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	histiocytosis

Disease ID	1465
Disease	histiocytosis
Definition	General term for the abnormal appearance of histiocytes in the blood. Based on the pathological features of the cells involved rather than on clinical findings, the histiocytic diseases are subdivided into three groups: HISTIOCYTOSIS, LANGERHANS CELL; HISTIOCYTOSIS, NON-LANGERHANS-CELL; and HISTIOCYTIC DISORDERS, MALIGNANT.
Synonym	histiocytic infiltrate histiocytic infiltrate (morphologic abnormality) histiocytic infiltrate, nos histiocytic reaction histiocytic reaction, nos histiocytic syndrome histiocytoses histiocytosis (morphologic abnormality) histiocytosis [disease/finding] histiocytosis, nos histiocytosis, unspecified histiocytosis, unspecified (disorder) reticuloendothelial cell infiltrate reticuloendothelial cell infiltrate, nos reticulohistiocytosis reticulohistiocytosis, nos
DOID	DOID:3405
UMLS	C0019618
MeSH	D015614
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:63) C0024299 \| lymphoma \| 5 C0011847 \| diabetes \| 5 C0011848 \| diabetes insipidus \| 4 C0003873 \| rheumatoid arthritis \| 3 C0242647 \| mucosa-associated lymphoid tissue \| 2 C0019204 \| liver carcinoma \| 2 C0687720 \| central diabetes insipidus \| 2 C0079748 \| lymphoblastic lymphoma \| 2 C0598894 \| monocytic leukemia \| 2 C0007115 \| thyroid ca \| 2 C0032285 \| pneumonia \| 2 C0549473 \| thyroid carcinoma \| 2 C0020542 \| pulmonary hypertension \| 2 C0238463 \| papillary thyroid carcinoma \| 2 C0011854 \| insulin dependent diabetes \| 1 C0023895 \| liver disease \| 1 C0029401 \| paget's disease \| 1 C0011854 \| insulin dependent diabetes mellitus \| 1 C0020305 \| hydrops fetalis \| 1 C0242647 \| marginal zone b-cell lymphoma \| 1 C0023467 \| acute myeloid leukemia \| 1 C0878675 \| erdheim-chester disease \| 1 C0011633 \| dermatomyositis \| 1 C0085669 \| acute leukemia \| 1 C0007137 \| squamous cell carcinoma \| 1 C0006285 \| bronchopneumonia \| 1 C0029408 \| osteoarthritis \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0030326 \| panniculitis \| 1 C0032131 \| plasmacytoma \| 1 C0004030 \| aspergillosis \| 1 C0023470 \| myeloid leukaemia \| 1 C0024291 \| hemophagocytic lymphohistiocytosis \| 1 C0002726 \| amyloidosis \| 1 C0019621 \| langerhans cell histiocytosis \| 1 C0078981 \| arachnoid cyst \| 1 C0023470 \| myeloid leukemia \| 1 C0011615 \| atopic dermatitis \| 1 C0024214 \| lymphangiectasia \| 1 C0008370 \| cholestasis \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0085669 \| acute leukemias \| 1 C0023467 \| acute myeloid leukaemia \| 1 C0684249 \| carcinoma of the lung \| 1 C0029182 \| orbital disease \| 1 C0032226 \| pleural disease \| 1 C1261473 \| sarcoma \| 1 C0001418 \| adenocarcinoma \| 1 C0021933 \| intussusception \| 1 C0152013 \| adenocarcinoma of the lung \| 1 C0029443 \| osteomyelitis \| 1 C0020538 \| hypertension \| 1 C0079731 \| b-cell lymphoma \| 1 C0948303 \| peritoneal carcinoma \| 1 C1136085 \| monoclonal gammopathy \| 1 C1527336 \| sjogren's syndrome \| 1 C0007134 \| renal cell carcinoma \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0042384 \| vasculitis \| 1 C0242647 \| mucosa-associated lymphoid tissue lymphoma \| 1 C0024115 \| lung disorders \| 1 C0015624 \| fanconi syndrome \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 673 \| BRAF \| GHR 6609 \| SMPD1 \| UniProtKB-KW;GHR 4864 \| NPC1 \| UniProtKB-KW;GHR 55315 \| SLC29A3 \| CTD_human 10577 \| NPC2 \| UniProtKB-KW;GHR
