eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine

HOME
QUERY
- DISEASE
- GENOTYPE
NETWORK
- PHENOTYPE
- GENE
- COMMON
- DISEASE PAIR
DOWNLOAD
SUBMIT CASE
HELP&FAQ
- HELP&FAQ
- CONTACT US


	lichen planus

Disease ID	715
Disease	lichen planus
Definition	An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a "saw-tooth" pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.
Synonym	lichen planus (disorder) lichen planus [disease/finding] lichen planus nos lichen planus nos (disorder) lichen ruber planus lichen rubra planus lichen, ruber planus lp - lichen planus ruber planus
DOID	DOID:9201
UMLS	C0023646
MeSH	D008010
SNOMED-CT	SNOMEDCT_US_2016_09_01:4776004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:42) C0019196 \| hepatitis c \| 9 C0019158 \| hepatitis \| 8 C0003467 \| anxiety \| 5 C0042769 \| virus infection \| 5 C0017574 \| gingivitis \| 4 C0011570 \| depression \| 3 C0021053 \| immune disease \| 3 C0007137 \| squamous cell carcinoma \| 2 C0019163 \| hepatitis b \| 2 C0040128 \| thyroid disease \| 2 C0948265 \| metabolic syndrome \| 2 C0008049 \| varicella \| 1 C0006840 \| candidosis \| 1 C0026896 \| myasthenia gravis \| 1 C0221027 \| good syndrome \| 1 C1568868 \| oral mucositis \| 1 C0376480 \| gingival enlargement \| 1 C0032580 \| polyposis coli \| 1 C0155550 \| neural deafness \| 1 C0032580 \| adenomatous polyposis coli \| 1 C0006849 \| oral candidosis \| 1 C0006840 \| candidiasis \| 1 C0026640 \| oral cancer \| 1 C0040100 \| thymoma \| 1 C0265334 \| pachyonychia congenita \| 1 C0022572 \| keratoacanthomas \| 1 C0022593 \| keratosis \| 1 C0039128 \| syphilis \| 1 C0013415 \| dysthymia \| 1 C0006840 \| candida infection \| 1 C0375071 \| vulvar cancer \| 1 C0162839 \| porokeratosis \| 1 C0026769 \| multiple sclerosis \| 1 C0007570 \| celiac disease \| 1 C0018784 \| sensorineural deafness \| 1 C0346054 \| verruciform xanthoma \| 1 C0019360 \| zoster \| 1 C0002170 \| alopecia \| 1 C0206706 \| verrucous carcinoma \| 1 C0085253 \| adult-onset still's disease \| 1 C0031099 \| periodontitis \| 1 C0036202 \| sarcoidosis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 3123 \| HLA-DRB1 \| CIPHER 7124 \| TNF \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:112) 11173 \| ADAMTS7 \| 1.383 \| DISEASES 276 \| AMY1A \| 1.044 \| DISEASES 277 \| AMY1B \| 1.044 \| DISEASES 278 \| AMY1C \| 1.044 \| DISEASES 481 \| ATP1B1 \| 1.575 \| DISEASES 488 \| ATP2A2 \| 2.345 \| DISEASES 538 \| ATP7A \| 1.183 \| DISEASES 283149 \| BCL9L \| 1.603 \| DISEASES 9184 \| BUB3 \| 1.442 \| DISEASES 59082 \| CARD18 \| 2.801 \| DISEASES 6364 \| CCL20 \| 1.242 \| DISEASES 910 \| CD1B \| 1.755 \| DISEASES 914 \| CD2 \| 1.717 \| DISEASES 50489 \| CD207 \| 2.373 \| DISEASES 51744 \| CD244 \| 1.104 \| DISEASES 29126 \| CD274 \| 2.137 \| DISEASES 958 \| CD40 \| 1.017 \| DISEASES 959 \| CD40LG \| 3.43 \| DISEASES 960 \| CD44 \| 1.292 \| DISEASES 965 \| CD58 \| 1.981 \| DISEASES 1029 \| CDKN2A \| 1.988 \| DISEASES 1041 \| CDSN \| 1.791 \| DISEASES 387836 \| CLEC2A \| 2.041 \| DISEASES 170482 \| CLEC4C \| 2.584 \| DISEASES 1308 \| COL17A1 \| 4.527 \| DISEASES 