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	leptospirosis

Disease ID	554
Disease	leptospirosis
Definition	Infections with bacteria of the genus LEPTOSPIRA.
Synonym	[x]leptospirosis, unspecified [x]leptospirosis, unspecified (disorder) cane cutter's fever fort bragg fever harvest fever infection due to leptospira infection due to leptospira, nos japanese autumnal fever leptospiroses leptospirosis (disorder) leptospirosis [disease/finding] leptospirosis nos leptospirosis nos (disorder) leptospirosis, nos leptospirosis, unspecified mud fever queensland fever red water fever rice-field worker's disease spirochaetal jaundice spirochetal jaundice stuttgart disease weil disease
Orphanet	ORPHANET:509
DOID	DOID:2297 DOID:5086
ICD10	ICD10CM:A27.9
UMLS	C0023364
MeSH	D007922 D014895
SNOMED-CT	SNOMEDCT_US_2016_09_01:77377001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:28) C0035078 \| renal failure \| 7 C0040034 \| thrombocytopenia \| 5 C0022660 \| acute renal failure \| 5 C0027059 \| myocarditis \| 4 C1145670 \| respiratory failure \| 3 C0030305 \| pancreatitis \| 3 C0019101 \| hemorrhagic fever with renal syndrome \| 1 C0031046 \| pericarditis \| 1 C0032285 \| pneumonitis \| 1 C0041466 \| typhoid fever \| 1 C1565489 \| renal insufficiency \| 1 C0034155 \| thrombotic thrombocytopenic purpura \| 1 C0022667 \| papillary necrosis \| 1 C0041466 \| typhoid \| 1 C0155686 \| acute myocarditis \| 1 C0085293 \| hepatitis e \| 1 C0001973 \| alcoholism \| 1 C0042164 \| uveitis \| 1 C0027697 \| nephritis \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0022116 \| ischaemia \| 1 C0001339 \| acute pancreatitis \| 1 C0267841 \| acalculous cholecystitis \| 1 C0019158 \| hepatitis \| 1 C0008325 \| cholecystitis \| 1 C0027707 \| interstitial nephritis \| 1 C0024198 \| lyme disease \| 1 C0001126 \| renal tubular acidosis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 3119 \| HLA-DQB1 \| CIPHER 3123 \| HLA-DRB1 \| CIPHER 7124 \| TNF \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:55) 55811 \| ADCY10 \| 1.366 \| DISEASES 2334 \| AFF2 \| 1.935 \| DISEASES 8852 \| AKAP4 \| 1.949 \| DISEASES 27329 \| ANGPTL3 \| 1.383 \| DISEASES 10018 \| BCL2L11 \| 2.705 \| DISEASES 140707 \| BRI3BP \| 3.811 \| DISEASES 149466 \| C1orf210 \| 1.696 \| DISEASES 721 \| C4B \| 3.421 \| DISEASES 959 \| CD40LG \| 6.13 \| DISEASES 1003 \| CDH5 \| 1.202 \| DISEASES 9635 \| CLCA2 \| 1.35 \| DISEASES 7464 \| CORO2A \| 2.06 \| DISEASES 1431 \| CS \| 1.011 \| DISEASES 51428 \| DDX41 \| 1.009 \| DISEASES 29940 \| DSE \| 2.065 \| DISEASES 1837 \| DTNA \| 1.443 \| DISEASES 2021 \| ENDOG \| 1.273 \| DISEASES 2152 \| F3 \| 2.525 \| DISEASES 2242 \| FES \| 1.049 \| DISEASES 2266 \| FGG \| 1.445 \| DISEASES 2582 \| GALE \| 1.982 \| DISEASES 2710 \| GK \| 1.528 \| DISEASES 29889 \| GNL2 \| 1.143 \| DISEASES 3033 \| HADH \| 1.01 \| DISEASES 3030 \| HADHA \| 2.165 \| DISEASES 54363 \| HAO1 \| 1.351 \| DISEASES 3052 \| HCCS \| 1.142 \| DISEASES 55733 \| HHAT \| 1.271 \| DISEASES 3127 \| HLA-DRB5 \| 1.589 \| DISEASES 81502 \| HM13 \| 1.034 \| DISEASES 3240 \| HP \| 1.044 \| DISEASES 3329 \| HSPD1 \| 2.714 \| DISEASES 3586 \| IL10 \| 2.904 \| DISEASES 3594 \| IL12RB1 \| 1.095 \| DISEASES 4018 \| LPA \| 1.05 \| DISEASES 4050 \| LTB \| 2.504 \| DISEASES 4151 \| MB \| 1.89 \| DISEASES 8972 \| MGAM \| 1.651 \| DISEASES 4615 \| MYD88 \| 1.653 \| DISEASES 255743 \| NPNT \| 2.256 \| DISEASES 56980 \| PRDM10 \| 1.346 \| DISEASES 23221 \| RHOBTB2 \| 1.89 \| DISEASES 6181 \| RPLP2 \| 3.046 \| DISEASES 6189 \| RPS3A \| 1.541 \| DISEASES 54938 \| SARS2 \| 1.287 \| DISEASES 462 \| SERPINC1 \| 1.013 \| DISEASES 6557 \| SLC12A1 \| 3.059 \| DISEASES 55576 \| STAB2 \| 3.118 \| DISEASES 3925 \| STMN1 \| 1.402 \| DISEASES 25870 \| SUMF2 \| 3.757 \| DISEASES 7096 \| TLR1 \| 1.572 \| DISEASES 7099 \| TLR4 \| 3.441 \| DISEASES 7124 \| TNF \| 2.659 \| DISEASES 7709 \| ZBTB17 \| 2.056 \| DISEASES 643836 \| ZFP62 \| 3.166 \| DISEASES
Locus	(Waiting for update.)

