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	nephroblastoma

Disease ID	117
Disease	nephroblastoma
Definition	pediatric nephroblastoma originating from embryonic kidney stem cells; usually affects children before the fifth year, but may occur in the fetus or rarely in later life; caused by defects in one or more tumor suppressor genes.
Synonym	[m]nephroblastoma nos embryonal adenosarcoma embryonal nephroma kidney wilms tumor kidney, adenomyosarcoma, embryonal kidney, carcinosarcoma, embryonal kidney, embryoma kidney, embryonal mixed tumor nephroblastoma (disorder) nephroblastoma (m-89603) nephroblastoma (morphologic abnormality) nephroblastoma (wilms tumor) nephroblastoma, malignant nephroblastoma, nos nephroblastomas nephroma nephroma, nos nephromas perlman syndrome renal adenosarcoma renal cancer, wilms renal wilms tumor renal wilms' tumor tumor wilm's tumor wilms tumor wilms' tumor wilms's tumor, wilms tumor, wilms' tumors wilm's tumors wilms wilm tumor wilm's tumor wilms tumor wilms tumor (nephroblastoma) wilms tumor 1 wilms tumor [disease/finding] wilms tumor of the kidney wilms tumour wilms' tumor wilms' tumor and other childhood kidney tumors wilms' tumor of the kidney wilms' tumour wt1
Orphanet	ORPHANET:654 ORPHANET:2849
OMIM	OMIM:194070 OMIM:267000 OMIM:607102
DOID	DOID:2154 DOID:0060476 DOID:5183 DOID:5176
UMLS	C0027708
MeSH	D009396
SNOMED-CT	SNOMEDCT_US_2016_09_01:302849000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:64) C0153676 \| lung metastasis \| 3 C1261473 \| sarcoma \| 3 C0040053 \| thrombus \| 3 C0153676 \| lung metastases \| 3 C0153676 \| pulmonary metastases \| 3 C0020538 \| hypertension \| 3 C0027708 \| wilm's tumor \| 2 C0553580 \| ewing's sarcoma \| 2 C0023418 \| leukemia \| 2 C0027726 \| nephrotic syndrome \| 2 C0027697 \| nephritis \| 2 C0555198 \| malignant glioma \| 2 C0039446 \| telangiectasia \| 1 C0032461 \| polycythaemia \| 1 C0004134 \| ataxia \| 1 C0022658 \| renal disease \| 1 C0008479 \| chondrosarcoma \| 1 C0002871 \| anemia \| 1 C0035412 \| rhabdomyosarcoma \| 1 C1140680 \| ovarian cancer \| 1 C0007134 \| renal carcinoma \| 1 C0035078 \| renal failure \| 1 C0023467 \| acute myelogenous leukemia \| 1 C0027819 \| neuroblastoma \| 1 C0024115 \| lung disease \| 1 C0030486 \| paraplegia \| 1 C0015625 \| fanconi anemia \| 1 C0494165 \| liver metastasis \| 1 C0677886 \| epithelial ovarian cancer \| 1 C1370740 \| adrenal carcinoma \| 1 C0740394 \| hyperuricemia \| 1 C0950121 \| denys-drash syndrome \| 1 C0023467 \| acute myeloid leukemia \| 1 C0024143 \| lupus nephritis \| 1 C0206656 \| embryonal rhabdomyosarcoma \| 1 C0010481 \| cushing syndrome \| 1 C1140680 \| ovarian ca \| 1 C0004779 \| gorlin syndrome \| 1 C0007134 \| renal cell carcinoma \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0206633 \| angiomyolipoma \| 1 C0022972 \| myasthenic syndrome \| 1 C0022972 \| lambert-eaton myasthenic syndrome \| 1 C1266045 \| metanephric adenoma \| 1 C0022661 \| chronic kidney disease \| 1 C0020541 \| portal hypertension \| 1 C0686619 \| lymph node metastases \| 1 C0041341 \| tuberous sclerosis complex \| 1 C0006142 \| breast cancer \| 1 C0001430 \| adenoma \| 1 C0950121 \| drash syndrome \| 1 C0936282 \| blastoma \| 1 C0022661 \| end stage renal disease \| 1 C0005859 \| bloom syndrome \| 1 C0020598 \| hypoglycaemia \| 1 C0019829 \| hodgkin lymphoma \| 1 C0041341 \| phacomatosis \| 1 C0041341 \| tuberous sclerosis \| 1 C0021843 \| bowel obstruction \| 1 C0948265 \| metabolic syndrome \| 1 C0392784 \| dermatofibrosarcoma protuberans \| 1 C0022658 \| kidney disease \| 1 C0023470 \| myelogenous leukemia \| 1 C0555198 \| malignant gliomas \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:16) 3481 \| IGF2 \| CTD_human 255738 \| PCSK9 \| GWASCAT 675 \| BRCA2 \| CTD_human;UNIPROT 7490 \| WT1 \| CTD_human;ORPHANET;UNIPROT 1499 \| CTNNB1 \| CTD_human 129563 \| DIS3L2 \| ORPHANET 6948 \| TCN2 \| GWASCAT 1740 \| DLG2 \| GWASCAT 7428 \| VHL \| CTD_human 283120 \| H19 \| ORPHANET 5978 \| REST \| CTD_human 11281 \| POU6F2 \| ORPHANET 11010 \| GLIPR1 \| CTD_human 2719 \| GPC3 \| CTD_human;UNIPROT 4810 \| NHS \| GWASCAT 1653 \| DDX1 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:8) 7490 \| WT1 \| CIPHER;CTD_human 1499 \| CTNNB1 \| CTD_human 5978 \| REST \| CTD_human 11010 \| GLIPR1 \| CTD_human 2719 \| GPC3 \| CTD_human 7428 \| VHL \| CTD_human 675 \| BRCA2 \| CTD_human 3481 \| IGF2 \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:224) 6833 \| ABCC8 \| 1.736 \| DISEASES 25 \| ABL1 \| 2.424 \| DISEASES 60 \| ACTB \| 1.208 \| DISEASES 174 \| AFP \| 2.19 \| DISEASES 60529 \| ALX4 \| 1.511 \| DISEASES 23600 \| AMACR \| 1.694 \| DISEASES 367 \| AR \| 1.504 \| DISEASES 430 \| ASCL2 \| 1.647 \| DISEASES 567 \| B2M \| 1.186 \| DISEASES 8938 \| BAIAP3 \| 1.733 \| DISEASES 618 \| BCYRN1 \| 4.017 \| DISEASES 627 \| BDNF \| 1.199 \| DISEASES 10904 \| BLCAP \| 1.068 \| DISEASES 675 \| BRCA2 \| 1.218 \| DISEASES 777 \| CACNA1E \| 1.132 \| DISEASES 797 \| CALCB \| 1.061 \| DISEASES 79872 \| CBLL1 \| 1.489 \| DISEASES 10575 \| CCT4 \| 1.113 \| DISEASES 23607 \| CD2AP \| 1.422 \| DISEASES 960 \| CD44 \| 1.615 \| DISEASES 966 \| CD59 \| 1.471 \| DISEASES 9308 \| CD83 \| 1.42 \| DISEASES 942 \| CD86 \| 1.14 \| DISEASES 4267 \| CD99 \| 2.344 \| DISEASES 79577 \| CDC73 \| 1.072 \| DISEASES 1028 \| CDKN1C \| 4.056 \| DISEASES 1028 \| CDKN1C \| 2.083 \| DISEASES 1045 \| CDX2 \| 1.263 \| DISEASES 9391 \| CIAO1 \| 3.315 \| DISEASES 4435 \| CITED1 \| 3.959 \| DISEASES 10256 \| CNKSR1 \| 1.693 \| DISEASES 57175 \| CORO1B \| 1.794 \| DISEASES 1382 \| CRABP2 \| 1.365 \| DISEASES 1471 \| CST3 \| 1.227 \| DISEASES 1490 \| CTGF \| 2.156 \| DISEASES 29119 \| CTNNA3 \| 1.448 \| DISEASES 1499 \| CTNNB1 \| 3.86 \| DISEASES 56998 \| CTNNBIP1 \| 1.333 \| DISEASES 80319 \| CXXC4 \| 1.372 \| DISEASES 3491 \| CYR61 \| 1.914 \| DISEASES 64858 \| DCLRE1B \| 1.447 \| DISEASES 55635 \| DEPDC1 \| 2.082 \| DISEASES 1607 \| DGKB \| 1.065 \| DISEASES 23405 \| DICER1 \| 2.321 \| DISEASES 23405 \| DICER1 \| 1.929 \| DISEASES 22894 \| DIS3 \| 5.229 \| DISEASES 22894 \| DIS3 \| 1.959 \| DISEASES 115752 \| DIS3L \| 4.862 \| DISEASES 115752 \| DIS3L \| 2.151 \| DISEASES 8788 \| DLK1 \| 1.449 \| DISEASES 29102 \| DROSHA \| 1.96 \| DISEASES 1781 \| DYNC1I2 \| 2.545 \| DISEASES 1961 \| EGR4 \| 3.032 \| DISEASES 2109 \| ETFB \| 1.206 \| DISEASES 2120 \| ETV6 \| 1.12 \| DISEASES 2130 \| EWSR1 \| 3.77 \| DISEASES 2138 \| EYA1 \| 1.466 \| DISEASES 474383 \| F8A2 \| 1.416 \| DISEASES 474384 \| F8A3 \| 1.598 \| DISEASES 2254 \| FGF9 \| 1.174 \| DISEASES 387758 \| FIBIN \| 2.279 \| DISEASES 9158 \| FIBP \| 3.028 \| DISEASES 