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encyclopedia of Rare Disease Annotation for Precision Medicine

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	hyperthyroidism

Disease ID	753
Disease	hyperthyroidism
Definition	Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.
Synonym	hyperthyroid hyperthyroidism (disorder) hyperthyroidism [disease/finding] hyperthyroidism nos hyperthyroidism, nos hyperthyroids overactive thyroid
DOID	DOID:7998
UMLS	C0020550
MeSH	D006980
SNOMED-CT	SNOMEDCT_US_2016_09_01:34486009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:150) C0018213 \| graves' disease \| 20 C0018799 \| heart disease \| 12 C0020676 \| hypothyroidism \| 10 C0010068 \| coronary heart disease \| 9 C0018801 \| heart failure \| 8 C0040147 \| thyroiditis \| 8 C0018021 \| goiter \| 8 C0020538 \| hypertension \| 6 C0007115 \| thyroid ca \| 5 C0040137 \| thyroid nodule \| 5 C0011847 \| diabetes \| 5 C0040156 \| thyrotoxicosis \| 5 C0007115 \| thyroid cancer \| 4 C0018021 \| goitre \| 4 C0878544 \| cardiomyopathy \| 4 C0151468 \| thyroid adenoma \| 3 C0398623 \| hypercoagulability \| 3 C0027051 \| myocardial infarction \| 3 C0032000 \| pituitary adenoma \| 3 C0027051 \| myocardial infarct \| 3 C0235250 \| hyperemesis \| 3 C0018801 \| cardiac failure \| 3 C0018802 \| congestive heart failure \| 3 C0020450 \| hyperemesis gravidarum \| 3 C0029456 \| osteoporosis \| 3 C0001430 \| adenoma \| 3 C0030443 \| periodic paralysis \| 2 C0497327 \| dementia \| 2 C0398623 \| hypercoagulable state \| 2 C0040128 \| thyroid disease \| 2 C0018213 \| graves disease \| 2 C0020542 \| pulmonary hypertension \| 2 C0042870 \| vitamin d defic \| 2 C0042870 \| vitamin d deficiency \| 2 C0034065 \| pulmonary embolism \| 2 C0018023 \| nodular goiter \| 2 C0040127 \| thyroid storm \| 2 C0020437 \| hypercalcemia \| 2 C0032914 \| preeclampsia \| 2 C0040053 \| thrombosis \| 2 C0745140 \| hyperthyroid \| 2 C0001824 \| agranulocytosis \| 2 C0022116 \| ischemia \| 2 C0030319 \| panic disorder \| 2 C0033975 \| psychosis \| 2 C0020550 \| hyperthyroidism \| 2 C0026848 \| myopathy \| 2 C0030312 \| pancytopenia \| 2 C0032000 \| pituitary adenomas \| 1 C0085655 \| polymyositis \| 1 C1135868 \| gestational trophoblastic neoplasia \| 1 C1619734 \| pulmonary arterial hypertension \| 1 C0549473 \| thyroid carcinoma \| 1 C0018023 \| nodular goitre \| 1 C0031039 \| pericardial effusion \| 1 C0020456 \| hyperglycemia \| 1 C0677607 \| hashimoto's thyroiditis \| 1 C0010278 \| craniosynostosis \| 1 C0028754 \| obesity \| 1 C0013395 \| indigestion \| 1 C0027145 \| myxedema \| 1 C0018099 \| gout \| 1 C0032002 \| pituitary disease \| 1 C0033038 \| premature ejaculation \| 1 C0154143 \| toxic multinodular goitre \| 1 C0008370 \| cholestasis \| 1 C0030567 \| parkinson's disease \| 1 C0000809 \| recurrent miscarriages \| 1 C0040100 \| thymoma \| 1 C0040137 \| thyroid nodules \| 1 C0020502 \| hyperparathyroidism \| 1 C0011860 \| type 2 diabetes \| 1 C0015397 \| eye disease \| 1 C0159069 \| impaired glucose tolerance \| 1 C0085681 \| hyperphosphatemia \| 1 C0042721 \| viral hepatitis \| 1 C0018799 \| cardiac disease \| 1 C0018024 \| intrathoracic goiter \| 1 C0242604 \| thyroid hormone resistance \| 1 C0022658 \| renal disease \| 1 C0041696 \| major depressive disorder \| 1 C0002170 \| alopecia \| 1 C0339143 \| thyroid eye disease \| 1 C0342208 \| multinodular goitre \| 1 C0011570 \| depression \| 1 C0042164 \| uveitis \| 1 C0011848 \| diabetes insipidus \| 1 C0013473 \| eating disorder \| 1 C1868720 \| periventricular nodular heterotopia \| 1 C0004096 \| asthma \| 1 C0022658 \| nephropathy \| 1 C0259779 \| fibrous dysplasia \| 1 C0339143 \| graves' ophthalmopathy \| 1 C0004245 \| atrioventricular block \| 1 C0040150 \| acute suppurative thyroiditis \| 1 C0206682 \| follicular carcinoma \| 1 C0019158 \| hepatitis \| 1 C0002395 \| alzheimer's disease \| 1 C0152171 \| idiopathic pulmonary hypertension \| 1 C0221002 \| primary hyperparathyroidism \| 1 C0019196 \| hepatitis c \| 1 C0013384 \| dyskinesia \| 1 C0042384 \| vasculitis \| 1 C0242231 \| coronary stenoses \| 1 C0031511 \| pheochromocytoma \| 1 C0010308 \| cretinism \| 1 C0010073 \| coronary spasm \| 1 C0023418 \| leukemia \| 1 C0005586 \| bipolar disorder \| 1 C0025183 \| meige's syndrome \| 1 C0002878 \| hemolytic anemia \| 1 C0000786 \| miscarriage \| 1 C0002871 \| anemia \| 1 C0262587 \| parathyroid adenoma \| 1 C0242520 \| chronic thyroiditis \| 1 C0030920 \| peptic ulcer \| 1 C0042373 \| vascular disorder \| 1 C0009171 \| cocaine abuse \| 1 C1561644 \| chronic kidney disease (ckd) \| 1 C0026848 \| muscular disorders \| 1 C0002871 \| anaemia \| 1 C0030499 \| parasitosis \| 1 C0042373 \| vascular disorders \| 1 C0023895 \| liver disease \| 1 C0272126 \| evans' syndrome \| 1 C0677607 \| hashimoto's disease \| 1 C0152025 \| polyneuropathy \| 1 C0022116 \| ischaemia \| 1 C0027868 \| neuromuscular disorders \| 1 C0022661 \| chronic kidney disease \| 1 C0238358 \| hypokalemic periodic paralysis \| 1 C0342199 \| iodine deficiency \| 1 C0920350 \| autoimmune thyroiditis \| 1 C0013473 \| eating disorders \| 1 C0004153 \| atherosclerosis \| 1 C0034372 \| quadriplegia \| 1 C0018799 \| heart diseases \| 1 C0026896 \| myasthenia gravis \| 1 C0155626 \| acute myocardial infarction \| 1 C0006142 \| breast cancer \| 1 C0022661 \| end stage renal disease (esrd) \| 1 C0020676 \| hypothyroid \| 1 C0000809 \| recurrent miscarriage \| 1 C0022661 \| end stage renal disease \| 1 C0007222 \| cardiovascular disorders \| 1 C0022354 \| cholestatic jaundice \| 1 C0018024 \| retrosternal goitre \| 1 C0677607 \| hashimoto thyroiditis \| 1 C0033687 \| proteinuria \| 1 C0021053 \| immune disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:9) 5444 \| PON1 \| CTD_human 7253 \| TSHR \| CTD_human 2876 \| GPX1 \| CTD_human 6647 \| SOD1 \| CTD_human 6648 \| SOD2 \| CTD_human 847 \| CAT \| CTD_human 358 \| AQP1 \| CTD_human 9607 \| CARTPT \| CTD_human 2936 \| GSR \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:11) 4524 \| MTHFR \| CIPHER 7421 \| VDR \| CIPHER 2876 \| GPX1 \| CTD_human 7253 \| TSHR \| CTD_human 9607 \| CARTPT \| CTD_human 358 \| AQP1 \| CTD_human 847 \| CAT \| CTD_human 5444 \| PON1 \| CTD_human 2936 \| GSR \| CTD_human 6647 \| SOD1 \| CTD_human 6648 \| SOD2 \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:168) 31 \| ACACA \| 1.355 \| DISEASES 26027 \| ACOT11 \| 1.069 \| DISEASES 55811 \| ADCY10 \| 1.433 \| DISEASES 9370 \| ADIPOQ \| 2.289 \| DISEASES 135 \| ADORA2A \| 1.5 \| DISEASES 153 \| ADRB1 \| 1.153 \| DISEASES 3267 \| AGFG1 \| 1.492 \| DISEASES 183 \| AGT \| 1.72 \| DISEASES 262 \| AMD1 \| 1.275 \| DISEASES 336 \| APOA2 \| 1.69 \| DISEASES 56624 \| ASAH2 \| 1.224 \| DISEASES 23245 \| ASTN2 \| 1.207 \| DISEASES 481 \| ATP1B1 \| 1.051 \| DISEASES 487 \| ATP2A1 \| 2.091 \| DISEASES 488 \| ATP2A2 \| 2.466 \| DISEASES 93974 \| ATPIF1 \| 1.138 \| DISEASES 551 \| AVP \| 1.297 \| DISEASES 567 \| B2M \| 1.18 \| DISEASES 632 \| BGLAP \| 4.722 \| DISEASES 114904 \| C1QTNF6 \| 1.466 \| DISEASES 779 \| CACNA1S \| 1.712 \| DISEASES 796 \| CALCA \| 3.773 \| DISEASES 816 \| CAMK2B \| 1.555 \| DISEASES 84290 \| CAPNS2 \| 2.674 \| DISEASES 844 \| CASQ1 \| 2.973 \| DISEASES 930 \| CD19 \| 1.221 \| DISEASES 958 \| CD40 \| 2.03 \| DISEASES 959 \| CD40LG \| 2.006 \| DISEASES 1043 \| CD52 \| 1.602 \| DISEASES 91012 \| CERS5 \| 1.573 \| DISEASES 1103 \| CHAT \| 1.083 \| DISEASES 4850 \| CNOT4 \| 1.302 \| DISEASES 22796 \| COG2 \| 1.88 \| DISEASES 10488 \| CREB3 \| 1.172 \| DISEASES 1471 \| CST3 \| 2.101 \| DISEASES 51428 \| DDX41 \| 3.507 \| DISEASES 1733 \| DIO1 \| 3.155 \| DISEASES 1734 \| DIO2 \| 4.347 \| DISEASES 1735 \| DIO3 \| 3.245 \| DISEASES 6993 \| DYNLT1 \| 1.144 \| DISEASES 1906 \| EDN1 \| 1.274 \| DISEASES 64787 \| EPS8L2 \| 2.27 \| DISEASES 2145 \| EZH1 \| 1.337 \| DISEASES 2152 \| F3 \| 2.029 \| DISEASES 2157 \| F8 \| 1.48 \| DISEASES 2187 \| FANCB \| 1.393 \| DISEASES 201456 \| FBXO15 \| 1.91 \| DISEASES 115352 \| FCRL3 \| 1.813 \| DISEASES 11116 \| FGFR1OP \| 1.475 \| DISEASES 2274 \| FHL2 \| 3.044 \| DISEASES 2317 \| FLNB \| 1.204 \| DISEASES 252995 \| FNDC5 \| 1.261 \| DISEASES 2304 \| FOXE1 \| 2.821 \| DISEASES 50943 \| FOXP3 \| 1.339 \| DISEASES 23732 \| FRRS1L \| 1.444 \| DISEASES 2492 \| FSHR \| 1.52 \| DISEASES 2520 \| GAST \| 2.504 \| DISEASES 2624 \| GATA2 \| 1.02 \| DISEASES 2641 \| GCG \| 3.176 \| DISEASES 728441 \| GGT2 \| 1.248 \| DISEASES 51738 \| GHRL \| 3.034 \| DISEASES 2764 \| GMFB \| 1.506 \| DISEASES 2778 \| GNAS \| 3.138 \| DISEASES 2782 \| GNB1 \| 1.41 \| DISEASES 2863 \| GPR39 \| 1.039 \| DISEASES 9464 \| HAND2 \| 1.193 \| DISEASES 3055 \| HCK \| 1.56 \| DISEASES 3098 \| HK1 \| 1.163 \| DISEASES 3105 \| HLA-A \| 1.935 \| DISEASES 3250 \| HPR \| 1.515 \| DISEASES 3363 \| HTR7 \| 1.705 \| DISEASES 3451 \| IFNA17 \| 1.323 \| DISEASES 3440 \| IFNA2 \| 2.368 \| DISEASES 3456 \| IFNB1 \| 1.026 \| DISEASES 3481 \| IGF2 \| 1.152 \| DISEASES 3486 \| IGFBP3 \| 2.036 \| DISEASES 10989 \| IMMT \| 1.127 \| DISEASES 54617 \| INO80 \| 1.21 \| DISEASES 253430 \| IPMK \| 1.186 \| DISEASES 9452 \| ITM2A \| 1.659 \| DISEASES 102723508 \| KANTR \| 2.305 \| DISEASES 3739 \| KCNA4 \| 1.258 \| DISEASES 3745 \| KCNB1 \| 2.532 \| DISEASES 3751 \| KCND2 \| 2.106 \| DISEASES 3767 \| KCNJ11 \| 1.16 \| DISEASES 3768 \| KCNJ12 \| 1.995 \| DISEASES 3770 \| KCNJ14 \| 1.739 \| DISEASES 3772 \| KCNJ15 \| 1.427 \| DISEASES 64077 \| LHPP \| 2.036 \| DISEASES 8022 \| LHX3 \| 1.317 \| DISEASES 348120 \| LINC01193 \| 1.791 \| DISEASES 4018 \| LPA \| 2.115 \| DISEASES 4151 \| MB \| 1.445 \| DISEASES 51562 \| MBIP \| 1.973 \| DISEASES 90550 \| MCU \| 1.212 \| DISEASES 10724 \| MGEA5 \| 1.741 \| DISEASES 4295 \| MLN \| 1.114 \| DISEASES 57380 \| MRS2 \| 1.403 \| DISEASES 100288485 \| MTRNR2L7 \| 1.513 \| DISEASES 4624 \| MYH6 \| 1.276 \| DISEASES 10004 \| NAALADL1 \| 1.495 \| DISEASES 100132406 \| NBPF10 \| 1.432 \| DISEASES 4700 \| NDUFA6 \| 1.392 \| DISEASES 4803 \| NGF \| 1.237 \| DISEASES 4808 \| NHLH2 \| 1.489 \| DISEASES 4828 \| NMB \| 2.037 \| DISEASES 2831 \| NPBWR1 \| 1.501 \| DISEASES 2832 \| NPBWR2 \| 1.835 \| DISEASES 4878 \| NPPA \| 1.462 \| DISEASES 4879 \| NPPB \| 1.413 \| DISEASES 594857 \| NPS \| 1.889 \| DISEASES 283869 \| NPW \| 1.212 \| DISEASES 4975 \| OMP \| 1.029 \| DISEASES 5073 \| PARN \| 1.068 \| DISEASES 7849 \| PAX8 \| 1.902 \| DISEASES 5133 \| PDCD1 \| 1.632 \| DISEASES 5160 \| PDHA1 \| 1.897 \| DISEASES 5164 \| PDK2 \| 1.014 \| DISEASES 5297 \| PI4KA \| 1.417 \| DISEASES 6992 \| PPP1R11 \| 1.939 \| DISEASES 5618 \| PRLR \| 1.135 \| DISEASES 5744 \| PTHLH \| 1.149 \| DISEASES 26191 \| PTPN22 \| 2.427 \| DISEASES 8635 \| RNASET2 \| 2.199 \| DISEASES 54476 \| RNF216 \| 1.359 \| DISEASES 6152 \| RPL24 \| 1.5 \| DISEASES 6257 \| RXRB \| 1.824 \| DISEASES 286133 \| SCARA5 \| 1.349 \| DISEASES 6329 \| SCN4A \| 1.994 \| DISEASES 80274 \| SCUBE1 \| 1.287 \| DISEASES 51150 \| SDF4 \| 2.365 \| DISEASES 6401 \| SELE \| 1.463 \| DISEASES 866 \| SERPINA6 \| 2.933 \| DISEASES 6906 \| SERPINA7 \| 5.929 \| DISEASES 6462 \| SHBG \| 4.449 \| DISEASES 117247 \| SLC16A10 \| 1.495 \| DISEASES 8604 \| SLC25A12 \| 1.07 \| DISEASES 6513 \| SLC2A1 \| 1.1 \| DISEASES 144195 \| SLC2A14 \| 1.557 \| DISEASES 6517 \| SLC2A4 \| 2.084 \| DISEASES 83650 \| SLC35G5 \| 1.446 \| DISEASES 57181 \| SLC39A10 \| 1.343 \| DISEASES 23428 \| SLC7A8 \| 1.319 \| DISEASES 55234 \| SMU1 \| 1.636 \| DISEASES 23583 \| SMUG1 \| 1.376 \| DISEASES 23642 \| SNHG1 \| 1.02 \| DISEASES 6649 \| SOD3 \| 1.457 \| DISEASES 6345 \| SRL \| 2.515 \| DISEASES 6752 \| SSTR2 \| 1.463 \| DISEASES 84144 \| SYDE2 \| 2.693 \| DISEASES 6863 \| TAC1 \| 1.296 \| DISEASES 353164 \| TAS2R42 \| 2.746 \| DISEASES 29110 \| TBK1 \| 1.385 \| DISEASES 27004 \| TCL6 \| 1.776 \| DISEASES 6996 \| TDG \| 2.051 \| DISEASES 6999 \| TDO2 \| 1.293 \| DISEASES 7018 \| TF \| 1.202 \| DISEASES 7068 \| THRB \| 5.588 \| DISEASES 7124 \| TNF \| 1.921 \| DISEASES 8718 \| TNFRSF25 \| 3.616 \| DISEASES 10587 \| TXNRD2 \| 4.786 \| DISEASES 7316 \| UBC \| 1.735 \| DISEASES 7352 \| UCP3 \| 2.45 \| DISEASES 7432 \| VIP \| 1.38 \| DISEASES 79001 \| VKORC1 \| 1.053 \| DISEASES 51322 \| WAC \| 1.15 \| DISEASES 23038 \| WDTC1 \| 2.527 \| DISEASES 114786 \| XKR4 \| 1.838 \| DISEASES
Locus	(Waiting for update.)

