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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine



   klatskin tumor
  

Disease ID 502
Disease klatskin tumor
Definition
Cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts (COMMON HEPATIC DUCT). These tumors are generally small, sharply localized, and seldom metastasizing.
Synonym
[m] klatskin's tumor
[m] klatskin's tumour
[m]klatskin's tumor
[m]klatskin's tumour
cholangiocarcinoma, hilar
cholangiocarcinomas, hilar
hilar cc
hilar cholangiocarcinoma
hilar cholangiocarcinomas
klatskin tumor (bile duct bifurcation)
klatskin tumor [disease/finding]
klatskin tumors
klatskin's tumor
klatskin's tumor (disorder)
klatskin's tumor (morphologic abnormality)
klatskin's tumor morphology
klatskin's tumour
klatskin's tumour morphology
klatskins tumor
klatzkin tumor
tumor, klatskin
tumor, klatskin's
Orphanet
DOID
UMLS
C0206702
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:18)
C0022354  |  obstructive jaundice  |  6
C0153452  |  gallbladder ca  |  2
C0686619  |  lymph node metastases  |  2
C0008313  |  sclerosing cholangitis  |  1
C0019158  |  hepatitis  |  1
C0024299  |  lymphoma  |  1
C0005684  |  bladder cancer  |  1
C0153452  |  gallbladder cancer  |  1
C0010068  |  coronary artery disease  |  1
C0566602  |  primary sclerosing cholangitis  |  1
C0262401  |  ampullary carcinoma  |  1
C0267792  |  hepatobiliary disease  |  1
C0235782  |  gallbladder carcinoma  |  1
C0016977  |  biliary disease  |  1
C0699885  |  bladder carcinoma  |  1
C0079731  |  b-cell lymphoma  |  1
C0079744  |  diffuse large b-cell lymphoma  |  1
C1261473  |  sarcoma  |  1
Curated Gene(Waiting for update.)
Inferring Gene(Waiting for update.)
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:36)
174  |  AFP  |  1.062  |  DISEASES
210  |  ALAD  |  1.837  |  DISEASES
1233  |  CCR4  |  2.955  |  DISEASES
1025  |  CDK9  |  1.098  |  DISEASES
1499  |  CTNNB1  |  1.014  |  DISEASES
7852  |  CXCR4  |  1.273  |  DISEASES
30827  |  CXXC1  |  3.321  |  DISEASES
2153  |  F5  |  1.529  |  DISEASES
356  |  FASLG  |  1.284  |  DISEASES
3068  |  HDGF  |  3.154  |  DISEASES
3098  |  HK1  |  1.895  |  DISEASES
11009  |  IL24  |  1.424  |  DISEASES
3713  |  IVL  |  1.008  |  DISEASES
346389  |  MACC1  |  2.048  |  DISEASES
378938  |  MALAT1  |  1.406  |  DISEASES
4153  |  MBL2  |  1.345  |  DISEASES
4318  |  MMP9  |  1.999  |  DISEASES
10232  |  MSLN  |  1.201  |  DISEASES
9788  |  MTSS1  |  2.13  |  DISEASES
4803  |  NGF  |  1.111  |  DISEASES
5095  |  PCCA  |  2.207  |  DISEASES
55124  |  PIWIL2  |  2.189  |  DISEASES
112476  |  PRRT2  |  2.845  |  DISEASES
11186  |  RASSF1  |  1.848  |  DISEASES
8434  |  RECK  |  1.766  |  DISEASES
8732  |  RNGTT  |  2.23  |  DISEASES
23212  |  RRS1  |  1.639  |  DISEASES
6390  |  SDHB  |  1.064  |  DISEASES
2810  |  SFN  |  1.413  |  DISEASES
81539  |  SLC38A1  |  4.215  |  DISEASES
23583  |  SMUG1  |  2.872  |  DISEASES
64754  |  SMYD3  |  2.328  |  DISEASES
10011  |  SRA1  |  1.862  |  DISEASES
4070  |  TACSTD2  |  1.818  |  DISEASES
6925  |  TCF4  |  1.472  |  DISEASES
7398  |  USP1  |  2.452  |  DISEASES
Locus(Waiting for update.)
Disease ID 502
Disease klatskin tumor
Integrated Phenotype
HPO | Name(Total Integrated Phenotypes:10)
HP:0002716  |  Lymphadenopathy
HP:0004936  |  Venous thrombosis
HP:0012378  |  Fatigue
HP:0030153  |  Cholangiocarcinoma
HP:0002027  |  Abdominal pain
HP:0001824  |  Weight loss
HP:0012334  |  Extrahepatic cholestasis
HP:0001945  |  Fever
HP:0002240  |  Hepatomegaly
HP:0000952  |  Jaundice
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:12)
HP:0000952  |  Yellow skin  |  9
HP:0002664  |  Neoplasia  |  6
HP:0009725  |  Bladder neoplasm  |  1
HP:0001945  |  Fever  |  1
HP:0002665  |  Lymphoma  |  1
HP:0100242  |  Sarcoma  |  1
HP:0012115  |  Liver inflammation  |  1
HP:0002862  |  Bladder carcinoma  |  1
HP:0001677  |  Coronary artery disease  |  1
HP:0100806  |  Sepsis  |  1
HP:0012191  |  B-cell lymphoma  |  1
HP:0030731  |  Carcinoma  |  1
Disease ID 502
Disease klatskin tumor
Manually Symptom
UMLS  | Name(Total Manually Symptoms:1)
C0023892  |  biliary liver cirrhosis
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:1)
C0022354  |  obstructive jaundice  |  6
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:0)
(Waiting for update.)
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:1)
HP ID HP Name MP ID MP Name Annotation
HP:0001824Weight lossMP:0005114premature hair lossrelease of fur at an earlier than expected time
Mapped by homologous gene(Total Items:9)
HP ID HP Name MP ID MP Name Annotation
HP:0004936Venous thrombosisMP:0014166ectopic cranial bonethe appearance of an extra bone structure at an atypical location in or near the cranium
HP:0001945FeverMP:0020254decreased collagen leveldecreased level of the main structural protein of the various connective tissues in animals
HP:0001824Weight lossMP:0020220decreased tear productiondecreased production of the amount of fluid produced in the eye
HP:0002027Abdominal painMP:0020220decreased tear productiondecreased production of the amount of fluid produced in the eye
HP:0002716LymphadenopathyMP:0020215impaired blood coagulationimpaired ability of the blood to clot
HP:0002240HepatomegalyMP:0020329decreased capillary densityreduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0012378FatigueMP:0013659abnormal erythroid lineage cell morphologyany structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes
HP:0030153CholangiocarcinomaMP:0010123increased bone mineral contentelevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area
HP:0000952JaundiceMP:0020215impaired blood coagulationimpaired ability of the blood to clot
Disease ID 502
Disease klatskin tumor
Case(Waiting for update.)