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	hyperaldosteronism

Disease ID	952
Disease	hyperaldosteronism
Definition	A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
Synonym	aldosteronism aldosteronism (disorder) aldosteronism nos aldosteronism, nos elevated plasma aldosterone hyperaldosteronism [disease/finding] hyperaldosteronism nos hyperaldosteronism nos (disorder) hyperaldosteronism, nos hyperaldosteronism, unspecified increased aldosterone increased aldosterone production mineralocorticoid excess
DOID	DOID:446
ICD10	ICD10CM:E26.9
UMLS	C0020428
MeSH	D006929
SNOMED-CT	SNOMEDCT_US_2016_09_01:88213004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:45) C0020538 \| hypertension \| 24 C0001430 \| adenoma \| 6 C0155616 \| secondary hypertension \| 5 C0206667 \| adrenal adenoma \| 4 C0221002 \| primary hyperparathyroidism \| 4 C1621895 \| adrenal hyperplasia \| 4 C0018801 \| heart failure \| 4 C0334684 \| renal adenoma \| 4 C0020502 \| hyperparathyroidism \| 3 C0010481 \| cushing's syndrome \| 3 C0042373 \| vascular disease \| 2 C0022661 \| chronic kidney disease \| 2 C0010481 \| cushing syndrome \| 2 C0011847 \| diabetes \| 2 C0037315 \| sleep apnea \| 2 C0948265 \| metabolic syndrome \| 1 C0001815 \| myeloid metaplasia \| 1 C0033687 \| proteinuria \| 1 C0020456 \| hyperglycemia \| 1 C0027819 \| neuroblastoma \| 1 C0022679 \| cystic kidney \| 1 C0024586 \| carcinoid syndrome \| 1 C1384514 \| primary aldosteronism \| 1 C0085413 \| autosomal dominant polycystic kidney \| 1 C0085413 \| autosomal dominant polycystic kidney disease \| 1 C0022658 \| kidney disease \| 1 C0007222 \| cardiovascular disease \| 1 C0221043 \| pseudohyperaldosteronism \| 1 C0022658 \| renal disease \| 1 C0042373 \| vascular diseases \| 1 C1370740 \| adrenal carcinoma \| 1 C0007222 \| cardiovascular diseases \| 1 C0030443 \| periodic paralysis \| 1 C0031036 \| polyarteritis nodosa \| 1 C0007134 \| renal carcinoma \| 1 C0085580 \| essential hypertension \| 1 C0033804 \| pseudohermaphroditism \| 1 C0001621 \| adrenal disease \| 1 C0028754 \| adiposity \| 1 C0206667 \| adrenocortical adenoma \| 1 C0027051 \| heart attack \| 1 C0011849 \| diabetes mellitus \| 1 C0677607 \| hashimoto's thyroiditis \| 1 C0020540 \| accelerated hypertension \| 1 C0001622 \| hypercortisolism \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 776 \| CACNA1D \| CTD_human 1584 \| CYP11B1 \| CTD_human 476 \| ATP1A1 \| CTD_human 1585 \| CYP11B2 \| CTD_human 492 \| ATP2B3 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:48) 183 \| AGT \| 3.452 \| DISEASES 249 \| ALPL \| 1.239 \| DISEASES 408 \| ARRB1 \| 2.383 \| DISEASES 480 \| ATP1A4 \| 4.02 \| DISEASES 93974 \| ATPIF1 \| 1.702 \| DISEASES 551 \| AVP \| 3.351 \| DISEASES 7809 \| BSND \| 3.132 \| DISEASES 153571 \| C5orf38 \| 1.005 \| DISEASES 774 \| CACNA1B \| 1.223 \| DISEASES 8912 \| CACNA1H \| 3.502 \| DISEASES 801 \| CALM1 \| 1.913 \| DISEASES 1188 \| CLCNKB \| 4.316 \| DISEASES 1408 \| CRY2 \| 2.335 \| DISEASES 1585 \| CYP11B2 \| 6.763 \| DISEASES 1586 \| CYP17A1 \| 2.676 \| DISEASES 1555 \| CYP2B6 \| 2.444 \| DISEASES 2232 \| FDXR \| 1.238 \| DISEASES 285943 \| HOXA-AS2 \| 2.498 \| DISEASES 3283 \| HSD3B1 \| 2.996 \| DISEASES 3284 \| HSD3B2 \| 1.857 \| DISEASES 3360 \| HTR4 \| 2.201 \| DISEASES 3753 \| KCNE1 \| 1.13 \| DISEASES 3758 \| KCNJ1 \| 4.119 \| DISEASES 3762 \| KCNJ5 \| 5.662 \| DISEASES 3778 \| KCNMA1 \| 1.201 \| DISEASES 9365 \| KL \| 2.637 \| DISEASES 9622 \| KLK4 \| 3.089 \| DISEASES 4158 \| MC2R \| 1.683 \| DISEASES 4221 \| MEN1 \| 1.685 \| DISEASES 8972 \| MGAM \| 2.351 \| DISEASES 4878 \| NPPA \| 1.834 \| DISEASES 4306 \| NR3C2 \| 5.581 \| DISEASES 3164 \| NR4A1 \| 1.072 \| DISEASES 4929 \| NR4A2 \| 2.389 \| DISEASES 2516 \| NR5A1 \| 1.165 \| DISEASES 54681 \| P4HTM \| 1.226 \| DISEASES 5121 \| PCP4 \| 2.451 \| DISEASES 5573 \| PRKAR1A \| 2.159 \| DISEASES 5575 \| PRKAR1B \| 2.677 \| DISEASES 6337 \| SCNN1A \| 2.115 \| DISEASES 6338 \| SCNN1B \| 2.033 \| DISEASES 6446 \| SGK1 \| 2.431 \| DISEASES 6557 \| SLC12A1 \| 3.752 \| DISEASES 6559 \| SLC12A3 \| 4.497 \| DISEASES 1811 \| SLC26A3 \| 2.879 \| DISEASES 55553 \| SOX6 \| 1.008 \| DISEASES 200734 \| SPRED2 \| 1.889 \| DISEASES 50834 \| TAS2R1 \| 2.555 \| DISEASES
Locus	(Waiting for update.)

