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	interstitial cystitis

Disease ID	389
Disease	interstitial cystitis
Definition	A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.
Synonym	cystitides, interstitial cystitis interstitial cystitis ulcerative cystitis, interstitial cystitis, interstitial [disease/finding] ic - interstitial cystitis interstitial cystitides interstitial cystitis (ic) painful bladder syndrome (pbs) ulcerative cystitis ulcerative cystitis (disorder)
Orphanet	ORPHANET:37202
DOID	DOID:13949
UMLS	C0282488
MeSH	D018856
SNOMED-CT	SNOMEDCT_US_2016_09_01:111409009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:12) C1527336 \| sjogren's syndrome \| 3 C0033953 \| sexual dysfunction \| 2 C0011570 \| depression \| 2 C0005684 \| bladder cancer \| 1 C0014175 \| endometriosis \| 1 C0019204 \| hepatocarcinoma \| 1 C0042580 \| vesicoureteral reflux \| 1 C0003467 \| anxiety \| 1 C0014868 \| esophagitis \| 1 C0003469 \| anxiety disorder \| 1 C0014869 \| reflux esophagitis \| 1 C0010692 \| cystitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 4283 \| CXCL9 \| CTD_human 3627 \| CXCL10 \| CTD_human 6373 \| CXCL11 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:8) 146 \| ADRA1D \| CIPHER 154 \| ADRB2 \| CIPHER 155 \| ADRB3 \| CIPHER 3565 \| IL4 \| CIPHER 3566 \| IL4R \| CIPHER 3627 \| CXCL10 \| CTD_human 6373 \| CXCL11 \| CTD_human 4283 \| CXCL9 \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:78) 60 \| ACTB \| 1.168 \| DISEASES 116 \| ADCYAP1 \| 1.525 \| DISEASES 146 \| ADRA1D \| 1.586 \| DISEASES 9048 \| ARTN \| 1.411 \| DISEASES 627 \| BDNF \| 2.259 \| DISEASES 633 \| BGN \| 1.536 \| DISEASES 6354 \| CCL7 \| 2.654 \| DISEASES 10970 \| CKAP4 \| 4.682 \| DISEASES 1394 \| CRHR1 \| 1.381 \| DISEASES 1395 \| CRHR2 \| 1.766 \| DISEASES 4283 \| CXCL9 \| 1.432 \| DISEASES 2833 \| CXCR3 \| 1.833 \| DISEASES 954 \| ENTPD2 \| 1.481 \| DISEASES 2138 \| EYA1 \| 1.382 \| DISEASES 2205 \| FCER1A \| 1.108 \| DISEASES 2268 \| FGR \| 1.032 \| DISEASES 8325 \| FZD8 \| 4.564 \| DISEASES 2633 \| GBP1 \| 1.431 \| DISEASES 2634 \| GBP2 \| 2.201 \| DISEASES 115362 \| GBP5 \| 2.536 \| DISEASES 10052 \| GJC1 \| 2.275 \| DISEASES 2935 \| GSPT1 \| 2.17 \| DISEASES 3052 \| HCCS \| 1.099 \| DISEASES 3109 \| HLA-DMB \| 2.006 \| DISEASES 3269 \| HRH1 \| 2.941 \| DISEASES 3274 \| HRH2 \| 2.274 \| DISEASES 90865 \| IL33 \| 1.658 \| DISEASES 3635 \| INPP5D \| 2.267 \| DISEASES 3664 \| IRF6 \| 1.691 \| DISEASES 102723508 \| KANTR \| 1.932 \| DISEASES 3739 \| KCNA4 \| 1.216 \| DISEASES 9622 \| KLK4 \| 2.16 \| DISEASES 3853 \| KRT6A \| 1.435 \| DISEASES 8649 \| LAMTOR3 \| 2.447 \| DISEASES 4038 \| LRP4 \| 1.359 \| DISEASES 55227 \| LRRC1 \| 2.8 \| DISEASES 84557 \| MAP1LC3A \| 1.066 \| DISEASES 83881 \| MIXL1 \| 1.024 \| DISEASES 8569 \| MKNK1 \| 1.756 \| DISEASES 22921 \| MSRB2 \| 2.139 \| DISEASES 253827 \| MSRB3 \| 2.336 \| DISEASES 4490 \| MT1B \| 2.391 \| DISEASES 4494 \| MT1F \| 2.038 \| DISEASES 4495 \| MT1G \| 1.591 \| DISEASES 4496 \| MT1H \| 1.883 \| DISEASES 4501 \| MT1X \| 1.783 \| DISEASES 4685 \| NCAM2 \| 2.702 \| DISEASES 4803 \| NGF \| 4.902 \| DISEASES 654364 \| NME1-NME2 \| 5.738 \| DISEASES 27035 \| NOX1 \| 1.431 \| DISEASES 594857 \| NPS \| 2.939 \| DISEASES 8021 \| NUP214 \| 2.082 \| DISEASES 100506658 \| OCLN \| 2.173 \| DISEASES 22953 \| P2RX2 \| 4.426 \| DISEASES 5032 \| P2RY11 \| 1.775 \| DISEASES 5179 \| PENK \| 1.683 \| DISEASES 11168 \| PSIP1 \| 2.697 \| DISEASES 5737 \| PTGFR \| 1.871 \| DISEASES 5743 \| PTGS2 \| 1.812 \| DISEASES 1757 \| SARDH \| 1.746 \| DISEASES 6318 \| SERPINB4 \| 1.366 \| DISEASES 10572 \| SIVA1 \| 1.837 \| DISEASES 63910 \| SLC17A9 \| 2.553 \| DISEASES 9152 \| SLC6A5 \| 1.806 \| DISEASES 6625 \| SNRNP70 \| 1.233 \| DISEASES 9580 \| SOX13 \| 1.749 \| DISEASES 6706 \| SPRR2G \| 3.416 \| DISEASES 11276 \| SYNRG \| 2.839 \| DISEASES 6863 \| TAC1 \| 4.628 \| DISEASES 6865 \| TACR2 \| 1.218 \| DISEASES 7099 \| TLR4 \| 1.285 \| DISEASES 7124 \| TNF \| 1.861 \| DISEASES 8740 \| TNFSF14 \| 1.575 \| DISEASES 7442 \| TRPV1 \| 3.834 \| DISEASES 51393 \| TRPV2 \| 1.199 \| DISEASES 114131 \| UCN3 \| 1.538 \| DISEASES 7422 \| VEGFA \| 1.591 \| DISEASES 11260 \| XPOT \| 2.62 \| DISEASES
Locus	(Waiting for update.)

