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	liposarcoma

Disease ID	669
Disease	liposarcoma
Definition	A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)
Synonym	[m]liposarcoma nos [m]liposarcoma nos (morphologic abnormality) fibroliposarcoma liposarcoma (disorder) liposarcoma (morphologic abnormality) liposarcoma [disease/finding] liposarcoma morphology liposarcoma not otherwise specified liposarcoma, malignant liposarcoma, no icd-o subtype liposarcoma, no icd-o subtype (morphologic abnormality) liposarcoma, no international classification of diseases for oncology subtype liposarcoma, no international classification of diseases for oncology subtype (morphologic abnormality) liposarcoma, nos liposarcomas
Orphanet	ORPHANET:69078
DOID	DOID:3382
UMLS	C0023827
MeSH	D008080
SNOMED-CT	SNOMEDCT_US_2016_09_01:254829001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:30) C0023798 \| lipoma \| 4 C1261473 \| sarcomas \| 3 C0007134 \| renal cell carcinoma \| 3 C0023827 \| liposarcoma \| 3 C1261473 \| sarcoma \| 2 C0039101 \| synovial sarcoma \| 2 C1261473 \| soft tissue sarcomas \| 1 C0600139 \| prostatic carcinoma \| 1 C0023798 \| lipomas \| 1 C1266042 \| chromophobe renal cell carcinoma \| 1 C1261473 \| soft tissue sarcoma \| 1 C0019294 \| inguinal hernia \| 1 C0334121 \| inflammatory myofibroblastic tumor \| 1 C0585129 \| retroperitoneal sarcoma \| 1 C0036220 \| kaposi's sarcoma \| 1 C0007112 \| prostatic adenocarcinoma \| 1 C0494165 \| hepatic metastasis \| 1 C1266119 \| solitary fibrous tumor \| 1 C0019829 \| hodgkin lymphoma \| 1 C0334121 \| inflammatory pseudotumor \| 1 C0153676 \| pulmonary metastases \| 1 C0025202 \| malignant melanoma \| 1 C0010346 \| crohn's disease \| 1 C0029463 \| osteosarcoma \| 1 C0751483 \| hereditary retinoblastoma \| 1 C0021845 \| bowel perforation \| 1 C0085113 \| neurofibromatosis \| 1 C0740457 \| renal cancer \| 1 C1334699 \| mesenchymal tumor \| 1 C0024305 \| non-hodgkin lymphoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 2194 \| FASN \| CTD_human 4763 \| NF1 \| CTD_human 8089 \| YEATS4 \| CTD_human 1019 \| CDK4 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:116) 149685 \| ADIG \| 1.854 \| DISEASES 238 \| ALK \| 1.533 \| DISEASES 154796 \| AMOT \| 1.435 \| DISEASES 283 \| ANG \| 1.46 \| DISEASES 55107 \| ANO1 \| 1.651 \| DISEASES 9138 \| ARHGEF1 \| 2.596 \| DISEASES 488 \| ATP2A2 \| 1.584 \| DISEASES 546 \| ATRX \| 1.426 \| DISEASES 800 \| CALD1 \| 2.827 \| DISEASES 4267 \| CD99 \| 1.601 \| DISEASES 996 \| CDC27 \| 1.387 \| DISEASES 23097 \| CDK19 \| 1.779 \| DISEASES 1029 \| CDKN2A \| 2.982 \| DISEASES 1050 \| CEBPA \| 1.523 \| DISEASES 1675 \| CFD \| 1.321 \| DISEASES 9074 \| CLDN6 \| 1.284 \| DISEASES 283971 \| CLEC18C \| 5.486 \| DISEASES 1368 \| CPM \| 2.889 \| DISEASES 1380 \| CR2 \| 1.832 \| DISEASES 64764 \| CREB3L2 \| 6.338 \| DISEASES 1485 \| CTAG1B \| 2.805 \| DISEASES 1499 \| CTNNB1 \| 1.364 \| DISEASES 1649 \| DDIT3 \| 5.39 \| DISEASES 26052 \| DNM3 \| 1.49 \| DISEASES 29102 \| DROSHA \| 1.304 \| DISEASES 8445 \| DYRK2 \| 1.317 \| DISEASES 1874 \| E2F4 \| 1.241 \| DISEASES 10480 \| EIF3M \| 2.115 \| DISEASES 2115 \| ETV1 \| 2.038 \| DISEASES 2130 \| EWSR1 \| 5.282 \| DISEASES 2195 \| FAT1 \| 1.428 \| DISEASES 2199 \| FBLN2 \| 1.246 \| DISEASES 2259 \| FGF14 \| 1.433 \| DISEASES 2260 \| FGFR1 \| 1.221 \| DISEASES 2314 \| FLII \| 1.608 \| DISEASES 2300 \| FOXL1 \| 1.326 \| DISEASES 2308 \| FOXO1 \| 1.743 \| DISEASES 4303 \| FOXO4 \| 1.771 \| DISEASES 2356 \| FPGS \| 1.117 \| DISEASES 50486 \| G0S2 \| 1.248 \| DISEASES 23193 \| GANAB \| 1.212 \| DISEASES 2874 \| GPS2 \| 2.396 \| DISEASES 3039 \| HBA1 \| 2.258 \| DISEASES 3052 \| HCCS \| 5.488 \| DISEASES 85236 \| HIST1H2BK \| 2.258 \| DISEASES 8091 \| HMGA2 \| 4.035 \| DISEASES 29911 \| HOOK2 \| 1.979 \| DISEASES 10561 \| IFI44 \| 1.705 \| DISEASES 91156 \| IGFN1 \| 3.178 \| DISEASES 11172 \| INSL6 \| 2.271 \| DISEASES 55705 \| IPO9 \| 2.875 \| DISEASES 10379 \| IRF9 \| 1.056 \| DISEASES 3725 \| JUN \| 1.809 \| DISEASES 1316 \| KLF6 \| 1.436 \| DISEASES 25804 \| LSM4 \| 2.302 \| DISEASES 7786 \| MAP3K12 \| 1.057 \| DISEASES 4151 \| MB \| 2.201 \| DISEASES 154141 \| MBOAT1 \| 2.324 \| DISEASES 4168 \| MCF2 \| 2.195 \| DISEASES 4193 \| MDM2 \| 6.512 \| DISEASES 4194 \| MDM4 \| 1.789 \| DISEASES 9968 \| MED12 \| 1.342 \| DISEASES 57496 \| MKL2 \| 2.534 \| DISEASES 2315 \| MLANA \| 2.589 \| DISEASES 4311 \| MME \| 1.821 \| DISEASES 4338 \| MOCS2 \| 1.557 \| DISEASES 4609 \| MYC \| 1.912 \| DISEASES 89795 \| NAV3 \| 1.495 \| DISEASES 10499 \| NCOA2 \| 1.492 \| DISEASES 4763 \| NF1 \| 1.965 \| DISEASES 64332 \| NFKBIZ \| 1.21 \| DISEASES 10360 \| NPM3 \| 2.05 \| DISEASES 8013 \| NR4A3 \| 2.592 \| DISEASES 55611 \| OTUB1 \| 1.783 \| DISEASES 5074 \| PAWR \| 1.771 \| DISEASES 5081 \| PAX7 \| 1.762 \| DISEASES 5155 \| PDGFB \| 1.405 \| DISEASES 5236 \| PGM1 \| 1.371 \| DISEASES 23612 \| PHLDA3 \| 2.064 \| DISEASES 5324 \| PLAG1 \| 3.72 \| DISEASES 5499 \| PPP1CA \| 2.034 \| DISEASES 5501 \| PPP1CC \| 2.171 \| DISEASES 5515 \| PPP2CA \| 1.739 \| DISEASES 23532 \| PRAME \| 2.018 \| DISEASES 400736 \| PRAMEF13 \| 3.527 \| DISEASES 9055 \| PRC1 \| 2.16 \| DISEASES 5728 \| PTEN \| 1.627 \| DISEASES 84795 \| PYROXD2 \| 2.53 \| DISEASES 26064 \| RAI14 \| 1.979 \| DISEASES 8437 \| RASAL1 \| 1.297 \| DISEASES 9939 \| RBM8A \| 1.633 \| DISEASES 1102 \| RCBTB2 \| 1.788 \| DISEASES 5979 \| RET \| 1.549 \| DISEASES 6187 \| RPS2 \| 1.218 \| DISEASES 53637 \| S1PR5 \| 1.135 \| DISEASES 64218 \| SEMA4A \| 1.366 \| DISEASES 29072 \| SETD2 \| 1.166 \| DISEASES 23583 \| SMUG1 \| 2.911 \| DISEASES 6663 \| SOX10 \| 1.862 \| DISEASES 11166 \| SOX21 \| 2.949 \| DISEASES 10927 \| SPIN1 \| 1.704 \| DISEASES 10772 \| SRSF10 \| 3.258 \| DISEASES 6760 \| SS18 \| 2.66 \| DISEASES 6756 \| SSX1 \| 1.414 \| DISEASES 727837 \| SSX2B \| 2.431 \| DISEASES 55342 \| STRBP \| 2.017 \| DISEASES 8148 \| TAF15 \| 2.975 \| DISEASES 8115 \| TCL1A \| 1.185 \| DISEASES 58476 \| TP53INP2 \| 1.72 \| DISEASES 131405 \| TRIM71 \| 1.954 \| DISEASES 10103 \| TSPAN1 \| 1.305 \| DISEASES 6675 \| UAP1 \| 1.598 \| DISEASES 7321 \| UBE2D1 \| 1.885 \| DISEASES 7490 \| WT1 \| 2.605 \| DISEASES 4904 \| YBX1 \| 1.653 \| DISEASES 81030 \| ZBP1 \| 1.059 \| DISEASES
Locus	(Waiting for update.)

