All Snps(Total Genotypes:465) |
|---|
| snpId |
pubmedId |
geneId |
geneSymbol |
diseaseId |
sourceId |
sentence |
score |
Year |
geneSymbol_dbSNP |
CHROMOSOME |
POS |
REF |
ALT |
| rs10010131 | 18853134 | 6934 | TCF7L2 | umls:C0524620 | BeFree | Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004). | 0.129001189 | 2008 | WFS1 | 4 | 6291188 | A | G |
| rs10096633 | 25023634 | 4023 | LPL | umls:C0524620 | BeFree | A novel African American-specific variant, rs12721054/APOC1, and rs10096633/LPL are associated with ≥3 MetS components. | 0.139631029 | 2015 | NA | 8 | 19973410 | C | T |
| rs102275 | 20694148 | 746 | TMEM258 | umls:C0524620 | GWASCAT | A genome-wide association study of the metabolic syndrome in Indian Asian men. | 0.12 | 2010 | TMEM258 | 11 | 61790331 | T | C |
| rs10282458 | 22383892 | 3123 | HLA-DRB1 | umls:C0524620 | BeFree | Corresponding eSNPs were tested for association with MetS-related phenotypes in two GWAS of >100,000 individuals; rs10282458, affecting expression of RARRES2 (encoding chemerin), was associated with body mass index (BMI) (P = 6.0×10(-4)); and rs2395185, affecting inter-depot differences of HLA-DRB1 expression, was associated with high-density lipoprotein (P = 8.7×10(-4)) and BMI-adjusted waist-to-hip ratio (P = 2.4×10(-4)). | 0.000814326 | 2012 | NA | 7 | 150348213 | G | A |
| rs10282458 | 22383892 | 5919 | RARRES2 | umls:C0524620 | BeFree | Corresponding eSNPs were tested for association with MetS-related phenotypes in two GWAS of >100,000 individuals; rs10282458, affecting expression of RARRES2 (encoding chemerin), was associated with body mass index (BMI) (P = 6.0×10(-4)); and rs2395185, affecting inter-depot differences of HLA-DRB1 expression, was associated with high-density lipoprotein (P = 8.7×10(-4)) and BMI-adjusted waist-to-hip ratio (P = 2.4×10(-4)). | 0.002171535 | 2012 | NA | 7 | 150348213 | G | A |
| rs1028583 | 21633728 | 3172 | HNF4A | umls:C0524620 | BeFree | Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. | 0.001357209 | 2011 | HNF4A | 20 | 44422121 | T | G |
| rs1040288 | 21471972 | 4306 | NR3C2 | umls:C0524620 | BeFree | In the MS population, the C/G and G/G genotypes of single-nucleotide polymorphism rs1040288 (NR3C2) and A/G and G/G of rs11099680 (NR3C2) were associated with uncontrolled AHT (odds ratio (OR)=2.94 (1.34-6.47) and OR=2.54 (1.09-5.93), respectively). | 0.001357209 | 2011 | NR3C2 | 4 | 148126966 | G | C |
| rs1041981 | 20177654 | 7124 | TNF | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.022074006 | 2010 | LTA;LOC100287329 | 6 | 31573007 | C | A |
| rs1041981 | 20177654 | 4049 | LTA | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.008729747 | 2010 | LTA;LOC100287329 | 6 | 31573007 | C | A |
| rs1041981 | 15729581 | 4049 | LTA | umls:C0524620 | BeFree | The common T60N polymorphism of the lymphotoxin-alpha gene is associated with type 2 diabetes and other phenotypes of the metabolic syndrome. | 0.008729747 | 2005 | LTA;LOC100287329 | 6 | 31573007 | C | A |
| rs1042711 | 22900502 | 154 | ADRB2 | umls:C0524620 | BeFree | ADRB2 haplotypes (comprising rs1042711, rs1801704, rs1042713 and rs1042714 in that order), genotyping and statistical analysis to evaluate associations with continuous variables and traits related to IR and MS in a PCOS population. | 0.013463811 | 2013 | ADRB2 | 5 | 148826785 | C | A,T |
| rs1042713 | 22900502 | 154 | ADRB2 | umls:C0524620 | BeFree | ADRB2 haplotypes (comprising rs1042711, rs1801704, rs1042713 and rs1042714 in that order), genotyping and statistical analysis to evaluate associations with continuous variables and traits related to IR and MS in a PCOS population. | 0.013463811 | 2013 | ADRB2 | 5 | 148826877 | G | A |
| rs1042714 | 22900502 | 154 | ADRB2 | umls:C0524620 | BeFree | ADRB2 haplotypes (comprising rs1042711, rs1801704, rs1042713 and rs1042714 in that order), genotyping and statistical analysis to evaluate associations with continuous variables and traits related to IR and MS in a PCOS population. | 0.013463811 | 2013 | ADRB2 | 5 | 148826910 | G | C,T |
| rs10447248 | 21700879 | 9370 | ADIPOQ | umls:C0524620 | BeFree | In addition, we found that FER SNP rs10447248 was related to HDL cholesterol levels (P = 0.009); ADIPOQ variation was associated with fasting glucose (P = 0.04), HDL cholesterol (P = 0.04), and a metabolic syndrome score (P = 0.002). | 0.184894604 | 2011 | NA | 5 | 108580035 | A | G |
| rs10447248 | 21700879 | 2241 | FER | umls:C0524620 | BeFree | In addition, we found that FER SNP rs10447248 was related to HDL cholesterol levels (P = 0.009); ADIPOQ variation was associated with fasting glucose (P = 0.04), HDL cholesterol (P = 0.04), and a metabolic syndrome score (P = 0.002). | 0.000271442 | 2011 | NA | 5 | 108580035 | A | G |
| rs10468017 | 21386085 | 102724766 | LOC102724766 | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.12 | 2011 | LOC102724766 | 15 | 58386313 | C | T |
| rs10790162 | 21386085 | 84811 | BUD13 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.122638474 | 2011 | BUD13 | 11 | 116768388 | A | G,T |
| rs10790162 | 21386085 | 84811 | BUD13 | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.122638474 | 2011 | BUD13 | 11 | 116768388 | A | G,T |
| rs10838681 | 22399527 | 10062 | NR1H3 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.125005506 | 2012 | NR1H3 | 11 | 47253513 | G | A |
| rs10838681 | 22399527 | 10062 | NR1H3 | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.125005506 | 2012 | NR1H3 | 11 | 47253513 | G | A |
| rs10850335 | 22170361 | 84811 | BUD13 | umls:C0524620 | BeFree | Dietary calcium intake appears to be inversely associated with the risk of metabolic syndrome and may modulate susceptibility to the syndrome in subjects who are minor allele carriers of rs6445834 in ARHGEF3, rs10850335 in TBX5, or rs180349 in BUD13. | 0.122638474 | 2012 | TBX5 | 12 | 114375303 | T | C |
| rs10938397 | 21147891 | 132789 | GNPDA2 | umls:C0524620 | BeFree | GNPDA2 rs10938397 was also significantly associated with MetS (P(age, sex-adjusted)=0.011, OR (95% CI): 1.20 (1.04, 1.38)) in the case-control study. | 0.000542884 | 2011 | NA | 4 | 45180510 | A | G |
| rs10938397 | 24269186 | 132789 | GNPDA2 | umls:C0524620 | BeFree | Of 11 SNPs, GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 were nominally associated with risk of MetS (GNPDA2 rs10938397: odds ratio (OR)=1.21, 95% confidence interval (CI)=1.04-1.40, P=0.016; BDNF rs6265: OR=1.19, 95% CI=1.03-1.39, P=0.021; FAIM2 rs7138803: OR=1.20, 95% CI=1.02-1.40, P=0.025); genetic risk score (GRS) was significantly associated with risk of MetS (OR=1.09, 95% CI=1.04-1.15, P=5.26×10(-4)). | 0.000542884 | 2013 | NA | 4 | 45180510 | A | G |
| rs11066280 | 25705158 | 283450 | HECTD4 | umls:C0524620 | GWASCAT | Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE) Cohorts. | 0.12 | 2014 | HECTD4 | 12 | 112379979 | T | A |
| rs11099680 | 21471972 | 4306 | NR3C2 | umls:C0524620 | BeFree | In the MS population, the C/G and G/G genotypes of single-nucleotide polymorphism rs1040288 (NR3C2) and A/G and G/G of rs11099680 (NR3C2) were associated with uncontrolled AHT (odds ratio (OR)=2.94 (1.34-6.47) and OR=2.54 (1.09-5.93), respectively). | 0.001357209 | 2011 | NR3C2 | 4 | 148182095 | G | A |
| rs1127065 | 22399527 | 816 | CAMK2B | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.122367032 | 2012 | CAMK2B | 7 | 44220272 | C | T,G |
| rs1127065 | 22399527 | 816 | CAMK2B | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.122367032 | 2012 | CAMK2B | 7 | 44220272 | C | T,G |
| rs1133607 | 16521160 | 123876 | ACSM2A | umls:C0524620 | BeFree | The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population. | 0.000271442 | 2006 | ACSM2A | 16 | 20483086 | C | G,T |
| rs1133607 | 16521160 | 4082 | MARCKS | umls:C0524620 | BeFree | Association studies in the Japanese Suita cohort of MACS polymorphisms and various phenotypes revealed the contribution of the Leu513Ser polymorphism in MACS2 to multiple risk factors of the metabolic syndrome. | 0.000271442 | 2006 | ACSM2A | 16 | 20483086 | C | G,T |
| rs1133607 | 16521160 | 54453 | RIN2 | umls:C0524620 | BeFree | Association studies in the Japanese Suita cohort of MACS polymorphisms and various phenotypes revealed the contribution of the Leu513Ser polymorphism in MACS2 to multiple risk factors of the metabolic syndrome. | 0.000271442 | 2006 | ACSM2A | 16 | 20483086 | C | G,T |
| rs1133607 | 16521160 | 116285 | ACSM1 | umls:C0524620 | BeFree | The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population. | 0.000271442 | 2006 | ACSM2A | 16 | 20483086 | C | G,T |
| rs1137101 | 19344216 | 3953 | LEPR | umls:C0524620 | BeFree | Association between the Gln223Arg polymorphism of the leptin receptor and metabolic syndrome in free-living community elderly. | 0.012453989 | 2009 | LEPR | 1 | 65592830 | A | G |
| rs1137101 | 22734460 | 3952 | LEP | umls:C0524620 | BeFree | Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers. | 0.216948948 | 2012 | LEPR | 1 | 65592830 | A | G |
| rs1137101 | 22734460 | 3953 | LEPR | umls:C0524620 | BeFree | Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers. | 0.012453989 | 2012 | LEPR | 1 | 65592830 | A | G |
| rs11545881 | 18328351 | 1149 | CIDEA | umls:C0524620 | BeFree | Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men. | 0.003181358 | 2008 | CIDEA | 18 | 12274105 | G | A,C,T |
| rs11545881 | 21106268 | 1149 | CIDEA | umls:C0524620 | BeFree | Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population. | 0.003181358 | 2011 | CIDEA | 18 | 12274105 | G | A,C,T |
| rs11724758 | 23911300 | 2169 | FABP2 | umls:C0524620 | BeFree | Correlations between FABP2 rs11724758 polymorphisms and components of MetS reveal that high-density lipoprotein cholesterol (HDL-c) levels are significantly higher in FABP2 rs11724758 AA genotype carrier compared with noncarriers, whereas triglycerides (TG) and fasting plasma glucose (FG) were to be significantly lower in the AA genotype carrier. | 0.017188052 | 2013 | FABP2 | 4 | 119318723 | G | A |
| rs1175543 | 25366759 | 5468 | PPARG | umls:C0524620 | BeFree | Analysis of the haplotype and linkage disequilibrium of PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province. | 0.145004224 | 2015 | PPARG | 3 | 12424934 | A | G |
| rs11774572 | 19364639 | 3630 | INS | umls:C0524620 | BeFree | Polymorphism rs11774572 was significantly associated with MetS (P=0.020), mainly driven by the association of the C allele with lower HDL-C (P=0.043) and higher triglycerides (P=0.049) and insulin (P=0.040) concentrations than TT subjects. | 0.166959444 | 2010 | NA | 8 | 11589291 | C | T |
| rs11820589 | 21386085 | 84811 | BUD13 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.122638474 | 2011 | BUD13 | 11 | 116763146 | G | A |
| rs11820589 | 21386085 | 84811 | BUD13 | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.122638474 | 2011 | BUD13 | 11 | 116763146 | G | A |
| rs11823543 | 21386085 | 8882 | ZPR1 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.125276948 | 2011 | ZPR1 | 11 | 116778419 | G | A |
| rs11825181 | 21386085 | 84811 | BUD13 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.122638474 | 2011 | BUD13 | 11 | 116755542 | G | A |
| rs11868035 | 23985808 | 1401 | CRP | umls:C0524620 | BeFree | We followed up 212 randomly selected, nonobese, nondiabetic, insulin-sensitive participants in a population-based study without NAFLD or metabolic syndrome at baseline who were characterized for the common SREBF-1c gene rs11868035 A/G polymorphism, dietary habits, physical activity, adipokine profile, C-reactive protein (CRP), and circulating markers of endothelial dysfunction. | 0.13695888 | 2013 | SREBF1;RAI1 | 17 | 17811787 | G | A |
| rs11887534 | 15175352 | 64240 | ABCG5 | umls:C3714619 | BeFree | Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene. | 0.000271442 | 2004 | ABCG5;ABCG8 | 2 | 43839108 | G | A,C |
| rs11887534 | 15175352 | 64241 | ABCG8 | umls:C3714619 | BeFree | Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene. | 0.000271442 | 2004 | ABCG5;ABCG8 | 2 | 43839108 | G | A,C |
| rs11887534 | 15175352 | 64240 | ABCG5 | umls:C0524620 | BeFree | Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene. | 0.000271442 | 2004 | ABCG5;ABCG8 | 2 | 43839108 | G | A,C |
| rs11887534 | 15175352 | 64241 | ABCG8 | umls:C0524620 | BeFree | Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene. | 0.002909916 | 2004 | ABCG5;ABCG8 | 2 | 43839108 | G | A,C |
| rs12051272 | 25875811 | 3630 | INS | umls:C0524620 | BeFree | After further adjustment for the adiponectin levels, participants with a minor allele of rs12051272 revealed a considerable association with a more favorable metabolic profile, including higher insulin sensitivity, high-density lipoprotein cholesterol levels, lower diastolic blood pressure, circulating levels of fasting plasma glucose, and triglycerides, and as a lower risk of metabolic syndrome (all P < 0.05). | 0.166959444 | 2015 | CDH13 | 16 | 82629683 | G | T |
| rs12086634 | 23869418 | 3290 | HSD11B1 | umls:C0524620 | BeFree | We conclude that in a South Indian population, a polymorphism of the HSD11B1 gene containing the single-nucleotide polymorphism (SNP) rs12086634 T→G confers increased risk of metabolic syndrome. | 0.086167218 | 2014 | HSD11B1;LOC101930114 | 1 | 209706914 | T | G |
| rs12286037 | 21386085 | 8882 | ZPR1 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.125276948 | 2011 | ZPR1 | 11 | 116781491 | C | T |
| rs12286037 | 21386085 | 8882 | ZPR1 | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.125276948 | 2011 | ZPR1 | 11 | 116781491 | C | T |
