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	large cell carcinoma

Disease ID	1734
Disease	large cell carcinoma
Definition	A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
Synonym	[m]large cell carcinoma nos [m]large cell carcinoma nos (morphologic abnormality) carcinoma, large cell carcinoma, large cell [disease/finding] carcinomas, large cell cell carcinoma, large cell carcinomas, large large cell carcinoma (morphologic abnormality) large cell carcinoma, nos large cell carcinomas
DOID	DOID:4552
UMLS	C0206704
MeSH	D018287
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:9) C0001418 \| adenocarcinoma \| 2 C0007137 \| squamous cell carcinoma \| 2 C0149925 \| small cell lung cancer \| 1 C0206623 \| adenosquamous carcinoma \| 1 C0242379 \| lung cancer \| 1 C0007131 \| non-small cell lung carcinoma \| 1 C0007137 \| squamous cell carcinomas \| 1 C0149925 \| small cell lung carcinoma \| 1 C0684249 \| lung carcinoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 29108 \| PYCARD \| CTD_human 1548 \| CYP2A6 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:102) 174 \| AFP \| 1.755 \| DISEASES 11214 \| AKAP13 \| 2.1 \| DISEASES 238 \| ALK \| 2.833 \| DISEASES 369 \| ARAF \| 1.307 \| DISEASES 444 \| ASPH \| 2.021 \| DISEASES 9776 \| ATG13 \| 2.026 \| DISEASES 55765 \| C1orf106 \| 3.073 \| DISEASES 128602 \| C20orf85 \| 1.646 \| DISEASES 722 \| C4BPA \| 1.409 \| DISEASES 796 \| CALCA \| 1.846 \| DISEASES 388743 \| CAPN8 \| 2.348 \| DISEASES 960 \| CD44 \| 1.694 \| DISEASES 923 \| CD6 \| 1.539 \| DISEASES 926 \| CD8B \| 1.274 \| DISEASES 1029 \| CDKN2A \| 2.464 \| DISEASES 1045 \| CDX2 \| 2.126 \| DISEASES 55743 \| CHFR \| 1.122 \| DISEASES 1382 \| CRABP2 \| 1.073 \| DISEASES 1443 \| CSH2 \| 1.945 \| DISEASES 115908 \| CTHRC1 \| 1.52 \| DISEASES 147906 \| DACT3 \| 1.808 \| DISEASES 1825 \| DSC3 \| 2.977 \| DISEASES 1893 \| ECM1 \| 1.048 \| DISEASES 84455 \| EFCAB7 \| 3.274 \| DISEASES 8661 \| EIF3A \| 2.652 \| DISEASES 2045 \| EPHA7 \| 1.531 \| DISEASES 2117 \| ETV3 \| 1.062 \| DISEASES 2260 \| FGFR1 \| 1.728 \| DISEASES 2317 \| FLNB \| 1.115 \| DISEASES 2526 \| FUT4 \| 2.109 \| DISEASES 8087 \| FXR1 \| 1.393 \| DISEASES 126626 \| GABPB2 \| 3.359 \| DISEASES 2730 \| GCLM \| 1.232 \| DISEASES 56287 \| GKN1 \| 1.762 \| DISEASES 51512 \| GTSE1 \| 2.078 \| DISEASES 3098 \| HK1 \| 1.03 \| DISEASES 3181 \| HNRNPA2B1 \| 1.211 \| DISEASES 3231 \| HOXD1 \| 2.26 \| DISEASES 3452 \| IFNA21 \| 2.587 \| DISEASES 3476 \| IGBP1 \| 1.275 \| DISEASES 3321 \| IGSF3 \| 1.83 \| DISEASES 84289 \| ING5 \| 2.191 \| DISEASES 3713 \| IVL \| 1.146 \| DISEASES 3880 \| KRT19 \| 2.486 \| DISEASES 3850 \| KRT3 \| 1.429 \| DISEASES 3855 \| KRT7 \| 3.111 \| DISEASES 3939 \| LDHA \| 1.206 \| DISEASES 5606 \| MAP2K3 \| 1.004 \| DISEASES 79648 \| MCPH1 \| 1.288 \| DISEASES 388931 \| MFSD2B \| 3.784 \| DISEASES 23515 \| MORC3 \| 1.481 \| DISEASES 9788 \| MTSS1 \| 1.265 \| DISEASES 4588 \| MUC6 \| 1.323 \| DISEASES 4609 \| MYC \| 1.47 \| DISEASES 4637 \| MYL6 \| 1.964 \| DISEASES 100132406 \| NBPF10 \| 2.345 \| DISEASES 400818 \| NBPF9 \| 3.221 \| DISEASES 7080 \| NKX2-1 \| 3.615 \| DISEASES 4839 \| NOP2 \| 2.398 \| DISEASES 131870 \| NUDT16 \| 1.836 \| DISEASES 4988 \| OPRM1 \| 1.452 \| DISEASES 11240 \| PADI2 \| 1.183 \| DISEASES 9159 \| PCSK7 \| 1.343 \| DISEASES 54704 \| PDP1 \| 1.723 \| DISEASES 5213 \| PFKM \| 1.091 \| DISEASES 5328 \| PLAU \| 1.642 \| DISEASES 653247 \| PRB2 \| 2.043 \| DISEASES 5663 \| PSEN1 \| 1.093 \| DISEASES 25797 \| QPCT \| 4.816 \| DISEASES 57111 \| RAB25 \| 1.571 \| DISEASES 5865 \| RAB3B \| 2.726 \| DISEASES 11186 \| RASSF1 \| 1.851 \| DISEASES 83593 \| RASSF5 \| 1.683 \| DISEASES 5979 \| RET \| 1.434 \| DISEASES 6098 \| ROS1 \| 2.378 \| DISEASES 6273 \| S100A2 \| 2.134 \| DISEASES 5268 \| SERPINB5 \| 1.731 \| DISEASES 6439 \| SFTPB \| 1.704 \| DISEASES 6520 \| SLC3A2 \| 1.56 \| DISEASES 55974 \| SLC50A1 \| 1.379 \| DISEASES 23583 \| SMUG1 \| 2.307 \| DISEASES 6668 \| SP2 \| 1.439 \| DISEASES 56910 \| STARD7 \| 2.296 \| DISEASES 6794 \| STK11 \| 1.851 \| DISEASES 3925 \| STMN1 \| 1.313 \| DISEASES 6917 \| TCEA1 \| 1.6 \| DISEASES 7075 \| TIE1 \| 1.005 \| DISEASES 10440 \| TIMM17A \| 2.704 \| DISEASES 57113 \| TRPC7 \| 1.894 \| DISEASES 4308 \| TRPM1 \| 1.293 \| DISEASES 54575 \| UGT1A10 \| 1.581 \| DISEASES 54659 \| UGT1A3 \| 1.509 \| DISEASES 54579 \| UGT1A5 \| 2.309 \| DISEASES 54577 \| UGT1A7 \| 1.291 \| DISEASES 54576 \| UGT1A8 \| 1.573 \| DISEASES 54600 \| UGT1A9 \| 1.191 \| DISEASES 51720 \| UIMC1 \| 1.601 \| DISEASES 7874 \| USP7 \| 1.285 \| DISEASES 7422 \| VEGFA \| 1.132 \| DISEASES 8565 \| YARS \| 1.962 \| DISEASES 7694 \| ZNF135 \| 1.493 \| DISEASES 84450 \| ZNF512 \| 3.784 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1734
Disease	large cell carcinoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:5) HP:0030731 \| Carcinoma \| 3 HP:0002860 \| Squamous cell carcinoma \| 2 HP:0030357 \| Small cell lung carcinoma \| 2 HP:0030358 \| Non-small cell lung carcinoma \| 1 HP:0002664 \| Neoplasia \| 1

