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	laryngeal carcinoma

Disease ID	1729
Disease	laryngeal carcinoma
Definition	A carcinoma of the larynx. [HPO:probinson]
Synonym	carcinoma laryngeal carcinoma larynx carcinoma of larynx carcinoma of larynx (disorder) carcinoma of the larynx larnyx carcinoma larynx carcinoma
DOID	DOID:2600
UMLS	C0595989
SNOMED-CT	SNOMEDCT_US_2016_09_01:276975007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:12) C0280324 \| squamous cell carcinoma of the larynx \| 19 C0007137 \| squamous cell carcinoma \| 19 C0007115 \| thyroid ca \| 2 C0007137 \| epidermoid carcinoma \| 1 C0238301 \| nasopharyngeal carcinoma \| 1 C0024205 \| lymphadenitis \| 1 C0023269 \| leiomyosarcoma \| 1 C0149925 \| small cell carcinoma \| 1 C0149642 \| cervical lymphadenitis \| 1 C0280324 \| epidermoid carcinoma of the larynx \| 1 C0153676 \| lung metastasis \| 1 C0006840 \| candidiasis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:180) 176 \| ACAN \| 1.973 \| DISEASES 60 \| ACTB \| 1.886 \| DISEASES 8038 \| ADAM12 \| 1.417 \| DISEASES 80332 \| ADAM33 \| 1.469 \| DISEASES 9507 \| ADAMTS4 \| 1.091 \| DISEASES 79026 \| AHNAK \| 2.377 \| DISEASES 113146 \| AHNAK2 \| 2.272 \| DISEASES 283 \| ANG \| 2.398 \| DISEASES 8905 \| AP1S2 \| 2.338 \| DISEASES 317 \| APAF1 \| 1.343 \| DISEASES 8539 \| API5 \| 1.305 \| DISEASES 50807 \| ASAP1 \| 2.431 \| DISEASES 9334 \| B4GALT5 \| 1.408 \| DISEASES 573 \| BAG1 \| 1.293 \| DISEASES 596 \| BCL2 \| 1.518 \| DISEASES 90427 \| BMF \| 1.091 \| DISEASES 648 \| BMI1 \| 2.767 \| DISEASES 664 \| BNIP3 \| 1.061 \| DISEASES 25855 \| BRMS1 \| 2.317 \| DISEASES 682 \| BSG \| 1.853 \| DISEASES 768 \| CA9 \| 2.287 \| DISEASES 285782 \| CAGE1 \| 1.979 \| DISEASES 157922 \| CAMSAP1 \| 2.82 \| DISEASES 11132 \| CAPN10 \| 1.112 \| DISEASES 841 \| CASP8 \| 1.456 \| DISEASES 842 \| CASP9 \| 2.25 \| DISEASES 857 \| CAV1 \| 1.709 \| DISEASES 100507056 \| CCAT1 \| 1.073 \| DISEASES 6364 \| CCL20 \| 1.121 \| DISEASES 896 \| CCND3 \| 1.283 \| DISEASES 1233 \| CCR4 \| 1.012 \| DISEASES 1235 \| CCR6 \| 2.39 \| DISEASES 4345 \| CD200 \| 1.178 \| DISEASES 960 \| CD44 \| 2.691 \| DISEASES 961 \| CD47 \| 1.032 \| DISEASES 923 \| CD6 \| 2.576 \| DISEASES 9308 \| CD83 \| 1.515 \| DISEASES 1024 \| CDK8 \| 1.882 \| DISEASES 1029 \| CDKN2A \| 3.77 \| DISEASES 55165 \| CEP55 \| 1.35 \| DISEASES 55743 \| CHFR \| 2.188 \| DISEASES 1164 \| CKS2 \| 1.185 \| DISEASES 123920 \| CMTM3 \| 1.969 \| DISEASES 10987 \| COPS5 \| 2.077 \| DISEASES 1496 \| CTNNA2 \| 1.308 \| DISEASES 1499 \| CTNNB1 \| 2.454 \| DISEASES 2017 \| CTTN \| 1.9 \| DISEASES 1543 \| CYP1A1 \| 1.888 \| DISEASES 1565 \| CYP2D6 \| 1.52 \| DISEASES 1612 \| DAPK1 \| 1.428 \| DISEASES 729582 \| DIRC3 \| 2.315 \| DISEASES 1786 \| DNMT1 \| 1.237 \| DISEASES 1791 \| DNTT \| 1.313 \| DISEASES 1893 \| ECM1 \| 2.511 \| DISEASES 1977 \| EIF4E \| 2.859 \| DISEASES 1981 \| EIF4G1 \| 1.462 \| DISEASES 1994 \| ELAVL1 \| 2.186 \| DISEASES 2022 \| ENG \| 3.675 \| DISEASES 957 \| ENTPD5 \| 1.466 \| DISEASES 2113 \| ETS1 \| 1.655 \| DISEASES 7430 \| EZR \| 1.641 \| DISEASES 2272 \| FHIT \| 2.642 \| DISEASES 2305 \| FOXM1 \| 1.631 \| DISEASES 50943 \| FOXP3 \| 1.089 \| DISEASES 6624 \| FSCN1 \| 1.786 \| DISEASES 23464 \| GCAT \| 1.51 \| DISEASES 11245 \| GPR176 \| 1.899 \| DISEASES 2948 \| GSTM4 \| 1.692 \| DISEASES 2950 \| GSTP1 \| 1.205 \| DISEASES 10456 \| HAX1 \| 1.526 \| DISEASES 3039 \| HBA1 \| 1.647 \| DISEASES 3091 \| HIF1A \| 2.675 \| DISEASES 8091 \| HMGA2 \| 1.347 \| DISEASES 100124700 \| HOTAIR \| 2.104 \| DISEASES 3262 \| HPVC1 \| 3.047 \| DISEASES 3326 \| HSP90AB1 \| 1.544 \| DISEASES 10553 \| HTATIP2 \| 2.019 \| DISEASES 3451 \| IFNA17 \| 2.033 \| DISEASES 3440 \| IFNA2 \| 1.268 \| DISEASES 3664 \| IRF6 \| 1.15 \| DISEASES 8516 \| ITGA8 \| 1.675 \| DISEASES 3709 \| ITPR2 \| 1.179 \| DISEASES 3725 \| JUN \| 1.041 \| DISEASES 9928 \| KIF14 \| 2.179 \| DISEASES 3796 \| KIF2A \| 1.759 \| DISEASES 688 \| KLF5 \| 1.446 \| DISEASES 3880 \| KRT19 \| 1.903 \| DISEASES 3851 \| KRT4 \| 1.11 \| DISEASES 84648 \| LCE3D \| 2.274 \| DISEASES 440556 \| LINC00982 \| 2.639 \| DISEASES 101928555 \| LINC01537 \| 1.877 \| DISEASES 4110 \| MAGEA11 \| 1.536 \| DISEASES 57134 \| MAN1C1 \| 1.15 \| DISEASES 5602 \| MAPK10 \| 2.036 \| DISEASES 4193 \| MDM2 \| 2.16 \| DISEASES 4237 \| MFAP2 \| 1.396 \| DISEASES 100507436 \| MICA \| 1.256 \| DISEASES 554202 \| MIR31HG \| 1.877 \| DISEASES 4288 \| MKI67 \| 1.121 \| DISEASES 4312 \| MMP1 \| 1.811 \| DISEASES 4318 \| MMP9 \| 2.775 \| DISEASES 9112 \| MTA1 \| 1.365 \| DISEASES 92140 \| MTDH \| 2.427 \| DISEASES 2475 \| MTOR \| 1.311 \| DISEASES 100463285 \| MTRNR2L4 \| 2.174 \| DISEASES 4604 \| MYBPC1 \| 1.68 \| DISEASES 4609 \| MYC \| 2.795 \| DISEASES 80177 \| MYCT1 \| 3.048 \| DISEASES 64859 \| NABP1 \| 2.464 \| DISEASES 57446 \| NDRG3 \| 1.852 \| DISEASES 51701 \| NLK \| 1.358 \| DISEASES 4831 \| NME2 \| 2.364 \| DISEASES 283820 \| NOMO2 \| 1.15 \| DISEASES 408050 \| NOMO3 \| 1.152 \| DISEASES 152559 \| PAQR3 \| 1.686 \| DISEASES 11315 \| PARK7 \| 2.501 \| DISEASES 27253 \| PCDH17 \| 1.659 \| DISEASES 9141 \| PDCD5 \| 1.009 \| DISEASES 5203 \| PFDN4 \| 1.383 \| DISEASES 80012 \| PHC3 \| 2.605 \| DISEASES 51230 \| PHF20 \| 1.164 \| DISEASES 57661 \| PHRF1 \| 2.18 \| DISEASES 23533 \| PIK3R5 \| 2.366 \| DISEASES 5328 \| PLAU \| 2.279 \| DISEASES 5464 \| PPA1 \| 1.203 \| DISEASES 9055 \| PRC1 \| 2.171 \| DISEASES 8842 \| PROM1 \| 3.038 \| DISEASES 122183 \| PRR20A \| 2.286 \| DISEASES 729240 \| PRR20C \| 2.684 \| DISEASES 729250 \| PRR20E \| 2.684 \| DISEASES 5698 \| PSMB9 \| 1.135 \| DISEASES 5728 \| PTEN \| 2.906 \| DISEASES 5743 \| PTGS2 \| 2.544 \| DISEASES 5747 \| PTK2 \| 1.135 \| DISEASES 53635 \| PTOV1 \| 1.224 \| DISEASES 5789 \| PTPRD \| 1.647 \| DISEASES 80223 \| RAB11FIP1 \| 1.825 \| DISEASES 5915 \| RARB \| 1.478 \| DISEASES 80196 \| RNF34 \| 1.068 \| DISEASES 6120 \| RPE \| 1.638 \| DISEASES 6146 \| RPL22 \| 1.252 \| DISEASES 6160 \| RPL31 \| 2.118 \| DISEASES 864 \| RUNX3 \| 1.984 \| DISEASES 6273 \| S100A2 \| 2.168 \| DISEASES 6274 \| S100A3 \| 1.646 \| DISEASES 6275 \| S100A4 \| 1.574 \| DISEASES 6278 \| S100A7 \| 1.241 \| DISEASES 6304 \| SATB1 \| 1.536 \| DISEASES 29843 \| SENP1 \| 1.763 \| DISEASES 26168 \| SENP3 \| 1.772 \| DISEASES 5268 \| SERPINB5 \| 2.946 \| DISEASES 6456 \| SH3GL2 \| 2.495 \| DISEASES 6513 \| SLC2A1 \| 3.063 \| DISEASES 23049 \| SMG1 \| 1.441 \| DISEASES 23583 \| SMUG1 \| 1.932 \| DISEASES 8651 \| SOCS1 \| 1.076 \| DISEASES 6657 \| SOX2 \| 2.115 \| DISEASES 347689 \| SOX2-OT \| 1.651 \| DISEASES 11262 \| SP140 \| 1.41 \| DISEASES 6696 \| SPP1 \| 1.551 \| DISEASES 6736 \| SRY \| 1.147 \| DISEASES 3925 \| STMN1 \| 1.392 \| DISEASES 4070 \| TACSTD2 \| 1.37 \| DISEASES 6925 \| TCF4 \| 1.024 \| DISEASES 84260 \| TCHP \| 1.287 \| DISEASES 10178 \| TENM1 \| 1.093 \| DISEASES 7053 \| TGM3 \| 1.466 \| DISEASES 84000 \| TMPRSS13 \| 1.257 \| DISEASES 8771 \| TNFRSF6B \| 1.986 \| DISEASES 8741 \| TNFSF13 \| 1.263 \| DISEASES 7158 \| TP53BP1 \| 1.057 \| DISEASES 7187 \| TRAF3 \| 1.243 \| DISEASES 7323 \| UBE2D3 \| 1.605 \| DISEASES 79465 \| ULBP3 \| 1.383 \| DISEASES 7422 \| VEGFA \| 2.904 \| DISEASES 55135 \| WRAP53 \| 1.483 \| DISEASES 331 \| XIAP \| 1.096 \| DISEASES 10771 \| ZMYND11 \| 1.622 \| DISEASES 80139 \| ZNF703 \| 1.557 \| DISEASES 7791 \| ZYX \| 1.009 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1729
Disease	laryngeal carcinoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:9) HP:0002860 \| Squamous cell carcinoma \| 21 HP:0002664 \| Neoplasia \| 11 HP:0030731 \| Carcinoma \| 3 HP:0100243 \| Leiomyosarcoma \| 1 HP:0001945 \| Fever \| 1 HP:0011459 \| Esophageal carcinoma \| 1 HP:0002835 \| Aspiration \| 1 HP:0000718 \| Aggressive behaviour \| 1 HP:0002840 \| Lymphadenitis \| 1

Disease ID	1729
Disease	laryngeal carcinoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:19) C2364133 \| infection C2248595 \| dedifferentiation C2239136 \| laryngocele C1862463 \| aryl hydrocarbon hydroxylase inducibility C1519670 \| tumor angiogenesis C1306459 \| primary malignant neoplasm C1135207 \| ataxia C0694889 \| retinoblastoma C0686619 \| lymph node metastases C0684830 \| axillary metastasis C0684249 \| lung cancer C0153687 \| skin metastasis C0042928 \| vocal cord paralysis C0036467 \| tuberculous cervical lymphadenitis C0024232 \| lymphatic metastasis C0023524 \| progressive multifocal leucoencephalopathy C0017168 \| gastroesophageal reflux disease C0014118 \| endocarditis C0001883 \| airway obstruction
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0036467 \| tuberculous cervical lymphadenitis \| 1 C0009450 \| infection \| 1 C0265761 \| laryngocele \| 1 C0001883 \| airway obstruction \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:13)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs11615	24563277	2067	ERCC1	umls:C0595989	BeFree	In summary, we suggest that genetic variations in ERCC1 rs11615 and ERCC5 rs17655 are associated with laryngeal cancer risk in a Chinese population, especially in ever smokers and drinkers.	0.000814326	2014	ERCC1	19	45420395	A	G
rs11615	24582975	2073	ERCC5	umls:C0595989	BeFree	In conclusion, our study suggests that ERCC1 rs11615 and ERCC5 rs17655 polymorphisms are associated with increased risk of laryngeal cancer, and that they confer more risk among smokers and drinkers.	0.000814326	2014	ERCC1	19	45420395	A	G