2296 \| FOXC1 \| 1.323 \| DISEASES 2297 \| FOXD1 \| 2.693 \| DISEASES 2308 \| FOXO1 \| 1.007 \| DISEASES 2512 \| FTL \| 2.762 \| DISEASES 2526 \| FUT4 \| 1.865 \| DISEASES 2623 \| GATA1 \| 1.673 \| DISEASES 2626 \| GATA4 \| 2.076 \| DISEASES 2668 \| GDNF \| 1.568 \| DISEASES 2674 \| GFRA1 \| 1.134 \| DISEASES 2719 \| GPC3 \| 3.45 \| DISEASES 2719 \| GPC3 \| 3.213 \| DISEASES 2239 \| GPC4 \| 3.817 \| DISEASES 2239 \| GPC4 \| 1.017 \| DISEASES 7107 \| GPR137B \| 2.142 \| DISEASES 2863 \| GPR39 \| 1.036 \| DISEASES 2971 \| GTF3A \| 1.477 \| DISEASES 283120 \| H19 \| 1.335 \| DISEASES 3043 \| HBB \| 1.052 \| DISEASES 3065 \| HDAC1 \| 1.27 \| DISEASES 333932 \| HIST2H3A \| 1.982 \| DISEASES 126961 \| HIST2H3C \| 2.689 \| DISEASES 3105 \| HLA-A \| 1.094 \| DISEASES 3161 \| HMMR \| 2.215 \| DISEASES 3167 \| HMX2 \| 1.897 \| DISEASES 3283 \| HSD3B1 \| 1.441 \| DISEASES 3347 \| HTN3 \| 2.303 \| DISEASES 3481 \| IGF2 \| 5.839 \| DISEASES 3481 \| IGF2 \| 2.554 \| DISEASES 51214 \| IGF2-AS \| 2.401 \| DISEASES 10265 \| IRX5 \| 1.229 \| DISEASES 8516 \| ITGA8 \| 1.299 \| DISEASES 10625 \| IVNS1ABP \| 2.256 \| DISEASES 3767 \| KCNJ11 \| 1.378 \| DISEASES 60598 \| KCNK15 \| 1.954 \| DISEASES 10984 \| KCNQ1OT1 \| 3.54 \| DISEASES 55243 \| KIRREL \| 1.187 \| DISEASES 83999 \| KREMEN1 \| 1.354 \| DISEASES 3855 \| KRT7 \| 2.708 \| DISEASES 3916 \| LAMP1 \| 1.552 \| DISEASES 3939 \| LDHA \| 1.573 \| DISEASES 56956 \| LHX9 \| 1.634 \| DISEASES 389421 \| LIN28B \| 1.172 \| DISEASES 4010 \| LMX1B \| 1.595 \| DISEASES 131578 \| LRRC15 \| 1.062 \| DISEASES 338645 \| LUZP2 \| 2.121 \| DISEASES 4101 \| MAGEA2 \| 1.516 \| DISEASES 266740 \| MAGEA2B \| 1.518 \| DISEASES 4102 \| MAGEA3 \| 1.727 \| DISEASES 4151 \| MB \| 1.842 \| DISEASES 4192 \| MDK \| 3.042 \| DISEASES 4222 \| MEOX1 \| 1.535 \| DISEASES 57721 \| METTL14 \| 1.907 \| DISEASES 92312 \| MEX3A \| 2.183 \| DISEASES 2315 \| MLANA \| 1.46 \| DISEASES 4311 \| MME \| 1.78 \| DISEASES 758 \| MPPED1 \| 3.114 \| DISEASES 744 \| MPPED2 \| 3.21 \| DISEASES 6150 \| MRPL23 \| 1.896 \| DISEASES 10232 \| MSLN \| 1.402 \| DISEASES 9961 \| MVP \| 1.932 \| DISEASES 4602 \| MYB \| 1.681 \| DISEASES 4609 \| MYC \| 2.601 \| DISEASES 10408 \| MYCNOS \| 1.472 \| DISEASES 4629 \| MYH11 \| 2.029 \| DISEASES 8736 \| MYOM1 \| 1.557 \| DISEASES 4664 \| NAB1 \| 1.928 \| DISEASES 4676 \| NAP1L4 \| 3.156 \| DISEASES 89796 \| NAV1 \| 1.009 \| DISEASES 4750 \| NEK1 \| 1.274 \| DISEASES 10763 \| NES \| 1.37 \| DISEASES 4763 \| NF1 \| 1.345 \| DISEASES 4803 \| NGF \| 1.178 \| DISEASES 7080 \| NKX2-1 \| 2.077 \| DISEASES 4868 \| NPHS1 \| 4.198 \| DISEASES 7827 \| NPHS2 \| 3.422 \| DISEASES 190 \| NR0B1 \| 2.848 \| DISEASES 2516 \| NR5A1 \| 3.888 \| DISEASES 2494 \| NR5A2 \| 1.77 \| DISEASES 4893 \| NRAS \| 1.503 \| DISEASES 4916 \| NTRK3 \| 1.723 \| DISEASES 56903 \| PAPOLB \| 1.769 \| DISEASES 164091 \| PAQR7 \| 1.16 \| DISEASES 84612 \| PARD6B \| 1.821 \| DISEASES 5074 \| PAWR \| 1.607 \| DISEASES 5076 \| PAX2 \| 4.889 \| DISEASES 5077 \| PAX3 \| 1.797 \| DISEASES 5080 \| PAX6 \| 4.36 \| DISEASES 5081 \| PAX7 \| 1.675 \| DISEASES 7849 \| PAX8 \| 3.317 \| DISEASES 22976 \| PAXIP1 \| 1.108 \| DISEASES 5087 \| PBX1 \| 1.272 \| DISEASES 5154 \| PDGFA \| 2.825 \| DISEASES 10611 \| PDLIM5 \| 1.168 \| DISEASES 10471 \| PFDN6 \| 1.58 \| DISEASES 5241 \| PGR \| 1.288 \| DISEASES 10745 \| PHTF1 \| 1.654 \| DISEASES 93183 \| PIGM \| 1.347 \| DISEASES 148811 \| PM20D1 \| 1.946 \| DISEASES 10654 \| PMVK \| 1.005 \| DISEASES 5420 \| PODXL \| 3.5 \| DISEASES 5447 \| POR \| 1.347 \| DISEASES 11281 \| POU6F2 \| 3.9 \| DISEASES 5532 \| PPP3CB \| 1.052 \| DISEASES 23532 \| PRAME \| 2.722 \| DISEASES 58531 \| PRM3 \| 1.915 \| DISEASES 5727 \| PTCH1 \| 1.153 \| DISEASES 5764 \| PTN \| 1.683 \| DISEASES 5788 \| PTPRC \| 1.454 \| DISEASES 23475 \| QPRT \| 1.185 \| DISEASES 11186 \| RASSF1 \| 1.54 \| DISEASES 5931 \| RBBP7 \| 3.021 \| DISEASES 5973 \| RENBP \| 2.672 \| DISEASES 6023 \| RMRP \| 3.149 \| DISEASES 6029 \| RN7SL1 \| 5.056 \| DISEASES 6029 \| RN7SL1 \| 1.388 \| DISEASES 862 \| RUNX1T1 \| 1.542 \| DISEASES 6275 \| S100A4 \| 1.153 \| DISEASES 9294 \| S1PR2 \| 1.197 \| DISEASES 6297 \| SALL2 \| 1.989 \| DISEASES 5003 \| SLC22A18AS \| 2.518 \| DISEASES 6533 \| SLC6A6 \| 1.517 \| DISEASES 9748 \| SLK \| 1.494 \| DISEASES 23161 \| SNX13 \| 2.072 \| DISEASES 6666 \| SOX12 \| 1.71 \| DISEASES 6665 \| SOX15 \| 1.419 \| DISEASES 6736 \| SRY \| 2.975 \| DISEASES 727837 \| SSX2B \| 1.615 \| DISEASES 54823 \| SWT1 \| 3.349 \| DISEASES 11346 \| SYNPO \| 4.028 \| DISEASES 9096 \| TBX18 \| 1.439 \| DISEASES 256536 \| TCERG1L \| 1.688 \| DISEASES 7016 \| TESK1 \| 1.175 \| DISEASES 54790 \| TET2 \| 1.92 \| DISEASES 9967 \| THRAP3 \| 1.682 \| DISEASES 7091 \| TLE4 \| 1.001 \| DISEASES 3604 \| TNFRSF9 \| 1.385 \| DISEASES 10953 \| TOMM34 \| 1.368 \| DISEASES 10346 \| TRIM22 \| 2.148 \| DISEASES 7260 \| TSSC1 \| 2.279 \| DISEASES 7422 \| VEGFA \| 2.282 \| DISEASES 7481 \| WNT11 \| 1.38 \| DISEASES 7490 \| WT1 \| 8.453 \| DISEASES 7490 \| WT1 \| 3.564 \| DISEASES 51352 \| WT1-AS \| 4.701 \| DISEASES 9589 \| WTAP \| 4.929 \| DISEASES 25844 \| YIPF3 \| 3.667 \| DISEASES 79670 \| ZCCHC6 \| 5.253 \| DISEASES 23414 \| ZFPM2 \| 1.47 \| DISEASES 339318 \| ZNF181 \| 2.75 \| DISEASES 51222 \| ZNF219 \| 2.516 \| DISEASES 7767 \| ZNF224 \| 3.149 \| DISEASES 10782 \| ZNF274 \| 2.362 \| DISEASES 55900 \| ZNF302 \| 2.75 \| DISEASES 23567 \| ZNF346 \| 1.754 \| DISEASES 6940 \| ZNF354A \| 1.702 \| DISEASES 57862 \| ZNF410 \| 1.615 \| DISEASES 51710 \| ZNF44 \| 1.579 \| DISEASES 115560 \| ZNF501 \| 1.62 \| DISEASES 148266 \| ZNF569 \| 1.592 \| DISEASES 148103 \| ZNF599 \| 2.75 \| DISEASES 284390 \| ZNF763 \| 1.62 \| DISEASES 57829 \| ZP4 \| 1.237 \| DISEASES
Locus	Symbol \| Locus(Total Locus:5) DIS3L2 \| 2q37.1 REST \| 4q12 WT1 \| 11p13 H19 \| 11p15.5 POU6F2 \| 7p14.1

Disease ID	117
Disease	nephroblastoma
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:12) HP:0002716 \| Lymphadenopathy HP:0100526 \| Neoplasm of the lung HP:0002664 \| Neoplasm HP:0002667 \| Nephroblastoma HP:0000526 \| Aniridia HP:0002896 \| Neoplasm of the liver HP:0002027 \| Abdominal pain HP:0000822 \| Hypertension HP:0001824 \| Weight loss HP:0001945 \| Fever HP:0000790 \| Hematuria HP:0002667 \| Wilms tumor