| rs12490265 | 25366759 | 5468 | PPARG | umls:C0524620 | BeFree | Analysis of the haplotype and linkage disequilibrium of PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province. | 0.145004224 | 2015 | PPARG | 3 | 12343043 | G | A |
| rs12503643 | 20176858 | 4149 | MAX | umls:C0524620 | BeFree | We investigated the relationship between ACSL1 polymorphisms (rs4862417, rs6552828, rs13120078, rs9997745, and rs12503643) and MetS risk and determined potential interactions with dietary fat in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1,754). | 0.001357209 | 2010 | ACSL1;LOC105377587 | 4 | 184824934 | G | T |
| rs1260326 | 18853134 | 2646 | GCKR | umls:C0524620 | BeFree | A polymorphism in the GCKR gene predicted dyslipidaemia (rs1260326, OR 1.15, 95% CI 1.09-1.22, p < 0.00001) but not the metabolic syndrome. | 0.128729747 | 2008 | GCKR | 2 | 27508073 | T | C |
| rs12691 | 22269963 | 2805 | GOT1 | umls:C0524620 | BeFree | A gene variation (rs12691) in the CCAT/enhancer binding protein α modulates glucose metabolism in metabolic syndrome. | 0.000542884 | 2011 | CEBPA | 19 | 33300221 | G | A |
| rs12721054 | 25023634 | 4023 | LPL | umls:C0524620 | BeFree | A novel African American-specific variant, rs12721054/APOC1, and rs10096633/LPL are associated with ≥3 MetS components. | 0.139631029 | 2015 | APOC1 | 19 | 44919330 | A | G |
| rs13022873 | 21386085 | 84450 | ZNF512 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.002367032 | 2011 | ZNF512 | 2 | 27592643 | A | C |
| rs13120078 | 20176858 | 4149 | MAX | umls:C0524620 | BeFree | We investigated the relationship between ACSL1 polymorphisms (rs4862417, rs6552828, rs13120078, rs9997745, and rs12503643) and MetS risk and determined potential interactions with dietary fat in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1,754). | 0.001357209 | 2010 | ACSL1 | 4 | 184810288 | G | A |
| rs13226650 | 22399527 | 51085 | MLXIPL | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.122638474 | 2012 | MLXIPL | 7 | 73602675 | A | G |
| rs13226650 | 22399527 | 51085 | MLXIPL | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.122638474 | 2012 | MLXIPL | 7 | 73602675 | A | G |
| rs13283456 | 17979097 | 80142 | PTGES2 | umls:C0524620 | BeFree | Prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism and parameters of the metabolic syndrome. | 0.002638474 | 2007 | PTGES2 | 9 | 128122474 | C | A,T |
| rs133291 | 23274901 | 1401 | CRP | umls:C0524620 | BeFree | In a population-based study, we followed 175 nonobese, nondiabetic participants without NAFLD or metabolic syndrome at baseline, characterized for the SREBF-2 rs133291 C/T polymorphism, dietary habits, physical activity, adipokines, C-reactive protein (CRP), and endothelial adhesion molecules. | 0.13695888 | 2013 | SREBF2 | 22 | 41873624 | C | T |
| rs13431652 | 20622168 | 57818 | G6PC2 | umls:C0524620 | GAD | [Genetic and in situ functional data support a potential role for rs13431652, but not rs573225, as a causative SNP linking G6PC2 to variations in FPG, though a causative role for rs573225 in vivo cannot be ruled out.] | 0.124734064 | 2010 | NA | 2 | 168896905 | T | C |
| rs1411766 | 25646961 | 116519 | APOA5 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.171292716 | 2014 | LOC105370358;LOC105370359 | 13 | 109599813 | G | A |
| rs1411766 | 25646961 | 4036 | LRP2 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | LOC105370358;LOC105370359 | 13 | 109599813 | G | A |
| rs1411766 | 25646961 | 7350 | UCP1 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.003995683 | 2014 | LOC105370358;LOC105370359 | 13 | 109599813 | G | A |
| rs1411766 | 25646961 | 23158 | TBC1D9 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | LOC105370358;LOC105370359 | 13 | 109599813 | G | A |
| rs1411766 | 25646961 | 23026 | MYO16 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | LOC105370358;LOC105370359 | 13 | 109599813 | G | A |
| rs1411766 | 25646961 | 8660 | IRS2 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.003995683 | 2014 | LOC105370358;LOC105370359 | 13 | 109599813 | G | A |
| rs1423096 | 24123702 | 56729 | RETN | umls:C0524620 | BeFree | However, rs1423096, downstream of RETN, seems to be associated with MetS and T2DM risk more so than rs3745367. | 0.130901282 | 2013 | NA | 19 | 7674291 | T | C |
| rs1441756 | 21386085 | 4023 | LPL | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.139631029 | 2011 | NA | 8 | 20010875 | A | C |
| rs146052672 | 23512162 | 3630 | INS | umls:C0524620 | BeFree | Association between rs146052672 variant and MetS occurred independently of T2D, indicating that HMGA1 gene defects play a pathogenetic role in MetS and other insulin-resistance-related conditions. | 0.166959444 | 2013 | NA | NA | NA | NA | NA |
| rs1479355 | 25867398 | 3482 | IGF2R | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.000271442 | 2016 | IGF2R | 6 | 160109594 | T | C |
| rs1479355 | 25867398 | 6616 | SNAP25 | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.002638474 | 2016 | IGF2R | 6 | 160109594 | T | C |
| rs1479355 | 25867398 | 6833 | ABCC8 | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.002638474 | 2016 | IGF2R | 6 | 160109594 | T | C |
| rs15285 | 21386085 | 4023 | LPL | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.139631029 | 2011 | LPL | 8 | 19967156 | C | T |
| rs1532085 | 22399527 | 102724766 | LOC102724766 | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.12 | 2012 | LOC102724766 | 15 | 58391167 | A | G |
| rs1535 | 20694148 | 9415 | FADS2 | umls:C0524620 | GWASCAT | A genome-wide association study of the metabolic syndrome in Indian Asian men. | 0.122638474 | 2010 | FADS2 | 11 | 61830500 | A | G |
| rs1570070 | 25867398 | 6833 | ABCC8 | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.002638474 | 2016 | IGF2R | 6 | 160032946 | A | G |
| rs1570070 | 25867398 | 3482 | IGF2R | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.000271442 | 2016 | IGF2R | 6 | 160032946 | A | G |
| rs1570070 | 25867398 | 6616 | SNAP25 | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.002638474 | 2016 | IGF2R | 6 | 160032946 | A | G |
| rs157582 | 22399527 | 10452 | TOMM40 | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.122367032 | 2012 | TOMM40 | 19 | 44892962 | C | T |
| rs157582 | 22399527 | 10452 | TOMM40 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.122367032 | 2012 | TOMM40 | 19 | 44892962 | C | T |
| rs16147 | 24897239 | 4852 | NPY | umls:C0524620 | BeFree | Association of neuropeptide Y gene rs16147 polymorphism with metabolic syndrome in patients with documented coronary artery disease. | 0.003995683 | 2015 | NPY | 7 | 24283791 | T | C |
| rs16874954 | 25078067 | 7941 | PLA2G7 | umls:C0524620 | BeFree | Carriage of the V279F homozygous genotype, a rare allele, within the gene encoding Lp-PLA2 leads to changes in circulating intermediate metabolites in individuals without metabolic syndrome. | 0.080542884 | 2015 | NA | NA | NA | NA | NA |
| rs17173608 | 22982016 | 5919 | RARRES2 | umls:C0524620 | BeFree | Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome, a preliminary report. | 0.002171535 | 2012 | RARRES2 | 7 | 150339575 | T | G |
| rs173539 | 21386085 | 9709 | HERPUD1 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.004734064 | 2011 | NA | 16 | 56954132 | C | T |
| rs174546 | 20694148 | 3992 | FADS1 | umls:C0524620 | GWASCAT | A genome-wide association study of the metabolic syndrome in Indian Asian men. | 0.12 | 2010 | FADS1 | 11 | 61802358 | C | T |
| rs17602729 | 18855224 | 270 | AMPD1 | umls:C0524620 | GAD | [Association of C34T AMPD1 gene polymorphism with features of metabolic syndrome in patients with coronary artery disease or heart failure.] | 0.002638474 | 2009 | AMPD1 | 1 | 114693436 | G | A |
| rs17611 | 19619703 | 1493 | CTLA4 | umls:C0524620 | BeFree | In a marker-by-marker analysis, the ADRB2 rs180088 (OR 1.22, 95% CI 1.01-1.48) and PAI1 rs1799768 (OR 1.05, 95% CI 1.01-1.10) were associated with an increased MetS risk, whereas the C5 rs17611 (OR 0.95, 95% CI 0.91-1.00) and the CTLA4 rs5742909 (OR 0.91, 95% CI 0.84-0.99) were associated with a decreased risk. | 0.000271442 | 2009 | C5 | 9 | 121006922 | C | T |
| rs1761667 | 22588808 | 948 | CD36 | umls:C0524620 | BeFree | Our findings show that CD36 rs1761667 SNP is positively associated with increased risk of MetS and its components with genotype AG heterozygotes showing highest frequency among MetS patients. | 0.089348576 | 2012 | CD36 | 7 | 80615623 | G | A |
| rs17782312 | 23101478 | 4160 | MC4R | umls:C0524620 | BeFree | In this study we found support for the hypothesis that weight regulation and insulin metabolism are involved in MetS development.MC4R rs17782312 and IRS1 rs2943634 may explain part of the genetic variation in MetS. | 0.006362715 | 2012 | NA | NA | NA | NA | NA |
| rs17782312 | 23101478 | 3667 | IRS1 | umls:C0524620 | BeFree | In this study we found support for the hypothesis that weight regulation and insulin metabolism are involved in MetS development.MC4R rs17782312 and IRS1 rs2943634 may explain part of the genetic variation in MetS. | 0.087177041 | 2012 | NA | NA | NA | NA | NA |
| rs1797912 | 25366759 | 5468 | PPARG | umls:C0524620 | BeFree | Analysis of the haplotype and linkage disequilibrium of PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province. | 0.145004224 | 2015 | PPARG | 3 | 12428740 | A | C |
| rs1799768 | 19619703 | 1493 | CTLA4 | umls:C0524620 | BeFree | In a marker-by-marker analysis, the ADRB2 rs180088 (OR 1.22, 95% CI 1.01-1.48) and PAI1 rs1799768 (OR 1.05, 95% CI 1.01-1.10) were associated with an increased MetS risk, whereas the C5 rs17611 (OR 0.95, 95% CI 0.91-1.00) and the CTLA4 rs5742909 (OR 0.91, 95% CI 0.84-0.99) were associated with a decreased risk. | 0.000271442 | 2009 | SERPINE1 | 7 | 101126425 | - | G |
| rs1799768 | 19619703 | 5054 | SERPINE1 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.01633012 | 2009 | SERPINE1 | 7 | 101126425 | - | G |
| rs1799768 | 19619703 | 185 | AGTR1 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.01482102 | 2009 | SERPINE1 | 7 | 101126425 | - | G |
| rs1799768 | 19619703 | 154 | ADRB2 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.013463811 | 2009 | SERPINE1 | 7 | 101126425 | - | G |
| rs1799768 | 19619703 | 3552 | IL1A | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.003181358 | 2009 | SERPINE1 | 7 | 101126425 | - | G |
| rs1799821 | 22809552 | 1376 | CPT2 | umls:C0524620 | BeFree | We performed an analysis including three coding SNP in the muscle isoform of the CPT1b gene (rs3213445, rs2269383 and rs470117) and one coding SNP in the CPT2 gene (rs1799821) to find associations with traits of the metabolic syndrome (MetS). | 0.000542884 | 2013 | CPT2 | 1 | 53210776 | G | A |
| rs1799883 | 15869758 | 345 | APOC3 | umls:C0524620 | BeFree | AGT T174M, GNB3 825C>T, and APOC3 -455T>C genotypes were significantly associated with MetS (P = 0.018, 0.0056, and 0.029, respectively) for female adults, whereas FABP2 A54T genotype was associated with MetS (P = 0.040) for female adolescents. | 0.100726728 | 2006 | FABP2 | 4 | 119320747 | T | G,C,A |
| rs1799883 | 15547295 | 4547 | MTTP | umls:C3714619 | BeFree | Our objectives were to determine whether Ala54Thr FABP2 and G-493T MTP polymorphisms are associated with increased risks of insulin resistance syndrome (IRS) in youth and/or modify the expression of accompanying dyslipidemia. | 0.000542884 | 2005 | FABP2 | 4 | 119320747 | T | G,C,A |
| rs1799883 | 15547295 | 4547 | MTTP | umls:C0524620 | BeFree | Our objectives were to determine whether Ala54Thr FABP2 and G-493T MTP polymorphisms are associated with increased risks of insulin resistance syndrome (IRS) in youth and/or modify the expression of accompanying dyslipidemia. | 0.004810009 | 2005 | FABP2 | 4 | 119320747 | T | G,C,A |
| rs1799883 | 15869758 | 2169 | FABP2 | umls:C0524620 | BeFree | AGT T174M, GNB3 825C>T, and APOC3 -455T>C genotypes were significantly associated with MetS (P = 0.018, 0.0056, and 0.029, respectively) for female adults, whereas FABP2 A54T genotype was associated with MetS (P = 0.040) for female adolescents. | 0.017188052 | 2006 | FABP2 | 4 | 119320747 | T | G,C,A |
| rs1799883 | 15869758 | 183 | AGT | umls:C0524620 | BeFree | AGT T174M, GNB3 825C>T, and APOC3 -455T>C genotypes were significantly associated with MetS (P = 0.018, 0.0056, and 0.029, respectively) for female adults, whereas FABP2 A54T genotype was associated with MetS (P = 0.040) for female adolescents. | 0.089001189 | 2006 | FABP2 | 4 | 119320747 | T | G,C,A |
| rs1799883 | 16919542 | 2169 | FABP2 | umls:C0524620 | BeFree | Thr54 allele carriers of the Ala54Thr variant of FABP2 gene have associations with metabolic syndrome and hypertriglyceridemia in urban South Indians. | 0.017188052 | 2006 | FABP2 | 4 | 119320747 | T | G,C,A |
| rs1799883 | 15869758 | 2784 | GNB3 | umls:C0524620 | BeFree | AGT T174M, GNB3 825C>T, and APOC3 -455T>C genotypes were significantly associated with MetS (P = 0.018, 0.0056, and 0.029, respectively) for female adults, whereas FABP2 A54T genotype was associated with MetS (P = 0.040) for female adolescents. | 0.009001189 | 2006 | FABP2 | 4 | 119320747 | T | G,C,A |
| rs1799941 | 25647406 | 6462 | SHBG | umls:C0524620 | BeFree | SHBG gene polymorphism (rs1799941) associates with metabolic syndrome in children and adolescents. | 0.123257302 | 2014 | SHBG | 17 | 7630105 | G | A |
