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	hypertriglyceridemia

Disease ID	1894
Disease	hypertriglyceridemia
Definition	A condition of elevated levels of TRIGLYCERIDES in the blood.
Synonym	elevated triglycerides high triglycerides hyperglyceridaemia hyperglyceridemia hypertriglyceridaemia hypertriglyceridemia (disorder) hypertriglyceridemia [disease/finding] hypertriglyceridemias increased triglycerides raised triglycerides
UMLS	C0020557
MeSH	D015228
SNOMED-CT	SNOMEDCT_US_2016_09_01:302870006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:71) C0948265 \| metabolic syndrome \| 37 C0030305 \| pancreatitis \| 31 C0011847 \| diabetes \| 21 C0001339 \| acute pancreatitis \| 20 C0028754 \| obesity \| 17 C0011860 \| type 2 diabetes \| 12 C0011849 \| diabetes mellitus \| 7 C0011860 \| type 2 diabetes mellitus \| 6 C0020443 \| hypercholesterolemia \| 5 C0020538 \| hypertension \| 5 C0011880 \| diabetic ketoacidosis \| 5 C0007222 \| cardiovascular disease \| 4 C0020459 \| hyperinsulinemia \| 4 C0042373 \| vascular disease \| 4 C0020456 \| hyperglycemia \| 4 C0018099 \| gout \| 3 C0023787 \| lipodystrophy \| 3 C0004153 \| atherosclerosis \| 3 C0740394 \| hyperuricemia \| 3 C0022661 \| end-stage renal disease \| 2 C0020456 \| hyperglycaemia \| 2 C0030312 \| pancytopenia \| 2 C0159069 \| impaired glucose tolerance \| 2 C0027726 \| nephrotic syndrome \| 2 C0022661 \| chronic kidney disease \| 2 C0022658 \| kidney disease \| 2 C0027051 \| myocardial infarct \| 2 C0028754 \| adiposity \| 2 C0027051 \| myocardial infarction \| 2 C0042373 \| vascular diseases \| 1 C0013295 \| duodenal ulcer \| 1 C0442874 \| neuropathy \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0035078 \| renal failure \| 1 C0022658 \| renal disease \| 1 C0018799 \| heart disease \| 1 C0221032 \| generalized lipodystrophy \| 1 C0018995 \| hemochromatosis \| 1 C0006142 \| breast cancer \| 1 C0740394 \| hyperuricaemia \| 1 C0022104 \| irritable bowel \| 1 C0023418 \| leukaemia \| 1 C0149521 \| recurrent pancreatitis \| 1 C0022661 \| chronic renal failure \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0023418 \| leukemia \| 1 C0023817 \| lipoprotein lipase deficiency \| 1 C0878544 \| cardiomyopathy \| 1 C0033687 \| proteinuria \| 1 C0023449 \| acute lymphoblastic leukaemia \| 1 C0010068 \| coronary artery disease \| 1 C0039730 \| thalassemia \| 1 C0033860 \| psoriasis \| 1 C0013537 \| eclampsia \| 1 C0040034 \| thrombocytopenia \| 1 C0029456 \| osteoporosis \| 1 C0271650 \| glucose intolerance \| 1 C0221032 \| congenital lipodystrophy \| 1 C0221032 \| congenital generalized lipodystrophy \| 1 C0018799 \| heart diseases \| 1 C0023364 \| leptospirosis \| 1 C1561644 \| chronic kidney disease (ckd) \| 1 C0010068 \| coronary heart disease \| 1 C0020443 \| hypercholesterolaemia \| 1 C0271650 \| prediabetes \| 1 C0259749 \| autonomic neuropathy \| 1 C0541760 \| liver adenoma \| 1 C0003972 \| atherosclerotic cardiovascular disease \| 1 C0086543 \| cataract \| 1 C0022104 \| irritable bowel syndrome \| 1 C0007222 \| cardiovascular diseases \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:14) 338 \| APOB \| CTD_human 3630 \| INS \| CTD_human 3440 \| IFNA2 \| CTD_human 1401 \| CRP \| CTD_human 590 \| BCHE \| CTD_human 116519 \| APOA5 \| CTD_human 8882 \| ZPR1 \| GWASCAT 4023 \| LPL \| CTD_human 5465 \| PPARA \| CTD_human 1071 \| CETP \| CTD_human 64788 \| LMF1 \| CTD_human 2646 \| GCKR \| CTD_human;GWASCAT 85019 \| TMEM241 \| GWASCAT 5360 \| PLTP \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:32) 38 \| ACAT1 \| CIPHER 154 \| ADRB2 \| CIPHER 27329 \| ANGPTL3 \| CIPHER 335 \| APOA1 \| CIPHER 336 \| APOA2 \| CIPHER 337 \| APOA4 \| CIPHER 116519 \| APOA5 \| CIPHER;CTD_human 338 \| APOB \| CIPHER;CTD_human 345 \| APOC3 \| CIPHER 348 \| APOE \| CIPHER 8542 \| APOL1 \| CIPHER 9031 \| BAZ1B \| CIPHER 1071 \| CETP \| CIPHER;CTD_human 1581 \| CYP7A1 \| CIPHER 5167 \| ENPP1 \| CIPHER 2169 \| FABP2 \| CIPHER 2590 \| GALNT2 \| CIPHER 2646 \| GCKR \| CIPHER;CTD_human 9388 \| LIPG \| CIPHER 4023 \| LPL \| CIPHER;CTD_human 51085 \| MLXIPL \| CIPHER 5465 \| PPARA \| CIPHER;CTD_human 5468 \| PPARG \| CIPHER 6101 \| RP1 \| CIPHER 26608 \| TBL2 \| CIPHER 10221 \| TRIB1 \| CIPHER 590 \| BCHE \| CTD_human 1401 \| CRP \| CTD_human 64788 \| LMF1 \| CTD_human 3630 \| INS \| CTD_human 5360 \| PLTP \| CTD_human 3440 \| IFNA2 \| CTD_human
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1894
Disease	hypertriglyceridemia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:69) HP:0001733 \| Pancreatic inflammation \| 34 HP:0001735 \| Acute pancreatitis \| 19 HP:0000855 \| Insulin resistance \| 19 HP:0001513 \| Obesity \| 18 HP:0000819 \| Diabetes mellitus \| 7 HP:0012743 \| Central obesity \| 7 HP:0003124 \| Elevated serum cholesterol \| 6 HP:0001397 \| Hepatic steatosis \| 5 HP:0001953 \| Diabetic ketosis \| 5 HP:0003074 \| High blood glucose \| 5 HP:0000822 \| Hypertension \| 5 HP:0002149 \| Hyperuricemia \| 4 HP:0000842 \| Elevated insulin level \| 4 HP:0002621 \| Atherosclerosis \| 4 HP:0003233 \| Low HDL-cholesterol \| 4 HP:0001993 \| Ketoacidosis \| 3 HP:0001997 \| Gout \| 3 HP:0001945 \| Fever \| 3 HP:0003774 \| End-stage renal failure \| 3 HP:0001013 \| Eruptive xanthomas \| 3 HP:0000833 \| Glucose intolerance \| 3 HP:0009125 \| Lipodystrophy \| 3 HP:0001297 \| Cerebral vascular events \| 2 HP:0000100 \| Nephrosis \| 2 HP:0010980 \| Hyperlipoproteinemia \| 2 HP:0003077 \| Hyperlipidemia \| 2 HP:0002027 \| Abdominal pain \| 2 HP:0012622 \| Chronic kidney disease \| 2 HP:0001658 \| Myocardial infarction \| 2 HP:0001433 \| Enlarged liver and spleen \| 2 HP:0001876 \| Low blood cell count \| 2 HP:0002155 \| Increased triglycerides \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0002588 \| Duodenal ulcer \| 1 HP:0001909 \| Leukemia \| 1 HP:0000365 \| Hearing impairment \| 1 HP:0000159 \| Lip abnormality \| 1 HP:0000821 \| Underactive thyroid \| 1 HP:0001744 \| Splenomegaly \| 1 HP:0003146 \| Decreased circulating cholesterol level \| 1 HP:0100578 \| Lipoatrophy \| 1 HP:0001873 \| Low platelet count \| 1 HP:0002910 \| Elevated transaminases \| 1 HP:0002917 \| Low blood magnesium levels \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0000518 \| Cataract \| 1 HP:0002634 \| Arteriosclerosis \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0000093 \| Proteinuria \| 1 HP:0003765 \| Psoriasis \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0040216 \| Hypoinsulinemia \| 1 HP:0100027 \| Recurring pancreatitis \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0001414 \| Microvesicular hepatic steatosis \| 1 HP:0100033 \| Tic disorder \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0002020 \| Heartburn \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0009064 \| Generalized lipodystrophy \| 1 HP:0100601 \| Eclampsia \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0000716 \| Depression \| 1 HP:0009059 \| Congenital generalized lipodystrophy \| 1 HP:0003256 \| Coagulopathy \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0100602 \| Pre-eclampsia \| 1