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:54) HP:0002664 \| Neoplasia \| 13 HP:0000822 \| Hypertension \| 3 HP:0100242 \| Sarcoma \| 3 HP:0002667 \| Wilms tumor \| 2 HP:0030731 \| Carcinoma \| 2 HP:0000085 \| Horseshoe kidney \| 2 HP:0100528 \| Pleuropulmonary blastoma \| 2 HP:0005584 \| Renal cell carcinoma \| 2 HP:0012254 \| Ewing's sarcoma \| 2 HP:0000123 \| Nephritis \| 2 HP:0004808 \| Acute myelogenous leukemia \| 2 HP:0008643 \| Nephroblastomatosis \| 2 HP:0001909 \| Leukemia \| 2 HP:0000107 \| Renal cyst \| 2 HP:0000100 \| Nephrosis \| 2 HP:0100880 \| Nephrogenic rest \| 2 HP:0011796 \| Perilobar nephrogenic rests \| 1 HP:0001251 \| Ataxia \| 1 HP:0001399 \| Liver failure \| 1 HP:0012588 \| Steroid-resistant nephrotic syndrome \| 1 HP:0006743 \| Embryonal rhabdomyosarcoma \| 1 HP:0003006 \| Neuroblastoma \| 1 HP:0004448 \| Fulminant hepatic failure \| 1 HP:0001009 \| Telangiectases \| 1 HP:0009733 \| Glioma \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0001959 \| Polydipsia \| 1 HP:0008071 \| Maternal hypertension \| 1 HP:0001409 \| Portal hypertension \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0006254 \| Increased serum alpha-fetoprotein \| 1 HP:0002861 \| Melanoma \| 1 HP:0002176 \| Spinal cord compression \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0001903 \| Anemia \| 1 HP:0030767 \| Epignathus \| 1 HP:0007281 \| Developmental stagnation \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0001943 \| Hypoglycemia \| 1 HP:0006765 \| Chondrosarcoma \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0000110 \| Renal dysplasia \| 1 HP:0001578 \| Hypercortisolism \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0001520 \| Birthweight > 90th percentile \| 1 HP:0000028 \| Cryptorchidism \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0002859 \| Rhabdomyosarcoma \| 1 HP:0000103 \| Polyuria \| 1 HP:0010550 \| Paraplegia \| 1 HP:0006772 \| Angiomyolipoma \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0006744 \| Adrenal carcinoma \| 1

Disease ID	117
Disease	nephroblastoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:7) C0494165 \| liver metastases C0494165 \| hepatic metastases C0406657 \| self-healing juvenile cutaneous mucinosis C0302148 \| thrombus C0153690 \| bone metastases C0020437 \| hypercalcemia C0002793 \| anaplasia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:8) C0002793 \| anaplasia \| 4 C0020538 \| hypertension \| 3 C0085602 \| polydipsia \| 1 C0022661 \| end stage renal disease \| 1 C0030486 \| paraplegia \| 1 C0950121 \| drash syndrome \| 1 C0035078 \| renal failure \| 1 C0040053 \| thrombus \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:14)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1051266	25536437	4524	MTHFR	umls:C0027708	BeFree	The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.	0.002909916	2015	SLC19A1	21	45537880	T	C
rs16754	21189390	7490	WT1	umls:C0027708	BeFree	To analyze the prevalence and clinical implications of Wilms' tumor 1 (WT1) single nucleotide polymorphism (SNP) rs16754 in the context of other prognostic markers in pediatric acute myeloid leukemia (AML).	0.444098287	2011	WT1	11	32396399	T	C
rs16754	21659357	7490	WT1	umls:C0027708	BeFree	Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.	0.444098287	2011	WT1	11	32396399	T	C
rs1801133	25536437	4524	MTHFR	umls:C0027708	BeFree	The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.	0.002909916	2015	MTHFR	1	11796321	G	A
rs2234584	15150775	7490	WT1	umls:C0027708	UNIPROT	Twenty-four new cases of WT1 germline mutations and review of the literature: genotype/phenotype correlations for Wilms tumor development.	0.444098287	2004	WT1	11	32428521	G	T,A