| rs1799983 | 22304542 | 4846 | NOS3 | umls:C0524620 | BeFree | The eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNOS G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders. | 0.14382221 | 2012 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 20163778 | 627 | BDNF | umls:C0524620 | BeFree | We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase). | 0.003181358 | 2010 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 20163778 | 7054 | TH | umls:C0524620 | BeFree | We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase). | 0.002638474 | 2010 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 18640391 | 4846 | NOS3 | umls:C0524620 | BeFree | The association of endothelial nitric oxide synthase G894T polymorphism with C-reactive protein level and metabolic syndrome in a Chinese study group. | 0.14382221 | 2008 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 18640391 | 1401 | CRP | umls:C0524620 | BeFree | The association of endothelial nitric oxide synthase G894T polymorphism with C-reactive protein level and metabolic syndrome in a Chinese study group. | 0.13695888 | 2008 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 21816783 | 4846 | NOS3 | umls:C0524620 | BeFree | NOS3 Glu298Asp polymorphism interacts with virgin olive oil phenols to determine the postprandial endothelial function in patients with the metabolic syndrome. | 0.14382221 | 2011 | NOS3 | 7 | 150999023 | T | G |
| rs1799983 | 20163778 | 4524 | MTHFR | umls:C0524620 | BeFree | We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase). | 0.015635346 | 2010 | NOS3 | 7 | 150999023 | T | G |
| rs1799998 | 17261471 | 1585 | CYP11B2 | umls:C0524620 | BeFree | -344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men. | 0.002909916 | 2007 | CYP11B2;LOC105375793 | 8 | 142918184 | A | G |
| rs1800206 | 21877956 | 54512 | EXOSC4 | umls:C0524620 | BeFree | The frequency distribution of rare alleles for PPARα (L162V) and PPARγ (P12A and H449H) was compared using the chi square test in 363 HIV-1-infected patients classified according to the presence or absence of the metabolic syndrome after 48 months of follow-up on their first PI-containing regimen. | 0.001085767 | 2012 | PPARA | 22 | 46218377 | C | G |
| rs1800206 | 15309680 | 5465 | PPARA | umls:C0524620 | BeFree | Association between the PPARalpha-L162V polymorphism and components of the metabolic syndrome. | 0.007177041 | 2004 | PPARA | 22 | 46218377 | C | G |
| rs1800206 | 26673968 | 5467 | PPARD | umls:C0524620 | BeFree | This study aimed to investigate the association of peroxisome proliferator-activated receptor (PPAR) genes PPARα L162V, PPARγ2 C161T and PPARδ T294C single nucleotide polymorphisms (SNPs) with obesity and metabolic syndrome (Met-S) in a multi-ethnic population in Kampar, Malaysia. | 0.006362715 | 2016 | PPARA | 22 | 46218377 | C | G |
| rs1800587 | 19619703 | 185 | AGTR1 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.01482102 | 2009 | IL1A | 2 | 112785383 | G | C,A |
| rs1800587 | 19619703 | 154 | ADRB2 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.013463811 | 2009 | IL1A | 2 | 112785383 | G | C,A |
| rs1800587 | 19619703 | 5054 | SERPINE1 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.01633012 | 2009 | IL1A | 2 | 112785383 | G | C,A |
| rs1800587 | 19619703 | 3552 | IL1A | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.003181358 | 2009 | IL1A | 2 | 112785383 | G | C,A |
| rs1800592 | 25646961 | 116519 | APOA5 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.171292716 | 2014 | NA | 4 | 140572807 | T | C |
| rs1800592 | 24138564 | 155 | ADRB3 | umls:C0524620 | BeFree | We investigated whether the -3826A/G polymorphism (rs1800592) of the uncoupling protein 1 gene (UCP1) and the Trp64Arg polymorphism (rs4994) of the β3-adrenergic receptor gene (ADRB3) are associated with type 2 diabetes mellitus (T2DM) and features of metabolic syndrome in a Brazilian-Caucasian population. | 0.028827715 | 2014 | NA | 4 | 140572807 | T | C |
| rs1800592 | 25646961 | 4036 | LRP2 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | NA | 4 | 140572807 | T | C |
| rs1800592 | 25646961 | 23158 | TBC1D9 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | NA | 4 | 140572807 | T | C |
| rs1800592 | 25646961 | 7350 | UCP1 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.003995683 | 2014 | NA | 4 | 140572807 | T | C |
| rs1800592 | 25646961 | 8660 | IRS2 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.003995683 | 2014 | NA | 4 | 140572807 | T | C |
| rs1800592 | 25646961 | 23026 | MYO16 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | NA | 4 | 140572807 | T | C |
| rs1800592 | 24138564 | 7350 | UCP1 | umls:C0524620 | BeFree | We investigated whether the -3826A/G polymorphism (rs1800592) of the uncoupling protein 1 gene (UCP1) and the Trp64Arg polymorphism (rs4994) of the β3-adrenergic receptor gene (ADRB3) are associated with type 2 diabetes mellitus (T2DM) and features of metabolic syndrome in a Brazilian-Caucasian population. | 0.003995683 | 2014 | NA | 4 | 140572807 | T | C |
| rs1800610 | 20177654 | 7124 | TNF | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.022074006 | 2010 | TNF | 6 | 31576050 | G | A |
| rs1800610 | 20177654 | 4049 | LTA | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.008729747 | 2010 | TNF | 6 | 31576050 | G | A |
| rs1800629 | 20177654 | 4049 | LTA | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.008729747 | 2010 | TNF | 6 | 31575254 | G | A |
| rs1800629 | 20177654 | 7124 | TNF | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.022074006 | 2010 | TNF | 6 | 31575254 | G | A |
| rs1800630 | 20177654 | 7124 | TNF | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.022074006 | 2010 | LTA;TNF | 6 | 31574699 | C | A |
| rs1800630 | 20177654 | 4049 | LTA | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.008729747 | 2010 | LTA;TNF | 6 | 31574699 | C | A |
| rs1800797 | 20080841 | 28411 | IGHV3-71 | umls:C0524620 | BeFree | Possession of the IL-6 rs1800797 GG genotype by the LTA and TNF-alpha risk genotype carriers further increased risk of the MetS [OR 2.10 (CI 1.19-3.71) P = 0.009], fasting hyperglycemia [OR 2.65 (CI 1.12-6.28), P = 0.027], high systolic blood pressure [OR 1.99 (CI 1.07-3.72), P = 0.03], and abdominal obesity [OR 1.52 (CI 1.01-2.28), P = 0.04]. | 0.000271442 | 2010 | IL6;LOC541472 | 7 | 22726602 | A | G |
| rs180088 | 19619703 | 3552 | IL1A | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.003181358 | 2009 | NA | 17 | 69951455 | T | C |
| rs180088 | 19619703 | 185 | AGTR1 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.01482102 | 2009 | NA | 17 | 69951455 | T | C |
| rs180088 | 19619703 | 154 | ADRB2 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.013463811 | 2009 | NA | 17 | 69951455 | T | C |
| rs180088 | 19619703 | 1493 | CTLA4 | umls:C0524620 | BeFree | In a marker-by-marker analysis, the ADRB2 rs180088 (OR 1.22, 95% CI 1.01-1.48) and PAI1 rs1799768 (OR 1.05, 95% CI 1.01-1.10) were associated with an increased MetS risk, whereas the C5 rs17611 (OR 0.95, 95% CI 0.91-1.00) and the CTLA4 rs5742909 (OR 0.91, 95% CI 0.84-0.99) were associated with a decreased risk. | 0.000271442 | 2009 | NA | 17 | 69951455 | T | C |
| rs180088 | 19619703 | 5054 | SERPINE1 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.01633012 | 2009 | NA | 17 | 69951455 | T | C |
| rs1801132 | 22011627 | 2100 | ESR2 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.003452799 | 2012 | ESR1 | 6 | 151944387 | G | C |
| rs1801132 | 22011627 | 2099 | ESR1 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.006905599 | 2012 | ESR1 | 6 | 151944387 | G | C |
| rs1801253 | 24972470 | 155 | ADRB3 | umls:C0524620 | BeFree | The objective of this work was to analyze the association of polymorphisms in ADRB1 (rs1801253) (Arg389Gly) and ADRB3 (Trp64Arg) genes with T2D and metabolic syndrome (MS). | 0.028827715 | 2015 | ADRB1 | 10 | 114045297 | G | C |
| rs1801253 | 24972470 | 153 | ADRB1 | umls:C0524620 | BeFree | The objective of this work was to analyze the association of polymorphisms in ADRB1 (rs1801253) (Arg389Gly) and ADRB3 (Trp64Arg) genes with T2D and metabolic syndrome (MS). | 0.000271442 | 2015 | ADRB1 | 10 | 114045297 | G | C |
| rs1801260 | 24328727 | 9575 | CLOCK | umls:C0524620 | BeFree | Beneficial effect of CLOCK gene polymorphism rs1801260 in combination with low-fat diet on insulin metabolism in the patients with metabolic syndrome. | 0.012453989 | 2014 | CLOCK;TMEM165 | 4 | 55435202 | A | G |
| rs1801260 | 24328727 | 3630 | INS | umls:C0524620 | BeFree | Beneficial effect of CLOCK gene polymorphism rs1801260 in combination with low-fat diet on insulin metabolism in the patients with metabolic syndrome. | 0.166959444 | 2014 | CLOCK;TMEM165 | 4 | 55435202 | A | G |
| rs1801276 | 18716398 | 3667 | IRS1 | umls:C0524620 | BeFree | The polymorphisms PstI and MaeIII of INS, NsiI of INSR and Ala513Pro and Gly972Arg of IRS1 have been associated with metabolic syndrome; moreover, the products of these genes are functionally contiguous during insulin signaling. | 0.087177041 | 2009 | IRS1 | 2 | 226797205 | C | G |
| rs1801276 | 18716398 | 3630 | INS | umls:C0524620 | BeFree | The polymorphisms PstI and MaeIII of INS, NsiI of INSR and Ala513Pro and Gly972Arg of IRS1 have been associated with metabolic syndrome; moreover, the products of these genes are functionally contiguous during insulin signaling. | 0.166959444 | 2009 | IRS1 | 2 | 226797205 | C | G |
| rs1801276 | 18716398 | 3643 | INSR | umls:C0524620 | BeFree | The polymorphisms PstI and MaeIII of INS, NsiI of INSR and Ala513Pro and Gly972Arg of IRS1 have been associated with metabolic syndrome; moreover, the products of these genes are functionally contiguous during insulin signaling. | 0.000814326 | 2009 | IRS1 | 2 | 226797205 | C | G |
| rs1801278 | 18716398 | 3630 | INS | umls:C0524620 | BeFree | The polymorphisms PstI and MaeIII of INS, NsiI of INSR and Ala513Pro and Gly972Arg of IRS1 have been associated with metabolic syndrome; moreover, the products of these genes are functionally contiguous during insulin signaling. | 0.166959444 | 2009 | IRS1 | 2 | 226795828 | C | T,G,A |
| rs1801278 | 18716398 | 3643 | INSR | umls:C0524620 | BeFree | The polymorphisms PstI and MaeIII of INS, NsiI of INSR and Ala513Pro and Gly972Arg of IRS1 have been associated with metabolic syndrome; moreover, the products of these genes are functionally contiguous during insulin signaling. | 0.000814326 | 2009 | IRS1 | 2 | 226795828 | C | T,G,A |
| rs1801278 | 20170352 | 2784 | GNB3 | umls:C0524620 | BeFree | To assess the prevalence of IRS-1 Gly972Arg and GNB3 C825T polymorphisms in women with polycystic ovary syndrome (PCOS) and their relation to the metabolic syndrome and hyperandrogenaemia. | 0.009001189 | 2010 | IRS1 | 2 | 226795828 | C | T,G,A |
| rs1801278 | 20170352 | 3667 | IRS1 | umls:C0524620 | BeFree | To assess the prevalence of IRS-1 Gly972Arg and GNB3 C825T polymorphisms in women with polycystic ovary syndrome (PCOS) and their relation to the metabolic syndrome and hyperandrogenaemia. | 0.087177041 | 2010 | IRS1 | 2 | 226795828 | C | T,G,A |
| rs1801278 | 18716398 | 3667 | IRS1 | umls:C0524620 | BeFree | The polymorphisms PstI and MaeIII of INS, NsiI of INSR and Ala513Pro and Gly972Arg of IRS1 have been associated with metabolic syndrome; moreover, the products of these genes are functionally contiguous during insulin signaling. | 0.087177041 | 2009 | IRS1 | 2 | 226795828 | C | T,G,A |
| rs1801278 | 21645940 | 3667 | IRS1 | umls:C0524620 | BeFree | The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status. | 0.087177041 | 2011 | IRS1 | 2 | 226795828 | C | T,G,A |
| rs1801282 | 12630956 | 5468 | PPARG | umls:C0524620 | BeFree | These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome. | 0.145004224 | 2003 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 21877956 | 5468 | PPARG | umls:C0524620 | BeFree | There was no convincing association between any polymorphism of PPARα and PPARγ and each individual component of the metabolic syndrome, except for the relationship of the P12A polymorphism with diabetes. | 0.145004224 | 2012 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 24243083 | 5468 | PPARG | umls:C0524620 | BeFree | We investigated the synergism between variants at the PPARγ locus (C161T and Pro12Ala polymorphisms) with insulin resistance on metabolic syndrome (MS). | 0.145004224 | 2013 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 22168210 | 5468 | PPARG | umls:C0524620 | BeFree | PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. | 0.145004224 | 2011 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 19745552 | 5468 | PPARG | umls:C0524620 | BeFree | Healthy men, in particular nonsmokers, carrying the Ala12 allele of PPARG rs1801282 polymorphism, have a high risk for MetS and IR. | 0.145004224 | 2009 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 12161548 | 5468 | PPARG | umls:C3714619 | BeFree | Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. | 0.000814326 | 2002 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 16916989 | 348 | APOE | umls:C0524620 | BeFree | The Pro12Ala PPARG sequence variant together with a non-E3/E3 APOE genotype is associated with a high risk for postprandial hypertriglyceridemia in patients with the metabolic syndrome, indicating a close association between these genes and the regulation of lipoproteinase clearance. | 0.032009073 | 2006 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 21877956 | 54512 | EXOSC4 | umls:C0524620 | BeFree | The frequency distribution of rare alleles for PPARα (L162V) and PPARγ (P12A and H449H) was compared using the chi square test in 363 HIV-1-infected patients classified according to the presence or absence of the metabolic syndrome after 48 months of follow-up on their first PI-containing regimen. | 0.001085767 | 2012 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 22168210 | 1636 | ACE | umls:C0524620 | BeFree | PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. | 0.037100455 | 2011 