eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| kimura disease | ||||
| Disease ID | 1380 |
|---|---|
| Disease | kimura disease |
| Definition | A chronic, benign, inflammatory condition that is characterized by the swelling of lymph node in the head and neck. |
| Synonym | disease, kimura eosinophilic granuloma of soft tissue eosinophilic hyperplastic lymphogranuloma eosinophilic hyperplastic lymphogranulomas eosinophilic lymphofollicular granuloma eosinophilic lymphofollicular granulomas eosinophilic lymphofolliculoses eosinophilic lymphofolliculosis granuloma, eosinophilic lymphofollicular granulomas, eosinophilic lymphofollicular hyperplastic lymphogranuloma, eosinophilic hyperplastic lymphogranulomas, eosinophilic kimura dis kimura's disease kimura's disease (disorder) lymphofollicular granuloma, eosinophilic lymphofollicular granulomas, eosinophilic lymphofolliculoses, eosinophilic lymphofolliculosis, eosinophilic lymphogranuloma, eosinophilic hyperplastic lymphogranulomas, eosinophilic hyperplastic |
| Orphanet | |
| DOID | |
| UMLS | C0033838 |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:16) C0002989 | angiolymphoid hyperplasia | 6 C0027726 | nephrotic syndrome | 5 C0017665 | membranous nephropathy | 2 C0029883 | secretory otitis media | 1 C0042384 | vasculitis | 1 C0018916 | hemangioma | 1 C0030326 | panniculitis | 1 C0205788 | epithelioid hemangioma | 1 C0017658 | glomerulonephritis | 1 C0017661 | iga nephropathy | 1 C0040021 | buerger's disease | 1 C0042373 | vascular disease | 1 C0024115 | lung disease | 1 C0029882 | otitis media | 1 C0022658 | nephropathy | 1 C0235618 | proliferative glomerulonephritis | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:16) 800 | CALD1 | 1.642 | DISEASES 1232 | CCR3 | 1.512 | DISEASES 959 | CD40LG | 2.096 | DISEASES 387836 | CLEC2A | 2.118 | DISEASES 1380 | CR2 | 1.272 | DISEASES 64109 | CRLF2 | 2.264 | DISEASES 3039 | HBA1 | 2.774 | DISEASES 50616 | IL22 | 1.847 | DISEASES 90865 | IL33 | 1.286 | DISEASES 3684 | ITGAM | 1.476 | DISEASES 5268 | SERPINB5 | 1.419 | DISEASES 5269 | SERPINB6 | 3.312 | DISEASES 5271 | SERPINB8 | 2.795 | DISEASES 5272 | SERPINB9 | 2.53 | DISEASES 55576 | STAB2 | 2.461 | DISEASES 85480 | TSLP | 1.453 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 1380 |
|---|---|
| Disease | kimura disease |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:5) HP:0002729 | Follicular hyperplasia HP:0010286 | Abnormality of the salivary glands HP:0002716 | Lymphadenopathy HP:0003212 | Increased IgE level HP:0001880 | Eosinophilia |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:13) HP:0000100 | Nephrosis | 5 HP:0002716 | Lymph node hyperplasia | 3 HP:0001880 | Eosinophilia | 2 HP:0012578 | Membranous glomerulonephritis | 2 HP:0002170 | Intracranial hemorrhage | 1 HP:0002633 | Vasculitis | 1 HP:0000388 | Otitis media | 1 HP:0002835 | Aspiration | 1 HP:0012490 | Inflammation of fat tissue | 1 HP:0000099 | Glomerular nephritis | 1 HP:0002664 | Neoplasia | 1 HP:0001028 | Strawberry mark | 1 HP:0000112 | Nephropathy | 1 |
| Disease ID | 1380 |
|---|---|
| Disease | kimura disease |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:2) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:5) C0027726 | nephrotic syndrome | 5 C0024228 | lymphadenopathy | 3 C0014457 | eosinophilia | 1 C0235618 | proliferative glomerulonephritis | 1 C0042384 | vasculitis | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:3) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0010286 | Abnormality of the salivary glands | MP:0009657 | failure of chorioallantoic fusion | failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois |
| HP:0002729 | Follicular hyperplasia | MP:0010945 | lung epithelium hyperplasia | overdevelopment or increased size, usually due an increased number of cells in the epithelial layer of the lung |
| HP:0003212 | Increased IgE level | MP:0008635 | increased circulating interleukin-18 level | increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity |
Mapped by homologous gene(Total Items:5) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001880 | Eosinophilia | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0002716 | Lymphadenopathy | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0010286 | Abnormality of the salivary glands | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0003212 | Increased IgE level | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0002729 | Follicular hyperplasia | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| Disease ID | 1380 |
|---|---|
| Disease | kimura disease |
| Case | (Waiting for update.) |