Disease ID	1894
Disease	hypertriglyceridemia
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:10)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1260326	23505323	2646	GCKR	umls:C0020557	GWASCAT	Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.	0.249468128	2013	GCKR	2	27508073	T	C
rs1260326	20657596	2646	GCKR	umls:C0020557	GAD	[Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.]	0.249468128	2010	GCKR	2	27508073	T	C
rs1260326	20657596	2646	GCKR	umls:C0020557	GWASCAT	Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.	0.249468128	2010	GCKR	2	27508073	T	C
rs4635554	20657596	338	APOB	umls:C0020557	GAD	[Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.]	0.129468128	2010	NA	2	21166787	T	G
rs7016880	20657596	4023	LPL	umls:C0020557	GAD	[Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.]	0.271145155	2010	NA	8	20019235	G	C
rs714052	20657596	9031	BAZ1B	umls:C0020557	GAD	[Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.]	0.002367032	2010	BAZ1B	7	73450539	A	G
rs964184	20657596	8882	ZPR1	umls:C0020557	GWASCAT	Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.	0.122367032	2010	ZPR1	11	116778201	G	C
rs964184	20657596	8882	ZPR1	umls:C0020557	GAD	[Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.]	0.122367032	2010	ZPR1	11	116778201	G	C
rs964184	23505323	8882	ZPR1	umls:C0020557	GWASCAT	Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.	0.122367032	2013	ZPR1	11	116778201	G	C
rs9949617	23505323	85019	TMEM241	umls:C0020557	GWASCAT	Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.	0.12	2013	TMEM241	18	23299253	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1894
Disease	hypertriglyceridemia
Case	(Waiting for update.)

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