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 21877956 | 5465 | PPARA | umls:C0524620 | BeFree | There was no convincing association between any polymorphism of PPARα and PPARγ and each individual component of the metabolic syndrome, except for the relationship of the P12A polymorphism with diabetes. | 0.007177041 | 2012 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 24464185 | 5468 | PPARG | umls:C0524620 | BeFree | Associations between C1431T and Pro12Ala variants of PPARγ gene and their haplotypes with susceptibility to metabolic syndrome in an Iranian population. | 0.145004224 | 2014 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 19609844 | 5468 | PPARG | umls:C0524620 | BeFree | The Pro12Ala PPARgamma polymorphism does not seem to be associated with BMI or metabolic syndrome parameters in postmenopausal Polish women, although the X/Ala genotype seems to predispose to a less favorable lipid profile in this population. | 0.145004224 | 2009 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 12161548 | 5468 | PPARG | umls:C0524620 | BeFree | Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. | 0.145004224 | 2002 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 16916989 | 5468 | PPARG | umls:C0524620 | BeFree | Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome. | 0.145004224 | 2006 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 18362424 | 5468 | PPARG | umls:C0524620 | BeFree | The frequencies of 2 common polymorphisms of the PPARgamma gene, Pro12Ala single nucleotide polymorphism (SNP) in exon B and C161T SNP in exon 6, were investigated in 792 subjects and the correlations between the different genotypes, IR and metabolic syndrome (MS) were analyzed. | 0.145004224 | 2008 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 16216916 | 5225 | PGC | umls:C0524620 | BeFree | Our objective was to search for differences in genotypes of peroxisome proliferator-activated receptor gamma (PPARgamma) (Pro12 Ala) and its coactivator PGC-1alpha (Gly482 Ser) in adolescents harboring features of metabolic syndrome. | 0.000542884 | 2005 | PPARG | 3 | 12351626 | C | G |
| rs1801282 | 24200052 | 4023 | LPL | umls:C0524620 | BeFree | In the group of participants with PPARγ Pro12Ala or Ala12Ala genotypes, those with the LPL Pvu (-/+) or (+/+) genotype had greater odds for MetSy (odds ratio OR=5.98; 95% confidence interval CI: 1.46-24.47, p=0.013). | 0.139631029 | 2014 | PPARG | 3 | 12351626 | C | G |
| rs1801394 | 25429430 | 4552 | MTRR | umls:C0524620 | BeFree | Associations of MTHFR C677T and MTRR A66G gene polymorphisms with metabolic syndrome: a case-control study in Northern China. | 0.000271442 | 2014 | MTRR;FASTKD3 | 5 | 7870860 | A | G |
| rs1801394 | 25429430 | 4524 | MTHFR | umls:C0524620 | BeFree | Associations of MTHFR C677T and MTRR A66G gene polymorphisms with metabolic syndrome: a case-control study in Northern China. | 0.015635346 | 2014 | MTRR;FASTKD3 | 5 | 7870860 | A | G |
| rs1801704 | 22900502 | 154 | ADRB2 | umls:C0524620 | BeFree | ADRB2 haplotypes (comprising rs1042711, rs1801704, rs1042713 and rs1042714 in that order), genotyping and statistical analysis to evaluate associations with continuous variables and traits related to IR and MS in a PCOS population. | 0.013463811 | 2013 | ADRB2 | 5 | 148826812 | C | T |
| rs180349 | 22170361 | 84811 | BUD13 | umls:C0524620 | BeFree | Dietary calcium intake appears to be inversely associated with the risk of metabolic syndrome and may modulate susceptibility to the syndrome in subjects who are minor allele carriers of rs6445834 in ARHGEF3, rs10850335 in TBX5, or rs180349 in BUD13. | 0.122638474 | 2012 | NA | 11 | 116741111 | A | T |
| rs1805094 | 21744741 | 3953 | LEPR | umls:C0524620 | BeFree | Lys656Asn polymorphism of leptin receptor gene and metabolic syndrome in obese patients. | 0.012453989 | 2011 | LEPR | 1 | 65610269 | G | C |
| rs1805192 | 22168210 | 5468 | PPARG | umls:C0524620 | BeFree | PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. | 0.145004224 | 2011 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 12161548 | 5468 | PPARG | umls:C3714619 | BeFree | Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. | 0.000814326 | 2002 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 24200052 | 4023 | LPL | umls:C0524620 | BeFree | In the group of participants with PPARγ Pro12Ala or Ala12Ala genotypes, those with the LPL Pvu (-/+) or (+/+) genotype had greater odds for MetSy (odds ratio OR=5.98; 95% confidence interval CI: 1.46-24.47, p=0.013). | 0.139631029 | 2014 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 21877956 | 54512 | EXOSC4 | umls:C0524620 | BeFree | The frequency distribution of rare alleles for PPARα (L162V) and PPARγ (P12A and H449H) was compared using the chi square test in 363 HIV-1-infected patients classified according to the presence or absence of the metabolic syndrome after 48 months of follow-up on their first PI-containing regimen. | 0.001085767 | 2012 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 12630956 | 5468 | PPARG | umls:C0524620 | BeFree | These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome. | 0.145004224 | 2003 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 24464185 | 5468 | PPARG | umls:C0524620 | BeFree | Associations between C1431T and Pro12Ala variants of PPARγ gene and their haplotypes with susceptibility to metabolic syndrome in an Iranian population. | 0.145004224 | 2014 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 21877956 | 5468 | PPARG | umls:C0524620 | BeFree | There was no convincing association between any polymorphism of PPARα and PPARγ and each individual component of the metabolic syndrome, except for the relationship of the P12A polymorphism with diabetes. | 0.145004224 | 2012 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 18362424 | 5468 | PPARG | umls:C0524620 | BeFree | The frequencies of 2 common polymorphisms of the PPARgamma gene, Pro12Ala single nucleotide polymorphism (SNP) in exon B and C161T SNP in exon 6, were investigated in 792 subjects and the correlations between the different genotypes, IR and metabolic syndrome (MS) were analyzed. | 0.145004224 | 2008 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 16916989 | 5468 | PPARG | umls:C0524620 | BeFree | Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome. | 0.145004224 | 2006 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 21877956 | 5465 | PPARA | umls:C0524620 | BeFree | There was no convincing association between any polymorphism of PPARα and PPARγ and each individual component of the metabolic syndrome, except for the relationship of the P12A polymorphism with diabetes. | 0.007177041 | 2012 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 16216916 | 5225 | PGC | umls:C0524620 | BeFree | Our objective was to search for differences in genotypes of peroxisome proliferator-activated receptor gamma (PPARgamma) (Pro12 Ala) and its coactivator PGC-1alpha (Gly482 Ser) in adolescents harboring features of metabolic syndrome. | 0.000542884 | 2005 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 22168210 | 1636 | ACE | umls:C0524620 | BeFree | PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. | 0.037100455 | 2011 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 12161548 | 5468 | PPARG | umls:C0524620 | BeFree | Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. | 0.145004224 | 2002 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 19609844 | 5468 | PPARG | umls:C0524620 | BeFree | The Pro12Ala PPARgamma polymorphism does not seem to be associated with BMI or metabolic syndrome parameters in postmenopausal Polish women, although the X/Ala genotype seems to predispose to a less favorable lipid profile in this population. | 0.145004224 | 2009 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 16916989 | 348 | APOE | umls:C0524620 | BeFree | The Pro12Ala PPARG sequence variant together with a non-E3/E3 APOE genotype is associated with a high risk for postprandial hypertriglyceridemia in patients with the metabolic syndrome, indicating a close association between these genes and the regulation of lipoproteinase clearance. | 0.032009073 | 2006 | PPARG | 3 | 12379739 | C | G |
| rs1805192 | 24243083 | 5468 | PPARG | umls:C0524620 | BeFree | We investigated the synergism between variants at the PPARγ locus (C161T and Pro12Ala polymorphisms) with insulin resistance on metabolic syndrome (MS). | 0.145004224 | 2013 | PPARG | 3 | 12379739 | C | G |
| rs185847354 | 15063429 | 9370 | ADIPOQ | umls:C0524620 | BeFree | The I164T mutation in the adiponectin gene was a common genetic background associated with the metabolic syndrome and CAD in the Japanese population. | 0.184894604 | 2004 | ADIPOQ;ADIPOQ-AS1 | 3 | 186854460 | T | C |
| rs1883025 | 22399527 | 19 | ABCA1 | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.125819831 | 2012 | ABCA1 | 9 | 104902020 | C | T |
| rs1883025 | 22399527 | 19 | ABCA1 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.125819831 | 2012 | ABCA1 | 9 | 104902020 | C | T |
| rs1884613 | 21633728 | 3172 | HNF4A | umls:C0524620 | BeFree | Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. | 0.001357209 | 2011 | LOC105372629 | 20 | 44351775 | C | G |
| rs1884614 | 21633728 | 3172 | HNF4A | umls:C0524620 | BeFree | Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. | 0.001357209 | 2011 | LOC105372629 | 20 | 44351879 | C | T |
| rs1885088 | 21633728 | 3172 | HNF4A | umls:C0524620 | BeFree | Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. | 0.001357209 | 2011 | HNF4A | 20 | 44410400 | G | A |
| rs1919128 | 21386085 | 84226 | C2orf16 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.002367032 | 2011 | C2orf16 | 2 | 27578892 | A | G |
| rs2000813 | 19380136 | 9388 | LIPG | umls:C0524620 | BeFree | We examined associations between variants LIPG T111I (rs2000813) and LIPG i24582 (rs6507931), HDL and television viewing/computer use (screen time) as a marker for physical inactivity in a population with high prevalence of metabolic syndrome. | 0.001085767 | 2009 | LIPG | 18 | 49567494 | C | T |
| rs2043085 | 21386085 | 102724766 | LOC102724766 | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.12 | 2011 | LOC102724766 | 15 | 58388755 | T | C |
| rs2075263 | 20855566 | 4149 | MAX | umls:C0524620 | BeFree | This study determined the relationship between ACC2 polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). | 0.001357209 | 2010 | ACACB | 12 | 109266520 | C | T |
| rs2075290 | 21386085 | 8882 | ZPR1 | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.125276948 | 2011 | ZPR1 | 11 | 116782580 | C | T |
| rs2075290 | 21386085 | 8882 | ZPR1 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.125276948 | 2011 | ZPR1 | 11 | 116782580 | C | T |
| rs2108622 | 22484021 | 8529 | CYP4F2 | umls:C0524620 | BeFree | The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes. | 0.000271442 | 2012 | CYP4F2 | 19 | 15879621 | C | T |
| rs2144908 | 21633728 | 3172 | HNF4A | umls:C0524620 | BeFree | Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. | 0.001357209 | 2011 | HNF4A;LOC105372629 | 20 | 44357077 | G | A |
| rs2197089 | 21386085 | 4023 | LPL | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.139631029 | 2011 | NA | 8 | 19968862 | G | A |
| rs2206277 | 21386085 | 7021 | TFAP2B | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.122367032 | 2011 | TFAP2B | 6 | 50830813 | C | T |
| rs2206277 | 21386085 | 7021 | TFAP2B | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.122367032 | 2011 | TFAP2B | 6 | 50830813 | C | T |
| rs2228145 | 23479153 | 3570 | IL6R | umls:C0524620 | BeFree | Influence of the 48867A>C (Asp358Ala) IL6R polymorphism on response to a lifestyle modification intervention in individuals with metabolic syndrome. | 0.001085767 | 2014 | IL6R | 1 | 154454494 | A | C,T |
| rs2229094 | 20177654 | 4049 | LTA | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.008729747 | 2010 | LTA;LOC100287329 | 6 | 31572779 | T | C |
| rs2229094 | 20177654 | 7124 | TNF | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.022074006 | 2010 | LTA;LOC100287329 | 6 | 31572779 | T | C |
| rs2229616 | 18239646 | 4160 | MC4R | umls:C0524620 | BeFree | Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study. | 0.006362715 | 2008 | MC4R | 18 | 60372043 | C | T |
| rs2234693 | 22011627 | 2099 | ESR1 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.006905599 | 2012 | ESR1 | 6 | 151842200 | T | C |
| rs2234693 | 22011627 | 2100 | ESR2 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.003452799 | 2012 | ESR1 | 6 | 151842200 | T | C |
| rs2236242 | 22982016 | 5919 | RARRES2 | umls:C0524620 | BeFree | Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome, a preliminary report. | 0.002171535 | 2012 | SERPINA12 | 14 | 94493715 | T | A |
| rs2241766 | 23590605 | 9370 | ADIPOQ | umls:C0524620 | BeFree | Aim of the study was to evaluate the prevalence of metabolic symptoms in patients with PA compared to controls and the prevalence of two single nucleotide polymorphisms (SNPs), T45G and G276T, in the adiponectin gene and their relationship to metabolic syndrome (MS). | 0.184894604 | 2014 | ADIPOQ;ADIPOQ-AS1 | 3 | 186853103 | T | G |
| rs2241883 | 17485234 | 2168 | FABP1 | umls:C0524620 | BeFree | To determine the possible role of the common FABP1 T94A polymorphism in modulating susceptibility to traits of the metabolic syndrome, we analysed a random sample of 826 subjects from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort. | 0.002638474 | 2007 | FABP1 | 2 | 88124547 | T | C |
| rs225014 | 18198294 | 54512 | EXOSC4 | umls:C0524620 | BeFree | Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome. | 0.001085767 | 2007 | DIO2 | 14 | 80203237 | T | C |