Disease ID	753
Disease	hyperthyroidism
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:135) HP:0000853 \| Goitre \| 16 HP:0005110 \| Atrial fibrillation \| 16 HP:0001635 \| Congestive heart failure \| 11 HP:0000821 \| Underactive thyroid \| 11 HP:0100646 \| Thyroiditis \| 9 HP:0000855 \| Insulin resistance \| 7 HP:0000822 \| Hypertension \| 7 HP:0001824 \| Weight loss \| 5 HP:0000939 \| Osteoporosis \| 4 HP:0001876 \| Low blood cell count \| 4 HP:0011675 \| Arrhythmias \| 4 HP:0001638 \| Cardiomyopathy \| 4 HP:0002900 \| Hypokalemia \| 3 HP:0003768 \| Periodic paralysis \| 3 HP:0001658 \| Myocardial infarction \| 3 HP:0001649 \| Tachycardia \| 3 HP:0000854 \| Thyroid adenoma \| 3 HP:0000836 \| Overactive thyroid \| 3 HP:0001297 \| Cerebral vascular events \| 3 HP:0012188 \| Hyperemesis gravidarum \| 3 HP:0000872 \| Hashimoto's thyroiditis \| 3 HP:0002092 \| Pulmonary artery hypertension \| 3 HP:0002893 \| Pituitary adenoma \| 3 HP:0000952 \| Yellow skin \| 3 HP:0003470 \| Inability to move \| 3 HP:0100724 \| Hypercoagulability \| 3 HP:0001903 \| Anemia \| 3 HP:0030731 \| Carcinoma \| 3 HP:0002925 \| Increased serum thyroid-stimulating hormone \| 2 HP:0003287 \| Abnormality of mitochondrial metabolism \| 2 HP:0100029 \| Lingual thyroid \| 2 HP:0002072 \| Chorea \| 2 HP:0001399 \| Liver failure \| 2 HP:0000716 \| Depression \| 2 HP:0000726 \| Dementia \| 2 HP:0002664 \| Neoplasia \| 2 HP:0003072 \| Hypercalcemia \| 2 HP:0100647 \| Morbus Basedow \| 2 HP:0003198 \| Myopathic changes \| 2 HP:0011665 \| Takotsubo cardiomyopathy \| 2 HP:0100512 \| Vitamin D deficiency \| 2 HP:0001511 \| Prenatal onset growth retardation \| 2 HP:0005994 \| Nodular goiter \| 2 HP:0002930 \| Resistance to thyroid hormone \| 2 HP:0002204 \| Pulmonary embolism \| 2 HP:0001907 \| Thromboembolic disease \| 2 HP:0000709 \| Psychosis \| 2 HP:0004349 \| Reduced bone mineral density \| 2 HP:0002890 \| Thyroid carcinoma \| 2 HP:0001363 \| Early fusion of cranial sutures \| 2 HP:0000969 \| Dropsy \| 2 HP:0002099 \| Asthma \| 2 HP:0100602 \| Pre-eclampsia \| 2 HP:0000752 \| Hyperactive behavior \| 2 HP:0002046 \| Heat intolerance \| 2 HP:0012622 \| Chronic kidney disease \| 2 HP:0001324 \| Muscular weakness \| 2 HP:0012234 \| Agranulocytosis \| 2 HP:0000820 \| Thyroid abnormality \| 2 HP:0008249 \| Large thyroid \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0000833 \| Glucose intolerance \| 1 HP:0002666 \| Pheochromocytoma \| 1 HP:0100615 \| Neoplasm of the ovary \| 1 HP:0100539 \| Periorbital swelling \| 1 HP:0001997 \| Gout \| 1 HP:0012251 \| ST segment elevation \| 1 HP:0000112 \| Nephropathy \| 1 HP:0002445 \| Paralysis of all four limbs \| 1 HP:0002621 \| Atherosclerosis \| 1 HP:0002895 \| Papillary thyroid carcinoma \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0001396 \| Cholestasis \| 1 HP:0012876 \| Premature ejaculation \| 1 HP:0000078 \| Genital abnormalities \| 1 HP:0006554 \| Acute hepatic failure \| 1 HP:0010741 \| Peripheral edema of lower extremity \| 1 HP:0002516 \| Intracranial pressure elevation \| 1 HP:0001541 \| Ascites \| 1 HP:0002013 \| Emesis \| 1 HP:0000554 \| Uveitis \| 1 HP:0006562 \| Viral hepatitis \| 1 HP:0001622 \| Premature delivery \| 1 HP:0001623 \| Breech presentation at birth \| 1 HP:0100820 \| Glomerulopathy \| 1 HP:0002150 \| Hypercalcinuria \| 1 HP:0002094 \| Dyspnea \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0000967 \| Petechiae \| 1 HP:0001698 \| Pericardial effusions \| 1 HP:0001513 \| Obesity \| 1 HP:0000843 \| Hyperparathyroidism \| 1 HP:0002591 \| Voracious appetite \| 1 HP:0000093 \| Proteinuria \| 1 HP:0003146 \| Decreased circulating cholesterol level \| 1 HP:0002287 \| Progressive alopecia \| 1 HP:0003701 \| Proximal limb muscle weakness \| 1 HP:0100660 \| Dyskinesis \| 1 HP:0100246 \| Osteoma \| 1 HP:0002905 \| Hyperphosphatemia \| 1 HP:0001254 \| Lethargy \| 1 HP:0001337 \| Tremor \| 1 HP:0011787 \| Central hypothyroidism \| 1 HP:0000938 \| Decreased bone mineral density \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0001993 \| Ketoacidosis \| 1 HP:0001596 \| Hair loss \| 1 HP:0002897 \| Parathyroid adenoma \| 1 HP:0004308 \| Ventricular