers of the optic nerve |
| HP:0008240 | Secondary growth hormone deficiency | MP:0005418 | abnormal circulating hormone level | any anomaly in the blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the blood |
| HP:0008993 | Increased intraabdominal fat | MP:0011168 | abnormal fat cell differentiation | abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals |
| HP:0002017 | Nausea and vomiting | MP:0010426 | abnormal heart and great artery attachment | any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta |
| HP:0000868 | Decreased fertility in females | MP:0001921 | reduced fertility | diminished ability to produce live offspring |
| HP:0000824 | Growth hormone deficiency | MP:0003965 | abnormal pituitary hormone level | aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary |
Mapped by homologous gene(Total Items:46) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0000837 | Increased circulating gonadotropin level | MP:0014193 | decreased epididymal cell proliferation | decrease in the expansion rate of any epididymal cell population by cell division |
| HP:0000140 | Abnormality of the menstrual cycle | MP:0014169 | decreased brown adipose tissue mass | decreased physical bulk or volume of brown adipose tissue |
| HP:0000508 | Ptosis | MP:0020321 | increased vascular endothelial cell apoptosis | increase in the timing or the number of vascular endothelial cells undergoing programmed cell death |
| HP:0002315 | Headache | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0000044 | Hypogonadotrophic hypogonadism | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0000802 | Impotence | MP:0012504 | increased forebrain apoptosis | increase in the number of cells of the forebrain undergoing programmed cell death |
| HP:0001250 | Seizures | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0000529 | Progressive visual loss | MP:0020216 | decreased circulating complement protein level | less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes |
| HP:0000846 | Adrenal insufficiency | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0100639 | Erectile abnormalities | MP:0014198 | absent pituitary infundibular stalk | absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland |
| HP:0001117 | Sudden loss of visual acuity | MP:0013405 | increased circulating lactate level | greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase |
| HP:0012377 | Hemianopia | MP:0013405 | increased circulating lactate level | greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase |
| HP:0000824 | Growth hormone deficiency | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0000135 | Hypogonadism | MP:0014198 | absent pituitary infundibular stalk | absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland |
| HP:0012246 | Oculomotor nerve palsy | MP:0011967 | increased or absent threshold for auditory brainstem response | increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency o |
| HP:0000873 | Diabetes insipidus | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0000618 | Blindness | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0002920 | Decreased circulating ACTH level | MP:0014167 | ectopic bone | the appearance of an extra bone structure at an atypical location |
| HP:0010972 | Anemia of inadequate production | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0000868 | Decreased fertility in females | MP:0014169 | decreased brown adipose tissue mass | decreased physical bulk or volume of brown adipose tissue |
| HP:0008240 | Secondary growth hormone deficiency | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0008202 | Prolactin deficiency | MP:0014198 | absent pituitary infundibular stalk | absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland |
| HP:0002017 | Nausea and vomiting | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0011748 | Adrenocorticotropic hormone deficiency | MP:0011957 | decreased compensatory feeding amount | decreased amount of food consumed after a period of fasting |
| HP:0000863 | Central diabetes insipidus | MP:0013282 | urinary bladder exstrophy | a herniation of the urinary bladder through an anterior abdominal wall defect; refers to congenital absence of a portion of the lower anterior abdominal wall and the anterior urinary bladder wall, with eversion of the posterior bladder wall through the de |
| HP:0012378 | Fatigue | MP:0013659 | abnormal erythroid lineage cell morphology | any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes |
| HP:0000651 | Diplopia | MP:0020187 | altered susceptibility to prion infection | altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is |
| HP:0002321 | Vertigo | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0003335 | Low gonadotropins (secondary hypogonadism) | MP:0013603 | abnormal fetal Leydig cell differentiation | atypical formation of or inability to produce the first or fetal population of Leydig cells (FLCs); in mice, FLCs arise in the testicular interstitium between E12.5 and E13.0, approximately 1 day after the appearance of Sertoli cells; Sertoli cells trigge |
| HP:0008993 | Increased intraabdominal fat | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0003388 | Easy fatigability | MP:0020214 | susceptible to malignant hyperthermia | increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine |
| HP:0040075 | Hypopituitarism | MP:0011495 | abnormal head shape | any anomaly in the characteristic surface outline or contour of a head of an organism |
| HP:0000980 | Pallor | MP:0020186 | altered susceptibility to bacterial infection | a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria |
| HP:0000053 | Macroorchidism | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0002615 | Hypotension | MP:0020214 | susceptible to malignant hyperthermia | increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine |
| HP:0002013 | Vomiting | MP:0020316 | decreased vascular endothelial cell proliferation | decrease in the expansion rate of any vascular endothelial cell population by cell division |
| HP:0002050 | Macroorchidism, postpubertal | MP:0012144 | decreased b wave amplitude | reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram |
| HP:0000858 | Menstrual irregularities | MP:0014167 | ectopic bone | the appearance of an extra bone structure at an atypical location |
| HP:0008245 | Pituitary hypothyroidism | MP:0020087 | increased susceptibility to non-insulin-dependent diabetes | increased likelihood to develop non-insulin-dependent diabetes |
| HP:0000026 | Male hypogonadism | MP:0013737 | small bulbourethral gland | reduced size of either of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia o |
| HP:0000134 | Female hypogonadism | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0011734 | Central adrenal insufficiency | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0000830 | Anterior hypopituitarism | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0000871 | Panhypopituitarism | MP:0014198 | absent pituitary infundibular stalk | absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland |
| HP:0006824 | Cranial nerve paralysis | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0006897 | Cranial nerve VI palsy | MP:0012431 | increased lymphoma incidence | greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period |
| Disease ID | 1685 |
|---|---|
| Disease | non-functioning pituitary adenoma |
| Case | (Waiting for update.) |