| rs225014 | 18198294 | 1734 | DIO2 | umls:C0524620 | BeFree | Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome. | 0.002638474 | 2007 | DIO2 | 14 | 80203237 | T | C |
| rs2266788 | 21386085 | 8882 | ZPR1 | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.125276948 | 2011 | ZPR1;APOA5 | 11 | 116789970 | G | A |
| rs2266788 | 21386085 | 116519 | APOA5 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.171292716 | 2011 | ZPR1;APOA5 | 11 | 116789970 | G | A |
| rs2266788 | 21386085 | 116519 | APOA5 | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.171292716 | 2011 | ZPR1;APOA5 | 11 | 116789970 | G | A |
| rs2266788 | 21386085 | 8882 | ZPR1 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.125276948 | 2011 | ZPR1;APOA5 | 11 | 116789970 | G | A |
| rs2268387 | 20855566 | 4149 | MAX | umls:C0524620 | BeFree | This study determined the relationship between ACC2 polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). | 0.001357209 | 2010 | ACACB | 12 | 109205890 | A | G |
| rs2269383 | 22809552 | 1376 | CPT2 | umls:C0524620 | BeFree | We performed an analysis including three coding SNP in the muscle isoform of the CPT1b gene (rs3213445, rs2269383 and rs470117) and one coding SNP in the CPT2 gene (rs1799821) to find associations with traits of the metabolic syndrome (MetS). | 0.000542884 | 2013 | CPT1B;CHKB-CPT1B | 22 | 50574346 | C | T |
| rs2284685 | 20855566 | 4149 | MAX | umls:C0524620 | BeFree | This study determined the relationship between ACC2 polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). | 0.001357209 | 2010 | ACACB | 12 | 109248977 | G | C |
| rs2284689 | 20855566 | 4149 | MAX | umls:C0524620 | BeFree | This study determined the relationship between ACC2 polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). | 0.001357209 | 2010 | ACACB | 12 | 109247740 | A | G |
| rs2295490 | 19389818 | 57761 | TRIB3 | umls:C0524620 | BeFree | TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis. | 0.122638474 | 2009 | TRIB3 | 20 | 388261 | A | G |
| rs2300453 | 20855566 | 4149 | MAX | umls:C0524620 | BeFree | This study determined the relationship between ACC2 polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). | 0.001357209 | 2010 | ACACB | 12 | 109217349 | T | G |
| rs2395185 | 22383892 | 5919 | RARRES2 | umls:C0524620 | BeFree | Corresponding eSNPs were tested for association with MetS-related phenotypes in two GWAS of >100,000 individuals; rs10282458, affecting expression of RARRES2 (encoding chemerin), was associated with body mass index (BMI) (P = 6.0×10(-4)); and rs2395185, affecting inter-depot differences of HLA-DRB1 expression, was associated with high-density lipoprotein (P = 8.7×10(-4)) and BMI-adjusted waist-to-hip ratio (P = 2.4×10(-4)). | 0.002171535 | 2012 | NA | 6 | 32465390 | G | T |
| rs2395185 | 22383892 | 3123 | HLA-DRB1 | umls:C0524620 | BeFree | Corresponding eSNPs were tested for association with MetS-related phenotypes in two GWAS of >100,000 individuals; rs10282458, affecting expression of RARRES2 (encoding chemerin), was associated with body mass index (BMI) (P = 6.0×10(-4)); and rs2395185, affecting inter-depot differences of HLA-DRB1 expression, was associated with high-density lipoprotein (P = 8.7×10(-4)) and BMI-adjusted waist-to-hip ratio (P = 2.4×10(-4)). | 0.000814326 | 2012 | NA | 6 | 32465390 | G | T |
| rs247617 | 22399527 | 9709 | HERPUD1 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.004734064 | 2012 | NA | 16 | 56956804 | C | A |
| rs2526246 | 21920065 | 28965 | SLC27A6 | umls:C0524620 | BeFree | A total of 755 male participants from a Metabolic Intervention Cohort Kiel were genotyped for the FATP6-7T>A polymorphism (rs2526246) and phenotyped for features of the metabolic syndrome. | 0.000542884 | 2012 | SLC27A6 | 5 | 128966131 | T | A |
| rs2544390 | 25646961 | 116519 | APOA5 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.171292716 | 2014 | LRP2 | 2 | 169348336 | C | T |
| rs2544390 | 25646961 | 7350 | UCP1 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.003995683 | 2014 | LRP2 | 2 | 169348336 | C | T |
| rs2544390 | 25646961 | 8660 | IRS2 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.003995683 | 2014 | LRP2 | 2 | 169348336 | C | T |
| rs2544390 | 25646961 | 23026 | MYO16 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | LRP2 | 2 | 169348336 | C | T |
| rs2544390 | 25646961 | 4036 | LRP2 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | LRP2 | 2 | 169348336 | C | T |
| rs2544390 | 25646961 | 23158 | TBC1D9 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | LRP2 | 2 | 169348336 | C | T |
| rs266729 | 23845780 | 3630 | INS | umls:C0524620 | BeFree | No association was detected between SNP rs266729 and other clusters of metabolic syndrome or their traits except for HOMA-IR and fasting plasma insulin levels, p-values 0.035 and 0.004, respectively. | 0.166959444 | 2013 | ADIPOQ | 3 | 186841685 | C | G |
| rs268 | 22399527 | 4023 | LPL | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.139631029 | 2012 | LPL | 8 | 19956018 | A | G |
| rs268 | 22399527 | 4023 | LPL | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.139631029 | 2012 | LPL | 8 | 19956018 | A | G |
| rs2813544 | 22011627 | 2100 | ESR2 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.003452799 | 2012 | NA | 6 | 152104447 | A | G |
| rs2813544 | 22011627 | 2099 | ESR1 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.006905599 | 2012 | NA | 6 | 152104447 | A | G |
| rs2910164 | 25958310 | 406938 | MIR146A | umls:C0524620 | BeFree | Association of MicroRNA-146a rs2910164 Gene Polymorphism with Metabolic Syndrome. | 0.000271442 | 2016 | LOC285628;MIR146A | 5 | 160485411 | C | G |
| rs2918419 | 18194492 | 595 | CCND1 | umls:C0524620 | BeFree | Our objective was to test the association of rs2918419, a T-->C single nucleotide change in intron 2 downstream of the Bcl1 locus, with components of the metabolic syndrome and its interaction with the Bcl1 locus. | 0.000271442 | 2008 | NR3C1 | 5 | 143342788 | T | C |
| rs2943634 | 23101478 | 3667 | IRS1 | umls:C0524620 | BeFree | In this study we found support for the hypothesis that weight regulation and insulin metabolism are involved in MetS development.MC4R rs17782312 and IRS1 rs2943634 may explain part of the genetic variation in MetS. | 0.087177041 | 2012 | NA | 2 | 226203364 | A | C,G |
| rs2943634 | 23101478 | 4160 | MC4R | umls:C0524620 | BeFree | In this study we found support for the hypothesis that weight regulation and insulin metabolism are involved in MetS development.MC4R rs17782312 and IRS1 rs2943634 may explain part of the genetic variation in MetS. | 0.006362715 | 2012 | NA | 2 | 226203364 | A | C,G |
| rs295 | 21386085 | 4023 | LPL | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.139631029 | 2011 | LPL | 8 | 19958727 | A | C |
| rs295 | 21386085 | 4023 | LPL | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.139631029 | 2011 | LPL | 8 | 19958727 | A | C |
| rs2954033 | 21386085 | 10221 | TRIB1 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.002638474 | 2011 | LOC105375745 | 8 | 125481504 | A | G |
| rs301 | 21386085 | 4023 | LPL | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.139631029 | 2011 | LPL | 8 | 19959423 | T | C |
| rs301 | 21386085 | 4023 | LPL | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.139631029 | 2011 | LPL | 8 | 19959423 | T | C |
| rs3017887 | 25888935 | 1535 | CYBA | umls:C0524620 | BeFree | The results suggest that the evaluated NOX4 and CYBA SNPs are not direct genetic determinants of fibrosis in HCV patients, but nevertheless NOX4 rs3017887 SNP could indirectly influence fibrosis susceptibility due to its inverse association with MS in male patients. | 0.080271442 | 2015 | NOX4 | 11 | 89492920 | A | C |
| rs3020450 | 22011627 | 2100 | ESR2 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.003452799 | 2012 | ESR2 | 14 | 64301584 | C | T,A |
| rs3020450 | 22011627 | 2099 | ESR1 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.006905599 | 2012 | ESR2 | 14 | 64301584 | C | T,A |
| rs3099844 | 22399527 | 352961 | HCG26 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.002367032 | 2012 | LOC102725068 | 6 | 31481199 | C | A |
| rs3135506 | 21749608 | 3569 | IL6 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.143712589 | 2011 | APOA5 | 11 | 116791691 | G | A,C |
| rs3135506 | 21749608 | 345 | APOC3 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.100726728 | 2011 | APOA5 | 11 | 116791691 | G | A,C |
| rs3135506 | 21749608 | 6934 | TCF7L2 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.129001189 | 2011 | APOA5 | 11 | 116791691 | G | A,C |
| rs3135506 | 21749608 | 116519 | APOA5 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.171292716 | 2011 | APOA5 | 11 | 116791691 | G | A,C |
| rs3213445 | 22809552 | 1376 | CPT2 | umls:C0524620 | BeFree | We performed an analysis including three coding SNP in the muscle isoform of the CPT1b gene (rs3213445, rs2269383 and rs470117) and one coding SNP in the CPT2 gene (rs1799821) to find associations with traits of the metabolic syndrome (MetS). | 0.000542884 | 2013 | CPT1B;CHKB-CPT1B | 22 | 50577409 | T | C |
| rs361525 | 20177654 | 7124 | TNF | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.022074006 | 2010 | TNF | 6 | 31575324 | G | A |
| rs361525 | 20177654 | 4049 | LTA | umls:C0524620 | BeFree | Six common genetic variants (rs2229094, rs1041981, rs1800630, rs1800629, rs361525, and rs1800610) in the TNF-LTA locus encoding the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha have been shown to be associated with various metabolic traits including susceptibility to type 2 diabetes, metabolic syndrome, insulin resistance, and increased body mass index (BMI) in Caucasians from different geographic locations and have yielded mixed results. | 0.008729747 | 2010 | TNF | 6 | 31575324 | G | A |
| rs362551 | 25867398 | 6616 | SNAP25 | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.002638474 | 2016 | NA | 20 | 10314788 | C | A |
| rs362551 | 25867398 | 6833 | ABCC8 | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.002638474 | 2016 | NA | 20 | 10314788 | C | A |
| rs362551 | 25867398 | 3482 | IGF2R | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.000271442 | 2016 | NA | 20 | 10314788 | C | A |
| rs369953112 | 21749608 | 6934 | TCF7L2 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.129001189 | 2011 | IL6 | 7 | 22731416 | T | C |
| rs369953112 | 21749608 | 116519 | APOA5 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.171292716 | 2011 | IL6 | 7 | 22731416 | T | C |
| rs369953112 | 21749608 | 3569 | IL6 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.143712589 | 2011 | IL6 | 7 | 22731416 | T | C |
| rs369953112 | 21749608 | 345 | APOC3 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.100726728 | 2011 | IL6 | 7 | 22731416 | T | C |
| rs3732581 | 18758826 | 55486 | PARL | umls:C0524620 | GAD | [Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease.] | 0.002367032 | 2008 | PARL | 3 | 183840614 | C | T,G |
| rs3732581 | 18758826 | 3630 | INS | umls:C0524620 | BeFree | No significant associations were observed between rs3732581 and levels of plasma insulin, glucose, BMI or MetS in either population. | 0.166959444 | 2008 | PARL | 3 | 183840614 | C | T,G |
| rs3742023 | 20855566 | 4149 | MAX | umls:C0524620 | BeFree | This study determined the relationship between ACC2 polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). | 0.001357209 | 2010 | ACACB | 12 | 109256177 | C | T |
| rs3742026 | 20855566 | 4149 | MAX | umls:C0524620 | BeFree | This study determined the relationship between ACC2 polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). | 0.001357209 | 2010 | ACACB | 12 | 109232852 | G | T,C |
| rs3745367 | 24123702 | 56729 | RETN | umls:C0524620 | BeFree | However, rs1423096, downstream of RETN, seems to be associated with MetS and T2DM risk more so than rs3745367. | 0.130901282 | 2013 | RETN | 19 | 7669625 | G | A |
| rs3749147 | 21386085 | 79635 | CCDC121 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.002367032 | 2011 | GPN1;CCDC121 | 2 | 27629051 | G | A |
| rs3749147 | 21386085 | 11321 | GPN1 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.002367032 | 2011 | GPN1;CCDC121 | 2 | 27629051 | G | A |
| rs3757840 | 22399527 | 2645 | GCK | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.005819831 | 2012 | NA | 7 | 44191617 | T | G |
| rs3758391 | 20503258 | 3087 | HHEX | umls:C0524620 | BeFree | Nominally significant associations were also observed between T2D and the SIRT1 rs3758391 SNP and MS and the HHEX rs5015480 polymorphism. | 0.000271442 | 2010 | SIRT1 | 10 | 67883584 | T | C |
| rs3758391 | 20503258 | 23411 | SIRT1 | umls:C0524620 | BeFree | Nominally significant associations were also observed between T2D and the SIRT1 rs3758391 SNP and MS and the HHEX rs5015480 polymorphism. | 0.204267125 | 2010 | SIRT1 | 10 | 67883584 | T | C |
| rs375945855 | 21749608 | 345 | APOC3 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.100726728 | 2011 | TCF7L2 | 10 | 113165792 | C | T |
| rs375945855 | 21749608 | 3569 | IL6 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.143712589 | 2011 | TCF7L2 | 10 | 113165792 | C | T |
| rs375945855 | 21749608 | 116519 | APOA5 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.171292716 | 2011 | TCF7L2 | 10 | 113165792 | C | T |
| rs375945855 | 21749608 | 6934 | TCF7L2 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.129001189 | 2011 | TCF7L2 | 10 | 113165792 | C | T |
| rs3764261 | 21386085 | 9709 | HERPUD1 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.004734064 | 2011 | NA | 16 | 56959412 | C | A |
