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	mycosis fungoides

Disease ID	216
Disease	mycosis fungoides
Definition	A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.
Synonym	[m]mycosis fungoides [m]mycosis fungoides (disorder) [m]mycosis fungoides nos [m]mycosis fungoides nos (morphologic abnormality) ctcl/ mycosis fungoides cutaneous t-cell lymphoma/mycosis fungoides granuloma, fungoides mf - mycosis fungoides mycosis fungoides (clinical) mycosis fungoides (disorder) mycosis fungoides (morphologic abnormality) mycosis fungoides [disease/finding] mycosis fungoides lymphoma mycosis fungoides nos mycosis fungoides nos (disorder) mycosis fungoides of unspecified site mycosis fungoides of unspecified site (disorder)
OMIM	OMIM:254400
DOID	DOID:8691
UMLS	C0026948
MeSH	D009182
SNOMED-CT	SNOMEDCT_US_2016_09_01:118618005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:40) C0002173 \| follicular mucinosis \| 5 C0024299 \| lymphoma \| 4 C0162855 \| mucinosis \| 4 C1276146 \| cutaneous lymphoma \| 2 C0002726 \| amyloidosis \| 2 C0036920 \| sezary syndrome \| 1 C0037315 \| sleep apnea \| 1 C0002170 \| alopecia \| 1 C0334254 \| lymphoepithelioma \| 1 C0039590 \| testicular cancer \| 1 C0206180 \| anaplastic large-cell lymphoma \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0024299 \| lymphomas \| 1 C0520679 \| obstructive sleep apnea \| 1 C0079773 \| cutaneous t-cell lymphoma \| 1 C0000889 \| acanthosis nigricans \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0022658 \| nephropathy \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0019829 \| hodgkin lymphoma \| 1 C1302772 \| primary cutaneous lymphoma \| 1 C0016436 \| folliculitis \| 1 C0037274 \| dermatosis \| 1 C0023348 \| lepromatous leprosy \| 1 C0409974 \| lupus erythematosus \| 1 C0037998 \| splenic infarction \| 1 C0042373 \| vascular disease \| 1 C0017661 \| iga nephropathy \| 1 C0023434 \| chronic lymphocytic leukaemia \| 1 C0020437 \| hypercalcemia \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0030805 \| bullous pemphigoid \| 1 C0021843 \| bowel obstruction \| 1 C0007222 \| cardiovascular disease \| 1 C0152965 \| staphylococcal sepsis \| 1 C0023448 \| lymphocytic leukaemia \| 1 C0206141 \| hypereosinophilic syndrome \| 1 C0011603 \| dermatitis \| 1 C0268397 \| cutaneous amyloidosis \| 1 C1332362 \| b-cell neoplasm \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 7133 \| TNFRSF1B \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:102) 238 \| ALK \| 3.154 \| DISEASES 51378 \| ANGPT4 \| 1.586 \| DISEASES 488 \| ATP2A2 \| 1.054 \| DISEASES 567 \| B2M \| 1.988 \| DISEASES 85316 \| BAGE5 \| 1.045 \| DISEASES 64919 \| BCL11B \| 1.864 \| DISEASES 605 \| BCL7A \| 2.844 \| DISEASES 1232 \| CCR3 \| 2.626 \| DISEASES 1237 \| CCR8 \| 1.726 \| DISEASES 9332 \| CD163 \| 2.221 \| DISEASES 930 \| CD19 \| 1.175 \| DISEASES 914 \| CD2 \| 4.303 \| DISEASES 50489 \| CD207 \| 2.672 \| DISEASES 51744 \| CD244 \| 1.015 \| DISEASES 959 \| CD40LG \| 2.189 \| DISEASES 921 \| CD5 \| 4.265 \| DISEASES 1043 \| CD52 \| 3.455 \| DISEASES 1029 \| CDKN2A \| 2.2 \| DISEASES 170482 \| CLEC4C \| 1.65 \| DISEASES 1380 \| CR2 \| 1.31 \| DISEASES 4283 \| CXCL9 \| 2.165 \| DISEASES 2833 \| CXCR3 \| 3.335 \| DISEASES 26052 \| DNM3 \| 1.564 \| DISEASES 1791 \| DNTT \| 1.66 \| DISEASES 1803 \| DPP4 \| 3.008 \| DISEASES 56940 \| DUSP22 \| 3.016 \| DISEASES 10938 \| EHD1 \| 1.416 \| DISEASES 30816 \| ERVW-1 \| 2.867 \| DISEASES 355 \| FAS \| 2.205 \| DISEASES 100302740 \| FAS-AS1 \| 1.456 \| DISEASES 2214 \| FCGR3A \| 1.816 \| DISEASES 115352 \| FCRL3 \| 1.778 \| DISEASES 50943 \| FOXP3 \| 3.062 \| DISEASES 6624 \| FSCN1 \| 1.451 \| DISEASES 2526 \| FUT4 \| 2.628 \| DISEASES 2533 \| FYB \| 1.092 \| DISEASES 2625 \| GATA3 \| 1.276 \| DISEASES 51696 \| HECA \| 3.605 \| DISEASES 3440 \| IFNA2 \| 2.114 \| DISEASES 338376 \| IFNE \| 1.544 \| DISEASES 147920 \| IGFL2 \| 3.026 \| DISEASES 3586 \| IL10 \| 1.672 \| DISEASES 112744 \| IL17F \| 1.536 \| DISEASES 3559 \| IL2RA \| 1.632 \| DISEASES 3561 \| IL2RG \| 1.051 \| DISEASES 386653 \| IL31 \| 2.391 \| DISEASES 9235 \| IL32 \| 2.218 \| DISEASES 3662 \| IRF4 \| 2.427 \| DISEASES 3676 \| ITGA4 \| 1.968 \| DISEASES 3683 \| ITGAL \| 1.64 \| DISEASES 3684 \| ITGAM \| 1.09 \| DISEASES 3718 \| JAK3 \| 1.799 \| DISEASES 3811 \| KIR3DL1 \| 2.603 \| DISEASES 3812 \| KIR3DL2 \| 4.354 \| DISEASES 3838 \| KPNA2 \| 1.072 \| DISEASES 54900 \| LAX1 \| 2.147 \| DISEASES 51213 \| LUZP4 \| 1.705 \| DISEASES 407975 \| MIR17HG \| 1.219 \| DISEASES 4311 \| MME \| 2.246 \| DISEASES 4507 \| MTAP \| 2.239 \| DISEASES 4609 \| MYC \| 1.913 \| DISEASES 89795 \| NAV3 \| 3.551 \| DISEASES 64332 \| NFKBIZ \| 1.195 \| DISEASES 4942 \| OAT \| 3.196 \| DISEASES 56666 \| PANX2 \| 1.592 \| DISEASES 5079 \| PAX5 \| 1.955 \| DISEASES 5133 \| PDCD1 \| 1.244 \| DISEASES 5358 \| PLS3 \| 3.949 \| DISEASES 5406 \| PNLIP \| 2.107 \| DISEASES 5788 \| PTPRC \| 3.025 \| DISEASES 5793 \| PTPRG \| 1.296 \| DISEASES 9349 \| RPL23 \| 1.822 \| DISEASES 6257 \| RXRB \| 1.391 \| DISEASES 6278 \| S100A7 \| 1.436 \| DISEASES 6280 \| S100A9 \| 1.882 \| DISEASES 6304 \| SATB1 \| 2.219 \| DISEASES 6401 \| SELE \| 1.501 \| DISEASES 140885 \| SIRPA \| 1.443 \| DISEASES 8631 \| SKAP1 \| 2.048 \| DISEASES 23583 \| SMUG1 \| 1.217 \| DISEASES 26801 \| SNORD48 \| 1.52 \| DISEASES 54345 \| SOX18 \| 1.265 \| DISEASES 6693 \| SPN \| 2.561 \| DISEASES 6759 \| SSX4 \| 1.228 \| DISEASES 548313 \| SSX4B \| 1.234 \| DISEASES 6775 \| STAT4 \| 2.25 \| DISEASES 6776 \| STAT5A \| 2.176 \| DISEASES 6847 \| SYCP1 \| 1.882 \| DISEASES 7037 \| TFRC \| 1.095 \| DISEASES 7060 \| THBS4 \| 1.272 \| DISEASES 387357 \| THEMIS \| 2.95 \| DISEASES 7072 \| TIA1 \| 4.163 \| DISEASES 7110 \| TMF1 \| 4.12 \| DISEASES 7124 \| TNF \| 1.495 \| DISEASES 7133 \| TNFRSF1B \| 1.355 \| DISEASES 7293 \| TNFRSF4 \| 2.027 \| DISEASES 9760 \| TOX \| 3.854 \| DISEASES 80342 \| TRAF3IP3 \| 2.855 \| DISEASES 80705 \| TSGA10 \| 2.131 \| DISEASES 9094 \| UNC119 \| 1.022 \| DISEASES 10497 \| UNC13B \| 1.488 \| DISEASES 7694 \| ZNF135 \| 1.104 \| DISEASES
Locus	(Waiting for update.)

