eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| myeloid leukemia | ||||
| Disease ID | 705 |
|---|---|
| Disease | myeloid leukemia |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:6) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:6) C0009450 | infection | 15 C0005699 | blast crisis | 14 C0019080 | hemorrhage | 3 C0152276 | chloroma | 2 C0012739 | disseminated intravascular coagulation (dic) | 1 C0836924 | thrombocythemia | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:14) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs10514611 | 24886876 | 3394 | IRF8 | umls:C0023470 | BeFree | In adult myeloid leukemias we found significant associations between the variant allele of PML_rs9479 and decreased AML risk (OR = 0.61 (0.38-0.97), and between variant alleles of IRF8_ rs10514611 and ARHGAP26_rs187729 and increased CML risk (OR = 2.4 (1.12-5.15) and 1.63 (1.07-2.47), respectively). | 0.000814326 | 2014 | IRF8 | 16 | 85921636 | C | T |
| rs10514611 | 24886876 | 5371 | PML | umls:C0023470 | BeFree | In adult myeloid leukemias we found significant associations between the variant allele of PML_rs9479 and decreased AML risk (OR = 0.61 (0.38-0.97), and between variant alleles of IRF8_ rs10514611 and ARHGAP26_rs187729 and increased CML risk (OR = 2.4 (1.12-5.15) and 1.63 (1.07-2.47), respectively). | 0.001357209 | 2014 | IRF8 | 16 | 85921636 | C | T |
| rs10514611 | 24886876 | 23092 | ARHGAP26 | umls:C0023470 | BeFree | In adult myeloid leukemias we found significant associations between the variant allele of PML_rs9479 and decreased AML risk (OR = 0.61 (0.38-0.97), and between variant alleles of IRF8_ rs10514611 and ARHGAP26_rs187729 and increased CML risk (OR = 2.4 (1.12-5.15) and 1.63 (1.07-2.47), respectively). | 0.000271442 | 2014 | IRF8 | 16 | 85921636 | C | T |
| rs187729 | 24886876 | 3394 | IRF8 | umls:C0023470 | BeFree | In adult myeloid leukemias we found significant associations between the variant allele of PML_rs9479 and decreased AML risk (OR = 0.61 (0.38-0.97), and between variant alleles of IRF8_ rs10514611 and ARHGAP26_rs187729 and increased CML risk (OR = 2.4 (1.12-5.15) and 1.63 (1.07-2.47), respectively). | 0.000814326 | 2014 | ARHGAP26 | 5 | 143226004 | C | T |
| rs187729 | 24886876 | 23092 | ARHGAP26 | umls:C0023470 | BeFree | In adult myeloid leukemias we found significant associations between the variant allele of PML_rs9479 and decreased AML risk (OR = 0.61 (0.38-0.97), and between variant alleles of IRF8_ rs10514611 and ARHGAP26_rs187729 and increased CML risk (OR = 2.4 (1.12-5.15) and 1.63 (1.07-2.47), respectively). | 0.000271442 | 2014 | ARHGAP26 | 5 | 143226004 | C | T |
| rs187729 | 24886876 | 5371 | PML | umls:C0023470 | BeFree | In adult myeloid leukemias we found significant associations between the variant allele of PML_rs9479 and decreased AML risk (OR = 0.61 (0.38-0.97), and between variant alleles of IRF8_ rs10514611 and ARHGAP26_rs187729 and increased CML risk (OR = 2.4 (1.12-5.15) and 1.63 (1.07-2.47), respectively). | 0.001357209 | 2014 | ARHGAP26 | 5 | 143226004 | C | T |
| rs35602083 | 16320249 | 2322 | FLT3 | umls:C0023470 | BeFree | D324N single-nucleotide polymorphism in the FLT3 gene is associated with higher risk of myeloid leukemias. | 0.056970589 | 2006 | FLT3 | 13 | 28049450 | C | T |
| rs386626619 | 19254349 | 3717 | JAK2 | umls:C0023470 | BeFree | The association of V617F JAK2 expression levels with disease behavior has not been studied in patients with nonchronic myelogenous leukemia (CML) myeloproliferative disease (MPD). | 0.01801231 | 2010 | NA | NA | NA | NA | NA |
| rs386626619 | 22579713 | 3717 | JAK2 | umls:C0023470 | BeFree | GVS inhibited colony formation and proliferation and induced apoptosis at doses two- to threefold lower in a panel of JAK2(V617F) MPN compared to JAK2 wild-type myeloid leukemia cell lines. | 0.01801231 | 2012 | NA | NA | NA | NA | NA |
| rs77375493 | 19254349 | 3717 | JAK2 | umls:C0023470 | BeFree | The association of V617F JAK2 expression levels with disease behavior has not been studied in patients with nonchronic myelogenous leukemia (CML) myeloproliferative disease (MPD). | 0.01801231 | 2010 | JAK2;INSL6 | 9 | 5073770 | G | A,T |
| rs77375493 | 22579713 | 3717 | JAK2 | umls:C0023470 | BeFree | GVS inhibited colony formation and proliferation and induced apoptosis at doses two- to threefold lower in a panel of JAK2(V617F) MPN compared to JAK2 wild-type myeloid leukemia cell lines. | 0.01801231 | 2012 | JAK2;INSL6 | 9 | 5073770 | G | A,T |
| rs9479 | 24886876 | 23092 | ARHGAP26 | umls:C0023470 | BeFree | In adult myeloid leukemias we found significant associations between the variant allele of PML_rs9479 and decreased AML risk (OR = 0.61 (0.38-0.97), and between variant alleles of IRF8_ rs10514611 and ARHGAP26_rs187729 and increased CML risk (OR = 2.4 (1.12-5.15) and 1.63 (1.07-2.47), respectively). | 0.000271442 | 2014 | PML | 15 | 74036235 | A | G |
| rs9479 | 24886876 | 3394 | IRF8 | umls:C0023470 | BeFree | In adult myeloid leukemias we found significant associations between the variant allele of PML_rs9479 and decreased AML risk (OR = 0.61 (0.38-0.97), and between variant alleles of IRF8_ rs10514611 and ARHGAP26_rs187729 and increased CML risk (OR = 2.4 (1.12-5.15) and 1.63 (1.07-2.47), respectively). | 0.000814326 | 2014 | PML | 15 | 74036235 | A | G |
| rs9479 | 24886876 | 5371 | PML | umls:C0023470 | BeFree | In adult myeloid leukemias we found significant associations between the variant allele of PML_rs9479 and decreased AML risk (OR = 0.61 (0.38-0.97), and between variant alleles of IRF8_ rs10514611 and ARHGAP26_rs187729 and increased CML risk (OR = 2.4 (1.12-5.15) and 1.63 (1.07-2.47), respectively). | 0.001357209 | 2014 | PML | 15 | 74036235 | A | G |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
| Disease ID | 705 |
|---|---|
| Disease | myeloid leukemia |
| Case | (Waiting for update.) |