| rs3790433 | 20032477 | 54741 | LEPROT | umls:C0524620 | BeFree | LEPR rs3790433 GG homozygotes had increased MetS risk compared with the minor A allele carriers [odds ratio (OR) = 1.65; 95% CI: 1.05-2.57; P = 0.028], which may be accounted for by their increased risk of elevated insulin concentrations (OR 2.40; 95% CI: 1.28-4.50; P = 0.006) and insulin resistance (OR = 2.15; 95% CI: 1.18-3.90; P = 0.012). | 0.001357209 | 2010 | LEPR;LEPROT | 1 | 65428659 | C | T |
| rs3813929 | 18515891 | 3358 | HTR2C | umls:C0524620 | BeFree | Patients (n=134) were assessed for measures of obesity, other factors contributing to metabolic syndrome, and two genetic polymorphisms (5-HT(2C) receptor -759C/T and leptin -2548A/G). | 0.126362715 | 2008 | HTR2C | X | 114584047 | C | T |
| rs3816873 | 16721486 | 4547 | MTTP | umls:C0524620 | BeFree | Emerging evidence has indicated that the functional MTP exon polymorphism I128T is associated with dyslipidemia and other traits of the insulin-resistance syndrome, and the T128 variant seems to confer a reduced stability of MTP, resulting in reduced binding of LDL particles. | 0.004810009 | 2006 | MTTP | 4 | 99583507 | T | C |
| rs3816873 | 16721486 | 4547 | MTTP | umls:C3714619 | BeFree | Emerging evidence has indicated that the functional MTP exon polymorphism I128T is associated with dyslipidemia and other traits of the insulin-resistance syndrome, and the T128 variant seems to confer a reduced stability of MTP, resulting in reduced binding of LDL particles. | 0.000542884 | 2006 | MTTP | 4 | 99583507 | T | C |
| rs3818247 | 21633728 | 3172 | HNF4A | umls:C0524620 | BeFree | Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. | 0.001357209 | 2011 | HNF4A | 20 | 44428840 | G | T |
| rs3818569 | 25867398 | 6616 | SNAP25 | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.002638474 | 2016 | NA | NA | NA | NA | NA |
| rs3818569 | 25867398 | 6833 | ABCC8 | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.002638474 | 2016 | NA | NA | NA | NA | NA |
| rs3818569 | 25867398 | 3482 | IGF2R | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.000271442 | 2016 | NA | NA | NA | NA | NA |
| rs3856806 | 25896411 | 5468 | PPARG | umls:C0524620 | BeFree | The C1431T polymorphism of peroxisome proliferator activated receptor-γ (PPAR-γ) gene is related to diabetes and metabolic-syndrome. | 0.145004224 | 2015 | PPARG | 3 | 12434058 | C | T |
| rs3856806 | 25366759 | 5468 | PPARG | umls:C0524620 | BeFree | Analysis of the haplotype and linkage disequilibrium of PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province. | 0.145004224 | 2015 | PPARG | 3 | 12434058 | C | T |
| rs3856806 | 24464185 | 5468 | PPARG | umls:C0524620 | BeFree | Associations between C1431T and Pro12Ala variants of PPARγ gene and their haplotypes with susceptibility to metabolic syndrome in an Iranian population. | 0.145004224 | 2014 | PPARG | 3 | 12434058 | C | T |
| rs3856806 | 21643757 | 5468 | PPARG | umls:C0524620 | BeFree | The C1431T polymorphism in peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to be associated with diabetes, obesity, and metabolic syndrome. | 0.145004224 | 2012 | PPARG | 3 | 12434058 | C | T |
| rs3856806 | 21156835 | 5468 | PPARG | umls:C0524620 | BeFree | We concluded that the CC genotype of C1431T in the PPARγ2 gene together with low cardiorespiratory fitness may increase the risk of MetS in younger men (age < 40 yr), even with adjustment for age. | 0.145004224 | 2011 | PPARG | 3 | 12434058 | C | T |
| rs386513644 | 20851297 | 1268 | CNR1 | umls:C0524620 | BeFree | G1359A polymorphism in the cannabinoid receptor-1 gene is associated with metabolic syndrome in the Chinese Han population. | 0.003995683 | 2010 | NA | NA | NA | NA | NA |
| rs386513644 | 21472841 | 1268 | CNR1 | umls:C0524620 | BeFree | Relation of G1359A polymorphism of the cannabinoid receptor (CB1) gene with metabolic syndrome by ATP III classification. | 0.003995683 | 2011 | NA | NA | NA | NA | NA |
| rs386527835 | 17979097 | 80142 | PTGES2 | umls:C0524620 | BeFree | Prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism and parameters of the metabolic syndrome. | 0.002638474 | 2007 | NA | NA | NA | NA | NA |
| rs386539811 | 22308535 | 4852 | NPY | umls:C0524620 | BeFree | Neuropeptide Y Leu7Pro polymorphism associated with the metabolic syndrome and its features in patients with coronary artery disease. | 0.003995683 | 2013 | NA | NA | NA | NA | NA |
| rs386602118 | 20163778 | 7054 | TH | umls:C0524620 | BeFree | We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase). | 0.002638474 | 2010 | NA | NA | NA | NA | NA |
| rs386602118 | 20163778 | 4524 | MTHFR | umls:C0524620 | BeFree | We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase). | 0.015635346 | 2010 | NA | NA | NA | NA | NA |
| rs386602118 | 23967328 | 627 | BDNF | umls:C0524620 | BeFree | Association study of Val66Met polymorphism in brain-derived neurotrophic factor gene with clozapine-induced metabolic syndrome: preliminary results. | 0.003181358 | 2013 | NA | NA | NA | NA | NA |
| rs386602118 | 20163778 | 627 | BDNF | umls:C0524620 | BeFree | We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase). | 0.003181358 | 2010 | NA | NA | NA | NA | NA |
| rs397507444 | 22370993 | 4524 | MTHFR | umls:C0524620 | BeFree | Subjects were screened for the metabolic syndrome (National Cholesterol Education Program Adult Treatment Panel III criteria) and MTHFR 677C/T, MTHFR 1298A/C, and Val158Met genotypes. | 0.015635346 | 2012 | MTHFR | 1 | 11794407 | T | G |
| rs397508822 | 23810505 | 1080 | CFTR | umls:C0524620 | BeFree | Ten novel variants (c.2554_2555insT, p.F1107L, c.-152G>C, p.L323P, p.L32M, c.2883_2886dupGTCA, c.2349_2350insT, p.K114del, c.-602A>T, and c.2822delT) were associated with a CF phenotype (42% of participants were diagnosed at 4 to 25 months of age), whereas 26 were associated with CFTR-related metabolic syndrome to date. | 0.001357209 | 2013 | CFTR | 7 | 117540201 | C | T |
| rs4343 | 18057531 | 1636 | ACE | umls:C0524620 | GAD | [Homogeneous assay of rs4343, an ACE I/D proxy, and an analysis in the British Women's Heart and Health Study (BWHHS).] | 0.037100455 | 2008 | ACE | 17 | 63488670 | G | A |
| rs4402960 | 18853134 | 6934 | TCF7L2 | umls:C0524620 | BeFree | Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004). | 0.129001189 | 2008 | IGF2BP2 | 3 | 185793899 | G | T |
| rs4641 | 17327460 | 4000 | LMNA | umls:C0524620 | BeFree | LMNA maps to the well-replicated diabetes-linkage region on chromosome 1q, and there are reported associations between LMNA single nucleotide polymorphisms (SNPs) (particularly rs4641; H566H) and metabolic syndrome components. | 0.005081451 | 2007 | LMNA | 1 | 156137743 | C | T |
| rs470117 | 22809552 | 1376 | CPT2 | umls:C0524620 | BeFree | We performed an analysis including three coding SNP in the muscle isoform of the CPT1b gene (rs3213445, rs2269383 and rs470117) and one coding SNP in the CPT2 gene (rs1799821) to find associations with traits of the metabolic syndrome (MetS). | 0.000542884 | 2013 | CPT1B;CHKB-CPT1B | 22 | 50571524 | C | T |
| rs4766587 | 20855566 | 4149 | MAX | umls:C0524620 | BeFree | This study determined the relationship between ACC2 polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). | 0.001357209 | 2010 | ACACB | 12 | 109247525 | G | A |
| rs4766587 | 20855566 | 32 | ACACB | umls:C0524620 | BeFree | In conclusion, the ACC2 rs4766587 polymorphism influences MetS risk, which was modulated by dietary fat, suggesting novel gene-nutrient interactions. | 0.005276948 | 2010 | ACACB | 12 | 109247525 | G | A |
| rs4810424 | 21633728 | 3172 | HNF4A | umls:C0524620 | BeFree | Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. | 0.001357209 | 2011 | R3HDML | 20 | 44346383 | G | C |
| rs4846922 | 22399527 | 2590 | GALNT2 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.122367032 | 2012 | GALNT2 | 1 | 230171436 | T | C |
| rs4846922 | 22399527 | 2590 | GALNT2 | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.122367032 | 2012 | GALNT2 | 1 | 230171436 | T | C |
| rs4862417 | 20176858 | 4149 | MAX | umls:C0524620 | BeFree | We investigated the relationship between ACSL1 polymorphisms (rs4862417, rs6552828, rs13120078, rs9997745, and rs12503643) and MetS risk and determined potential interactions with dietary fat in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1,754). | 0.001357209 | 2010 | ACSL1 | 4 | 184769447 | A | G |
| rs4986938 | 22011627 | 2100 | ESR2 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.003452799 | 2012 | ESR2 | 14 | 64233098 | C | T |
| rs4986938 | 22011627 | 2099 | ESR1 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.006905599 | 2012 | ESR2 | 14 | 64233098 | C | T |
| rs4994 | 21034552 | 155 | ADRB3 | umls:C0524620 | BeFree | Relationship between Trp64Arg mutation in the β3-adrenergic receptor gene and metabolic syndrome: a seven-year follow-up study. | 0.028827715 | 2010 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 9250462 | 155 | ADRB3 | umls:C0524620 | BeFree | The Trp64Arg polymorphism of the beta 3-Adrenergic receptor gene. Lack of association with NIDDM and features of insulin resistance syndrome. | 0.028827715 | 1997 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 24972470 | 155 | ADRB3 | umls:C0524620 | BeFree | The objective of this work was to analyze the association of polymorphisms in ADRB1 (rs1801253) (Arg389Gly) and ADRB3 (Trp64Arg) genes with T2D and metabolic syndrome (MS). | 0.028827715 | 2015 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 24138564 | 155 | ADRB3 | umls:C0524620 | BeFree | We investigated whether the -3826A/G polymorphism (rs1800592) of the uncoupling protein 1 gene (UCP1) and the Trp64Arg polymorphism (rs4994) of the β3-adrenergic receptor gene (ADRB3) are associated with type 2 diabetes mellitus (T2DM) and features of metabolic syndrome in a Brazilian-Caucasian population. | 0.028827715 | 2014 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 8721782 | 155 | ADRB3 | umls:C0524620 | BeFree | A possible pathogenic mutation in the beta 3-adrenergic-receptor gene (Trp64Arg) has been reported to be associated with an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and clinical features of the insulin resistance syndrome in Pima Indian, Finnish and French subjects. | 0.028827715 | 1996 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 8923875 | 155 | ADRB3 | umls:C0524620 | BeFree | We recently identified a mutation in the human beta 3-adrenergic receptor (beta 3AR) gene (codon 64 TGGTrp -> CGGArg; TRP64ARG) that associates with features of the insulin resistance syndrome and an earlier onset of noninsulin-dependent diabetes mellitus (NIDDM). | 0.028827715 | 1996 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 20503258 | 155 | ADRB3 | umls:C0524620 | BeFree | In contrast, the non-synonymous ADRB3 rs4994 polymorphism is associated with T2D and MS. | 0.028827715 | 2010 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 8721782 | 155 | ADRB3 | umls:C3714619 | BeFree | A possible pathogenic mutation in the beta 3-adrenergic-receptor gene (Trp64Arg) has been reported to be associated with an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and clinical features of the insulin resistance syndrome in Pima Indian, Finnish and French subjects. | 0.002442977 | 1996 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 8923875 | 155 | ADRB3 | umls:C3714619 | BeFree | We recently identified a mutation in the human beta 3-adrenergic receptor (beta 3AR) gene (codon 64 TGGTrp -> CGGArg; TRP64ARG) that associates with features of the insulin resistance syndrome and an earlier onset of noninsulin-dependent diabetes mellitus (NIDDM). | 0.002442977 | 1996 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 9250462 | 155 | ADRB3 | umls:C3714619 | BeFree | The Trp64Arg polymorphism of the beta 3-Adrenergic receptor gene. Lack of association with NIDDM and features of insulin resistance syndrome. | 0.002442977 | 1997 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 10441039 | 155 | ADRB3 | umls:C3714619 | BeFree | The Trp64Arg beta3AR variant is associated in some, but not all, studies with an earlier onset of Type 2 diabetes mellitus and features of the insulin resistance syndrome. | 0.002442977 | 1999 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 12965109 | 155 | ADRB3 | umls:C3714619 | BeFree | To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro. | 0.002442977 | 2003 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 23282015 | 155 | ADRB3 | umls:C0524620 | BeFree | Trp64Arg polymorphism of the ADRB3 gene may affect VF accumulation and be associated with MS, a cluster of conditions involving aggravated lipid metabolism and higher blood pressure, in Japanese children. | 0.028827715 | 2012 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 10441039 | 155 | ADRB3 | umls:C0524620 | BeFree | The Trp64Arg beta3AR variant is associated in some, but not all, studies with an earlier onset of Type 2 diabetes mellitus and features of the insulin resistance syndrome. | 0.028827715 | 1999 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 24972470 | 153 | ADRB1 | umls:C0524620 | BeFree | The objective of this work was to analyze the association of polymorphisms in ADRB1 (rs1801253) (Arg389Gly) and ADRB3 (Trp64Arg) genes with T2D and metabolic syndrome (MS). | 0.000271442 | 2015 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 24138564 | 7350 | UCP1 | umls:C0524620 | BeFree | We investigated whether the -3826A/G polymorphism (rs1800592) of the uncoupling protein 1 gene (UCP1) and the Trp64Arg polymorphism (rs4994) of the β3-adrenergic receptor gene (ADRB3) are associated with type 2 diabetes mellitus (T2DM) and features of metabolic syndrome in a Brazilian-Caucasian population. | 0.003995683 | 2014 | ADRB3 | 8 | 37966280 | A | G |
