eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| linear iga dermatosis | ||||
| Disease ID | 1371 |
|---|---|
| Disease | linear iga dermatosis |
| Definition | Autoimmune disease characterized by subepidermal blisters and linear deposition of autoantibodies at the dermoepidermal junction. The accumulated autoantibodies are of IMMUNOGLOBULIN A and occasionally IMMUNOGLOBULIN G classes against epidermal BASEMENT MEMBRANE proteins. The dermatosis is sometimes associated with malignancies and use of certain drugs (e.g., VANCOMYCIN). |
| Synonym | dermatoses, linear iga dermatosis iga linear dermatosis, linear iga iga - linear immunoglobulin a bullous dermatosis iga dermatoses, linear iga dermatosis, linear lad - linear iga disease linear iga linear iga bullous dermatosis linear iga bullous dermatosis [disease/finding] linear iga dermatoses linear iga dermatosis (disorder) linear iga disease linear immunoglobulin a bullous dermatosis linear immunoglobulin a dermatosis linear immunoglobulin a dermatosis (disorder) |
| Orphanet | |
| UMLS | C0406650 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:16) C0009324 | ulcerative colitis | 4 C0030805 | pemphigoid | 2 C0027947 | neutropenia | 1 C0024115 | lung disorders | 1 C0033860 | psoriasis | 1 C0022658 | nephropathy | 1 C0010346 | crohn's disease | 1 C0017661 | iga nephropathy | 1 C0009319 | colitis | 1 C1527336 | sjogren's syndrome | 1 C0043117 | idiopathic thrombocytopenic purpura | 1 C0042769 | virus infection | 1 C0019348 | herpes simplex virus infection | 1 C0014742 | erythema multiforme | 1 C0002312 | alpha thalassemia | 1 C0019348 | herpes simplex | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 1371 |
|---|---|
| Disease | linear iga dermatosis |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:9) HP:0000421 | Epistaxis HP:0009725 | Bladder neoplasm HP:0000155 | Oral ulcer HP:0002960 | Autoimmunity HP:0002037 | Inflammation of the large intestine HP:0000989 | Pruritus HP:0009726 | Renal neoplasm HP:0200034 | Papule HP:0008066 | Abnormal blistering of the skin |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:7) HP:0100279 | Ulcerative colitis | 4 HP:0001875 | Neutropenia | 1 HP:0008066 | Skin bullae | 1 HP:0100280 | Morbus Crohn | 1 HP:0003765 | Psoriasis | 1 HP:0002583 | Colitis | 1 HP:0000112 | Nephropathy | 1 |
| Disease ID | 1371 |
|---|---|
| Disease | linear iga dermatosis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:2) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:2) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0008066 | Abnormal blistering of the skin | MP:0009536 | abnormal interstitial cell of Cajal morphology | any structural anomaly in the type of cell found in the gastrointestinal tract and serving as a pacemaker that triggers gut contraction; ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which |
| HP:0002037 | Inflammation of the large intestine | MP:0004842 | abnormal large intestine crypts of Lieberkuhn morphology | any structural anomaly of the tubular intestinal glands found in the mucosal membranes of the large intestine |
Mapped by homologous gene(Total Items:8) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0000421 | Epistaxis | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0200034 | Papule | MP:0013745 | abnormal eyelid margin morphology | any structural anomaly of the confluence of the mucosal surface of the conjunctiva, the edge of the orbicularis, and the cutaneous epithelium |
| HP:0002037 | Inflammation of the large intestine | MP:0013803 | increased IgG2 level | greater than normal immunoglobulin class G2 level |
| HP:0000155 | Oral ulcer | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0002960 | Autoimmunity | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0000989 | Pruritus | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0009726 | Renal neoplasm | MP:0014171 | increased fatty acid oxidation | increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydr |
| HP:0008066 | Abnormal blistering of the skin | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| Disease ID | 1371 |
|---|---|
| Disease | linear iga dermatosis |
| Case | (Waiting for update.) |