eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| lassa fever | ||||
| Disease ID | 320 |
|---|---|
| Disease | lassa fever |
| Definition | An acute febrile human disease caused by the LASSA VIRUS. |
| Synonym | fever lassa fever, lassa fevers, lassa lassa fever (disorder) lassa fever [disease/finding] lassa fevers lassa hemorrhagic fever |
| Orphanet | |
| DOID | |
| ICD10 | |
| UMLS | C0023092 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:3) |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:28) 27032 | ATP2C1 | 1.411 | DISEASES 959 | CD40LG | 3.211 | DISEASES 9023 | CH25H | 3.068 | DISEASES 339390 | CLEC4G | 3.777 | DISEASES 23586 | DDX58 | 1.381 | DISEASES 1977 | EIF4E | 1.44 | DISEASES 30816 | ERVW-1 | 1.878 | DISEASES 2813 | GP2 | 3.966 | DISEASES 29933 | GPR132 | 2.908 | DISEASES 3329 | HSPD1 | 1.009 | DISEASES 3456 | IFNB1 | 2.052 | DISEASES 3916 | LAMP1 | 1.439 | DISEASES 3980 | LIG3 | 1.742 | DISEASES 131578 | LRRC15 | 1.565 | DISEASES 4065 | LY75 | 2.238 | DISEASES 8720 | MBTPS1 | 3.294 | DISEASES 25834 | MGAT4C | 2.161 | DISEASES 284424 | MIR7-3HG | 1.599 | DISEASES 4288 | MKI67 | 1.719 | DISEASES 4734 | NEDD4 | 2.09 | DISEASES 4843 | NOS2 | 1.011 | DISEASES 344022 | NOTO | 2.618 | DISEASES 5888 | RAD51 | 1 | DISEASES 3516 | RBPJ | 1.741 | DISEASES 5970 | RELA | 1.208 | DISEASES 6672 | SP100 | 1.958 | DISEASES 6772 | STAT1 | 1.618 | DISEASES 23038 | WDTC1 | 2.19 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 320 |
|---|---|
| Disease | lassa fever |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:29) HP:0002239 | Gastrointestinal hemorrhage HP:0002202 | Pleural effusion HP:0012378 | Fatigue HP:0000365 | Hearing impairment HP:0001482 | Subcutaneous nodule HP:0002027 | Abdominal pain HP:0400008 | Menometrorrhagia HP:0002829 | Arthralgia HP:0002716 | Lymphadenopathy HP:0003326 | Myalgia HP:0001873 | Thrombocytopenia HP:0001882 | Leukopenia HP:0001254 | Lethargy HP:0002014 | Diarrhea HP:0002516 | Increased intracranial pressure HP:0002017 | Nausea and vomiting HP:0012375 | Chemosis HP:0100776 | Recurrent pharyngitis HP:0001250 | Seizures HP:0005268 | Spontaneous abortion HP:0001945 | Fever HP:0012735 | Cough HP:0000988 | Skin rash HP:0002321 | Vertigo HP:0100749 | Chest pain HP:0000509 | Conjunctivitis HP:0006543 | Cardiorespiratory arrest HP:0002315 | Headache HP:0100540 | Palpebral edema |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:2) |
| Disease ID | 320 |
|---|---|
| Disease | lassa fever |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:6) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:3) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0100540 | Palpebral edema | MP:0001786 | skin edema | accumulation of an excessive amount of fluid in the skin layers or just underneath the skin |
| HP:0002017 | Nausea and vomiting | MP:0010426 | abnormal heart and great artery attachment | any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta |
| HP:0002239 | Gastrointestinal hemorrhage | MP:0012305 | umbilical cord hemorrhage | bleeding into or from the umbilical cord |
Mapped by homologous gene(Total Items:28) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0012735 | Cough | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0001945 | Fever | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0012375 | Chemosis | MP:0012732 | abnormal perineural vascular plexus morphology | any structural anomaly of the capillary bed that initially surrounds the relative avascular brain and spinal cord; the perineural vascular plexus (PNVP) is the precursor to the blood brain barrier formed by angioblasts which migrate away from somites and |
| HP:0000509 | Conjunctivitis | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0002516 | Increased intracranial pressure | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0002315 | Headache | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0001250 | Seizures | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0001482 | Subcutaneous nodule | MP:0013542 | abnormal submandibular gland branching morphogenesis | |
| HP:0002202 | Pleural effusion | MP:0014233 | bile duct epithelium hyperplasia | |
| HP:0002239 | Gastrointestinal hemorrhage | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0001873 | Thrombocytopenia | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0002014 | Diarrhea | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0002017 | Nausea and vomiting | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0012378 | Fatigue | MP:0013659 | abnormal erythroid lineage cell morphology | any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes |
| HP:0002321 | Vertigo | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0001882 | Leukopenia | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0002829 | Arthralgia | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0005268 | Spontaneous abortion | MP:0020040 | decreased bone ossification | decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0002027 | Abdominal pain | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0001254 | Lethargy | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0000365 | Hearing impairment | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0100540 | Palpebral edema | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0003326 | Myalgia | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0100749 | Chest pain | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0100776 | Recurrent pharyngitis | MP:0013716 | hypolactation | partial failure, or reduced ability to produce or secrete milk from the mammary gland |
| HP:0002716 | Lymphadenopathy | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0006543 | Cardiorespiratory arrest | MP:0011100 | preweaning lethality, complete penetrance | death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age) |
| HP:0000988 | Skin rash | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| Disease ID | 320 |
|---|---|
| Disease | lassa fever |
| Case | (Waiting for update.) |