arrhythmia \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0002157 \| Azotaemia \| 1 HP:0004936 \| Blood clot in vein \| 1 HP:0008200 \| Primary hyperparathyroidism \| 1 HP:0000873 \| Diabetes insipidus \| 1 HP:0003473 \| Fatigable weakness \| 1 HP:0001259 \| Coma \| 1 HP:0100522 \| Thymoma \| 1 HP:0001901 \| Abnormally shaped erythrocytes \| 1 HP:0000826 \| Precocious puberty \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0002633 \| Vasculitis \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0001045 \| Blotchy loss of skin color \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0002045 \| Abnormally low body temperature \| 1 HP:0007302 \| Bipolar disorder \| 1 HP:0001909 \| Leukemia \| 1 HP:0004757 \| Paroxysmal atrial fibrillation \| 1 HP:0100028 \| Abnormal thryoid location \| 1 HP:0004398 \| Peptic ulcer \| 1 HP:0000738 \| Sensory hallucination \| 1 HP:0003074 \| High blood glucose \| 1 HP:0002015 \| Swallowing difficulty \| 1

Disease ID	753
Disease	hyperthyroidism
Manually Symptom	UMLS \| Name(Total Manually Symptoms:255) C2712340 \| dyspnoea C2712332 \| vomiting C2712323 \| hypoglycaemia C2712322 \| tachycardia C2711227 \| hepatic steatosis C2700526 \| erythrocytosis C2678504 \| osteoporosis C2676454 \| h syndrome C2364377 \| delirium C2364324 \| increased intracranial pressure C2364133 \| infection C2364118 \| weakness C2364108 \| stigma C2364072 \| depression C2364051 \| fatigue C2364050 \| hypothermia C2348360 \| atrial enlargement C2240374 \| eosinophilia C2219717 \| amenorrhea C2203646 \| jaundice C2186532 \| liver disease C2108109 \| sinus tachycardia C2108077 \| atrioventricular block C2048468 \| male infertility C2015956 \| throat pain C1963279 \| viral hepatitis C1963274 \| vasculitis C1963235 \| sick sinus syndrome C1963220 \| pulmonary hypertension C1963165 \| malabsorption C1963138 \| hypertension C1963135 \| hepatic necrosis C1963120 \| gynecomastia C1963091 \| diarrhea C1963064 \| anxiety C1956391 \| temporal arteritis C1868682 \| paroxysmal kinesigenic choreoathetosis C1839141 \| thyroxine-binding globulin deficiency C1704212 \| embolism C1619734 \| pulmonary arterial hypertension C1609519 \| adrenal myelolipoma C1565489 \| renal insufficiency C1555754 \| cardiovascular disease C1527330 \| pyridoxine deficiency C1522057 \| duodenitis C1456784 \| paranoid disorder C1442871 \| craniosynostosis C1442837 \| myocardial necrosis C1384672 \| hypoparathyroidism C1336753 \| thyroid lymphoma C1330961 \| acidity C1279412 \| periodic paralysis C1135191 \| systolic heart failure C1135188 \| critical illness myopathy C1059185 \| exophthalmus C1000483 \| anemia C0948266 \| latent tetany C0948008 \| ischemic stroke C0920157 \| mesenteric ischemia C0917981 \| progressive spinal muscular atrophy C0878544 \| cardiomyopathy C0851578 \| sleep disorders C0848676 \| male subfertility C0752303 \| urological manifestations C0752303 \| urological manifestation C0752196 \| ballism C0748159 \| pulmonary involvement C0743711 \| eye lesion C0741949 \| cardiovascular pathology C0740394 \| hyperuricemia C0700323 \| neuromuscular blockade C0679466 \| cognitive deficits C0678222 \| breast cancer C0600336 \| subcorneal pustular dermatosis C0600086 \| toxic goiter C0549473 \| thyroid gland carcinoma C0549473 \| thyroid carcinoma C0549473 \| thyroid cancer C0549473 \| carcinoma of the thyroid C0549473 \| cancer of the thyroid C0549124 \| arterial embolism C0542052 \| coronary insufficiency C0497327 \| dementia C0494491 \| mononeuropathy C0476270 \| cardiovascular symptoms C0428908 \| sinus node dysfunction C0427008 \| stiffness C0426768 \| o sign C0424755 \| fever C0422833 \| ent symptoms C0419203 \| osteopathy C0410198 \| proximal myopathy C0400916 \| acute hepatitis e C0398623 \| hypercoagulable state C0398623 \| hypercoagulability state C0376293 \| stigmata C0342882 \| heterozygous familial hypercholesterolemia C0342342 \| idiopathic hypoparathyroidism C0339143 \| thyroid ophthalmopathy C0338573 \| cerebral venous sinus thrombosis C0311223 \| frozen shoulder C0277928 \| venous hum C0271650 \| impaired glucose tolerance C0271650 \| glucose intolerance C0270823 \| petit mal status C0270739 \| hemichorea C0270327 \| enuresis C0268445 \| normokalemic periodic paralysis C0268283 \| disorders of steroid metabolism C0267804 \| centrilobular hepatic necrosis C0266928 \| rapidly progressive periodontitis C0264886 \| conduction disorders C0264757 \| rheumatic valvular disease C0264686 \| coronary embolism C0262587 \| parathyroid adenoma C0243050 \| cardiovascular abnormalities C0242342 \| sheehan's syndrome C0242292 \| mccune-albright syndrome C0241885 \| exercise intolerance C0238462 \| medullary thyroid carcinoma C0236663 \| alcohol withdrawal syndrome C0235527 \| right-sided heart failure C0235527 \| right heart failure C0235480 \| paroxysmal atrial fibrillation C0235430 \| ketonaemia C0235401 \| abnormal glucose tolerance C0235394 \| wasting C0235369 \| granulomatous hepatitis C0235250 \| hyperemesis C0235169 \| excitability C0234132 \| pyramidal sign C0233401 \| psychiatric symptoms C0233397 \| psychological symptoms C0232848 \| secondary enuresis C0232197 \| fibrillation C0231230 \| fatigability C0221505 \| cerebral lesions C0221002 \| primary hyperparathyroidism C0206682 \| follicular carcinoma C0206146 \| myocardial stunning C0162568 \| erythropoietic protoporphyria C0162565 \| acute intermittent porphyria C0162316 \| iron deficiency anemia C0156259 \| renal hypertrophy C0155301 \| retrobulbar neuritis C0152171 \| primary pulmonary hypertension C0152171 \| idiopathic pulmonary hypertension C0152025 \| polyneuropathy C0151945 \| cerebral venous thrombosis C0151798 \| liver necrosis C0151744 \| myocardial ischemia C0149670 \| disorders of carbohydrate metabolism C0085681 \| hyperphosphatemia C0085681 \| hyperphosphataemia C0085661 \| onycholysis C0085655 \| polymyositis C0085583 \| choreoathetosis C0043117 \| idiopathic thrombocytopenic purpura C0043117 \| autoimmune thrombocytopenic purpura C0042024 \| loss of bladder control C0041326 \| pleural tuberculosis C0040149 \| subacute thyroiditis C0040137 \| thyroid nodules C0040034 \| thrombocytopenia C0039621 \| tetany C0038478 \| struma ovarii C0038238 \| steatorrhoea C0038218 \| status asthmaticus C0038013 \| ankylosing spondylitis C0037763 \| muscle spasms C0037672 \| sleepwalking C0035579 \| rickets C0035435 \| rheumatism C0034150 \| purpura C0034063 \| pulmonary edema C0033774 \| pruritus C0033103 \| pretibial myxedema C0033038 \| premature ejaculation C0032617 \| polyuria C0032000 \| pituitary adenomas C0031117 \| peripheral neuropathy C0030552 \| muscle pareses C0030517 \| parathyroid disease C0030312 \| pancytopenia C0029458 \| postmenopausal bone loss C0029132 \| optic neuropathies C0029089 \| oculomotor paralysis C0027947 \| neutropenia C0027868 \| neuromuscular disorders C0027726 \| nephrotic syndrome C0027145 \| myxoedema C0027145 \| myxedema C0027126 \| myotonic dystrophy C0027066 \| myoclonus C0027051 \| myocardial infarction C0026896 \| myasthenia gravis C0026848 \| myopathy C0026848 \| myopathies C0026848 \| muscular disorders C0026848 \| muscular diseases C0026846 \| muscle wasting C0026650 \| movement disorders C0026267 \| mitral valve prolapse C0026266 \| mitral regurgitation C0025517 \| metabolism disorder C0025517 \| metabolic disorders C0024141 \| systemic lupus erythematosus C0023895 \| hepatic pathology C0022972 \| lambert-eaton syndrome C0022354 \| cholestatic jaundice C0020640 \| hypoprothrombinemia C0020615 \| hypoglycemia C0020505 \| hyperphagia C0020502 \| hyperparathyroidism C0020456 \| hyperglycemia C0020437 \| hypercalcemia C0020437 \| hypercalcaemia C0020217 \| molar pregnancy C0019158 \| hepatitis C0018817 \| atrial septal defect C0018802 \| congestive heart failure C0018801 \| heart failure C0018801 \| cardiac insufficiency C0018801 \| cardiac failure C0018799 \| cardiac disorders C0018794 \| heart block C0018418 \| gynaecomastia C0018213 \| graves-basedow disease C0018213 \| graves' disease C0018021 \| goitre C0018021 \| goiter C0016065 \| polyostotic fibrous dysplasia C0015300 \| exophthalmos C0012569 \| diplopia C0012242 \| digestive diseases C0011880 \| diabetic ketosis C0011860 \| diabetes C0011849 \| diabetes mellitus C0011168 \| dysphagia C0010073 \| coronary vasospasm C0010073 \| coronary artery spasm C0008497 \| choriocarcinoma C0008489 \| chorea C0008372 \| intrahepatic cholestasis C0008312 \| primary biliary cirrhosis C0007222 \| cardiovascular disorders C0007193 \| dilated cardiomyopathy C0005779 \| blood coagulation disorders C0005586 \| bipolar disorder C0004936 \| mental disorders C0004364 \| autoimmune disorder C0004245 \| av blocks C0003811 \| rhythm disorder C0002892 \| pernicious anaemia C0001403 \| addison's disease