rs2283873	22544364	6948	TCN2	umls:C0027708	GWASCAT	A genome-wide association study identifies susceptibility loci for Wilms tumor.	0.12	2012	TCN2	22	30617309	G	A
rs2495478	22544364	255738	PCSK9	umls:C0027708	GWASCAT	A genome-wide association study identifies susceptibility loci for Wilms tumor.	0.12	2012	PCSK9	1	55047322	G	A
rs2857461	21793187	2130	EWSR1	umls:C0027708	BeFree	One SNP in EWSR1 (rs2857461) showed a low level of statistical association with the diagnosis of Ewing sarcoma compared to Wilms tumor.	0.002442977	2012	EWSR1	22	29272015	C	T
rs368087026	25536437	4524	MTHFR	umls:C0027708	BeFree	The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.	0.002909916	2015	SLC19A1	21	45530890	G	A
rs3755132	22544364	1653	DDX1	umls:C0027708	GWASCAT	A genome-wide association study identifies susceptibility loci for Wilms tumor.	0.12	2012	DDX1	2	15589696	T	G
rs386514057	25536437	4524	MTHFR	umls:C0027708	BeFree	The aim of this study was to investigate the association between MTHFR rs1801133 (C677T) and RFC-1 rs1051266 (G80A) genotypes with the risk of developing nephroblastoma and neuroblastoma.	0.002909916	2015	NA	NA	NA	NA	NA
rs5955543	22544364	4810	NHS	umls:C0027708	GWASCAT	A genome-wide association study identifies susceptibility loci for Wilms tumor.	0.12	2012	NHS	X	17680277	A	G
rs662	24972570	5444	PON1	umls:C0027708	BeFree	The presence of at least one variant PON1 rs662 R allele increased the risk of developing Wilms´ Tumor although without statistical power.	0.000271442	2014	PON1	7	95308134	T	C
rs790356	22544364	1740	DLG2	umls:C0027708	GWASCAT	A genome-wide association study identifies susceptibility loci for Wilms tumor.	0.12	2012	DLG2;LOC105369418	11	83909744	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:51)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	55512995	rs2495478	G	A	rs2495478	22544364	1.00E-07	NA	1.4	[1.15-1.72]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs2495478-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	PCSK9
2	15729820	rs3755132	T	G	rs3755132	22544364	1.00E-14	NA	1.45	[1.29-1.64]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs3755132-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	NA
2	15737343	rs2302930	A	G	rs2302930	22544364	3.10E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	DDX1
2	15737480	rs2302931	C	A	rs2302931	22544364	3.10E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	DDX1
2	15750443	rs4668942	T	C	rs4668942	22544364	3.10E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	DDX1
2	15750640	rs7594193	A	G	rs7594193	22544364	3.10E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	DDX1
2	15758293	rs3770466	T	C	rs3770466	22544364	3.10E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	DDX1
2	15762935	rs3770467	G	A	rs3770467	22544364	3.14E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	DDX1
2	15763788	rs41264163	C	T	rs41264163	22544364	3.14E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	DDX1
2	15764078	rs4668945	G	C	rs4668945	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	DDX1
2	15765425	rs6734471	C	T	rs6734471	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	DDX1
2	15767761	rs6743036	G	A	rs6743036	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	NA	DDX1
2	15768256	rs6743630	G	A	rs6743630	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	DDX1