rs11615	24563277	2073	ERCC5	umls:C0595989	BeFree	In summary, we suggest that genetic variations in ERCC1 rs11615 and ERCC5 rs17655 are associated with laryngeal cancer risk in a Chinese population, especially in ever smokers and drinkers.	0.000814326	2014	ERCC1	19	45420395	A	G
rs1229984	21378355	125	ADH1B	umls:C0595989	BeFree	Alcohol-dehydrogenase (ADH1B) Arg48His polymorphism in Basque Country patients with oral and laryngeal cancer: preliminary study.	0.000542884	2011	ADH1B	4	99318162	T	C
rs142863665	7509279	7124	TNF	umls:C0595989	BeFree	The TNFR55-selective mutants (R32W, E146K and R32W-S86T) which bind poorly to TNFR75 displayed similar potency to wild-type TNF in causing cytotoxicity of a human laryngeal carcinoma-derived cell line (HEp-2) and cytostasis in a human leukaemic cell line (U937).	0.001357209	1994	CUX1	7	102111708	G	A
rs142863665	7509279	1523	CUX1	umls:C0595989	BeFree	The TNFR55-selective mutants (R32W, E146K and R32W-S86T) which bind poorly to TNFR75 displayed similar potency to wild-type TNF in causing cytotoxicity of a human laryngeal carcinoma-derived cell line (HEp-2) and cytostasis in a human leukaemic cell line (U937).	0.000271442	1994	CUX1	7	102111708	G	A
rs142863665	7509279	7132	TNFRSF1A	umls:C0595989	BeFree	The TNFR55-selective mutants (R32W, E146K and R32W-S86T) which bind poorly to TNFR75 displayed similar potency to wild-type TNF in causing cytotoxicity of a human laryngeal carcinoma-derived cell line (HEp-2) and cytostasis in a human leukaemic cell line (U937).	0.000271442	1994	CUX1	7	102111708	G	A
rs17655	24563277	2067	ERCC1	umls:C0595989	BeFree	In summary, we suggest that genetic variations in ERCC1 rs11615 and ERCC5 rs17655 are associated with laryngeal cancer risk in a Chinese population, especially in ever smokers and drinkers.	0.000814326	2014	ERCC5;BIVM-ERCC5	13	102875652	G	C
rs17655	24563277	2073	ERCC5	umls:C0595989	BeFree	In summary, we suggest that genetic variations in ERCC1 rs11615 and ERCC5 rs17655 are associated with laryngeal cancer risk in a Chinese population, especially in ever smokers and drinkers.	0.000814326	2014	ERCC5;BIVM-ERCC5	13	102875652	G	C
rs17655	24582975	2073	ERCC5	umls:C0595989	BeFree	In conclusion, our study suggests that ERCC1 rs11615 and ERCC5 rs17655 polymorphisms are associated with increased risk of laryngeal cancer, and that they confer more risk among smokers and drinkers.	0.000814326	2014	ERCC5;BIVM-ERCC5	13	102875652	G	C
rs25487	24194393	7515	XRCC1	umls:C0595989	BeFree	Association of XRCC1 genetic polymorphism (Arg399Gln) with laryngeal cancer: a meta-analysis based on 4,031 subjects.	0.000542884	2013	XRCC1	19	43551574	T	C
rs386493716	24194393	7515	XRCC1	umls:C0595989	BeFree	Association of XRCC1 genetic polymorphism (Arg399Gln) with laryngeal cancer: a meta-analysis based on 4,031 subjects.	0.000542884	2013	NA	NA	NA	NA	NA
rs61754966	24079363	4683	NBN	umls:C0595989	BeFree	We have previously shown that the p.I171V NBN gene mutation may contribute to the development of laryngeal cancer.	0.000542884	2013	NBN	8	89978293	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1729
Disease	laryngeal carcinoma
Case	(Waiting for update.)

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