eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine

HOME
QUERY
- DISEASE
- GENOTYPE
NETWORK
- PHENOTYPE
- GENE
- COMMON
- DISEASE PAIR
DOWNLOAD
SUBMIT CASE
HELP&FAQ
- HELP&FAQ
- CONTACT US


	hypopituitarism

Disease ID	508
Disease	hypopituitarism
Definition	Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.
Synonym	adenohypophyseal hyposecret adenohypophyseal hyposecretion anterior pituitary hyposecret syndrome anterior pituitary hyposecretion syndrome deficiencies pituitary deficient secretion of one or more pituitary hormones hypopituitarism (disorder) hypopituitarism [disease/finding] hypopituitarism nos hypopituitarism nos (disorder) hypopituitarism, nos hypopitutitarism hyposecret adenohypophyseal hyposecret syndrome anterior pituitary hyposecretion syndrome, anterior pituitary hyposecretion, adenohypophyseal insufficiency pituitary insufficiency, pituitary pituitary deficiency pituitary failure pituitary hypofunction pituitary insufficiency pituitary insufficiency nos pituitary insufficiency, nos
Orphanet	ORPHANET:101957
DOID	DOID:9406
ICD10	ICD10CM:E23.0
UMLS	C0020635
MeSH	D007018
SNOMED-CT	SNOMEDCT_US_2016_09_01:74728003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:49) C0013338 \| growth hormone deficiency \| 5 C0020619 \| hypogonadism \| 4 C0020676 \| hypothyroidism \| 4 C0032000 \| pituitary adenoma \| 4 C0242342 \| sheehan's syndrome \| 3 C0032000 \| pituitary adenomas \| 3 C0011848 \| diabetes insipidus \| 3 C0030312 \| pancytopenia \| 2 C0011847 \| diabetes \| 2 C0010276 \| craniopharyngioma \| 2 C0001206 \| acromegaly \| 2 C0022735 \| hypogonadotropic hypogonadism \| 2 C0020598 \| hypoglycemia \| 2 C0079731 \| b-cell lymphoma \| 2 C0020514 \| hyperprolactinemia \| 2 C0005940 \| bone disease \| 1 C0687720 \| central diabetes insipidus \| 1 C0271558 \| pituitary necrosis \| 1 C0376358 \| prostate cancer \| 1 C0854486 \| functioning pituitary adenoma \| 1 C0271789 \| tsh deficiency \| 1 C0007222 \| cardiovascular disease \| 1 C0014038 \| encephalitis \| 1 C0004903 \| beckwith-wiedemann syndrome \| 1 C0155307 \| chiasmal syndrome \| 1 C0007115 \| thyroid ca \| 1 C0151740 \| increased intracranial pressure \| 1 C0029456 \| osteoporosis \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0948740 \| pituitary hypoplasia \| 1 C0042373 \| vascular disease \| 1 C0342388 \| adrenocorticotropic hormone deficiency \| 1 C0020635 \| pituitary