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encyclopedia of Rare Disease Annotation for Precision Medicine

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	mesothelioma

Disease ID	1463
Disease	mesothelioma
Definition	A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Synonym	[m]mesothelioma, unspecified [m]mesothelioma, unspecified (morphologic abnormality) [x]mesothelioma, unspecified [x]mesothelioma, unspecified (disorder) mesothelioma (disorder) mesothelioma [disease/finding] mesothelioma, nos mesotheliomas
UMLS	C0025500
MeSH	D008654
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:42) C0014175 \| endometriosis \| 3 C0003949 \| asbestosis \| 2 C0027726 \| nephrotic syndrome \| 2 C0338106 \| colonic adenocarcinoma \| 2 C0206701 \| serous carcinoma \| 2 C0476089 \| endometrial ca \| 2 C0014859 \| esophageal tumor \| 1 C0206062 \| interstitial lung disease \| 1 C0149782 \| squamous cell carcinoma of the lung \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0476089 \| endometrial carcinoma \| 1 C0019322 \| umbilical hernia \| 1 C0376545 \| hematologic malignancies \| 1 C0279130 \| cns metastases \| 1 C0476089 \| endometrial cancer \| 1 C0152013 \| lung adenocarcinoma \| 1 C0684249 \| carcinoma of the lung \| 1 C0031069 \| periodic disease \| 1 C0001418 \| adenocarcinoma \| 1 C0080032 \| malignant effusion \| 1 C0158699 \| renal agenesis \| 1 C0153676 \| pulmonary metastases \| 1 C0036421 \| systemic sclerosis \| 1 C0032326 \| pneumothorax \| 1 C0001418 \| adenocarcinomas \| 1 C0155912 \| pulmonary alveolar microlithiasis \| 1 C0031046 \| pericarditis \| 1 C0024299 \| lymphoma \| 1 C0205697 \| sarcomatoid carcinoma \| 1 C0031048 \| constrictive pericarditis \| 1 C0007137 \| squamous cell carcinoma \| 1 C0020598 \| hypoglycemia \| 1 C1266119 \| localized fibrous tumor \| 1 C0220650 \| brain metastases \| 1 C0024314 \| lymphoproliferative disorder \| 1 C1720771 \| hydrocele \| 1 C0024115 \| lung disease \| 1 C0024623 \| gastric cancer \| 1 C0206681 \| clear cell carcinoma \| 1 C1334811 \| mucinous tumor \| 1 C0334607 \| psammoma \| 1 C0079419 \| li-fraumeni syndrome \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:41) 2247 \| FGF2 \| CTD_human 4831 \| NME2 \| CTD_human 54716 \| SLC6A20 \| CTD_human 8314 \| BAP1 \| CTD_human 3458 \| IFNG \| CTD_human 1956 \| EGFR \| CTD_human 84700 \| MYO18B \| CTD_human 8915 \| BCL10 \| CLINVAR 5241 \| PGR \| CTD_human 1029 \| CDKN2A \| CTD_human 6648 \| SOD2 \| CTD_human 23741 \| EID1 \| CTD_human 7490 \| WT1 \| CLINVAR 1958 \| EGR1 \| CTD_human 847 \| CAT \| CTD_human 324 \| APC \| CTD_human 22827 \| PUF60 \| CTD_human 2944 \| GSTM1 \| CTD_human 1027 \| CDKN1B \| CTD_human 7517 \| XRCC3 \| CTD_human 10232 \| MSLN \| CTD_human 999 \| CDH1 \| CTD_human 6696 \| SPP1 \| CTD_human 7515 \| XRCC1 \| CTD_human 2099 \| ESR1 \| CTD_human 4771 \| NF2 \| CTD_human 2934 \| GSN \| CTD_human 2662 \| GDF10 \| CTD_human 11186 \| RASSF1 \| CTD_human 6850 \| SYK \| CTD_human 55600 \| ITLN1 \| CTD_human 2475 \| MTOR \| CTD_human 94274 \| PPP1R14A \| CTD_human 4582 \| MUC1 \| CTD_human 5154 \| PDGFA \| CTD_human 56034 \| PDGFC \| CTD_human 2719 \| GPC3 \| CTD_human 1734 \| DIO2 \| CTD_human 7296 \| TXNRD1 \| CTD_human 2272 \| FHIT \| CTD_human 2246 \| FGF1 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1463
Disease	mesothelioma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:30) HP:0002664 \| Neoplasia \| 19 HP:0002202 \| Pleural effusion \| 9 HP:0030731 \| Carcinoma \| 4 HP:0012531 \| Pain \| 4 HP:0030127 \| Endometriosis \| 3 HP:0001541 \| Ascites \| 2 HP:0000100 \| Nephrosis \| 2 HP:0002716 \| Lymph node hyperplasia \| 2 HP:0030078 \| Lung adenocarcinoma \| 1 HP:0004872 \| Recurrent abdominal hernia \| 1 HP:0100751 \| Esophageal neoplasm \| 1 HP:0002665 \| Lymphoma \| 1 HP:0001945 \| Fever \| 1 HP:0001698 \| Pericardial effusions \| 1 HP:0012579 \| Minimal change glomerulonephritis \| 1 HP:0000104 \| Renal agenesis \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0001537 \| Umbilical hernias \| 1 HP:0012114 \| Endometrial carcinoma \| 1 HP:0002107 \| Collapsed lung \| 1 HP:0001943 \| Hypoglycemia \| 1 HP:0000718 \| Aggressive behaviour \| 1 HP:0002563 \| Constrictive pericarditis \| 1 HP:0006530 \| Interstitial lung disease \| 1 HP:0012889 \| Cervical endometriosis \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0001701 \| Pericarditis \| 1 HP:0001510 \| Growth deficiency \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0100615 \| Neoplasm of the ovary \| 1

Disease ID	1463
Disease	mesothelioma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:18) C2364133 \| infection C2119038 \| pleural metastasis C2073625 \| pleural effusion C1660219 \| analgesia C1373218 \| immunosuppression C0347016 \| spinal cord metastasis C0333516 \| oncolysis C0264545 \| pleural thickening C0080032 \| malignant pleural effusion C0080032 \| malignant effusion C0042338 \| herpes zoster C0032227 \| pleural effusions C0020615 \| hypoglycemia C0020437 \| hypercalcemia C0018794 \| heart block C0011168 \| dysphagia C0008031 \| chest pain C0002726 \| amyloidosis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0032227 \| pleural effusion \| 8 C0032227 \| pleural effusions \| 1 C0020598 \| hypoglycemia \| 1 C0347016 \| spinal cord metastasis \| 1 C0080032 \| malignant effusion \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121907908	NA	7490	WT1	umls:C0025500	CLINVAR	NA	0.12408156	NA	WT1	11	32400025	T	C
rs387906350	NA	8915	BCL10	umls:C0025500	CLINVAR	NA	0.120542884	NA	BCL10	1	85267829	-	A
rs587776639	NA	8915	BCL10	umls:C0025500	CLINVAR	NA	0.120542884	NA	BCL10	1	85270828	T	-

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1463
Disease	mesothelioma
Case	(Waiting for update.)

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