eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine

HOME
QUERY
- DISEASE
- GENOTYPE
NETWORK
- PHENOTYPE
- GENE
- COMMON
- DISEASE PAIR
DOWNLOAD
SUBMIT CASE
HELP&FAQ
- HELP&FAQ
- CONTACT US


	hyperprolactinemia

Disease ID	599
Disease	hyperprolactinemia
Definition	Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)
Synonym	hprl hyperprolactinaemia hyperprolactinaemia (disorder) hyperprolactinaemia, nos hyperprolactinemia (disorder) hyperprolactinemia [disease/finding] hyperprolactinemia, nos hyperprolactinemias hypersecretion syndrome, prolactin idiopathic hyperprolactinemia idiopathic hyperprolactinemia (disorder) idiopathic hyperprolactinemia [dup] inappropriate prolactin secret inappropriate prolactin secret syndrome inappropriate prolactin secretion inappropriate prolactin secretion syndrome inappropriate secretion prolactin prolactin excess prolactin hypersecret syndrome prolactin hypersecretion syndrome prolactin inappropriate secret prolactin secretion, inappropriate prolactin, inappropriate secretion secretion prolactin, inappropriate secretion, inappropriate prolactin syndrome, prolactin hypersecretion
OMIM	OMIM:615555
DOID	DOID:12700
ICD10	ICD10CM:E22.1
UMLS	C0020514
MeSH	D006966
SNOMED-CT	SNOMEDCT_US_2016_09_01:237662005;SNOMEDCT_US_2016_09_01:237663000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:42) C0021359 \| infertile \| 7 C0036341 \| schizophrenia \| 6 C0020619 \| hypogonadism \| 6 C0002453 \| amenorrhea \| 5 C0020676 \| hypothyroidism \| 5 C0032000 \| pituitary adenoma \| 4 C0033375 \| prolactinomas \| 3 C0021359 \| infertility \| 3 C0001430 \| adenoma \| 3 C0338078 \| non-functioning pituitary adenoma \| 2 C0235660 \| galactorrhea \| 2 C0854486 \| functioning pituitary adenoma \| 2 C0006142 \| breast cancer \| 2 C0242343 \| panhypopituitarism \| 2 C0154208 \| ovarian dysfunction \| 1 C0021053 \| immune disorders \| 1 C0271623 \| secondary hypogonadism \| 1 C0153349 \| tongue cancer \| 1 C0159069 \| impaired glucose tolerance \| 1 C0948265 \| metabolic syndrome \| 1 C0014175 \| endometriosis \| 1 C0155307 \| chiasmal syndrome \| 1 C0678222 \| breast carcinoma \| 1 C0154209 \| hyperestrogenism \| 1 C0221765 \| chronic schizophrenia \| 1 C0032000 \| pituitary adenomas \| 1 C0020676 \| hypothyroid \| 1 C0027086 \| myoma \| 1 C0021053 \| immune disorder \| 1 C0033375 \| prolactinoma \| 1 C0028754 \| obesity \| 1 C0022735 \| hypogonadotropic hypogonadism \| 1 C0002871 \| anemia \| 1 C0021053 \| immune disease \| 1 C0020635 \| pituitary deficiency \| 1 C0020635 \| hypopituitarism \| 1 C0020459 \| hyperinsulinemia \| 1 C0011847 \| diabetes \| 1 C0085278 \| antiphospholipid syndrome \| 1 C0032002 \| pituitary disease \| 1 C0004153 \| atherosclerosis \| 1 C0041948 \| uraemia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:6) 3972 \| LHB \| CTD_human 5617 \| PRL \| CTD_human 2571 \| GAD1 \| CTD_human 2796 \| GNRH1 \| CTD_human 1813 \| DRD2 \| CTD_human 5618 \| PRLR \| CLINVAR;ORPHANET;UNIPROT