Disease ID	1734
Disease	large cell carcinoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:2) C0221390 \| nonbacterial thrombotic endocarditis C0007131 \| non-small cell lung cancer
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121434569	21635547	1956	EGFR	umls:C0206704	BeFree	We analyzed 147 NSCLC tissues [70 adenocarcinomas (AD), 62 squamous cell carcinomas (SQ), 12 large cell carcinomas (LC), and three adenosquamous carcinomas] that had not been exposed to the TKI therapies, and found 12 (8.2%; 12/147) EGFR T790M mutation in eight AD (11.4%), three SQ (4.8%), and one LC (8.3%) by the PNA-clamping PCR.	0.004267125	2011	EGFR;EGFR-AS1	7	55181378	C	T
rs28934578	19287302	7157	TP53	umls:C0206704	BeFree	The results demonstrate that the excision of incorporated nucleoside analogs in mitochondrial fractions of H1299 cells increased in the presence of purified recombinant p53, or cytoplasmic extracts of large cell carcinoma 2 cells expressing endogenous wild-type p53 (but not specifically predepleted extracts) or cytoplasmic extracts of H1299 cells overexpressing wild-type p53, but not exonuclease-deficient mutant p53-R175H.	0.004895885	2009	TP53	17	7675088	C	T,A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1734
Disease	large cell carcinoma
Case	(Waiting for update.)

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