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	keratitis

Disease ID	722
Disease	keratitis
Definition	Inflammation of the cornea.
Synonym	corneal inflammation corneal keratitis inflammation corneal keratitides keratitis (disorder) keratitis [disease/finding] keratitis nos keratitis nos (disorder) keratitis, nos unspecified keratitis
DOID	DOID:4677
ICD10	ICD10CM:H16.9
UMLS	C0022568
MeSH	D007634
SNOMED-CT	SNOMEDCT_US_2016_09_01:5888003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:78) C0456909 \| blindness \| 14 C0010043 \| corneal ulcer \| 10 C0003873 \| rheumatoid arthritis \| 6 C0042164 \| uveitis \| 6 C0152226 \| lagophthalmos \| 5 C0007137 \| squamous cell carcinoma \| 4 C0042165 \| anterior uveitis \| 4 C0010043 \| corneal ulceration \| 4 C0456909 \| vision loss \| 4 C0019348 \| herpes simplex \| 4 C0314719 \| dry eye \| 4 C0014236 \| endophthalmitis \| 4 C0043092 \| wegener's granulomatosis \| 3 C0019360 \| zoster \| 3 C0019360 \| herpes zoster \| 3 C0085109 \| corneal neovascularization \| 3 C0042769 \| viral infection \| 2 C0026946 \| fungal infection \| 2 C0086543 \| cataract \| 2 C0010036 \| corneal dystrophy \| 2 C0019364 \| herpes zoster ophthalmicus \| 2 C0022573 \| keratoconjunctivitis \| 2 C0026946 \| fungal infections \| 2 C0006840 \| candidiasis \| 2 C0004623 \| bacterial infection \| 2 C0553662 \| juvenile rheumatoid arthritis \| 1 C0262428 \| collagen vascular disease \| 1 C0268483 \| tyrosinemia \| 1 C0276758 \| fusarium infection \| 1 C0085435 \| reactive arthritis \| 1 C0010346 \| crohn's disease \| 1 C0036689 \| streptococcal pharyngitis \| 1 C0009806 \| constipation \| 1 C0701807 \| acute anterior uveitis \| 1 C0010346 \| crohn disease \| 1 C0235270 \| keratopathy \| 1 C1510471 \| hypovitaminosis \| 1 C0021831 \| intestinal disease \| 1 C0043092 \| wegener granulomatosis \| 1 C0020490 \| hyperopia \| 1 C0019364 \| zoster ophthalmicus \| 1 C0010034 \| corneal disease \| 1 C0085109 \| corneal vascularization \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C0042373 \| vascular disease \| 1 C0271270 \| cogan syndrome \| 1 C0021390 \| inflammatory bowel disease \| 1 C0021053 \| immune disease \| 1 C0018179 \| granular corneal dystrophy \| 1 C0009763 \| conjunctivitis \| 1 C0042384 \| vasculitis \| 1 C0004943 \| behcet's disease \| 1 C0013238 \| dry eye syndrome \| 1 C1527336 \| sjogren's syndrome \| 1 C0003864 \| arthritis \| 1 C0155111 \| bullous keratopathy \| 1 C0031350 \| pharyngitis \| 1 C0343068 \| familial cold autoinflammatory syndrome \| 1 C0021831 \| bowel disease \| 1 C0001175 \| acquired immune deficiency \| 1 C0017601 \| glaucoma \| 1 C0153131 \| syphilitic interstitial keratitis \| 1 C0026764 \| multiple myeloma \| 1 C0013592 \| ectropion \| 1 C0004623 \| bacterial infections \| 1 C0022575 \| keratoconjunctivitis sicca \| 1 C0038325 \| stevens-johnson syndrome \| 1 C0010037 \| corneal edema \| 1 C0001175 \| acquired immune deficiency syndrome (aids) \| 