eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| kuru | ||||
| Disease ID | 1675 |
|---|---|
| Disease | kuru |
| Definition | A prion disease found exclusively among the Fore linguistic group natives of the highlands of NEW GUINEA. The illness is primarily restricted to adult females and children of both sexes. It is marked by the subacute onset of tremor and ataxia followed by motor weakness and incontinence. Death occurs within 3-6 months of disease onset. The condition is associated with ritual cannibalism, and has become rare since this practice has been discontinued. Pathologic features include a noninflammatory loss of neurons that is most prominent in the cerebellum, glial proliferation, and amyloid plaques. (From Adams et al., Principles of Neurology, 6th ed, p773) |
| Synonym | enceph kuru encephalopathy, kuru kuru (disorder) kuru [disease/finding] kuru enceph kuru encephalitis kuru encephalopathy |
| DOID | |
| ICD10 | |
| UMLS | C0022802 |
| MeSH | |
| SNOMED-CT | |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:17) 100 | ADA | 1.231 | DISEASES 64506 | CPEB1 | 3.673 | DISEASES 5476 | CTSA | 1.427 | DISEASES 23085 | ERC1 | 3.061 | DISEASES 2534 | FYN | 1.256 | DISEASES 3704 | ITPA | 1.805 | DISEASES 3767 | KCNJ11 | 1.546 | DISEASES 51520 | LARS | 1.301 | DISEASES 4477 | MSMB | 2.849 | DISEASES 1482 | NKX2-5 | 1.426 | DISEASES 10687 | PNMA2 | 3.151 | DISEASES 5621 | PRNP | 7.103 | DISEASES 5915 | RARB | 2.464 | DISEASES 503542 | SPRN | 2.39 | DISEASES 11075 | STMN2 | 3.769 | DISEASES 7072 | TIA1 | 1.276 | DISEASES 253461 | ZBTB38 | 3.594 | DISEASES |
| Locus | Symbol | Locus(Total Locus:1) PRNP | 20p13 |
| Disease ID | 1675 |
|---|---|
| Disease | kuru |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | (Waiting for update.) |
| Disease ID | 1675 |
|---|---|
| Disease | kuru |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
| Disease ID | 1675 |
|---|---|
| Disease | kuru |
| Case | (Waiting for update.) |