eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| large granular lymphocyte leukemia | ||||
| Disease ID | 1746 |
|---|---|
| Disease | large granular lymphocyte leukemia |
| Definition | A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease. |
| Synonym | aggressive natural killer cell leukemia large granular lymphocytic leukaemia large granular lymphocytic leukemia large granular lymphocytic leukemia (disorder) large granular lymphocytosis leukemia, large granular lymphocytic leukemia, large granular lymphocytic [disease/finding] leukemia, lgl leukemia, lymphocytic, large granular leukemias, lgl lgl (large granular lymphocyte) leukemia lgl leukemia lgl leukemias lgll - large granular lymphocytic leukaemia lgll - large granular lymphocytic leukemia lymphoproliferative disease of granular lymphocytes lymphoproliferative disease of large granular lymphocytes |
| DOID | |
| UMLS | C1522378 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:37) C0281963 | red cell aplasia | 5 C0034902 | pure red cell aplasia | 5 C0027947 | neutropenia | 4 C0003873 | rheumatoid arthritis | 3 C0023418 | leukemia | 3 C0024299 | lymphoma | 3 C0030312 | bone marrow failure | 2 C0003864 | arthritis | 2 C0042769 | virus infection | 2 C0021053 | immune disorders | 1 C0004623 | bacterial infections | 1 C0001815 | bone marrow fibrosis | 1 C0018854 | franklin disease | 1 C0026764 | myeloma | 1 C1527336 | sjogren's syndrome | 1 C0205969 | malignant thymoma | 1 C0015773 | felty syndrome | 1 C0023443 | hairy cell leukemia | 1 C0026986 | myelodysplastic syndrome | 1 C0023473 | chronic myelogenous leukemia | 1 C0002871 | anemia | 1 C0040028 | essential thrombocythemia | 1 C0019196 | hepatitis c | 1 C0024314 | lymphoproliferative disease | 1 C0023470 | myelogenous leukemia | 1 C0022972 | lambert-eaton myasthenic syndrome | 1 C0026764 | multiple myeloma | 1 C0038463 | strongyloidiasis | 1 C0004623 | bacterial infection | 1 C0024314 | lymphoproliferative disorder | 1 C0022972 | myasthenic syndrome | 1 C0040034 | thrombocytopenia | 1 C0007570 | celiac disease | 1 C0021053 | immune disorder | 1 C0019158 | hepatitis | 1 C0334634 | mantle cell lymphoma | 1 C0023473 | chronic myelogenous leukemia (cml) | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 1746 |
|---|---|
| Disease | large granular lymphocyte leukemia |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:20) HP:0012410 | Pure red cell aplasia | 6 HP:0001875 | Neutropenia | 4 HP:0001909 | Leukemia | 3 HP:0002665 | Lymphoma | 3 HP:0001370 | Rheumatoid arthritis | 3 HP:0001369 | Arthritis | 2 HP:0005528 | Bone marrow hypoplasia | 2 HP:0002608 | Celiac disease | 1 HP:0002960 | Autoimmune condition | 1 HP:0002863 | Myelodysplastic syndrome | 1 HP:0001903 | Anemia | 1 HP:0002719 | infections, recurrent | 1 HP:0012115 | Liver inflammation | 1 HP:0005506 | Chronic myeloid leukemia | 1 HP:0005523 | Lymphoproliferative disorder | 1 HP:0002633 | Vasculitis | 1 HP:0012190 | T cell lymphoma | 1 HP:0006775 | Multiple myeloma | 1 HP:0001873 | Low platelet count | 1 HP:0001904 | Autoimmune neutropenia | 1 |
| Disease ID | 1746 |
|---|---|
| Disease | large granular lymphocyte leukemia |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:7) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:3) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
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| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
| Disease ID | 1746 |
|---|---|
| Disease | large granular lymphocyte leukemia |
| Case | (Waiting for update.) |