Disease ID	952
Disease	hyperaldosteronism
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:47) HP:0000822 \| Hypertension \| 29 HP:0002900 \| Hypokalemia \| 11 HP:0008221 \| Enlarged adrenal glands \| 6 HP:0001685 \| Myocardial fibrosis \| 4 HP:0001635 \| Congestive heart failure \| 4 HP:0008200 \| Primary hyperparathyroidism \| 4 HP:0002615 \| Low blood pressure \| 3 HP:0001578 \| Hypercortisolism \| 3 HP:0200114 \| Metabolic alkalosis \| 3 HP:0000843 \| Hyperparathyroidism \| 3 HP:0001948 \| Alkalosis \| 3 HP:0000848 \| Hyperreninemia \| 2 HP:0012622 \| Chronic kidney disease \| 2 HP:0100570 \| Carcinoid tumor \| 2 HP:0010535 \| Sleep apnea \| 2 HP:0001960 \| Hypokalemic metabolic alkalosis \| 2 HP:0003470 \| Inability to move \| 2 HP:0002385 \| Paraparesis \| 2 HP:0002104 \| Absence of spontaneous respiration \| 2 HP:0001658 \| Myocardial infarction \| 1 HP:0000093 \| Proteinuria \| 1 HP:0008256 \| Adrenocortical adenomas \| 1 HP:0001712 \| Left ventricular hypertrophy \| 1 HP:0000121 \| Nephrocalcinosis \| 1 HP:0003074 \| High blood glucose \| 1 HP:0006744 \| Adrenal carcinoma \| 1 HP:0004308 \| Ventricular arrhythmia \| 1 HP:0008231 \| Macronodular adrenal hyperplasia \| 1 HP:0012408 \| Medullary nephrocalcinosis \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1 HP:0002917 \| Low blood magnesium levels \| 1 HP:0002170 \| Intracranial hemorrhage \| 1 HP:0003768 \| Periodic paralysis \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0001714 \| Ventricular hypertrophy \| 1 HP:0002153 \| Elevated serum potassium levels \| 1 HP:0000037 \| Male pseudohermaphroditism \| 1 HP:0001250 \| Seizures \| 1 HP:0003006 \| Neuroblastoma \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0000855 \| Insulin resistance \| 1 HP:0001518 \| Small for gestational age \| 1 HP:0000113 \| Polycystic kidney dysplasia \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0002150 \| Hypercalcinuria \| 1

Disease ID	952
Disease	hyperaldosteronism
Manually Symptom	UMLS \| Name(Total Manually Symptoms:15) C2364118 \| weakness C1963138 \| hypertension C1609519 \| adrenal myelolipoma C1555754 \| cardiovascular disease C1279412 \| periodic paralysis syndrome C0334684 \| renal adenoma C0232197 \| fibrillation C0220983 \| metabolic alkalosis C0206635 \| myelolipoma C0162565 \| acute intermittent porphyria C0033806 \| pseudohypoparathyroidism C0020538 \| vascular hypertension C0020488 \| sodium retention C0010481 \| hypercortisolism C0003125 \| anorexia nervosa
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:7) C0020538 \| hypertension \| 11 C0220983 \| metabolic alkalosis \| 4 C1393529 \| vascular complications \| 1 C0020488 \| sodium retention \| 1 C0334684 \| renal adenoma \| 1 C0001622 \| hypercortisolism \| 1 C0206635 \| myelolipoma \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	952
Disease	hyperaldosteronism
Case	(Waiting for update.)

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