Disease ID	554
Disease	leptospirosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:29) HP:0001945 \| Fever \| 9 HP:0001873 \| Low platelet count \| 6 HP:0000083 \| Renal insufficiency \| 6 HP:0001919 \| Acute renal failure \| 5 HP:0012819 \| Myocarditis \| 4 HP:0002878 \| Respiratory failure \| 3 HP:0001733 \| Pancreatic inflammation \| 3 HP:0012115 \| Liver inflammation \| 2 HP:0001399 \| Liver failure \| 2 HP:0006554 \| Acute hepatic failure \| 2 HP:0002385 \| Paraparesis \| 2 HP:0100806 \| Sepsis \| 1 HP:0000123 \| Nephritis \| 1 HP:0002155 \| Increased triglycerides \| 1 HP:0001082 \| Cholecystitis \| 1 HP:0000952 \| Yellow skin \| 1 HP:0002105 \| Hemoptysis \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0012418 \| Low blood oxygen level \| 1 HP:0001947 \| Renal tubular acidosis \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0001701 \| Pericarditis \| 1 HP:0001970 \| Interstitial nephritis \| 1 HP:0008341 \| Renal tubular acidosis, type I \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0000554 \| Uveitis \| 1 HP:0100520 \| Oliguria \| 1 HP:0001941 \| acidemia \| 1

Disease ID	554
Disease	leptospirosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:57) C2364133 \| infection C2364118 \| weakness C2203646 \| jaundice C2073625 \| pleural effusion C1963266 \| uveitis C1963211 \| pericarditis C1963198 \| pancreatitis C1963164 \| lymphopenia C1963154 \| renal failure C1839611 \| n syndrome C1565662 \| acute renal insufficiency C1565489 \| renal insufficiency C1402315 \| vascular lesions C1299910 \| keratouveitis C1145670 \| respiratory failure C1000483 \| anemia C0948600 \| organ failure C0871189 \| psychotic symptoms C0836924 \| thrombocytosis C0796095 \| c syndrome C0752303 \| urological manifestations C0748159 \| pulmonary involvement C0542035 \| erythroid hypoplasia C0341697 \| renal impairment C0275544 \| congenital infection C0267842 \| acute acalculous cholecystitis C0221773 \| hyperamylasemia C0162557 \| acute liver failure C0162293 \| papillitis C0152025 \| polyneuropathy C0151295 \| mononeuritis multiplex C0085655 \| polymyositis C0085593 \| chills C0042165 \| anterior uveitis C0040034 \| thrombocytopenia C0037090 \| respiratory symptoms C0035222 \| adult respiratory distress syndrome C0033975 \| psychosis C0031154 \| peritonitis C0030312 \| pancytopenia C0025289 \| meningitis C0022660 \| acute renal failure C0022660 \| acute kidney failure C0022658 \| renal disease C0022658 \| nephropathy C0022073 \| iridocyclitis C0020433 \| hyperbilirubinaemia C0019087 \| hemorrhagic diathesis C0019080 \| hemorrhage C0019061 \| hemolytic uremic syndrome C0015469 \| facial palsy C0015469 \| facial nerve palsy C0012739 \| disseminated intravascular coagulation C0007773 \| cerebral arteritis C0007222 \| cardiovascular disorders C0002878 \| hemolytic anemia C0001339 \| acute pancreatitis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:17) C0019080 \| hemorrhage \| 10 C0009450 \| infection \| 6 C0040034 \| thrombocytopenia \| 6 C0035078 \| renal failure \| 5 C0748159 \| pulmonary involvement \| 5 C0948600 \| organ failure \| 5 C0022660 \| acute renal failure \| 4 C1145670 \| respiratory failure \| 3 C0030305 \| pancreatitis \| 3 C0162557 \| acute liver failure \| 2 C0031046 \| pericarditis \| 1 C1839611 \| n syndrome \| 1 C0341697 \| renal impairment \| 1 C0001339 \| acute pancreatitis \| 1 C0042164 \| uveitis \| 1 C1565489 \| renal insufficiency \| 1 C0796095 \| c syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:4)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs5743618	25784560	7096	TLR1	umls:C0023364	BeFree	Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an Argentine population.	0.000271442	2015	TLR1	4	38797027	C	A
rs5743618	25784560	7097	TLR2	umls:C0023364	BeFree	Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an Argentine population.	0.000542884	2015	TLR1	4	38797027	C	A
rs5743708	25784560	7096	TLR1	umls:C0023364	BeFree	Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an Argentine population.	0.000271442	2015	TLR2	4	153705165	G	A
rs5743708	25784560	7097	TLR2	umls:C0023364	BeFree	Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an Argentine population.	0.000542884	2015	TLR2	4	153705165	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	554
Disease	leptospirosis
Case	(Waiting for update.)

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