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:65) 367 \| AR \| 1.093 \| DISEASES 551 \| AVP \| 2.336 \| DISEASES 632 \| BGLAP \| 2.11 \| DISEASES 796 \| CALCA \| 1.629 \| DISEASES 101805488 \| CCAT2 \| 1.153 \| DISEASES 388512 \| CLEC17A \| 2.765 \| DISEASES 23019 \| CNOT1 \| 1.203 \| DISEASES 1312 \| COMT \| 1.03 \| DISEASES 1443 \| CSH2 \| 2.553 \| DISEASES 1447 \| CSN2 \| 1.152 \| DISEASES 1565 \| CYP2D6 \| 2.237 \| DISEASES 168002 \| DACT2 \| 1.641 \| DISEASES 1621 \| DBH \| 1.539 \| DISEASES 1644 \| DDC \| 3.439 \| DISEASES 123872 \| DNAAF1 \| 1.763 \| DISEASES 1813 \| DRD2 \| 4.338 \| DISEASES 1814 \| DRD3 \| 1.644 \| DISEASES 51013 \| EXOSC1 \| 1.041 \| DISEASES 2274 \| FHL2 \| 2.205 \| DISEASES 2520 \| GAST \| 2.208 \| DISEASES 2641 \| GCG \| 1.541 \| DISEASES 2912 \| GRM2 \| 1.196 \| DISEASES 414768 \| HCG24 \| 2.544 \| DISEASES 3250 \| HPR \| 1.79 \| DISEASES 3274 \| HRH2 \| 1.657 \| DISEASES 3356 \| HTR2A \| 3.387 \| DISEASES 3363 \| HTR7 \| 2.422 \| DISEASES 3486 \| IGFBP3 \| 1.621 \| DISEASES 3547 \| IGSF1 \| 1.216 \| DISEASES 3717 \| JAK2 \| 1.485 \| DISEASES 3814 \| KISS1 \| 1.837 \| DISEASES 3953 \| LEPR \| 1.039 \| DISEASES 4221 \| MEN1 \| 3.303 \| DISEASES 64223 \| MLST8 \| 1.621 \| DISEASES 4578 \| MT-TW \| 1.716 \| DISEASES 9520 \| NPEPPS \| 1.359 \| DISEASES 594857 \| NPS \| 1.573 \| DISEASES 115209 \| OMA1 \| 1.012 \| DISEASES 5179 \| PENK \| 1.089 \| DISEASES 5293 \| PIK3CD \| 1.495 \| DISEASES 5292 \| PIM1 \| 1.069 \| DISEASES 9677 \| PPIP5K1 \| 1.42 \| DISEASES 5618 \| PRLR \| 6.451 \| DISEASES 5744 \| PTHLH \| 1.468 \| DISEASES 23475 \| QPRT \| 1.373 \| DISEASES 866 \| SERPINA6 \| 1.08 \| DISEASES 6462 \| SHBG \| 4.051 \| DISEASES 677833 \| SNORA54 \| 1.508 \| DISEASES 9021 \| SOCS3 \| 1.495 \| DISEASES 6776 \| STAT5A \| 2.055 \| DISEASES 246744 \| STH \| 2.544 \| DISEASES 342898 \| SYCN \| 1.36 \| DISEASES 6863 \| TAC1 \| 1.685 \| DISEASES 9095 \| TBX19 \| 1.113 \| DISEASES 7053 \| TGM3 \| 1.278 \| DISEASES 10618 \| TGOLN2 \| 1.493 \| DISEASES 7054 \| TH \| 3.818 \| DISEASES 55858 \| TMEM165 \| 1.673 \| DISEASES 7142 \| TNP2 \| 1.85 \| DISEASES 58476 \| TP53INP2 \| 1.455 \| DISEASES 7225 \| TRPC6 \| 1.853 \| DISEASES 51506 \| UFC1 \| 1.625 \| DISEASES 7432 \| VIP \| 3.826 \| DISEASES 11169 \| WDHD1 \| 1.045 \| DISEASES 23038 \| WDTC1 \| 1.007 \| DISEASES
Locus	(Waiting for update.)