| rs4994 | 12965109 | 155 | ADRB3 | umls:C0524620 | BeFree | To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro. | 0.028827715 | 2003 | ADRB3 | 8 | 37966280 | A | G |
| rs5015480 | 20503258 | 3087 | HHEX | umls:C0524620 | BeFree | Nominally significant associations were also observed between T2D and the SIRT1 rs3758391 SNP and MS and the HHEX rs5015480 polymorphism. | 0.000271442 | 2010 | NA | 10 | 92705802 | C | T |
| rs5015480 | 20503258 | 23411 | SIRT1 | umls:C0524620 | BeFree | Nominally significant associations were also observed between T2D and the SIRT1 rs3758391 SNP and MS and the HHEX rs5015480 polymorphism. | 0.204267125 | 2010 | NA | 10 | 92705802 | C | T |
| rs512535 | 21122859 | 3630 | INS | umls:C0524620 | BeFree | ApoB rs512535 and ApoA1 rs670 major G allele homozygotes had increased MetS risk (OR 1.65 [CI 1.24, 2.20], P = 0.0006; OR 1.42 [CI 1.08, 1.87], P = 0.013), which may be, partly, explained by their increased abdominal obesity and impaired insulin sensitivity (P<0.05) but not dyslipidemia. | 0.166959444 | 2011 | APOB | 2 | 21044910 | T | C |
| rs5186 | 19619703 | 154 | ADRB2 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.013463811 | 2009 | AGTR1 | 3 | 148742201 | A | C |
| rs5186 | 19619703 | 5054 | SERPINE1 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.01633012 | 2009 | AGTR1 | 3 | 148742201 | A | C |
| rs5186 | 17211857 | 185 | AGTR1 | umls:C0524620 | BeFree | Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. | 0.01482102 | 2007 | AGTR1 | 3 | 148742201 | A | C |
| rs5186 | 19619703 | 185 | AGTR1 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.01482102 | 2009 | AGTR1 | 3 | 148742201 | A | C |
| rs5186 | 19619703 | 3552 | IL1A | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.003181358 | 2009 | AGTR1 | 3 | 148742201 | A | C |
| rs5443 | 15033462 | 2784 | GNB3 | umls:C0524620 | BeFree | The C825T polymorphism in the gene coding for the beta3 subunit of G proteins (GNB3) has been shown to be associated with several phenotypes such as hypertension, obesity, and diabetes mellitus comprising the metabolic syndrome. | 0.009001189 | 2004 | GNB3;CDCA3 | 12 | 6845711 | C | T |
| rs5443 | 20170352 | 3667 | IRS1 | umls:C0524620 | BeFree | To assess the prevalence of IRS-1 Gly972Arg and GNB3 C825T polymorphisms in women with polycystic ovary syndrome (PCOS) and their relation to the metabolic syndrome and hyperandrogenaemia. | 0.087177041 | 2010 | GNB3;CDCA3 | 12 | 6845711 | C | T |
| rs5443 | 21979884 | 2784 | GNB3 | umls:C0524620 | BeFree | Clinically silent adrenal adenomas - their relation to the metabolic syndrome and to GNB3 C825T gene polymorphism. | 0.009001189 | 2011 | GNB3;CDCA3 | 12 | 6845711 | C | T |
| rs5443 | 20170352 | 2784 | GNB3 | umls:C0524620 | BeFree | To assess the prevalence of IRS-1 Gly972Arg and GNB3 C825T polymorphisms in women with polycystic ovary syndrome (PCOS) and their relation to the metabolic syndrome and hyperandrogenaemia. | 0.009001189 | 2010 | GNB3;CDCA3 | 12 | 6845711 | C | T |
| rs560887 | 22399527 | 57818 | G6PC2 | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.124734064 | 2012 | G6PC2 | 2 | 168906638 | T | C |
| rs560887 | 22399527 | 57818 | G6PC2 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.124734064 | 2012 | G6PC2 | 2 | 168906638 | T | C |
| rs569805 | 21386085 | 8647 | ABCB11 | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.122367032 | 2011 | ABCB11 | 2 | 168926370 | A | T |
| rs569805 | 21386085 | 8647 | ABCB11 | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.122367032 | 2011 | ABCB11 | 2 | 168926370 | A | T |
| rs5742909 | 19619703 | 1493 | CTLA4 | umls:C0524620 | BeFree | In a marker-by-marker analysis, the ADRB2 rs180088 (OR 1.22, 95% CI 1.01-1.48) and PAI1 rs1799768 (OR 1.05, 95% CI 1.01-1.10) were associated with an increased MetS risk, whereas the C5 rs17611 (OR 0.95, 95% CI 0.91-1.00) and the CTLA4 rs5742909 (OR 0.91, 95% CI 0.84-0.99) were associated with a decreased risk. | 0.000271442 | 2009 | CTLA4 | 2 | 203867624 | C | T |
| rs5742912 | 19619703 | 185 | AGTR1 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.01482102 | 2009 | SCNN1A | 12 | 6349184 | A | G |
| rs5742912 | 19619703 | 154 | ADRB2 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.013463811 | 2009 | SCNN1A | 12 | 6349184 | A | G |
| rs5742912 | 19619703 | 5054 | SERPINE1 | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.01633012 | 2009 | SCNN1A | 12 | 6349184 | A | G |
| rs5742912 | 19619703 | 6337 | SCNN1A | umls:C0524620 | BeFree | Effect modification of the SCNN1A rs5742912 on the MetS by hormone therapy use warrants further investigation. | 0.000271442 | 2009 | SCNN1A | 12 | 6349184 | A | G |
| rs5742912 | 19619703 | 3552 | IL1A | umls:C0524620 | BeFree | In postmenopausal women, an increased MetS risk was found for the ADRB2 rs180088 (OR 1.28, 95% CI 0.99-1.65), PAI1 rs1799768 (OR 1.07, 95% CI 1.01-1.14), SCNN1A rs5742912 (OR 1.22, 95% CI 1.01-1.47), and IL1A rs1800587 (OR 1.07, 95% CI 1.01-1.15), whereas the AGTR1 rs5186 (OR 0.93, 95% CI 0.87-0.99) was associated with decreased risk. | 0.003181358 | 2009 | SCNN1A | 12 | 6349184 | A | G |
| rs59914820 | 23746545 | 4000 | LMNA | umls:C0524620 | BeFree | We report on a 46-year-old female patient with a heterozygous p.R28W LMNA mutation, who presented with a novel clinical phenotype comprising severe limb-girdle muscular dystrophy, pronounced partial lipodystrophy, cardiac conduction defect, polycystic ovary disease and a metabolic syndrome with insulin-resistant diabetes mellitus and hypertriglyceridemia. | 0.005081451 | 2013 | LMNA | 1 | 156115000 | C | G,T |
| rs6031551 | 21633728 | 3172 | HNF4A | umls:C0524620 | BeFree | Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. | 0.001357209 | 2011 | HNF4A | 20 | 44361074 | T | C |
| rs6031552 | 21633728 | 3172 | HNF4A | umls:C0524620 | BeFree | Nine SNPs spanning the HNF4 alpha P2 promoter (rs4810424, rs1884613 and rs1884614) and coding region (rs2144908, rs6031551, rs6031552, rs1885088, rs1028583 and rs3818247) were genotyped in 160 subjects without diabetes or metabolic syndrome. | 0.001357209 | 2011 | HNF4A | 20 | 44361154 | C | A |
| rs6195 | 22801563 | 2908 | NR3C1 | umls:C0524620 | BeFree | Previous studies of the N363S and BclI SNP in the GR gene have shown a metabolic syndrome phenotype in mostly non-African populations. | 0.005352893 | 2012 | NA | NA | NA | NA | NA |
| rs6195 | 15919839 | 2908 | NR3C1 | umls:C0524620 | BeFree | The N363S polymorphism of the glucocorticoid receptor and metabolic syndrome factors in men. | 0.005352893 | 2005 | NA | NA | NA | NA | NA |
| rs6265 | 24269186 | 132789 | GNPDA2 | umls:C0524620 | BeFree | Of 11 SNPs, GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 were nominally associated with risk of MetS (GNPDA2 rs10938397: odds ratio (OR)=1.21, 95% confidence interval (CI)=1.04-1.40, P=0.016; BDNF rs6265: OR=1.19, 95% CI=1.03-1.39, P=0.021; FAIM2 rs7138803: OR=1.20, 95% CI=1.02-1.40, P=0.025); genetic risk score (GRS) was significantly associated with risk of MetS (OR=1.09, 95% CI=1.04-1.15, P=5.26×10(-4)). | 0.000542884 | 2013 | BDNF;BDNF-AS | 11 | 27658369 | C | T |
| rs6445834 | 22170361 | 84811 | BUD13 | umls:C0524620 | BeFree | Dietary calcium intake appears to be inversely associated with the risk of metabolic syndrome and may modulate susceptibility to the syndrome in subjects who are minor allele carriers of rs6445834 in ARHGEF3, rs10850335 in TBX5, or rs180349 in BUD13. | 0.122638474 | 2012 | ARHGEF3 | 3 | 56881691 | T | C |
| rs6507931 | 19380136 | 9388 | LIPG | umls:C0524620 | BeFree | We examined associations between variants LIPG T111I (rs2000813) and LIPG i24582 (rs6507931), HDL and television viewing/computer use (screen time) as a marker for physical inactivity in a population with high prevalence of metabolic syndrome. | 0.001085767 | 2009 | LIPG | 18 | 49586638 | C | T |
| rs6552828 | 20176858 | 4149 | MAX | umls:C0524620 | BeFree | We investigated the relationship between ACSL1 polymorphisms (rs4862417, rs6552828, rs13120078, rs9997745, and rs12503643) and MetS risk and determined potential interactions with dietary fat in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1,754). | 0.001357209 | 2010 | ACSL1 | 4 | 184804262 | A | G |
| rs6606697 | 20855566 | 4149 | MAX | umls:C0524620 | BeFree | This study determined the relationship between ACC2 polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). | 0.001357209 | 2010 | ACACB | 12 | 109173915 | A | G |
| rs662 | 25500007 | 5444 | PON1 | umls:C0524620 | BeFree | According to our results, PON1 Q192R polymorphism is a risk marker for insulin resistance, a pathological factor involved in the development of metabolic syndrome. | 0.127177041 | 2014 | PON1 | 7 | 95308134 | T | C |
| rs662 | 25037113 | 5444 | PON1 | umls:C0524620 | BeFree | Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity. | 0.127177041 | 2015 | PON1 | 7 | 95308134 | T | C |
| rs662799 | 25646961 | 23158 | TBC1D9 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 25646961 | 7350 | UCP1 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.003995683 | 2014 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 23468858 | 116519 | APOA5 | umls:C0524620 | BeFree | Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis. | 0.171292716 | 2013 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 24709297 | 116519 | APOA5 | umls:C0524620 | BeFree | Genetic variants of apolipoprotein A5 T-1131C and apolipoprotein E common polymorphisms and their relationship to features of metabolic syndrome in adult dyslipidemic patients. | 0.171292716 | 2014 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 24709297 | 348 | APOE | umls:C0524620 | BeFree | Genetic variants of apolipoprotein A5 T-1131C and apolipoprotein E common polymorphisms and their relationship to features of metabolic syndrome in adult dyslipidemic patients. | 0.032009073 | 2014 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 19055447 | 116519 | APOA5 | umls:C0524620 | BeFree | Apolipoprotein A5 gene -1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan. | 0.171292716 | 2008 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 25646961 | 4036 | LRP2 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 25646961 | 116519 | APOA5 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.171292716 | 2014 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 24161374 | 116519 | APOA5 | umls:C0524620 | BeFree | Apolipoprotein A5 T-1131C variant and risk for metabolic syndrome in obese adolescents. | 0.171292716 | 2013 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 25646961 | 23026 | MYO16 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 17922054 | 116519 | APOA5 | umls:C0524620 | BeFree | Apolipoprotein A5 T-1131C variant confers risk for metabolic syndrome. | 0.171292716 | 2007 | APOA5 | 11 | 116792991 | G | A |
| rs662799 | 25646961 | 8660 | IRS2 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.003995683 | 2014 | APOA5 | 11 | 116792991 | G | A |
| rs670 | 21122859 | 3630 | INS | umls:C0524620 | BeFree | ApoB rs512535 and ApoA1 rs670 major G allele homozygotes had increased MetS risk (OR 1.65 [CI 1.24, 2.20], P = 0.0006; OR 1.42 [CI 1.08, 1.87], P = 0.013), which may be, partly, explained by their increased abdominal obesity and impaired insulin sensitivity (P<0.05) but not dyslipidemia. | 0.166959444 | 2011 | APOA1;APOA1-AS | 11 | 116837697 | C | T |
| rs6711016 | 22399527 | 60526 | C2orf43 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.002367032 | 2012 | NA | 2 | 20923592 | C | A |
| rs6720173 | 15175352 | 64240 | ABCG5 | umls:C0524620 | BeFree | Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene. | 0.000271442 | 2004 | DYNC2LI1;ABCG5 | 2 | 43813262 | G | C |
| rs6720173 | 15175352 | 64241 | ABCG8 | umls:C0524620 | BeFree | Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene. | 0.002909916 | 2004 | DYNC2LI1;ABCG5 | 2 | 43813262 | G | C |
| rs6720173 | 15175352 | 64241 | ABCG8 | umls:C3714619 | BeFree | Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene. | 0.000271442 | 2004 | DYNC2LI1;ABCG5 | 2 | 43813262 | G | C |
| rs6720173 | 15175352 | 64240 | ABCG5 | umls:C3714619 | BeFree | Low serum cholesterol and cholesterol absorption were linked to the D19H polymorphism of the ABCG8 gene, and characteristics of the insulin resistance syndrome in men were linked with the Q604E polymorphism of the ABCG5 gene. | 0.000271442 | 2004 | DYNC2LI1;ABCG5 | 2 | 43813262 | G | C |
| rs673548 | 22399527 | 338 | APOB | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.131911105 | 2012 | APOB | 2 | 21014672 | G | A |
| rs673548 | 22399527 | 338 | APOB | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.131911105 | 2012 | APOB | 2 | 21014672 | G | A |
| rs6923761 | 25376528 | 2740 | GLP1R | umls:C0524620 | BeFree | Relation of the rs6923761 gene variant in glucagon-like peptide 1 receptor to metabolic syndrome in obese subjects. | 0.000542884 | 2014 | GLP1R | 6 | 39066296 | G | A,C |
| rs696217 | 16108842 | 51738 | GHRL | umls:C0524620 | BeFree | Large-scale studies of the Leu72Met polymorphism of the ghrelin gene in relation to the metabolic syndrome and associated quantitative traits. | 0.008729747 | 2005 | GHRL;GHRLOS | 3 | 10289773 | G | T |
| rs7138803 | 24269186 | 132789 | GNPDA2 | umls:C0524620 | BeFree | Of 11 SNPs, GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 were nominally associated with risk of MetS (GNPDA2 rs10938397: odds ratio (OR)=1.21, 95% confidence interval (CI)=1.04-1.40, P=0.016; BDNF rs6265: OR=1.19, 95% CI=1.03-1.39, P=0.021; FAIM2 rs7138803: OR=1.20, 95% CI=1.02-1.40, P=0.025); genetic risk score (GRS) was significantly associated with risk of MetS (OR=1.09, 95% CI=1.04-1.15, P=5.26×10(-4)). | 0.000542884 | 2013 | NA | 12 | 49853685 | G | A |