insufficiency \| 1 C0242342 \| postpartum pituitary necrosis \| 1 C0032002 \| pituitary disease \| 1 C0024299 \| lymphoma \| 1 C0020617 \| hypoglycaemic coma \| 1 C0342388 \| acth deficiency \| 1 C0034012 \| delayed puberty \| 1 C0007115 \| thyroid cancer \| 1 C0040053 \| thrombosis \| 1 C0001403 \| addison's disease \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0242342 \| sheehan syndrome \| 1 C1565489 \| renal insufficiency \| 1 C0001430 \| adenoma \| 1 C0878544 \| cardiomyopathy \| 1 C1333387 \| endocrine syndrome \| 1 C0001623 \| adrenal insufficiency \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:11) 1586 \| CYP17A1 \| CTD_human 1588 \| CYP19A1 \| CTD_human 5617 \| PRL \| CTD_human 5015 \| OTX2 \| GHR 2736 \| GLI2 \| GHR 6657 \| SOX2 \| GHR 8820 \| HESX1 \| GHR 5449 \| POU1F1 \| GHR 5626 \| PROP1 \| GHR 89884 \| LHX4 \| GHR 8022 \| LHX3 \| GHR
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 5626 \| PROP1 \| CIPHER 5617 \| PRL \| CTD_human 1586 \| CYP17A1 \| CTD_human 1588 \| CYP19A1 \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:104) 174 \| AFP \| 1.042 \| DISEASES 286410 \| ATP11C \| 1.591 \| DISEASES 545 \| ATR \| 1.662 \| DISEASES 84126 \| ATRIP \| 1.275 \| DISEASES 551 \| AVP \| 4.948 \| DISEASES 57596 \| BEGAIN \| 2.202 \| DISEASES 632 \| BGLAP \| 2.196 \| DISEASES 51244 \| CCDC174 \| 2.258 \| DISEASES 959 \| CD40LG \| 1.611 \| DISEASES 8318 \| CDC45 \| 1.034 \| DISEASES 55755 \| CDK5RAP2 \| 1.539 \| DISEASES 55835 \| CENPJ \| 1.241 \| DISEASES 91687 \| CENPL \| 3.241 \| DISEASES 22995 \| CEP152 \| 1.666 \| DISEASES 80254 \| CEP63 \| 2.091 \| DISEASES 55636 \| CHD7 \| 1.765 \| DISEASES 137075 \| CLDN23 \| 1.748 \| DISEASES 54875 \| CNTLN \| 3.021 \| DISEASES 1443 \| CSH2 \| 1.703 \| DISEASES 9820 \| CUL7 \| 1.18 \| DISEASES 55661 \| DDX27 \| 1.024 \| DISEASES 123872 \| DNAAF1 \| 1.631 \| DISEASES 26052 \| DNM3 \| 1.182 \| DISEASES 147409 \| DSG4 \| 3.31 \| DISEASES 9718 \| ECE2 \| 1.134 \| DISEASES 1967 \| EIF2B1 \| 1.279 \| DISEASES 80712 \| ESX1 \| 6.532 \| DISEASES 2253 \| FGF8 \| 1.45 \| DISEASES 2260 \| FGFR1 \| 2.008 \| DISEASES 2274 \| FHL2 \| 1.513 \| DISEASES 2316 \| FLNA \| 1.099 \| DISEASES 27022 \| FOXD3 \| 1.186 \| DISEASES 8928 \| FOXH1 \| 1.266 \| DISEASES 2492 \| FSHR \| 1.072 \| DISEASES 2641 \| GCG \| 3.582 \| DISEASES 2675 \| GFRA2 \| 1.791 \| DISEASES 51738 \| GHRL \| 2.166 \| DISEASES 2736 \| GLI2 \| 4.08 \| DISEASES 2737 \| GLI3 \| 1.695 \| DISEASES 2773 \| GNAI3 \| 1.285 \| DISEASES 8971 \| H1FX \| 1.467 \| DISEASES 3030 \| HADHA \| 1.133 \| DISEASES 3481 \| IGF2 \| 2.777 \| DISEASES 3483 \| IGFALS \| 2.067 \| DISEASES 3486 \| IGFBP3 \| 4.276 \| DISEASES 3543 \| IGLL1 \| 1.083 \| DISEASES 100423062 \| IGLL5 \| 2.409 \| DISEASES 3547 \| IGSF1 \| 3.065 \| DISEASES 3664 \| IRF6 \| 1.718 \| DISEASES 10300 \| KATNB1 \| 2.86 \| DISEASES 8861 \| LDB1 \| 2.195 \| DISEASES 9355 \| LHX2 \| 1.136 \| DISEASES 8022 \| LHX3 \| 6.406 \| DISEASES 9782 \| MATR3 \| 1.035 \| DISEASES 4221 \| MEN1 \| 1.233 \| DISEASES 284424 \| MIR7-3HG \| 2.791 \| DISEASES 54820 \| NDE1 \| 1.787 \| DISEASES 4791 \| NFKB2 \| 1.658 \| DISEASES 190 \| NR0B1 \| 1.874 \| DISEASES 8439 \| NSMAF \| 2.01 \| DISEASES 4998 \| ORC1 \| 2.187 \| DISEASES 5015 \| OTX2 \| 4.485 \| DISEASES 5080 \| PAX6 \| 2.6 \| DISEASES 5116 \| PCNT \| 4.413 \| DISEASES 84295 \| PHF6 \| 1.547 \| DISEASES 5449 \| POU1F1 \| 6.842 \| DISEASES 5618 \| PRLR \| 2.456 \| DISEASES 7737 \| RNF113A \| 2.62 \| DISEASES 55599 \| RNPC3 \| 3.541 \| DISEASES 100151683 \| RNU4ATAC \| 3.925 \| DISEASES 27164 \| SALL3 \| 1.685 \| DISEASES 83482 \| SCRT1 \| 2.687 \| DISEASES 6906 \| SERPINA7 \| 1.961 \| DISEASES 259230 \| SGMS1 \| 1.451 \| DISEASES 6462 \| SHBG \| 2.64 \| DISEASES 6473 \| SHOX \| 1.526 \| DISEASES 4990 \| SIX6 \| 1.55 \| DISEASES 6566 \| SLC16A1 \| 1.073 \| DISEASES 26503 \| SLC17A5 \| 1.506 \| DISEASES 84679 \| SLC9A7 \| 1.021 \| DISEASES 23137 \| SMC5 \| 1.673 \| DISEASES 677833 \| SNORA54 \| 1.376 \| DISEASES 692057 \| SNORD12 \| 1.305 \| DISEASES 6657 \| SOX2 \| 3.154 \| DISEASES 6658 \| SOX3 \| 5.677 \| DISEASES 60559 \| SPCS3 \| 3.163 \| DISEASES 246744 \| STH \| 2.122 \| DISEASES 64426 \| SUDS3 \| 2.79 \| DISEASES 9095 \| TBX19 \| 3.996 \| DISEASES 7088 \| TLE1 \| 1.378 \| DISEASES 7090 \| TLE3 \| 2.111 \| DISEASES 56889 \| TM9SF3 \| 1.631 \| DISEASES 80757 \| TMEM121 \| 3.237 \| DISEASES 10293 \| TRAIP \| 3.681 \| DISEASES 7225 \| TRPC6 \| 1.478 \| DISEASES 51506 \| UFC1 \| 1.493 \| DISEASES 10785 \| WDR4 \| 3.158 \| DISEASES 284403 \| WDR62 \| 1.152 \| DISEASES 7518 \| XRCC4 \| 2.334 \| DISEASES 23036 \| ZNF292 \| 1.883 \| DISEASES 24149 \| ZNF318 \| 2.365 \| DISEASES 63925 \| ZNF335 \| 1.98 \| DISEASES 163223 \| ZNF676 \| 2.424 \| DISEASES 57169 \| ZNFX1 \| 1.505 \| DISEASES
Locus	(Waiting for update.)