Disease ID	599
Disease	hyperprolactinemia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:31) HP:0000135 \| Hypogonadism \| 7 HP:0000141 \| Abnormal absence of menstruation \| 6 HP:0100753 \| Schizophrenia \| 6 HP:0000821 \| Underactive thyroid \| 5 HP:0100829 \| Galactorrhoea \| 4 HP:0002893 \| Pituitary adenoma \| 4 HP:0000789 \| Infertility \| 4 HP:0002664 \| Neoplasia \| 3 HP:0003002 \| Breast carcinoma \| 3 HP:0000858 \| Menstrual irregularity \| 2 HP:0012341 \| Microprolactinoma \| 2 HP:0000871 \| Panhypopituitarism \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0001631 \| Atria septal defect \| 2 HP:0000832 \| Primary hypothyroidism \| 2 HP:0002621 \| Atherosclerosis \| 2 HP:0030127 \| Endometriosis \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1 HP:0001596 \| Hair loss \| 1 HP:0000833 \| Glucose intolerance \| 1 HP:0045073 \| Serositis \| 1 HP:0000842 \| Elevated insulin level \| 1 HP:0000855 \| Insulin resistance \| 1 HP:0100646 \| Thyroiditis \| 1 HP:0001513 \| Obesity \| 1 HP:0000746 \| Delusions \| 1 HP:0001903 \| Anemia \| 1 HP:0001007 \| Hirsutism \| 1 HP:0000869 \| Secondary amenorrhea \| 1 HP:0040075 \| Hypopituitarism \| 1 HP:0000998 \| Hypertrichosis \| 1

Disease ID	599
Disease	hyperprolactinemia
Manually Symptom	UMLS \| Name(Total Manually Symptoms:44) C2678504 \| osteoporosis C2364072 \| depression C2219717 \| amenorrhea C2186538 \| thyroid disease C2048468 \| male infertility C2004489 \| regurgitation C1458155 \| breast tumors C1300347 \| atypical polypoid adenomyoma C0877018 \| pituitary gland enlargement C0877018 \| pituitary enlargement C0853662 \| estrogen deficiency C0700361 \| distress C0678222 \| mammary carcinoma C0554471 \| disorder of hair growth C0554400 \| galactorrhea C0553573 \| primary infertility C0549622 \| sexual dysfunction C0334403 \| juvenile granulosa cell tumor C0278488 \| metastatic breast cancer C0271737 \| autoimmune addison's disease C0271623 \| secondary hypogonadism C0271556 \| amenorrhea-galactorrhea syndrome C0232940 \| secondary amenorrhea C0232939 \| primary amenorrhea C0206713 \| intraductal papilloma C0206660 \| germinoma C0206633 \| angiomyolipoma C0154208 \| ovarian dysfunction C0034013 \| precocious puberty C0034012 \| delayed puberty C0032460 \| polycystic ovary syndrome C0032460 \| polycystic ovarian disease C0032019 \| pituitary tumors C0032019 \| pituitary tumor C0032000 \| pituitary adenomas C0032000 \| pituitary adenoma C0021361 \| female infertility C0021359 \| infertility C0020619 \| hypogonadism C0010276 \| craniopharyngioma C0004364 \| autoimmune disease C0003128 \| anovulations C0003128 \| anovulation C0001207 \| acromegalic gigantism
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:10) C0002453 \| amenorrhea \| 6 C0021359 \| infertility \| 4 C0020619 \| hypogonadism \| 4 C0032000 \| pituitary adenoma \| 3 C0235660 \| galactorrhea \| 3 C0032019 \| pituitary tumors \| 1 C0033953 \| sexual dysfunction \| 1 C0271623 \| secondary hypogonadism \| 1 C0235660 \| galactorrhoea \| 1 C0232940 \| secondary amenorrhea \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs398122522	NA	5618	PRLR	umls:C0020514	CLINVAR	NA	0.360542884	NA	PRLR	5	35070174	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	599
Disease	hyperprolactinemia
Case	(Waiting for update.)

Web Analytics Made Easy - StatCounter