Disease ID	669
Disease	liposarcoma
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:9) HP:0003401 \| Paresthesia HP:0000077 \| Abnormality of the kidney HP:0012378 \| Fatigue HP:0002027 \| Abdominal pain HP:0001482 \| Subcutaneous nodule HP:0002017 \| Nausea and vomiting HP:0001824 \| Weight loss HP:0100242 \| Sarcoma HP:0002619 \| Varicose veins
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:22) HP:0002664 \| Neoplasia \| 14 HP:0030731 \| Carcinoma \| 5 HP:0012032 \| Lipoma \| 4 HP:0012034 \| Liposarcoma \| 3 HP:0005584 \| Renal cell carcinoma \| 3 HP:0001289 \| Confusion \| 2 HP:0012570 \| Synovial sarcoma \| 2 HP:0100242 \| Sarcoma \| 2 HP:0030448 \| Soft tissue sarcoma \| 1 HP:0002669 \| Osteosarcoma \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0100544 \| Heart tumor \| 1 HP:0002861 \| Melanoma \| 1 HP:0012031 \| Lipomatous tumor \| 1 HP:0100726 \| Kaposi's sarcoma \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0000023 \| Inguinal hernia \| 1 HP:0100790 \| Hernia \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0100013 \| Tumours of the breast \| 1 HP:0000718 \| Aggressive behaviour \| 1 HP:0012189 \| Hodgkin disease \| 1

Disease ID	669
Disease	liposarcoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C2248595 \| dedifferentiation C1704231 \| meningeal metastases C0686377 \| central nervous system metastasis C0346976 \| pancreatic metastasis C0153685 \| renal metastases C0153676 \| pulmonary metastasis C0085077 \| sweet syndrome C0023798 \| lipoma C0021843 \| intestinal obstruction
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0002793 \| dedifferentiation \| 7 C0023798 \| lipoma \| 4

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:3)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002017	Nausea and vomiting	MP:0010426	abnormal heart and great artery attachment	any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta
HP:0001824	Weight loss	MP:0005114	premature hair loss	release of fur at an earlier than expected time
HP:0000077	Abnormality of the kidney	MP:0011665	d-loop transposition of the great arteries	complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and th

Mapped by homologous gene(Total Items:9)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001824	Weight loss	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0002027	Abdominal pain	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0002619	Varicose veins	MP:0011967	increased or absent threshold for auditory brainstem response	increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency o
HP:0000077	Abnormality of the kidney	MP:0013294	prenatal lethality prior to heart atrial septation	death prior to the completion of heart atrial septation (Mus: E14.5-15.5)
HP:0001482	Subcutaneous nodule	MP:0013542	abnormal submandibular gland branching morphogenesis
HP:0003401	Paresthesia	MP:0014185	cerebellum atrophy	acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal
HP:0100242	Sarcoma	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0012378	Fatigue	MP:0013659	abnormal erythroid lineage cell morphology	any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes
HP:0002017	Nausea and vomiting	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye

Disease ID	669
Disease	liposarcoma
Case	(Waiting for update.)

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