eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| microscopic polyangiitis | ||||
| Disease ID | 464 |
|---|---|
| Disease | microscopic polyangiitis |
| Definition | A systemic necrotizing vasculitis that typically affects the small and medium-sized muscular arteries. In some cases, however, microscopic vessels are also affected (e.g., in the kidneys), a condition that has been called microscopic polyarteritis or polyangiitis; this disorder is felt to be more closely associated with Wegener granulomatosis than to classic polyarteritis nodosa. |
| Synonym | microscopic polyangiitides microscopic polyangiitis [disease/finding] microscopic polyarteritis microscopic polyarteritis nodosa microscopic polyarteritis nodosa (disorder) polyangiitides, microscopic polyangiitis, microscopic polyarteritis nodosa microscopic |
| Orphanet | |
| ICD10 | |
| UMLS | C2347126 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:37) C0034069 | pulmonary fibrosis | 8 C0042384 | vasculitis | 6 C0017658 | glomerulonephritis | 3 C0023890 | cirrhosis | 2 C0008728 | churg-strauss syndrome | 2 C0019158 | hepatitis | 2 C0008312 | biliary cirrhosis | 2 C0013990 | emphysema | 2 C0008312 | primary biliary cirrhosis | 2 C0007785 | cerebral infarct | 1 C0002880 | autoimmune hemolytic anemia | 1 C0040053 | thrombus | 1 C1800706 | idiopathic pulmonary fibrosis | 1 C0034065 | pulmonary embolism | 1 C0003864 | arthritis | 1 C0039483 | giant cell arteritis | 1 C0024143 | lupus nephritis | 1 C0042769 | virus infection | 1 C0032285 | pneumonitis | 1 C0002878 | hemolytic anemia | 1 C0042373 | vascular disease | 1 C0003504 | aortic valve insufficiency | 1 C0010051 | coronary aneurysm | 1 C0027697 | nephritis | 1 C0037116 | silicosis | 1 C0026934 | mycoplasma | 1 C0442874 | neuropathy | 1 C0007785 | cerebral infarction | 1 C0152025 | polyneuropathy | 1 C0036421 | systemic sclerosis | 1 C0028866 | oculomotor nerve palsy | 1 C0019196 | hepatitis c | 1 C0241910 | autoimmune hepatitis | 1 C0920350 | autoimmune thyroiditis | 1 C0003873 | rheumatoid arthritis | 1 C0014121 | bacterial endocarditis | 1 C0019196 | hepatitis c infection | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 464 |
|---|---|
| Disease | microscopic polyangiitis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:27) C2697391 | rheumatoid arthritis C2364133 | infection C2186530 | kidney disease C2072946 | aortic aneurysm C2046121 | aortic dissection C1963274 | vasculitis C1801950 | g syndrome C1739395 | takotsubo cardiomyopathy C0878544 | cardiomyopathy C0748159 | pulmonary involvement C0600260 | obstructive lung disease C0267953 | pancreatic necrosis C0155002 | sudden visual loss C0151295 | mononeuritis multiplex C0041349 | tubulointerstitial nephritis C0039445 | hereditary hemorrhagic telangiectasia C0034069 | pulmonary fibrosis C0032453 | relapsing polychondritis C0030167 | pachymeningitis C0022658 | renal disease C0019080 | hemorrhage C0017661 | iga glomerulonephritis C0017658 | glomerulonephritis C0017658 | glomerulonephritides C0007785 | cerebral infarctions C0006902 | capillaritis C0002940 | aneurysms |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:8) C0034069 | pulmonary fibrosis | 8 C0042384 | vasculitis | 4 C0017658 | glomerulonephritis | 3 C0748159 | pulmonary involvement | 2 C0009450 | infection | 2 C0019080 | hemorrhage | 2 C0002940 | aneurysms | 1 C0003873 | rheumatoid arthritis | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:6) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001933 | Subcutaneous hemorrhage | MP:0011437 | glomerulus hemorrhage | bleeding in the renal glomerulus |
| HP:0002239 | Gastrointestinal hemorrhage | MP:0012305 | umbilical cord hemorrhage | bleeding into or from the umbilical cord |
| HP:0008046 | Abnormality of the retinal vasculature | MP:0004686 | decreased length of long bones | reduced end-to-end length of the several elongated bones of the extremities |
| HP:0000083 | Renal insufficiency | MP:0003335 | exocrine pancreatic insufficiency | inadequate synthesis and/or secretion of digestive enzymes by the exocrine portion of the pancreas, usually due to loss of acinar tissue from idiopathic atrophy or acute or chronic inflammation, causing maldigestion and malabsorption of nutrients |
| HP:0002017 | Nausea and vomiting | MP:0010426 | abnormal heart and great artery attachment | any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta |
| HP:0001635 | Congestive heart failure | MP:0011925 | abnormal heart echocardiography feature | any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features |
Mapped by homologous gene(Total Items:35) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001945 | Fever | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0008046 | Abnormality of the retinal vasculature | MP:0014059 | abnormal photoreceptor connecting cilium morphology | any structural anomaly of the nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the retinal photoreceptor inner and outer segments |