1 C0034212 \| pyoderma \| 1 C0085652 \| pyoderma gangrenosum \| 1 C0035854 \| rosacea \| 1 C0026946 \| mycoses \| 1 C0042373 \| vascular diseases \| 1 C0017178 \| gastrointestinal disease \| 1 C0037274 \| dermatosis \| 1 C0040188 \| tic disorders \| 1 C0001175 \| acquired immune deficiency syndrome \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 2706 \| GJB2 \| CTD_human 3576 \| CXCL8 \| CTD_human 7097 \| TLR2 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:153) 3983 \| ABLIM1 \| 1.688 \| DISEASES 202 \| AIM1 \| 2.15 \| DISEASES 283 \| ANG \| 1.547 \| DISEASES 284 \| ANGPT1 \| 1.652 \| DISEASES 23452 \| ANGPTL2 \| 1.613 \| DISEASES 10218 \| ANGPTL7 \| 1.305 \| DISEASES 820 \| CAMP \| 2.749 \| DISEASES 6364 \| CCL20 \| 1.619 \| DISEASES 388372 \| CCL4L1 \| 2.241 \| DISEASES 9560 \| CCL4L2 \| 1.138 \| DISEASES 1232 \| CCR3 \| 1.147 \| DISEASES 959 \| CD40LG \| 2.413 \| DISEASES 80781 \| COL18A1 \| 3.326 \| DISEASES 81035 \| COLEC12 \| 1.454 \| DISEASES 170622 \| COMMD6 \| 2.368 \| DISEASES 9244 \| CRLF1 \| 1.083 \| DISEASES 1413 \| CRYBA4 \| 1.521 \| DISEASES 1499 \| CTNNB1 \| 1.064 \| DISEASES 1524 \| CX3CR1 \| 1.432 \| DISEASES 2919 \| CXCL1 \| 3.308 \| DISEASES 6387 \| CXCL12 \| 1.706 \| DISEASES 2920 \| CXCL2 \| 3.538 \| DISEASES 4283 \| CXCL9 \| 1.844 \| DISEASES 2833 \| CXCR3 \| 1.459 \| DISEASES 7852 \| CXCR4 \| 1.365 \| DISEASES 1580 \| CYP4B1 \| 2.133 \| DISEASES 414325 \| DEFB103A \| 2.665 \| DISEASES 55894 \| DEFB103B \| 2.665 \| DISEASES 100289462 \| DEFB4B \| 1.521 \| DISEASES 1660 \| DHX9 \| 3.927 \| DISEASES 23234 \| DNAJC9 \| 2.193 \| DISEASES 1791 \| DNTT \| 1.485 \| DISEASES 81704 \| DOCK8 \| 1.34 \| DISEASES 8813 \| DPM1 \| 1.766 \| DISEASES 1805 \| DPT \| 1.446 \| DISEASES 1961 \| EGR4 \| 1.253 \| DISEASES 1999 \| ELF3 \| 1.378 \| DISEASES 23065 \| EMC1 \| 3.525 \| DISEASES 2047 \| EPHB1 \| 1.859 \| DISEASES 104355217 \| ERICD \| 2.183 \| DISEASES 56975 \| FAM20C \| 3.826 \| DISEASES 356 \| FASLG \| 1.587 \| DISEASES 9873 \| FCHSD2 \| 1.372 \| DISEASES 2258 \| FGF13 \| 1.567 \| DISEASES 2316 \| FLNA \| 1.089 \| DISEASES 2318 \| FLNC \| 1.215 \| DISEASES 2331 \| FMOD \| 1.951 \| DISEASES 50943 \| FOXP3 \| 1.712 \| DISEASES 2664 \| GDI1 \| 4.137 \| DISEASES 2706 \| GJB2 \| 5.425 \| DISEASES 2707 \| GJB3 \| 1.826 \| DISEASES 127534 \| GJB4 \| 2.883 \| DISEASES 2709 \| GJB5 \| 2.632 \| DISEASES 2737 \| GLI3 \| 1.449 \| DISEASES 3039 \| HBA1 \| 3.037 \| DISEASES 3105 \| HLA-A \| 1.044 \| DISEASES 8091 \| HMGA2 \| 1.455 \| DISEASES 3146 \| HMGB1 \| 1.057 \| DISEASES 3329 \| HSPD1 \| 1.41 \| DISEASES 3339 \| HSPG2 \| 1.292 \| DISEASES 3447 \| IFNA13 \| 1.642 \| DISEASES 3440 \| IFNA2 \| 1.755 \| DISEASES 3456 \| IFNB1 \| 2.349 \| DISEASES 3550 \| IK \| 1.166 \| DISEASES 3586 \| IL10 \| 3.304 \| DISEASES 3605 \| IL17A \| 2.878 \| DISEASES 23765 \| IL17RA \| 1.902 \| DISEASES 3559 \| IL2RA \| 1.154 \| DISEASES 3652 \| IPP \| 1.252 \| DISEASES 3684 \| ITGAM \| 2.758 \| DISEASES 