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:116) 19 \| ABCA1 \| 2.194 \| DISEASES 197 \| AHSG \| 1.231 \| DISEASES 238 \| ALK \| 1.134 \| DISEASES 347 \| APOD \| 1.858 \| DISEASES 367 \| AR \| 1.971 \| DISEASES 369 \| ARAF \| 3.186 \| DISEASES 414 \| ARSD \| 1.151 \| DISEASES 427 \| ASAH1 \| 1.357 \| DISEASES 551 \| AVP \| 3.244 \| DISEASES 2583 \| B4GALNT1 \| 2.005 \| DISEASES 54880 \| BCOR \| 1.266 \| DISEASES 857 \| CAV1 \| 1.004 \| DISEASES 6364 \| CCL20 \| 1.396 \| DISEASES 9332 \| CD163 \| 4.441 \| DISEASES 910 \| CD1B \| 3.271 \| DISEASES 911 \| CD1C \| 3.503 \| DISEASES 914 \| CD2 \| 2.765 \| DISEASES 50489 \| CD207 \| 6.233 \| DISEASES 959 \| CD40LG \| 2.483 \| DISEASES 921 \| CD5 \| 2.046 \| DISEASES 965 \| CD58 \| 1.67 \| DISEASES 9308 \| CD83 \| 2.368 \| DISEASES 942 \| CD86 \| 1.414 \| DISEASES 1118 \| CHIT1 \| 1.526 \| DISEASES 1378 \| CR1 \| 2.088 \| DISEASES 1380 \| CR2 \| 2.263 \| DISEASES 7812 \| CSDE1 \| 1.763 \| DISEASES 1435 \| CSF1 \| 2.488 \| DISEASES 5476 \| CTSA \| 2.145 \| DISEASES 1508 \| CTSB \| 1.425 \| DISEASES 1510 \| CTSE \| 1.685 \| DISEASES 1520 \| CTSS \| 1.514 \| DISEASES 10522 \| DEAF1 \| 2.298 \| DISEASES 100288687 \| DUX4 \| 1.442 \| DISEASES 653545 \| DUX4L5 \| 1.442 \| DISEASES 355 \| FAS \| 1.463 \| DISEASES 89885 \| FATE1 \| 1.828 \| DISEASES 2214 \| FCGR3A \| 1.82 \| DISEASES 2268 \| FGR \| 1.332 \| DISEASES 50943 \| FOXP3 \| 1.292 \| DISEASES 6624 \| FSCN1 \| 3.617 \| DISEASES 2526 \| FUT4 \| 2.787 \| DISEASES 53827 \| FXYD5 \| 1.786 \| DISEASES 9514 \| GAL3ST1 \| 1.785 \| DISEASES 2665 \| GDI2 \| 1.374 \| DISEASES 27069 \| GHITM \| 1.356 \| DISEASES 2760 \| GM2A \| 1.968 \| DISEASES 2934 \| GSN \| 1.142 \| DISEASES 51454 \| GULP1 \| 1.717 \| DISEASES 26762 \| HAVCR1 \| 3.277 \| DISEASES 3039 \| HBA1 \| 2.425 \| DISEASES 338376 \| IFNE \| 1.277 \| DISEASES 3321 \| IGSF3 \| 1.264 \| DISEASES 3586 \| IL10 \| 1.512 \| DISEASES 3605 \| IL17A \| 1.995 \| DISEASES 3559 \| IL2RA \| 1.542 \| DISEASES 3563 \| IL3RA \| 1.923 \| DISEASES 56623 \| INPP5E \| 1.628 \| DISEASES 3681 \| ITGAD \| 1.349 \| DISEASES 3683 \| ITGAL \| 1.673 \| DISEASES 3684 \| ITGAM \| 2.428 \| DISEASES 284359 \| IZUMO1 \| 1.089 \| DISEASES 57670 \| KIAA1549 \| 1.887 \| DISEASES 3805 \| KIR2DL4 \| 1.341 \| DISEASES 3916 \| LAMP1 \| 1.528 \| DISEASES 348120 \| LINC01193 \| 1.458 \| DISEASES 3988 \| LIPA \| 1.706 \| DISEASES 4018 \| LPA \| 1.277 \| DISEASES 5609 \| MAP2K7 \| 2.95 \| DISEASES 79104 \| MEG8 \| 1.056 \| DISEASES 10227 \| MFSD10 \| 1.719 \| DISEASES 4311 \| MME \| 1.13 \| DISEASES 4555 \| MT-TD \| 1.888 \| DISEASES 727897 \| MUC5B \| 1.247 \| DISEASES 4602 \| MYB \| 1.23 \| DISEASES 4763 \| NF1 \| 2.419 \| DISEASES 256933 \| NPB \| 3.6 \| DISEASES 10577 \| NPC2 \| 6.552 \| DISEASES 4893 \| NRAS \| 2.145 \| DISEASES 93034 \| NT5C1B \| 1.106 \| DISEASES 4942 \| OAT \| 2.911 \| DISEASES 5155 \| PDGFB \| 1.534 \| DISEASES 5229 \| PGGT1B \| 1.172 \| DISEASES 5236 \| PGM1 \| 3.725 \| DISEASES 5309 \| PITX3 \| 3.691 \| DISEASES 5321 \| PLA2G4A \| 1.223 \| DISEASES 9842 \| PLEKHM1 \| 1.642 \| DISEASES 5538 \| PPT1 \| 1.082 \| DISEASES 5660 \| PSAP \| 1.536 \| DISEASES 5781 \| PTPN11 \| 1.894 \| DISEASES 5788 \| PTPRC \| 3.409 \| DISEASES 9367 \| RAB9A \| 2.695 \| DISEASES 6280 \| S100A9 \| 4.652 \| DISEASES 404552 \| SCGB1D4 \| 1.343 \| DISEASES 57556 \| SEMA6A \| 1.001 \| DISEASES 57515 \| SERINC1 \| 1.691 \| DISEASES 5265 \| SERPINA1 \| 3.965 \| DISEASES 12 \| SERPINA3 \| 4.705 \| DISEASES 4068 \| SH2D1A \| 1.913 \| DISEASES 26503 \| SLC17A5 \| 1.062 \| DISEASES 55315 \| SLC29A3 \| 4.163 \| DISEASES 6609 \| SMPD1 \| 6.576 \| DISEASES 10924 \| SMPDL3A \| 2.359 \| DISEASES 23583 \| SMUG1 \| 3.432 \| DISEASES 6693 \| SPN \| 3.067 \| DISEASES 6696 \| SPP1 \| 1.208 \| DISEASES 6721 \| SREBF2 \| 1.419 \| DISEASES 8676 \| STX11 \| 2.368 \| DISEASES 6832 \| SUPV3L1 \| 1.466 \| DISEASES 441864 \| TARM1 \| 2.13 \| DISEASES 7037 \| TFRC \| 1.774 \| DISEASES 7072 \| TIA1 \| 1.838 \| DISEASES 84000 \| TMPRSS13 \| 1.142 \| DISEASES 7124 \| TNF \| 2.512 \| DISEASES 10210 \| TOPORS \| 1.206 \| DISEASES 7357 \| UGCG \| 2.929 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1465
Disease	histiocytosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:47) HP:0002716 \| Lymph node hyperplasia \| 103 HP:0002665 \| Lymphoma \| 5 HP:0000873 \| Diabetes insipidus \| 4 HP:0001370 \| Rheumatoid arthritis \| 3 HP:0002664 \| Neoplasia \| 3 HP:0002890 \| Thyroid carcinoma \| 2 HP:0002895 \| Papillary thyroid carcinoma \| 2 HP:0002092 \| Pulmonary artery hypertension \| 2 HP:0002090 \| Pneumonia \| 2 HP:0012325 \| Chronic myelomonocytic leukemia \| 2 HP:0000863 \| Neurohypophyseal diabetes insipidus \| 2 HP:0005584 \| Renal cell carcinoma \| 1 HP:0000822 \| Hypertension \| 1 HP:0002318 \| Cervical myelopathy \| 1 HP:0100242 \| Sarcoma \| 1 HP:0040189 \| Desquamation \| 1 HP:0001397 \| Hepatic steatosis \| 1 HP:0012393 \| Allergy \| 1 HP:0002633 \| Vasculitis \| 1 HP:0002107 \| Collapsed lung \| 1 HP:0030731 \| Carcinoma \| 1 HP:0100825 \| Inflammation of the lips \| 1 HP:0000078 \| Genital abnormalities \| 1 HP:0002835 \| Aspiration \| 1 HP:0002758 \| Osteoarthritis \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0002754 \| Bone infection \| 1 HP:0000969 \| Dropsy \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0012156 \| Hemophagocytosis \| 1 HP:0001789 \| Hydrops fetalis \| 1 HP:0100702 \| Arachnoid cyst \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0002576 \| Intussusception \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0001994 \| 'de toni-fanconi-debre' syndrome \| 1 HP:0012490 \| Inflammation of fat tissue \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0011857 \| Plasmacytoma \| 1 HP:0001396 \| Cholestasis \| 1 HP:0004808 \| Acute myelogenous leukemia \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0001047 \| Atopic dermatitis \| 1 HP:0002593 \| Intestinal lymphangiectasia \| 1 HP:0011034 \| Amyloid disease \| 1

Disease ID	1465
Disease	histiocytosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:3) C2363896 \| hypothalamic diabetes insipidus C2186532 \| liver disease C0376293 \| stigmata
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0023895 \| liver disease \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1465
Disease	histiocytosis
Case	(Waiting for update.)

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