eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| meningococcal meningitis | ||||
| Disease ID | 213 |
|---|---|
| Disease | meningococcal meningitis |
| Definition | A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8) |
| Synonym | epidemic meningitis epidemics meningitis meningitis meningococcal meningitis, meningococcal meningitis, meningococcal [disease/finding] meningitis, meningococcic meningococcal meningitis (disorder) meningococcal meningitis (disorder) [ambiguous] meningococcic meningitis |
| Orphanet | |
| DOID | |
| ICD10 | |
| UMLS | C0025294 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:6) C0022656 | renal cortical necrosis | 1 C0442874 | neuropathy | 1 C0014057 | japanese encephalitis | 1 C0025289 | meningitis | 1 C0031046 | pericarditis | 1 C0024530 | malaria | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:3) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:28) 25805 | BAMBI | 4.713 | DISEASES 720 | C4A | 1.3 | DISEASES 721 | C4B | 2.79 | DISEASES 730 | C7 | 3.845 | DISEASES 834 | CASP1 | 1.695 | DISEASES 959 | CD40LG | 1.453 | DISEASES 1789 | DNMT3B | 1.285 | DISEASES 1805 | DPT | 1.314 | DISEASES 2152 | F3 | 1.474 | DISEASES 2224 | FDPS | 1.696 | DISEASES 3586 | IL10 | 1.091 | DISEASES 3664 | IRF6 | 1.278 | DISEASES 4153 | MBL2 | 2.529 | DISEASES 4318 | MMP9 | 1.224 | DISEASES 4700 | NDUFA6 | 1.804 | DISEASES 64332 | NFKBIZ | 2.63 | DISEASES 246734 | NPCDR1 | 2.207 | DISEASES 8398 | PLA2G6 | 1.785 | DISEASES 2889 | RAPGEF1 | 2.105 | DISEASES 6295 | SAG | 1.287 | DISEASES 25870 | SUMF2 | 1.694 | DISEASES 7096 | TLR1 | 1.571 | DISEASES 7099 | TLR4 | 2.594 | DISEASES 10333 | TLR6 | 1.904 | DISEASES 54106 | TLR9 | 2.775 | DISEASES 7124 | TNF | 1.213 | DISEASES 7177 | TPSAB1 | 3.13 | DISEASES 7709 | ZBTB17 | 3.057 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 213 |
|---|---|
| Disease | meningococcal meningitis |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:3) |
| Disease ID | 213 |
|---|---|
| Disease | meningococcal meningitis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:22) C2364050 | hypothermia C1963266 | uveitis C1963211 | pericarditis C1963154 | renal failure C1868998 | cytotoxic edema C1510428 | cerebral abscess C1384666 | hearing impairment C0686709 | meningococcal conjunctivitis C0155320 | cortical blindness C0149754 | periorbital cellulitis C0085650 | purpura fulminans C0037284 | skin lesions C0034063 | pulmonary oedema C0034063 | pulmonary edema C0032231 | pleuritis C0026976 | transverse myelitis C0026837 | muscle rigidity C0024535 | falciparum malaria C0017662 | mesangiocapillary glomerulonephritis C0009450 | infectious diseases C0008513 | chorioretinitis C0003864 | arthritis |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:1) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs5743704 | 20500688 | 7097 | TLR2 | umls:C0025294 | BeFree | Our data, in combination with a report by others show that the TLR2-P631H allele could be associated with protection to meningococcal meningitis, suggest that by dominantly inhibiting the response of cells important in the immune response this mutant might confer either protection or susceptibility to meningitis or tuberculosis, respectively. | 0.003181358 | 2010 | TLR2 | 4 | 153704799 | C | A |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
| Disease ID | 213 |
|---|---|
| Disease | meningococcal meningitis |
| Case | (Waiting for update.) |