eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| lyell syndrome | ||||
| Disease ID | 1378 |
|---|---|
| Disease | lyell syndrome |
| Definition | A systemic, serious, and life-threatening disorder characterized by erythematous and necrotic lesions in the skin and mucous membranes that are associated with bullous detachment of the epidermis. The epidermal and mucous membranes detachment leads to sepsis and may be fatal. The lesions appear throughout the body and occupy more than 30% of the body surfaces. It is a hypersensitivity reaction usually caused by drugs (e.g., sulfonamides, nonsteroidal anti-inflammatory drugs, anticonvulsants, and antiretroviral drugs). |
| Synonym | antibiotic necrolysis epidermal necrolyses, toxic epidermal necrolysis tox epidermal necrolysis, toxic epidermolysis, acute toxic leyell's syndrome lyell lyell toxic epidermal necrolysis, subepidermal type lyell's syndrome lyell's syndromes lyell's toxic epidermal necrolysis, subepidermal type lyell's toxic epidermal necrolysis, subepidermal type (disorder) lyells lyells syndrome necrolyses, toxic epidermal necrolysis - toxic necrolysis, toxic epidermal nonstaph scalded skin syndrome nonstaphylococcal scalded skin syndrome scalded skin syndrome nonstaph scalded skin syndrome, nonstaphylococcal syndrome lyell's syndrome, lyell's syndromes, lyell's ten ten - toxic epidermal necrolysis tens tox epidermal necrolysis toxic epideoneal necrolysis toxic epidermal necrolyses toxic epidermal necrolysis toxic epidrml necrolysis toxic necrolysis |
| Orphanet | |
| UMLS | C0014518 |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:25) C0002766 | analgesia | 4 C0015230 | rash | 3 C0409974 | lupus erythematosus | 3 C0042769 | virus infection | 2 C0026934 | mycoplasma | 2 C0005940 | osteopathy | 2 C0600260 | obstructive pulmonary disease | 1 C0004096 | asthma | 1 C0032266 | pneumatosis cystoides intestinalis | 1 C0024117 | chronic obstructive pulmonary disease | 1 C0024141 | systemic lupus erythematosus | 1 C0025007 | measles | 1 C0079731 | b-cell lymphoma | 1 C0011847 | diabetes | 1 C0026780 | mumps | 1 C0039494 | temporomandibular disorder | 1 C0032051 | placental insufficiency | 1 C0024117 | chronic obstructive pulmonary disease (copd) | 1 C0006142 | breast cancer | 1 C0019829 | hodgkin's disease | 1 C0009492 | compartment syndrome | 1 C0032302 | mycoplasma pneumonia | 1 C0032285 | pneumoniae | 1 C1145670 | respiratory failure | 1 C0039494 | temporomandibular disorders | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 1378 |
|---|---|
| Disease | lyell syndrome |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:27) HP:0012531 | Pain | 8 HP:0003418 | Back pain | 5 HP:0003419 | Low back pain | 4 HP:0001880 | Eosinophilia | 3 HP:0030756 | Erythrodontia | 1 HP:0100750 | Pulmonary atelectasis | 1 HP:0002721 | Immunodeficiency | 1 HP:0030833 | Neck pain | 1 HP:0002653 | Bone pain | 1 HP:0200039 | Pustules | 1 HP:0002013 | Emesis | 1 HP:0200034 | Papule | 1 HP:0012191 | B-cell lymphoma | 1 HP:0001945 | Fever | 1 HP:0030692 | Brain tumor | 1 HP:0008066 | Skin bullae | 1 HP:0012532 | Chronic pain | 1 HP:0012378 | Fatigue | 1 HP:0002725 | Systemic lupus erythematosus | 1 HP:0003002 | Breast carcinoma | 1 HP:0006510 | Chronic obstructive pulmonary disease | 1 HP:0002099 | Asthma | 1 HP:0002878 | Respiratory failure | 1 HP:0002883 | Rapid breathing | 1 HP:0000988 | Exanthem | 1 HP:0002904 | High blood bilirubin levels | 1 HP:0000989 | pruritis | 1 |
| Disease ID | 1378 |
|---|---|
| Disease | lyell syndrome |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:1) C0008049 | chickenpox |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:3) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs28399499 | 23774940 | 1555 | CYP2B6 | umls:C0014518 | BeFree | CYP2B6 G516T and T983C single nucleotide polymorphisms (SNPs) were found to be associated with SJS/TEN susceptibility. | 0.000271442 | 2013 | CYP2B6 | 19 | 41012316 | T | C |
| rs3745274 | 23774940 | 1555 | CYP2B6 | umls:C0014518 | BeFree | CYP2B6 G516T and T983C single nucleotide polymorphisms (SNPs) were found to be associated with SJS/TEN susceptibility. | 0.000271442 | 2013 | CYP2B6 | 19 | 41006936 | G | A,T |
| rs56308434 | 23774940 | 1555 | CYP2B6 | umls:C0014518 | BeFree | CYP2B6 G516T and T983C single nucleotide polymorphisms (SNPs) were found to be associated with SJS/TEN susceptibility. | 0.000271442 | 2013 | NA | NA | NA | NA | NA |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
| Disease ID | 1378 |
|---|---|
| Disease | lyell syndrome |
| Case | (Waiting for update.) |