56704 \| JPH1 \| 1.126 \| DISEASES 57158 \| JPH2 \| 1.517 \| DISEASES 3880 \| KRT19 \| 1.247 \| DISEASES 3850 \| KRT3 \| 3.747 \| DISEASES 3851 \| KRT4 \| 1.474 \| DISEASES 3932 \| LCK \| 1.446 \| DISEASES 3965 \| LGALS9 \| 1.218 \| DISEASES 7786 \| MAP3K12 \| 1.249 \| DISEASES 5599 \| MAPK8 \| 1.186 \| DISEASES 4145 \| MATK \| 2.24 \| DISEASES 51360 \| MBTPS2 \| 1.871 \| DISEASES 81857 \| MED25 \| 1.718 \| DISEASES 4312 \| MMP1 \| 1.983 \| DISEASES 4318 \| MMP9 \| 4.066 \| DISEASES 26002 \| MOXD1 \| 1.66 \| DISEASES 4586 \| MUC5AC \| 2.109 \| DISEASES 4615 \| MYD88 \| 3.214 \| DISEASES 4641 \| MYO1C \| 1.411 \| DISEASES 4803 \| NGF \| 2.069 \| DISEASES 79576 \| NKAP \| 2.293 \| DISEASES 114548 \| NLRP3 \| 1.637 \| DISEASES 4843 \| NOS2 \| 1.085 \| DISEASES 594857 \| NPS \| 1.368 \| DISEASES 8828 \| NRP2 \| 1.581 \| DISEASES 59277 \| NTN4 \| 2.412 \| DISEASES 5080 \| PAX6 \| 2.362 \| DISEASES 5228 \| PGF \| 1.417 \| DISEASES 114770 \| PGLYRP2 \| 1.567 \| DISEASES 57115 \| PGLYRP4 \| 1.863 \| DISEASES 5328 \| PLAU \| 1.474 \| DISEASES 23646 \| PLD3 \| 2.463 \| DISEASES 139728 \| PNCK \| 1.347 \| DISEASES 11201 \| POLI \| 1.03 \| DISEASES 5542 \| PRB1 \| 1.079 \| DISEASES 5788 \| PTPRC \| 1.964 \| DISEASES 5795 \| PTPRJ \| 1.56 \| DISEASES 196475 \| RMST \| 1.585 \| DISEASES 8732 \| RNGTT \| 3.574 \| DISEASES 23429 \| RYBP \| 1.213 \| DISEASES 6283 \| S100A12 \| 1.519 \| DISEASES 6284 \| S100A13 \| 1.472 \| DISEASES 6303 \| SAT1 \| 1.08 \| DISEASES 388228 \| SBK1 \| 2.649 \| DISEASES 6401 \| SELE \| 1.482 \| DISEASES 5265 \| SERPINA1 \| 1.136 \| DISEASES 5275 \| SERPINB13 \| 1.295 \| DISEASES 29946 \| SERTAD3 \| 1.845 \| DISEASES 59307 \| SIGIRR \| 2.75 \| DISEASES 9353 \| SLIT2 \| 1.342 \| DISEASES 6586 \| SLIT3 \| 1.209 \| DISEASES 6590 \| SLPI \| 1.504 \| DISEASES 677833 \| SNORA54 \| 1.411 \| DISEASES 200162 \| SPAG17 \| 1.678 \| DISEASES 9806 \| SPOCK2 \| 1.588 \| DISEASES 6714 \| SRC \| 1.164 \| DISEASES 6850 \| SYK \| 1.482 \| DISEASES 6863 \| TAC1 \| 2.726 \| DISEASES 6898 \| TAT \| 4.101 \| DISEASES 7010 \| TEK \| 1.968 \| DISEASES 7045 \| TGFBI \| 1.328 \| DISEASES 7058 \| THBS2 \| 2.995 \| DISEASES 7096 \| TLR1 \| 2.03 \| DISEASES 7099 \| TLR4 \| 3.788 \| DISEASES 7100 \| TLR5 \| 2.839 \| DISEASES 54106 \| TLR9 \| 2.765 \| DISEASES 7114 \| TMSB4X \| 1.113 \| DISEASES 7124 \| TNF \| 3.543 \| DISEASES 8764 \| TNFRSF14 \| 1.193 \| DISEASES 9966 \| TNFSF15 \| 1.652 \| DISEASES 27229 \| TUBGCP4 \| 1.006 \| DISEASES 286753 \| TUSC5 \| 2.611 \| DISEASES 7318 \| UBA7 \| 1.152 \| DISEASES 7325 \| UBE2E2 \| 1.177 \| DISEASES 90249 \| UNC5A \| 1.099 \| DISEASES 219699 \| UNC5B \| 2.273 \| DISEASES 137970 \| UNC5D \| 1.564 \| DISEASES 11023 \| VAX1 \| 1.492 \| DISEASES 7422 \| VEGFA \| 5.235 \| DISEASES 7432 \| VIP \| 1.419 \| DISEASES 51534 \| VTA1 \| 2.033 \| DISEASES 6375 \| XCL1 \| 1.244 \| DISEASES 9278 \| ZBTB22 \| 1.29 \| DISEASES 55657 \| ZNF692 \| 3.241 \| DISEASES
Locus	(Waiting for update.)

