eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| neurosyphilis | ||||
| Disease ID | 1893 |
|---|---|
| Disease | neurosyphilis |
| Definition | Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8) |
| Synonym | [x]neurosyphilis, unspecified [x]neurosyphilis, unspecified (disorder) central nervous system syphilis cns syphilis neurosyphilis (disorder) neurosyphilis [disease/finding] neurosyphilis nos neurosyphilis nos (disorder) neurosyphilis, nos neurosyphilis, unspecified syphilis cns syphilis of central nervous system syphilis of central nervous system nos syphilis of central nervous system, nos syphilis, central nervous system syphilis, cns |
| ICD10 | |
| UMLS | C0027927 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:20) C0025289 | meningitis | 2 C0039128 | syphilis | 2 C0497327 | dementia | 2 C0004134 | ataxia | 1 C0743039 | progressive dementia | 1 C0014544 | epileptic seizure | 1 C0014544 | epileptic seizures | 1 C0032587 | polyradiculoneuropathy | 1 C0039223 | tabes dorsalis | 1 C0038220 | status epilepticus | 1 C0040053 | thrombosis | 1 C0153166 | syphilitic meningitis | 1 C0007758 | cerebellar ataxia | 1 C0024530 | malaria | 1 C0042373 | vascular disease | 1 C0033975 | psychosis | 1 C0024537 | vivax malaria | 1 C0041296 | tuberculosis | 1 C0020635 | hypopituitarism | 1 C0025290 | aseptic meningitis | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 1893 |
|---|---|
| Disease | neurosyphilis |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:15) HP:0000726 | Dementia | 3 HP:0001297 | Cerebral vascular events | 2 HP:0001287 | Meningitis | 2 HP:0001268 | Mental deterioration | 2 HP:0100543 | Cognitive deficits | 2 HP:0040075 | Hypopituitarism | 1 HP:0002133 | Status epilepticus | 1 HP:0001251 | Ataxia | 1 HP:0000709 | Psychosis | 1 HP:0010819 | drop attacks | 1 HP:0003470 | Inability to move | 1 HP:0001250 | Seizures | 1 HP:0002721 | Immunodeficiency | 1 HP:0000572 | Visual loss | 1 HP:0001336 | Myoclonic jerks | 1 |
| Disease ID | 1893 |
|---|---|
| Disease | neurosyphilis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:34) C2712333 | agitation C2364072 | depression C2029884 | hearing loss C1963946 | laryngeal dystonia C1393529 | vascular complications C0871189 | psychotic symptoms C0852949 | arterial disease C0751494 | convulsive seizures C0751354 | action myoclonus C0743841 | febrile illness C0743039 | progressive dementia C0740279 | cerebellar atrophy C0497327 | dementia C0423479 | ear symptoms C0422833 | ent symptoms C0271240 | unilateral blindness C0242422 | parkinsonism C0240735 | personality change C0236073 | cerebellar infarction C0234668 | argyll robertson pupil C0233401 | psychiatric symptoms C0205858 | general paresis C0153122 | induced malaria C0151818 | opisthotonus C0036572 | seizures C0033975 | psychosis C0029089 | oculomotor paralysis C0028866 | oculomotor nerve palsy C0027849 | neuroleptic malignant syndrome C0026650 | movement disorder C0020258 | normal pressure hydrocephalus C0014544 | seizure disorders C0008513 | chorioretinitis C0007398 | catatonia |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:7) C0871189 | psychotic symptoms | 4 C0233401 | psychiatric symptoms | 3 C0497327 | dementia | 2 C0743039 | progressive dementia | 1 C0036572 | seizures | 1 C0205858 | general paresis | 1 C0033975 | psychosis | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
| Disease ID | 1893 |
|---|---|
| Disease | neurosyphilis |
| Case | (Waiting for update.) |