10087 \| COL4A3BP \| 1.765 \| DISEASES 1294 \| COL7A1 \| 1.733 \| DISEASES 64109 \| CRLF2 \| 1.507 \| DISEASES 4283 \| CXCL9 \| 3.311 \| DISEASES 2833 \| CXCR3 \| 3.124 \| DISEASES 1565 \| CYP2D6 \| 1.35 \| DISEASES 100289462 \| DEFB4B \| 2.383 \| DISEASES 1832 \| DSP \| 2.614 \| DISEASES 7957 \| EPM2A \| 1.267 \| DISEASES 356 \| FASLG \| 2.108 \| DISEASES 2214 \| FCGR3A \| 2.232 \| DISEASES 389549 \| FEZF1 \| 1.026 \| DISEASES 2312 \| FLG \| 3.072 \| DISEASES 388698 \| FLG2 \| 2.213 \| DISEASES 2316 \| FLNA \| 2.011 \| DISEASES 342184 \| FMN1 \| 1.655 \| DISEASES 50943 \| FOXP3 \| 2.985 \| DISEASES 2625 \| GATA3 \| 1.276 \| DISEASES 392862 \| GRID2IP \| 2.304 \| DISEASES 51696 \| HECA \| 1.16 \| DISEASES 3105 \| HLA-A \| 1.113 \| DISEASES 3106 \| HLA-B \| 1.137 \| DISEASES 3107 \| HLA-C \| 1.504 \| DISEASES 3329 \| HSPD1 \| 1.064 \| DISEASES 3339 \| HSPG2 \| 1.272 \| DISEASES 8692 \| HYAL2 \| 1.029 \| DISEASES 3440 \| IFNA2 \| 1.455 \| DISEASES 3456 \| IFNB1 \| 1.345 \| DISEASES 8518 \| IKBKAP \| 1.374 \| DISEASES 3586 \| IL10 \| 2.36 \| DISEASES 3605 \| IL17A \| 2.643 \| DISEASES 50616 \| IL22 \| 1.179 \| DISEASES 3563 \| IL3RA \| 2.649 \| DISEASES 22801 \| ITGA11 \| 2.142 \| DISEASES 3683 \| ITGAL \| 2.185 \| DISEASES 3684 \| ITGAM \| 1.323 \| DISEASES 3713 \| IVL \| 3.317 \| DISEASES 8242 \| KDM5C \| 1.018 \| DISEASES 547 \| KIF1A \| 1.054 \| DISEASES 3812 \| KIR3DL2 \| 1.227 \| DISEASES 440900 \| LINC01191 \| 2.857 \| DISEASES 4014 \| LOR \| 2.395 \| DISEASES 64900 \| LPIN3 \| 1.869 \| DISEASES 80059 \| LRRTM4 \| 2.709 \| DISEASES 2315 \| MLANA \| 2.196 \| DISEASES 27030 \| MLH3 \| 1.066 \| DISEASES 4312 \| MMP1 \| 1.474 \| DISEASES 4318 \| MMP9 \| 1.907 \| DISEASES 4599 \| MX1 \| 2.868 \| DISEASES 594857 \| NPS \| 1.174 \| DISEASES 2516 \| NR5A1 \| 2.381 \| DISEASES 9542 \| NRG2 \| 1.575 \| DISEASES 4942 \| OAT \| 1.908 \| DISEASES 4946 \| OAZ1 \| 1.809 \| DISEASES 80380 \| PDCD1LG2 \| 2.425 \| DISEASES 5178 \| PEG3 \| 1.008 \| DISEASES 5339 \| PLEC \| 2.225 \| DISEASES 6490 \| PMEL \| 1.402 \| DISEASES 5493 \| PPL \| 2.902 \| DISEASES 9374 \| PPT2 \| 1.072 \| DISEASES 5743 \| PTGS2 \| 1.582 \| DISEASES 201475 \| RAB12 \| 1.996 \| DISEASES 6014 \| RIT2 \| 2.044 \| DISEASES 6097 \| RORC \| 1.552 \| DISEASES 58490 \| RPRD1B \| 2.057 \| DISEASES 6280 \| S100A9 \| 1.859 \| DISEASES 6401 \| SELE \| 1.988 \| DISEASES 6663 \| SOX10 \| 1.001 \| DISEASES 6677 \| SPAM1 \| 1.023 \| DISEASES 9901 \| SRGAP3 \| 1.491 \| DISEASES 54879 \| ST7L \| 2.983 \| DISEASES 6863 \| TAC1 \| 1.914 \| DISEASES 129685 \| TAF8 \| 1.346 \| DISEASES 126637 \| TCHHL1 \| 3.035 \| DISEASES 7072 \| TIA1 \| 2.123 \| DISEASES 114609 \| TIRAP \| 1.928 \| DISEASES 7096 \| TLR1 \| 2.358 \| DISEASES 7099 \| TLR4 \| 2.331 \| DISEASES 51284 \| TLR7 \| 1.544 \| DISEASES 54106 \| TLR9 \| 1.612 \| DISEASES 7124 \| TNF \| 3.778 \| DISEASES 8784 \| TNFRSF18 \| 1.272 \| DISEASES 7133 \| TNFRSF1B \| 2.2 \| DISEASES 8718 \| TNFRSF25 \| 2.151 \| DISEASES 85480 \| TSLP \| 1.721 \| DISEASES 9094 \| UNC119 \| 1.111 \| DISEASES 7422 \| VEGFA \| 1.439 \| DISEASES
Locus	(Waiting for update.)