Disease ID	722
Disease	keratitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:53) HP:0000618 \| Blindness \| 14 HP:0012804 \| Corneal ulceration \| 11 HP:0001370 \| Rheumatoid arthritis \| 6 HP:0000554 \| Uveitis \| 5 HP:0000572 \| Visual loss \| 5 HP:0100699 \| Scarring \| 5 HP:0100583 \| Corneal perforation \| 4 HP:0012122 \| Anterior uveitis \| 4 HP:0011496 \| Corneal vascularization \| 4 HP:0002860 \| Squamous cell carcinoma \| 4 HP:0007957 \| Corneal clouding \| 4 HP:0012531 \| Pain \| 4 HP:0000559 \| Corneal scarring \| 3 HP:0000518 \| Cataract \| 2 HP:0030731 \| Carcinoma \| 2 HP:0001131 \| Corneal dystrophy \| 2 HP:0001101 \| Iritis \| 2 HP:0000613 \| Extreme light sensitivity \| 2 HP:0002955 \| Granulomatosis \| 2 HP:0001096 \| Keratoconjunctivitis \| 2 HP:0005681 \| Juvenile idiopathic arthritis \| 2 HP:0007663 \| Central visual loss \| 1 HP:0007802 \| Granular corneal dystrophy \| 1 HP:0001094 \| Iridocyclitis \| 1 HP:0100033 \| Tic disorder \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0000726 \| Dementia \| 1 HP:0003474 \| Sensory impairment \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0001824 \| Weight loss \| 1 HP:0000540 \| Hypermetropia \| 1 HP:0001945 \| Fever \| 1 HP:0001059 \| Pterygium \| 1 HP:0002321 \| Vertigo \| 1 HP:0000999 \| Pyoderma \| 1 HP:0012375 \| Chemosis \| 1 HP:0001875 \| Neutropenia \| 1 HP:0003764 \| Naevus \| 1 HP:0011487 \| Increased corneal thickness \| 1 HP:0000656 \| Ectropion \| 1 HP:0000505 \| Poor vision \| 1 HP:0001097 \| Keratoconjunctivitis sicca \| 1 HP:0000509 \| Conjunctivitis \| 1 HP:0002633 \| Vasculitis \| 1 HP:0003231 \| Increased tyrosine in blood \| 1 HP:0002019 \| Dyschezia \| 1 HP:0002664 \| Neoplasia \| 1 HP:0004905 \| Vitamin A deficiency \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0012155 \| Reduced corneal sensation \| 1 HP:0000568 \| Abnormally small globe of eye \| 1 HP:0001369 \| Arthritis \| 1 HP:0000360 \| Ringing in the ears \| 1

Disease ID	722
Disease	keratitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:4) C0870082 \| hyperkeratosis C0042769 \| viral infections C0022596 \| palmoplantar keratosis C0010034 \| corneal disease
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0010034 \| corneal disease \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs28931594	23924173	2706	GJB2	umls:C0022568	BeFree	Heterozygous p.Asp50Asn mutation in the GJB2 gene in two Cameroonian patients with keratitis-ichthyosis-deafness (KID) syndrome.	0.124885954	2013	GJB2	13	20189434	C	T,A
rs72561723	18024254	2706	GJB2	umls:C0022568	BeFree	A familial case of Keratitis-Ichthyosis-Deafness (KID) syndrome with the GJB2 mutation G45E.	0.124885954	2008	GJB2	13	20189448	C	T
rs72561723	23756814	2706	GJB2	umls:C0022568	BeFree	Substitution of glycine at the position 45 of Cx26 to glutamic acid (p.G45E mutation) causes the Keratitis-ichthyosis-deafness (KID) syndrome.	0.124885954	2013	GJB2	13	20189448	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	722
Disease	keratitis
Case	(Waiting for update.)

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