Disease ID	508
Disease	hypopituitarism
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:49) HP:0000824 \| Growth hormone deficiency \| 6 HP:0000821 \| Underactive thyroid \| 5 HP:0000135 \| Hypogonadism \| 4 HP:0011787 \| Central hypothyroidism \| 4 HP:0000873 \| Diabetes insipidus \| 4 HP:0002893 \| Pituitary adenoma \| 4 HP:0002664 \| Neoplasia \| 3 HP:0000609 \| Optic nerve hypoplasia \| 3 HP:0001297 \| Cerebral vascular events \| 2 HP:0002140 \| Ischemic stroke \| 2 HP:0001876 \| Low blood cell count \| 2 HP:0012191 \| B-cell lymphoma \| 2 HP:0001638 \| Cardiomyopathy \| 2 HP:0000845 \| Acromegalic growth \| 2 HP:0030062 \| Craniopharyngioma \| 2 HP:0001943 \| Hypoglycemia \| 2 HP:0000870 \| Hyperprolactinemia \| 2 HP:0005103 \| Calcification of the auricular cartilage \| 1 HP:0030149 \| Cardiovascular shock \| 1 HP:0000846 \| Hypoadrenalism \| 1 HP:0100646 \| Thyroiditis \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0000823 \| Pubertal delay \| 1 HP:0002383 \| Encephalitis \| 1 HP:0000238 \| Nonsyndromal hydrocephalus \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0000871 \| Panhypopituitarism \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0002665 \| Lymphoma \| 1 HP:0002516 \| Intracranial pressure elevation \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0012125 \| Prostate cancer \| 1 HP:0001259 \| Coma \| 1 HP:0008245 \| Thyroid stimulating hormone deficiency \| 1 HP:0001508 \| Weight faltering \| 1 HP:0000938 \| Decreased bone mineral density \| 1 HP:0010627 \| Anterior pituitary hypoplasia \| 1 HP:0001325 \| Coma caused by low blood sugar \| 1 HP:0008207 \| Addison's disease \| 1 HP:0000505 \| Poor vision \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0000863 \| Neurohypophyseal diabetes insipidus \| 1 HP:0011748 \| Adrenocorticotropic hormone deficiency \| 1 HP:0011734 \| Central adrenal insufficiency \| 1 HP:0012342 \| Macroprolactinoma \| 1 HP:0003510 \| Proportionate dwarfism \| 1

Disease ID	508
Disease	hypopituitarism
Manually Symptom	UMLS \| Name(Total Manually Symptoms:46) C2697310 \| sarcoidosis C2364118 \| weakness C2318511 \| nonalcoholic steatohepatitis C1963059 \| adrenal insufficiency C1695689 \| non-dipping C1555754 \| cardiovascular disease C1112443 \| male sexual dysfunction C1000483 \| anemia C0878544 \| cardiomyopathy C0856169 \| endothelial dysfunction C0851302 \| hypoglycemic shock C0700502 \| primary hypothyroidism C0600142 \| hot flashes C0549473 \| thyroid carcinoma C0497327 \| dementia C0422833 \| ent symptoms C0342527 \| androgen deficiency C0339477 \| lipemia retinalis C0271801 \| central hypothyroidism C0271561 \| growth hormone deficiency C0242339 \| dyslipidemia C0235394 \| wasting C0234428 \| disturbances of consciousness C0233401 \| psychiatric symptom C0042373 \| vascular disease C0040156 \| thyrotoxicosis C0040147 \| thyroiditis C0033975 \| psychosis C0032000 \| pituitary adenomas C0032000 \| pituitary adenoma C0030421 \| paraganglioma C0030312 \| pancytopenia C0020676 \| thyroid insufficiency C0020625 \| hyponatremia C0020550 \| hyperthyroidism C0020473 \| hyperlipidaemia C0020473 \| hyperlipemia C0018802 \| congestive heart failure C0011849 \| diabetes mellitus C0011608 \| dermatitis herpetiformis C0009241 \| cognitive disorders C0004352 \| autism C0004153 \| atherosclerosis C0004096 \| asthma C0002940 \| aneurysm C0002871 \| anaemia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:12) C0013338 \| growth hormone deficiency \| 4 C0271801 \| central hypothyroidism \| 4 C0032000 \| pituitary adenoma \| 2 C0878544 \| cardiomyopathy \| 2 C0856169 \| endothelial dysfunction \| 2 C0030312 \| pancytopenia \| 2 C0040147 \| thyroiditis \| 1 C0032000 \| pituitary adenomas \| 1 C0001623 \| adrenal insufficiency \| 1 C0007115 \| thyroid cancer \| 1 C0007222 \| cardiovascular disease \| 1 C0042373 \| vascular disease \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	508
Disease	hypopituitarism
Case	(Waiting for update.)

Web Analytics Made Easy - StatCounter