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:71) C0018213 \| graves' disease \| 20 C0232197 \| fibrillation \| 14 C0018021 \| goiter \| 12 C0020538 \| hypertension \| 8 C0018801 \| heart failure \| 8 C0011847 \| diabetes \| 5 C0007115 \| thyroid cancer \| 4 C0878544 \| cardiomyopathy \| 4 C0029456 \| osteoporosis \| 4 C0018021 \| goitre \| 4 C0030312 \| pancytopenia \| 4 C0039231 \| tachycardia \| 3 C0030443 \| periodic paralysis \| 3 C0004093 \| weakness \| 3 C0235250 \| hyperemesis \| 3 C0497327 \| dementia \| 2 C0022346 \| jaundice \| 2 C0020542 \| pulmonary hypertension \| 2 C0027051 \| myocardial infarction \| 2 C0549473 \| thyroid carcinoma \| 2 C0020437 \| hypercalcemia \| 2 C0018802 \| congestive heart failure \| 2 C0018801 \| cardiac failure \| 2 C0011570 \| depression \| 2 C0013922 \| embolism \| 2 C0010278 \| craniosynostosis \| 2 C0007222 \| cardiovascular disorders \| 2 C0020217 \| molar pregnancy \| 2 C0398623 \| hypercoagulable state \| 2 C0026848 \| myopathy \| 2 C0040147 \| thyroiditis \| 2 C0023895 \| liver disease \| 2 C0033038 \| premature ejaculation \| 1 C0020505 \| hyperphagia \| 1 C0042384 \| vasculitis \| 1 C0026848 \| muscular disorders \| 1 C0032000 \| pituitary adenomas \| 1 C0019158 \| hepatitis \| 1 C0085681 \| hyperphosphatemia \| 1 C0270739 \| hemichorea \| 1 C0027868 \| neuromuscular disorders \| 1 C0235480 \| paroxysmal atrial fibrillation \| 1 C0042721 \| viral hepatitis \| 1 C0235527 \| right heart failure \| 1 C0221002 \| primary hyperparathyroidism \| 1 C0008489 \| chorea \| 1 C0206682 \| follicular carcinoma \| 1 C0020456 \| hyperglycemia \| 1 C0262587 \| parathyroid adenoma \| 1 C0011168 \| dysphagia \| 1 C0005586 \| bipolar disorder \| 1 C1527405 \| erythrocytosis \| 1 C0152171 \| idiopathic pulmonary hypertension \| 1 C0948008 \| ischemic stroke \| 1 C0020502 \| hyperparathyroidism \| 1 C0233401 \| psychiatric symptoms \| 1 C1619734 \| pulmonary arterial hypertension \| 1 C0020672 \| hypothermia \| 1 C0002871 \| anemia \| 1 C0042963 \| vomiting \| 1 C0410198 \| proximal myopathy \| 1 C0152025 \| polyneuropathy \| 1 C0027126 \| myotonic dystrophy \| 1 C0159069 \| impaired glucose tolerance \| 1 C0026896 \| myasthenia gravis \| 1 C0085655 \| polymyositis \| 1 C0040137 \| thyroid nodules \| 1 C0004096 \| asthma \| 1 C0027145 \| myxedema \| 1 C0151740 \| increased intracranial pressure \| 1 C0009450 \| infection \| 1

Manually Genotype(Total Text Mining Genotypes:0)
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Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121908873	18466076	7253	TSHR	umls:C0020550	BeFree	Interestingly, an additional constitutively active somatic mutation (S281N) was identified on the second parental TSHR allele of the hyperthyroid index patient.	0.152642545	2008	TSHR;LOC101928462	14	81139828	G	A,T
rs17879469	22968483	26191	PTPN22	umls:C0020550	BeFree	Evaluation of genotypes (HLA DRB103, DQA105, DQB1*02; CTLA4 49A/G, CT60 A/G; PTPN22 C/T) in relation to phenotypes (age, sex, severity (clinical, biochemical, and immunological)) of hyperthyroidism and environmental factors (smoking, stress questionnaires).	0.000271442	2012	HLA-DRB1;LOC105369230	6	32584333	C	G
rs17879469	22968483	3123	HLA-DRB1	umls:C0020550	BeFree	Evaluation of genotypes (HLA DRB103, DQA105, DQB1*02; CTLA4 49A/G, CT60 A/G; PTPN22 C/T) in relation to phenotypes (age, sex, severity (clinical, biochemical, and immunological)) of hyperthyroidism and environmental factors (smoking, stress questionnaires).	0.000271442	2012	HLA-DRB1;LOC105369230	6	32584333	C	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	753
Disease	hyperthyroidism
Case	(Waiting for update.)

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