| HP:0011675 | Arrhythmia | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0010783 | Erythema | MP:0013781 | abnormal mammary gland luminal epithelium morphology | any structural anomaly of the inner cell layer of the mammary epithelium bilayer that lines the luminal surface of mammary gland ducts and alveoli; luminal cells have only limited contact with the underlying basement membrane and surrounding connective ti |
| HP:0001369 | Arthritis | MP:0020316 | decreased vascular endothelial cell proliferation | decrease in the expansion rate of any vascular endothelial cell population by cell division |
| HP:0009830 | Peripheral neuropathy | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0100534 | Episcleritis | MP:0011080 | increased macrophage apoptosis | greater incidence of cell death in macrophages |
| HP:0002633 | Vasculitis | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0001482 | Subcutaneous nodule | MP:0013542 | abnormal submandibular gland branching morphogenesis | |
| HP:0003401 | Paresthesia | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0002960 | Autoimmunity | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0100820 | Glomerulopathy | MP:0014169 | decreased brown adipose tissue mass | decreased physical bulk or volume of brown adipose tissue |
| HP:0001701 | Pericarditis | MP:0011405 | tubulointerstitial nephritis | diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease |
| HP:0002239 | Gastrointestinal hemorrhage | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0002586 | Peritonitis | MP:0011085 | postnatal lethality, complete penetrance | premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age) |
| HP:0002014 | Diarrhea | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0002017 | Nausea and vomiting | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0002105 | Hemoptysis | MP:0011098 | embryonic lethality during organogenesis, complete penetrance | death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14) |
| HP:0000790 | Hematuria | MP:0020316 | decreased vascular endothelial cell proliferation | decrease in the expansion rate of any vascular endothelial cell population by cell division |
| HP:0002829 | Arthralgia | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0000554 | Uveitis | MP:0013501 | increased fibroblast apoptosis | increase in the timing or the number of fibroblast cells undergoing programmed cell death |
| HP:0002027 | Abdominal pain | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0000083 | Renal insufficiency | MP:0020316 | decreased vascular endothelial cell proliferation | decrease in the expansion rate of any vascular endothelial cell population by cell division |
| HP:0200042 | Skin ulcer | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0000246 | Sinusitis | MP:0020186 | altered susceptibility to bacterial infection | a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria |
| HP:0005244 | Gastrointestinal infarctions | MP:0011098 | embryonic lethality during organogenesis, complete penetrance | death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14) |
| HP:0003326 | Myalgia | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0000421 | Epistaxis | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0004936 | Venous thrombosis | MP:0014166 | ectopic cranial bone | the appearance of an extra bone structure at an atypical location in or near the cranium |
| HP:0001635 | Congestive heart failure | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0001733 | Pancreatitis | MP:0020134 | abnormal gallbladder size | an anomaly in the size of the gall bladder compared to average, the organ that serves as a storage reservoir for bile |
| HP:0001933 | Subcutaneous hemorrhage | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0100758 | Gangrene | MP:0011517 | hyperoxaluria | abnormally high levels of oxalic acid or oxalates in the urine; many metal ions form insoluble precipitates with oxalate, a prominent example being calcium oxalate, the primary constituent of the most common kind of kidney stones |
| HP:0000965 | Cutis marmorata | MP:0014179 | abnormal blood-retinal barrier function | anomaly in the function of the part of the blood-ocular barrier that consists of cells that are joined tightly together to prevent certain substances from entering the tissue of the retina; the BRB consists of non-fenestrated capillaries of the retinal ci |
| HP:0000988 | Skin rash | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| Disease ID | 464 |
|---|---|
| Disease | microscopic polyangiitis |
| Case | (Waiting for update.) |