Disease ID	389
Disease	interstitial cystitis
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:13) HP:0000078 \| Abnormality of the genital system HP:0000142 \| Abnormality of the vagina HP:0000014 \| Abnormality of the bladder HP:0100577 \| Urinary bladder inflammation HP:0000140 \| Abnormality of the menstrual cycle HP:0000017 \| Nocturia HP:0000795 \| Abnormality of the urethra HP:0030016 \| Dyspareunia HP:0012531 \| Pain HP:0000012 \| Urinary urgency HP:0000009 \| Functional abnormality of the bladder HP:0100515 \| Pollakisuria HP:0000058 \| Abnormality of the labia
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:17) HP:0012531 \| Pain \| 11 HP:0012532 \| Chronic pain \| 2 HP:0000716 \| Depression \| 2 HP:0030127 \| Endometriosis \| 1 HP:0100633 \| Inflammation of the esophagus \| 1 HP:0000076 \| Vesicoureteric reflux \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0000017 \| Nocturia \| 1 HP:0000020 \| Bladder incontinence \| 1 HP:0100607 \| Painful menstruation \| 1 HP:0010992 \| Stress urinary incontinence \| 1 HP:0008711 \| Benign prostatic hypertrophy \| 1 HP:0000739 \| Anxiety \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0009725 \| Bladder neoplasm \| 1 HP:0002500 \| Leukoaraiosis \| 1 HP:0100785 \| Insomnia \| 1

Disease ID	389
Disease	interstitial cystitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:19) C2598155 \| pain C1963176 \| bladder pain C1720830 \| painful bladder syndrome C1611280 \| allergy C1384606 \| dyspareunia C1112443 \| male sexual dysfunction C0850758 \| pelvic pain C0750103 \| vaginalis C0741548 \| bladder symptoms C0700361 \| distress C0545047 \| nephrogenic adenoma C0497552 \| nervous system abnormalities C0404484 \| chronic pelvic pain C0334664 \| mastocytosis C0268854 \| contracted bladder C0178879 \| obstructive uropathy C0028734 \| nocturia C0019080 \| hemorrhage C0005687 \| bladder distention
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0030193 \| pain \| 11 C0232849 \| bladder pain \| 4 C0028734 \| nocturia \| 1 C1720830 \| painful bladder syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1042713	16971769	154	ADRB2	umls:C0282488	BeFree	We examined the relationship between the Arg16Gly polymorphism of beta2-adrenoceptor (ADRB2) and the efficacy of tricyclic antidepressant therapy in patients with interstitial cystitis (IC).	0.005276948	2006	ADRB2	5	148826877	G	A
rs4994	12442007	155	ADRB3	umls:C0282488	BeFree	We analyzed 5 gene polymorphisms (G404781T, Arg16Gly, Trp64Arg, C589T and Ile50Val) per gene (ADRA1d, ADRB2, ADRB3, IL-4 and IL-4 receptor, respectively) and their relationship to interstitial cystitis.	0.002638474	2002	ADRB3	8	37966280	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:4)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0000078	Abnormality of the genital system	MP:0011205	excessive folding of visceral yolk sac	the appearance of wrinkles or folds on the surface of the visceral yolk sac
HP:0000142	Abnormality of the vagina	MP:0004502	decreased incidence of tumors by chemical induction	lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens
HP:0000140	Abnormality of the menstrual cycle	MP:0004499	increased incidence of tumors by chemical induction	higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens
HP:0000795	Abnormality of the urethra	MP:0002053	decreased incidence of induced tumors	reduced frequency of tumor incidence induced by a carcinogen, mutagen or virus

Mapped by homologous gene(Total Items:7)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0000012	Urinary urgency	MP:0014178	increased brain apoptosis	increase in the number of cells of the brain undergoing programmed cell death
HP:0012531	Pain	MP:0011968	decreased threshold for auditory brainstem response	reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system
HP:0000140	Abnormality of the menstrual cycle	MP:0014169	decreased brown adipose tissue mass	decreased physical bulk or volume of brown adipose tissue
HP:0000017	Nocturia	MP:0011108	embryonic lethality during organogenesis, incomplete penetrance	the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14)
HP:0000078	Abnormality of the genital system	MP:0020137	decreased bone mineralization	decrease in the rate at which minerals are deposited into bone
HP:0000795	Abnormality of the urethra	MP:0011966	abnormal auditory brainstem response waveform shape	any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to sho
HP:0000142	Abnormality of the vagina	MP:0013367	parotid gland inflammation	local accumulation of fluid, plasma proteins, and leukocytes in either of the largest of the major salivary glands situated below and in front of each ear

Disease ID	389
Disease	interstitial cystitis
Case	(Waiting for update.)

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