keratoacanthoma |
Disease ID | 1179 |
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Disease | keratoacanthoma |
Definition | A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption. |
Synonym | ka - keratoacanthoma keratoacanthoma (disorder) keratoacanthoma (morphologic abnormality) keratoacanthoma [disease/finding] keratoacanthoma, nos keratoacanthomas molluscum sebaceum |
DOID | |
UMLS | C0022572 |
MeSH | |
SNOMED-CT | |
Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:15) C0007137 | squamous cell carcinoma | 6 C0007137 | squamous cell carcinomas | 2 C0235974 | pancreatic cancer | 1 C0023646 | lichen planus | 1 C0019204 | hepatocellular carcinoma | 1 C0026986 | myelodysplastic syndrome | 1 C0003873 | rheumatoid arthritis | 1 C0346647 | pancreatic cancers | 1 C1321489 | muir-torre syndrome | 1 C0003864 | arthritis | 1 C1527336 | sjogren's syndrome | 1 C0022593 | keratosis | 1 C0022572 | keratoacanthoma | 1 C0007117 | basal cell carcinoma | 1 C0004623 | bacterial infection | 1 |
Curated Gene | (Waiting for update.) |
Inferring Gene | (Waiting for update.) |
Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:45) 55256 | ADI1 | 1.858 | DISEASES 238 | ALK | 1.422 | DISEASES 309 | ANXA6 | 1.912 | DISEASES 369 | ARAF | 1.883 | DISEASES 488 | ATP2A2 | 1.105 | DISEASES 578 | BAK1 | 1.597 | DISEASES 149483 | CCDC17 | 4.415 | DISEASES 9332 | CD163 | 1.455 | DISEASES 1029 | CDKN2A | 2.461 | DISEASES 1038 | CDR1 | 1.51 | DISEASES 10519 | CIB1 | 2.024 | DISEASES 387836 | CLEC2A | 3.006 | DISEASES 1382 | CRABP2 | 1.737 | DISEASES 1499 | CTNNB1 | 1.159 | DISEASES 2017 | CTTN | 2.15 | DISEASES 93099 | DMKN | 3.372 | DISEASES 7430 | EZR | 1.755 | DISEASES 2312 | FLG | 1.829 | DISEASES 4303 | FOXO4 | 1.351 | DISEASES 28996 | HIPK2 | 2.924 | DISEASES 3440 | IFNA2 | 1.164 | DISEASES 3570 | IL6R | 1.035 | DISEASES 3655 | ITGA6 | 1.334 | DISEASES 3713 | IVL | 3.624 | DISEASES 3851 | KRT4 | 1.829 | DISEASES 4014 | LOR | 2.379 | DISEASES 378938 | MALAT1 | 1.117 | DISEASES 5609 | MAP2K7 | 2.927 | DISEASES 4318 | MMP9 | 1.453 | DISEASES 4478 | MSN | 1.181 | DISEASES 64710 | NUCKS1 | 2.717 | DISEASES 5728 | PTEN | 1.017 | DISEASES 5962 | RDX | 1.255 | DISEASES 7905 | REEP5 | 1.805 | DISEASES 6194 | RPS6 | 1.289 | DISEASES 6273 | S100A2 | 1.796 | DISEASES 6277 | S100A6 | 2.666 | DISEASES 6278 | S100A7 | 2.356 | DISEASES 7062 | TCHH | 2.395 | DISEASES 84260 | TCHP | 1.401 | DISEASES 6999 | TDO2 | 1.735 | DISEASES 8742 | TNFSF12 | 1.277 | DISEASES 7170 | TPM3 | 1.542 | DISEASES 7171 | TPM4 | 2.348 | DISEASES 57178 | ZMIZ1 | 2.445 | DISEASES |
Locus | (Waiting for update.) |
Disease ID | 1179 |
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Disease | keratoacanthoma |
Integrated Phenotype | (Waiting for update.) |
Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:9) HP:0002860 | Squamous cell carcinoma | 6 HP:0030731 | Carcinoma | 2 HP:0001402 | Hepatocellular carcinoma | 1 HP:0001369 | Arthritis | 1 HP:0002894 | Neoplasia of the pancreas | 1 HP:0001370 | Rheumatoid arthritis | 1 HP:0002671 | Basalioma | 1 HP:0002863 | Myelodysplastic syndrome | 1 HP:0002829 | Arthralgias | 1 |
Disease ID | 1179 |
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Disease | keratoacanthoma |
Manually Symptom | UMLS | Name(Total Manually Symptoms:3) |
Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:1) |
Manually Genotype(Total Text Mining Genotypes:0) |
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(Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
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(Waiting for update.) |
All Snps(Total Genotypes:4) | |||||||||||||
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snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
rs113488022 | 22067401 | 22882 | ZHX2 | umls:C0022572 | BeFree | RAF inhibitors are effective against melanomas with BRAF V600E mutations but may induce keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cSCCs). | 0.000814326 | 2012 | BRAF | 7 | 140753336 | A | T,G,C |
rs113488022 | 24345644 | 673 | BRAF | umls:C0022572 | BeFree | Keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cuSCCs) develop in 15-30% of patients with BRAF(V600E) metastatic melanoma treated with BRAF inhibitors (BRAFi). | 0.001357209 | 2013 | BRAF | 7 | 140753336 | A | T,G,C |
rs113488022 | 22067401 | 673 | BRAF | umls:C0022572 | BeFree | RAF inhibitors are effective against melanomas with BRAF V600E mutations but may induce keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cSCCs). | 0.001357209 | 2012 | BRAF | 7 | 140753336 | A | T,G,C |
rs113488022 | 22067401 | 5894 | RAF1 | umls:C0022572 | BeFree | RAF inhibitors are effective against melanomas with BRAF V600E mutations but may induce keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cSCCs). | 0.000814326 | 2012 | BRAF | 7 | 140753336 | A | T,G,C |
GWASdb Annotation(Total Genotypes:0) | |
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(Waiting for update.) |
GWASdb Snp Trait(Total Genotypes:0) | |
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(Waiting for update.) |
Mapped by lexical matching(Total Items:0) |
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(Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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(Waiting for update.) |
Disease ID | 1179 |
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Disease | keratoacanthoma |
Case | (Waiting for update.) |