| rs7154455 | 22011627 | 2100 | ESR2 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.003452799 | 2012 | ESR2 | 14 | 64269942 | G | C |
| rs7154455 | 22011627 | 2099 | ESR1 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.006905599 | 2012 | ESR2 | 14 | 64269942 | G | C |
| rs7204609 | 21741858 | 79068 | FTO | umls:C0524620 | BeFree | The C allele of the rs7204609 polymorphism in the FTO gene increased the chance for the presence of MetS, especially central obesity, and microalbuminuria, independently of energy and nutrient intakes in this sample of type 2 diabetic patients from Southern Brazil. | 0.140097968 | 2012 | FTO | 16 | 53799693 | T | C |
| rs738409 | 24947770 | 80339 | PNPLA3 | umls:C0524620 | BeFree | Age and HOMA-IR were positive independent predictors of metabolic syndrome, while a negative independent association was found between metabolic syndrome and the homozygotes PNPLA3 I148M variant. | 0.006634157 | 2014 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 25939720 | 80339 | PNPLA3 | umls:C0524620 | BeFree | The PNPLA3 rs738409 polymorphism is associated already in youths with increased ALT, and is more frequent in obese with MetS of all ages. | 0.006634157 | 2015 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 25624712 | 80339 | PNPLA3 | umls:C0524620 | BeFree | First, we analyze the impact of demographic and ethnic characteristics of the PNPLA3 I148M variant and the presence of metabolic syndrome on the association between PNPLA3 I148M and NAFLD. | 0.006634157 | 2014 | PNPLA3 | 22 | 43928847 | C | G |
| rs75326924 | 11718687 | 948 | CD36 | umls:C3714619 | BeFree | Association of the Pro90Ser CD36 mutation with elevated free fatty acid concentrations but not with insulin resistance syndrome in Japanese. | 0.000271442 | 2001 | CD36 | 7 | 80656687 | C | T |
| rs75326924 | 11718687 | 948 | CD36 | umls:C0524620 | BeFree | Association of the Pro90Ser CD36 mutation with elevated free fatty acid concentrations but not with insulin resistance syndrome in Japanese. | 0.089348576 | 2001 | CD36 | 7 | 80656687 | C | T |
| rs7575840 | 21393584 | 338 | APOB | umls:C0524620 | BeFree | Furthermore, our transcript analyses of adipose RNA samples from 175 subjects in the Finnish Metabolic Syndrome in Men study indicate that rs7575840 alters expression of APOB (P=1.13×10(-10)) and a regional noncoding RNA (BU630349) (P=7.86×10(-6)) in adipose tissue. | 0.131911105 | 2011 | NA | 2 | 21050618 | G | T |
| rs767455 | 17200772 | 5054 | SERPINE1 | umls:C0524620 | BeFree | The aim of this study was to investigate the influence of polymorphism A36G of the TNF receptor 1 (TNFRSF1A +36A/G) on plasma concentrations of PAI-1 in 163 obese (31 with the metabolic syndrome, MetS) and 150 lean, healthy women. | 0.01633012 | 2007 | TNFRSF1A | 12 | 6341779 | T | C |
| rs767455 | 17200772 | 7124 | TNF | umls:C0524620 | BeFree | The aim of this study was to investigate the influence of polymorphism A36G of the TNF receptor 1 (TNFRSF1A +36A/G) on plasma concentrations of PAI-1 in 163 obese (31 with the metabolic syndrome, MetS) and 150 lean, healthy women. | 0.022074006 | 2007 | TNFRSF1A | 12 | 6341779 | T | C |
| rs767455 | 17200772 | 7132 | TNFRSF1A | umls:C0524620 | BeFree | The aim of this study was to investigate the influence of polymorphism A36G of the TNF receptor 1 (TNFRSF1A +36A/G) on plasma concentrations of PAI-1 in 163 obese (31 with the metabolic syndrome, MetS) and 150 lean, healthy women. | 0.000542884 | 2007 | TNFRSF1A | 12 | 6341779 | T | C |
| rs7757956 | 22011627 | 2099 | ESR1 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.006905599 | 2012 | ESR1 | 6 | 151996005 | T | A |
| rs7757956 | 22011627 | 2100 | ESR2 | umls:C0524620 | BeFree | To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. | 0.003452799 | 2012 | ESR1 | 6 | 151996005 | T | A |
| rs780093 | 21386085 | 2646 | GCKR | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.128729747 | 2011 | GCKR | 2 | 27519736 | T | C |
| rs780094 | 22399527 | 2646 | GCKR | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.128729747 | 2012 | GCKR | 2 | 27518370 | T | C |
| rs780094 | 22399527 | 2646 | GCKR | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.128729747 | 2012 | GCKR | 2 | 27518370 | T | C |
| rs782590 | 22399527 | 57223 | SMEK2 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.002367032 | 2012 | SMEK2 | 2 | 55616277 | C | T |
| rs7841189 | 22399527 | 4023 | LPL | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.139631029 | 2012 | NA | 8 | 19987865 | C | T |
| rs7903146 | 21749608 | 3569 | IL6 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.143712589 | 2011 | TCF7L2 | 10 | 112998590 | C | T |
| rs7903146 | 21749608 | 6934 | TCF7L2 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.129001189 | 2011 | TCF7L2 | 10 | 112998590 | C | T |
| rs7903146 | 18853134 | 6934 | TCF7L2 | umls:C0524620 | BeFree | Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004). | 0.129001189 | 2008 | TCF7L2 | 10 | 112998590 | C | T |
| rs7903146 | 19141698 | 6934 | TCF7L2 | umls:C0524620 | BeFree | In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease. | 0.129001189 | 2009 | TCF7L2 | 10 | 112998590 | C | T |
| rs7903146 | 21543200 | 4149 | MAX | umls:C0524620 | BeFree | This study investigated the relationship between the TCF7L2 rs7903146 polymorphism, insulin sensitivity/resistance and MetS in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n=1754) and determined potential interactions with dietary fat intake. | 0.001357209 | 2012 | TCF7L2 | 10 | 112998590 | C | T |
| rs7903146 | 21749608 | 345 | APOC3 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.100726728 | 2011 | TCF7L2 | 10 | 112998590 | C | T |
| rs7903146 | 21749608 | 116519 | APOA5 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.171292716 | 2011 | TCF7L2 | 10 | 112998590 | C | T |
| rs7903146 | 20694148 | 6934 | TCF7L2 | umls:C0524620 | GWASCAT | A genome-wide association study of the metabolic syndrome in Indian Asian men. | 0.129001189 | 2010 | TCF7L2 | 10 | 112998590 | C | T |
| rs7965413 | 25646961 | 7450 | VWF | umls:C0524620 | BeFree | Identification of an interaction between VWF rs7965413 and platelet count as a novel risk marker for metabolic syndrome: an extensive search of candidate polymorphisms in a case-control study. | 0.000542884 | 2014 | VWF | 12 | 6125723 | C | T |
| rs7965413 | 25646961 | 23026 | MYO16 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | VWF | 12 | 6125723 | C | T |
| rs7965413 | 25646961 | 116519 | APOA5 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.171292716 | 2014 | VWF | 12 | 6125723 | C | T |
| rs7965413 | 25646961 | 4036 | LRP2 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | VWF | 12 | 6125723 | C | T |
| rs7965413 | 25646961 | 8660 | IRS2 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.003995683 | 2014 | VWF | 12 | 6125723 | C | T |
| rs7965413 | 25646961 | 23158 | TBC1D9 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.000271442 | 2014 | VWF | 12 | 6125723 | C | T |
| rs7965413 | 25646961 | 7350 | UCP1 | umls:C0524620 | BeFree | Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2. | 0.003995683 | 2014 | VWF | 12 | 6125723 | C | T |
| rs8060686 | 22399527 | 23644 | EDC4 | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.122367032 | 2012 | EDC4 | 16 | 67877614 | T | C |
| rs8060686 | 22399527 | 23644 | EDC4 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.122367032 | 2012 | EDC4 | 16 | 67877614 | T | C |
| rs916829 | 25867398 | 6616 | SNAP25 | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.002638474 | 2016 | ABCC8 | 11 | 17418926 | A | G |
| rs916829 | 25867398 | 3482 | IGF2R | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.000271442 | 2016 | ABCC8 | 11 | 17418926 | A | G |
| rs916829 | 25867398 | 6833 | ABCC8 | umls:C0524620 | BeFree | For the SNP genotypes of rs362551 (SNAP25), rs3818569 (RXRG), rs1479355, rs1570070 (IGF2R), and rs916829 (ABCC8), heterozygotes showed a lower risk of MetS compared with the reference group. | 0.002638474 | 2016 | ABCC8 | 11 | 17418926 | A | G |
| rs9282541 | 18003760 | 19 | ABCA1 | umls:C0524620 | BeFree | The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. | 0.125819831 | 2008 | ABCA1 | 9 | 104858554 | G | A |
| rs964184 | 22399527 | 8882 | ZPR1 | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.125276948 | 2012 | ZPR1 | 11 | 116778201 | G | C |
| rs964184 | 22399527 | 335 | APOA1 | umls:C0524620 | BeFree | A previously known lipid locus, APOA1/C3/A4/A5 gene cluster region (SNP rs964184), was associated with MetS in all 4 study samples (P=7.23×10(-9) in meta-analysis). | 0.088262808 | 2012 | ZPR1 | 11 | 116778201 | G | C |
| rs964184 | 22399527 | 8882 | ZPR1 | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.125276948 | 2012 | ZPR1 | 11 | 116778201 | G | C |
| rs9939224 | 21386085 | 1071 | CETP | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.141650675 | 2011 | CETP | 16 | 56968820 | T | G |
| rs9939224 | 21386085 | 1071 | CETP | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.141650675 | 2011 | CETP | 16 | 56968820 | T | G |
| rs9939609 | 18339204 | 79068 | FTO | umls:C0524620 | GAD | [Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample.] | 0.140097968 | 2008 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 24675148 | 79068 | FTO | umls:C0524620 | BeFree | The FTO gene polymorphism (rs9939609) is associated with metabolic syndrome in morbidly obese subjects from southern Italy. | 0.140097968 | 2014 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 21749608 | 116519 | APOA5 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.171292716 | 2011 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 21749608 | 345 | APOC3 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.100726728 | 2011 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 23490278 | 79068 | FTO | umls:C0524620 | BeFree | The FTO gene polymorphism (rs9939609) was found to be associated with increased insulin resistance, insulin and triglyceride levels in obese females with TT variant and without metabolic syndrome. | 0.140097968 | 2013 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 18853134 | 6934 | TCF7L2 | umls:C0524620 | BeFree | Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004). | 0.129001189 | 2008 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 21749608 | 6934 | TCF7L2 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.129001189 | 2011 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 22311015 | 79068 | FTO | umls:C0524620 | BeFree | Common variant (rs9939609) in the FTO gene is associated with metabolic syndrome. | 0.140097968 | 2012 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 23490278 | 3630 | INS | umls:C0524620 | BeFree | The FTO gene polymorphism (rs9939609) was found to be associated with increased insulin resistance, insulin and triglyceride levels in obese females with TT variant and without metabolic syndrome. | 0.166959444 | 2013 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 22457394 | 79068 | FTO | umls:C0524620 | BeFree | In conclusion, FTO rs9939609 was associated with obesity measures, especially in those with the MetS, which was further exacerbated by high dietary SFA intake at baseline and 7.5 y later. | 0.140097968 | 2012 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 21749608 | 3569 | IL6 | umls:C0524620 | BeFree | The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. | 0.143712589 | 2011 | FTO | 16 | 53786615 | T | A |
| rs9939609 | 18339204 | 79068 | FTO | umls:C0524620 | BeFree | Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. | 0.140097968 | 2008 | FTO | 16 | 53786615 | T | A |
| rs9940128 | 22399527 | 79068 | FTO | umls:C0524620 | GWASCAT | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. | 0.140097968 | 2012 | FTO | 16 | 53766842 | G | A |
| rs9940128 | 22399527 | 79068 | FTO | umls:C0524620 | GAD | [Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and gluco] | 0.140097968 | 2012 | FTO | 16 | 53766842 | G | A |
| rs997509 | 18940878 | 5167 | ENPP1 | umls:C0524620 | BeFree | Effect of the rs997509 polymorphism on the association between ectonucleotide pyrophosphatase phosphodiesterase 1 and metabolic syndrome and impaired glucose tolerance in childhood obesity. | 0.014549579 | 2009 | ENPP1 | 6 | 131846837 | C | T |
| rs9987289 | 21386085 | 79660 | PPP1R3B | umls:C0524620 | GAD | [Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants.] | 0.002367032 | 2011 | LOC157273 | 8 | 9325848 | A | G |
| rs9987289 | 21386085 | 157273 | LOC157273 | umls:C0524620 | GWASCAT | A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. | 0.12 | 2011 | LOC157273 | 8 | 9325848 | A | G |
| rs9997745 | 20176858 | 3630 | INS | umls:C0524620 | BeFree | GG homozygotes for rs9997745 had increased MetS risk {odds ratio (OR) 1.90 [confidence interval (CI) 1.15, 3.13]; P = 0.01}, displayed elevated fasting glucose (P = 0.001) and insulin concentrations (P = 0.002) and increased insulin resistance (P = 0.03) relative to the A allele carriers. | 0.166959444 | 2010 | ACSL1 | 4 | 184816689 | G | A |
| rs9997745 | 20176858 | 4149 | MAX | umls:C0524620 | BeFree | We investigated the relationship between ACSL1 polymorphisms (rs4862417, rs6552828, rs13120078, rs9997745, and rs12503643) and MetS risk and determined potential interactions with dietary fat in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1,754). | 0.001357209 | 2010 | ACSL1 | 4 | 184816689 | G | A |