Disease ID	216
Disease	mycosis fungoides
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:7) HP:0010783 \| Erythema HP:0200035 \| Skin plaque HP:0002665 \| Lymphoma HP:0000964 \| Eczema HP:0002716 \| Lymph node hyperplasia HP:0000989 \| pruritis HP:0008069 \| Neoplasm of the skin
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:24) HP:0002665 \| Lymphoma \| 4 HP:0012190 \| T cell lymphoma \| 3 HP:0001596 \| Hair loss \| 2 HP:0011034 \| Amyloid disease \| 2 HP:0002721 \| Immunodeficiency \| 1 HP:0000112 \| Nephropathy \| 1 HP:0030731 \| Carcinoma \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0003072 \| Hypercalcemia \| 1 HP:0002835 \| Aspiration \| 1 HP:0012192 \| Cutaneous T-cell lymphoma \| 1 HP:0012309 \| Cutaneous amyloidosis \| 1 HP:0000966 \| Decreased sweating \| 1 HP:0012193 \| Anaplastic large-cell lymphoma \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0000956 \| Keratosis nigricans \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0010535 \| Sleep apnea \| 1 HP:0001880 \| Eosinophilia \| 1 HP:0002664 \| Neoplasia \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0002870 \| Obstructive sleep apnea \| 1 HP:0010783 \| Erythema \| 1

Disease ID	216
Disease	mycosis fungoides
Manually Symptom	UMLS \| Name(Total Manually Symptoms:77) C2717981 \| poromas C2697310 \| sarcoidosis C2240374 \| eosinophilia C2116082 \| thyroid nodule C1963254 \| tumor lysis syndrome C1963139 \| hypopigmentation C1565489 \| renal insufficiency C1373218 \| immunosuppression C1368404 \| hypopharyngeal carcinoma C1367970 \| pagetoid reticulosis C1336753 \| lymphoma of the thyroid gland C1333177 \| lymphoproliferative disorder of the skin C1000483 \| anemia C0936250 \| eczema herpeticum C0920350 \| hashimoto thyroiditis C0870082 \| hyperkeratosis C0748159 \| pulmonary involvement C0545080 \| composite lymphoma C0497156 \| lymphadenopathy C0475858 \| generalized pruritus C0442874 \| neuropathy C0403766 \| phimosis C0272398 \| dermatopathic lymphadenopathy C0271683 \| motor polyneuropathy C0268749 \| immunotactoid glomerulopathy C0268397 \| cutaneous amyloidosis C0263396 \| pigmented purpuric eruption C0238790 \| bone destruction C0238419 \| fournier's gangrene C0235896 \| lung infiltration C0221348 \| yellow nail syndrome C0221207 \| cold urticaria C0206744 \| idiopathic cd4+ t lymphocytopenia C0206182 \| lymphomatoid papulosis C0162855 \| mucinosis C0155365 \| disorder of vitreous C0150988 \| sclerodactyly C0085636 \| light sensitivity C0079772 \| t-cell lymphomas C0051981 \| leprosy C0043325 \| xanthomatosis C0042338 \| herpes zoster C0037926 \| spinal cord compression C0037299 \| skin ulcers C0037285 \| skin manifestation C0037284 \| skin lesions C0031117 \| peripheral neuropathy C0029166 \| oral manifestations C0027697 \| nephritis C0025202 \| malignant melanoma C0024958 \| maxillary sinus tumor C0024299 \| lymphomas C0024299 \| lymphoma C0022660 \| acute renal failure C0022603 \| seborrheic keratosis C0022568 \| keratitis C0022504 \| kaposi's varicelliform eruption C0022354 \| obstructive jaundice C0021843 \| intestinal obstruction C0021051 \| immunologic deficiency syndromes C0020598 \| hypocalcemia C0020097 \| htlv-i infection C0020097 \| htlv-i C0019829 \| hodgkin's lymphoma C0019829 \| hodgkin's disease C0019829 \| hodgkin lymphoma C0019372 \| herpes infection C0010043 \| ulcerative keratitis C0008489 \| chorea C0007137 \| squamous cell carcinomas C0007117 \| basal cell carcinomas C0003864 \| arthritis C0002880 \| autoimmune hemolytic anemia C0002514 \| hyperaminoaciduria C0002173 \| follicular mucinosis C0002173 \| alopecia mucinosa C0000889 \| acanthosis nigricans