2	15770507	rs3770470	G	T	rs3770470	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	DDX1
2	15770775	rs3770471	C	T	rs3770471	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	DDX1
2	15771586	rs4668948	A	C	rs4668948	22544364	2.55E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NA
2	15771615	rs4668949	C	T	rs4668949	22544364	1.51E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NA
2	15772546	rs976015	C	G	rs976015	22544364	3.14E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NA
2	15772958	rs16862822	G	A	rs16862822	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	NA
2	15774115	rs976233	C	T	rs976233	22544364	3.34E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NA
2	15775210	rs16862823	T	C	rs16862823	22544364	3.14E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NA
2	15782471	rs807624	G	T	rs807624	22544364	1.00E-14	NA	1.33	[1.22-1.45]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs807624-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NA
2	15786243	rs6724800	A	G	rs6724800	22544364	1.86E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NA
2	15788191	rs16862838	C	T	rs16862838	22544364	1.71E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NA
2	15789441	rs4668458	G	A	rs4668458	22544364	2.22E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	NA
2	15791937	rs6431721	C	T	rs6431721	22544364	2.66E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NA
5	91845809	rs6887553	A	G	rs6887553	22544364	5.35E-10	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	NA
5	91859029	rs10060683	T	C	rs10060683	22544364	2.41E-10	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NA
5	91893792	rs1027643	C	T	rs1027643	22544364	5.00E-10	NA	1.43	[1.18-1.73]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs1027643-T	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NA
5	91904447	rs61344503	G	T	rs61344503	22544364	2.40E-10	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NA
5	91907006	rs2221269	A	G	rs2221269	22544364	1.45E-10	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NA
11	83620787	rs790356	A	G	rs790356	22544364	4.00E-15	NA	1.28	[1.17-1.39]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs790356-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	DLG2
22	31009839	rs11913239	C	T	rs11913239	22544364	6.49E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31010997	rs2267162	C	T	rs2267162	22544364	1.12E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31011280	rs7290898	A	C,G,T	rs7290898	22544364	2.97E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31011923	rs16988855	T	C	rs16988855	22544364	5.40E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31013296	rs2283873	G	A	rs2283873	22544364	5.00E-12	NA	2.05	[1.57-2.69]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs2283873-A	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31014377	rs2009857	C	T	rs2009857	22544364	5.40E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	TCN2
22	31015562	rs7288627	G	A	rs7288627	22544364	5.40E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	TCN2
22	31015573	rs7288385	C	A	rs7288385	22544364	5.40E-09	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	TCN2
22	31018072	rs8141515	T	C	rs8141515	22544364	1.17E-08	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	TCN2