Disease ID	715
Disease	lichen planus
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:33) HP:0012115 \| Liver inflammation \| 9 HP:0000739 \| Anxiety \| 5 HP:0000230 \| Inflamed gums \| 5 HP:0030731 \| Carcinoma \| 3 HP:0000716 \| Depression \| 3 HP:0002960 \| Autoimmune condition \| 3 HP:0002745 \| Oral idiopathic leukoplakia \| 2 HP:0100699 \| Scarring \| 2 HP:0012531 \| Pain \| 2 HP:0002860 \| Squamous cell carcinoma \| 2 HP:0001596 \| Hair loss \| 2 HP:0200123 \| Chronic liver inflammation \| 2 HP:0000820 \| Thyroid abnormality \| 2 HP:0008404 \| Dystrophic nails \| 1 HP:0200120 \| Chronic active hepatitis \| 1 HP:0002608 \| Celiac disease \| 1 HP:0100522 \| Thymoma \| 1 HP:0000704 \| Pyorrhea \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0000989 \| pruritis \| 1 HP:0010783 \| Erythema \| 1 HP:0003473 \| Fatigable weakness \| 1 HP:0000212 \| Gingival overgrowth \| 1 HP:0003764 \| Naevus \| 1 HP:0000407 \| sensorineural hearing loss \| 1 HP:0002043 \| Esophageal stricture \| 1 HP:0007418 \| Alopecia totalis \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0008066 \| Skin bullae \| 1 HP:0008527 \| Hearing loss, congenital sensorineural \| 1 HP:0200016 \| Acral keratosis \| 1 HP:0000365 \| Hearing impairment \| 1 HP:0200044 \| Porokeratosis \| 1

Disease ID	715
Disease	lichen planus
Manually Symptom	UMLS \| Name(Total Manually Symptoms:38) C2364133 \| infection C2186532 \| liver disease C1420725 \| thymoma C1290886 \| chronic inflammatory disease C1274790 \| cicatrizing conjunctivitis C0878500 \| epithelial dysplasia C0850666 \| h. pylori infection C0849640 \| skin damage C0520463 \| active chronic hepatitis C0451641 \| urolithiasis C0409974 \| lupus erythematosus C0406443 \| twenty-nail dystrophy C0271650 \| glucose intolerance C0235401 \| abnormal glucose tolerance C0221260 \| nail dystrophy C0220847 \| hepatitis c C0220641 \| oral cancer C0151546 \| oral carcinomas C0086873 \| scarring alopecia C0042900 \| vitiligo C0042769 \| virus infection C0041408 \| turner's syndrome C0037285 \| skin manifestations C0037284 \| skin lesions C0033860 \| psoriasis C0033774 \| pruritus C0030805 \| bullous pemphigoid C0029166 \| oral manifestations C0029166 \| oral manifestation C0024141 \| le syndrome C0022906 \| canalicular obstruction C0022573 \| keratoconjunctivitis C0022572 \| keratoacanthoma C0021053 \| immune disorder C0017677 \| benign migratory glossitis C0017577 \| desquamative gingivitis C0014866 \| oesophageal stricture C0009763 \| conjunctivitis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:10) C0009450 \| infection \| 11 C0019196 \| hepatitis c \| 9 C0042769 \| virus infection \| 5 C0037284 \| skin lesions \| 2 C0017577 \| desquamative gingivitis \| 2 C0037285 \| skin manifestations \| 1 C0221260 \| nail dystrophy \| 1 C0033774 \| pruritus \| 1 C0040100 \| thymoma \| 1 C0026640 \| oral cancer \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	715
Disease	lichen planus
Case	(Waiting for update.)

Web Analytics Made Easy - StatCounter