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:11) C0002173 \| follicular mucinosis \| 5 C0162855 \| mucinosis \| 4 C0024299 \| lymphoma \| 4 C0206182 \| lymphomatoid papulosis \| 2 C0024299 \| lymphomas \| 1 C0014457 \| eosinophilia \| 1 C0019829 \| hodgkin lymphoma \| 1 C0000889 \| acanthosis nigricans \| 1 C1367970 \| pagetoid reticulosis \| 1 C0268397 \| cutaneous amyloidosis \| 1 C1333177 \| lymphoproliferative disorder of the skin \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:6)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1042522	17107393	7157	TP53	umls:C0026948	BeFree	Association of p53 Arg72Pro polymorphism and beta-catenin accumulation in mycosis fungoides.	0.001900093	2006	TP53	17	7676154	G	T,C
rs112445441	21209378	64061	TSPYL2	umls:C0026948	BeFree	One mycosis fungoides and one pleomorphic CTCL harbored a KRAS(G13D) mutation; one Sézary syndrome and one CD30(+) CTCL harbored a NRAS(Q61K) amino acid change.	0.000814326	2011	KRAS	12	25245347	C	A,G,T
rs11540654	17107393	7157	TP53	umls:C0026948	BeFree	Association of p53 Arg72Pro polymorphism and beta-catenin accumulation in mycosis fungoides.	0.001900093	2006	TP53	17	7676040	C	T,G,A
rs121434596	21209378	64061	TSPYL2	umls:C0026948	BeFree	One mycosis fungoides and one pleomorphic CTCL harbored a KRAS(G13D) mutation; one Sézary syndrome and one CD30(+) CTCL harbored a NRAS(Q61K) amino acid change.	0.000814326	2011	NRAS	1	114716123	C	T,G,A
rs121913238	21209378	64061	TSPYL2	umls:C0026948	BeFree	One mycosis fungoides and one pleomorphic CTCL harbored a KRAS(G13D) mutation; one Sézary syndrome and one CD30(+) CTCL harbored a NRAS(Q61K) amino acid change.	0.000814326	2011	KRAS	12	25227343	G	T,C
rs121913254	21209378	64061	TSPYL2	umls:C0026948	BeFree	One mycosis fungoides and one pleomorphic CTCL harbored a KRAS(G13D) mutation; one Sézary syndrome and one CD30(+) CTCL harbored a NRAS(Q61K) amino acid change.	0.000814326	2011	NRAS	1	114713909	G	T,C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0008069	Neoplasm of the skin	MP:0011205	excessive folding of visceral yolk sac	the appearance of wrinkles or folds on the surface of the visceral yolk sac

Mapped by homologous gene(Total Items:6)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0008069	Neoplasm of the skin	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0000989	Pruritus	MP:0020254	decreased collagen level	decreased level of the main structural protein of the various connective tissues in animals
HP:0000964	Eczema	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0010783	Erythema	MP:0013781	abnormal mammary gland luminal epithelium morphology	any structural anomaly of the inner cell layer of the mammary epithelium bilayer that lines the luminal surface of mammary gland ducts and alveoli; luminal cells have only limited contact with the underlying basement membrane and surrounding connective ti
HP:0002716	Lymphadenopathy	MP:0020215	impaired blood coagulation	impaired ability of the blood to clot
HP:0002665	Lymphoma	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells

Disease ID	216
Disease	mycosis fungoides
Case	(Waiting for update.)

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