22	31018078	rs2267166	G	A	rs2267166	22544364	1.17E-08	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G	TCN2
22	31022733	rs2072195	A	T	rs2072195	22544364	1.13E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	TCN2
X	17669042	rs4825280	T	A	rs4825280	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NHS
X	17677803	rs978158	A	T	rs978158	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NHS
X	17692151	rs6633014	C	T	rs6633014	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NHS
X	17693746	rs5955717	C	T	rs5955717	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T	NHS
X	17695190	rs5955731	C	A	rs5955731	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NHS
X	17698397	rs5955543	A	G	rs5955543	22544364	1.00E-09	NA	2.64	[1.74-4.01]	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	rs5955543-G	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NHS
X	17699505	rs12392874	C	A	rs12392874	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C	NHS
X	17699834	rs4825243	C	A	rs4825243	22544364	2.54E-06	NA	NA	NA	757 European ancestry cases; 1,879 European ancestry controls	European(2636)	ALL(2636)	EUR(2636)	ALL(2636)	Wilms tumor	HPOID:0002667	Nephroblastoma (Wilms tumor)	DOID:2154	nephroblastoma	D009396	Wilms Tumor	nephroblastoma	Nephroblastoma	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A	NHS

Mapped by lexical matching(Total Items:2)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0100526	Neoplasm of the lung	MP:0004500	increased incidence of tumors by ionizing radiation induction	higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays
HP:0001824	Weight loss	MP:0005114	premature hair loss	release of fur at an earlier than expected time

Mapped by homologous gene(Total Items:10)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0000790	Hematuria	MP:0020316	decreased vascular endothelial cell proliferation	decrease in the expansion rate of any vascular endothelial cell population by cell division
HP:0001945	Fever	MP:0020254	decreased collagen level	decreased level of the main structural protein of the various connective tissues in animals
HP:0001824	Weight loss	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0002664	Neoplasm	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0000526	Aniridia	MP:0014164	abnormal ciliary process morphology	any structural anomaly of any of the pigmented processes that radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye; these processes increase in thickness as they advance from the orbiculus ciliaris to the exter
HP:0002027	Abdominal pain	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0002716	Lymphadenopathy	MP:0020215	impaired blood coagulation	impaired ability of the blood to clot
HP:0100526	Neoplasm of the lung	MP:0014179	abnormal blood-retinal barrier function	anomaly in the function of the part of the blood-ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina; the BRB consists of non-fenestrated capillaries of the retinal ci
HP:0000822	Hypertension	MP:0020216	decreased circulating complement protein level	less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes
HP:0002667	Nephroblastoma (Wilms tumor)	MP:0013886	increased CD4-negative, CD25-positive NK T cell number	increase in the number of CD4-negative NK T cells expressing the activation marker CD25

Disease ID	117
Disease	nephroblastoma
Case	(Waiting for update.)