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encyclopedia of Rare Disease Annotation for Precision Medicine

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	hepatitis e

Disease ID	1295
Disease	hepatitis e
Definition	Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.
Synonym	e hepatitis enterically transmitted non a, non b hepatitis enterically-transmitted non-a, non-b hepatitis epidemic non a, non b hepatitis epidemic non-a, non-b hepatitis et nanbh et-nanbh hepatitides, water-borne hepatitis e [disease/finding] hepatitis e virus infection hepatitis, viral, non-a, non-b, enterically-transmitted hepatitis, water borne hepatitis, water-borne viral hepatitis e viral hepatitis type e viral hepatitis type e (disorder) water-borne hepatitides water-borne hepatitis
DOID	DOID:4411
UMLS	C0085293
MeSH	D016751
SNOMED-CT	SNOMEDCT_US_2016_09_01:7111000119109
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:184) C0019158 \| hepatitis \| 35 C0023890 \| cirrhosis \| 21 C0019163 \| hepatitis b \| 18 C0019204 \| hepatocellular carcinoma \| 13 C0023895 \| liver disease \| 11 C0042769 \| virus infection \| 10 C0018378 \| guillain-barre syndrome \| 9 C0023890 \| liver cirrhosis \| 8 C0085293 \| hepatitis e \| 7 C0008370 \| cholestasis \| 6 C0008311 \| cholangitis \| 6 C0085253 \| adult-onset still's disease \| 6 C0008312 \| primary biliary cirrhosis \| 5 C0001339 \| acute pancreatitis \| 5 C0030305 \| pancreatitis \| 5 C0003873 \| rheumatoid arthritis \| 5 C0042721 \| viral hepatitis \| 5 C0040034 \| thrombocytopenia \| 5 C0008312 \| biliary cirrhosis \| 5 C0026769 \| multiple sclerosis \| 4 C0007570 \| celiac disease \| 4 C0002871 \| anaemia \| 4 C0003864 \| arthritis \| 4 C0021053 \| immune disease \| 4 C0023418 \| leukemia \| 4 C0009319 \| colitis \| 3 C0040147 \| thyroiditis \| 3 C0034362 \| q fever \| 3 C0042769 \| viral infection \| 3 C0024299 \| lymphoma \| 3 C0019196 \| hepatitis c \| 3 C0022354 \| cholestatic jaundice \| 3 C0152025 \| polyneuropathy \| 3 C0241910 \| autoimmune hepatitis \| 3 C0281963 \| red cell aplasia \| 3 C0020538 \| hypertension \| 3 C0019187 \| alcoholic hepatitis \| 2 C0002878 \| hemolytic anemia \| 2 C0442874 \| neuropathy \| 2 C0030312 \| pancytopenia \| 2 C0005283 \| beta thalassemia \| 2 C0021390 \| inflammatory bowel disease \| 2 C0023895 \| hepatic disorders \| 2 C0085253 \| adult-onset still disease \| 2 C0002871 \| anemia \| 2 C0026896 \| myasthenia gravis \| 2 C0008313 \| sclerosing cholangitis \| 2 C0031036 \| polyarteritis nodosa \| 2 C0409974 \| lupus erythematosus \| 2 C0002880 \| autoimmune hemolytic anemia \| 2 C0018801 \| heart failure \| 2 C0040188 \| tic disorders \| 2 C0026946 \| fungal infection \| 2 C0022660 \| acute renal failure \| 2 C0031154 \| peritonitis \| 2 C0040149 \| subacute thyroiditis \| 2 C0021831 \| bowel disease \| 2 C0024141 \| systemic lupus erythematosus \| 2 C0009324 \| ulcerative colitis \| 2 C0035078 \| renal failure \| 2 C0085655 \| polymyositis \| 2 C0018213 \| graves' disease \| 2 C0023903 \| liver cancer \| 2 C0020541 \| portal hypertension \| 2 C0003467 \| anxiety \| 2 C0036421 \| systemic sclerosis \| 2 C0376175 \| bell's palsy \| 2 C0011847 \| diabetes \| 2 C0002878 \| haemolytic anaemia \| 2 C0040100 \| thymoma \| 2 C0017665 \| membranous glomerulonephritis \| 2 C0034902 \| pure red cell aplasia \| 2 C0920350 \| autoimmune thyroiditis \| 2 C0566602 \| primary sclerosing cholangitis \| 2 C0017658 \| glomerulonephritis \| 2 C0085253 \| adult onset still's disease \| 2 C0020455 \| hypergammaglobulinaemia \| 1 C0010414 \| cryptococcosis \| 1 C0025309 \| meningoencephalitis \| 1 C0008372 \| intrahepatic cholestasis \| 1 C0019147 \| hepatic coma \| 1 C0042721 \| virus hepatitis \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0023903 \| hepatic cancer \| 1 C0679466 \| cognitive deficits \| 1 C0701818 \| choledocholithiasis \| 1 C0393819 \| chronic inflammatory demyelinating polyneuropathy \| 1 C0554114 \| epstein-barr virus hepatitis \| 1 C0037061 \| siderosis \| 1 C0025289 \| meningitis \| 1 C0027059 \| myocarditis \| 1 C0026986 \| myelodysplastic syndromes \| 1 C0011991 \| diarrhea \| 1 C0836924 \| thrombocytosis \| 1 C0004712 \| balo's concentric sclerosis \| 1 C0677607 \| hashimoto's thyroiditis \| 1 C0019202 \| wilson's disease \| 1 C0023646 \| lichen planus \| 1 C0033860 \| psoriasis \| 1 C0019151 \| hepatic encephalopathy \| 1 C0023890 \| hepatic cirrhosis \| 1 C0011226 \| hepatitis d \| 1 C0036323 \| schistosomiasis \| 1 C0002726 \| amyloidosis \| 1 C0023895 \| hepatopathy \| 1 C0024291 \| hemophagocytic lymphohistiocytosis \| 1 C0019360 \| zoster \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0023470 \| myelocytic leukemia \| 1 C1527336 \| sjogren's syndrome \| 1 C0162429 \| poor nutrition \| 1 C0015930 \| fetal distress \| 1 C0018203 \| chronic granulomatous disease \| 1 C0039128 \| syphilis \| 1 C0040128 \| thyroid disease \| 1 C0002880 \| autoimmune haemolytic anaemia \| 1 C0025293 \| listeria monocytogenes meningitis \| 1 C0085652 \| pyoderma gangrenosum \| 1 C2700641 \| lymphoplasmacytic lymphoma \| 1 C0272286 \| immune thrombocytopenia \| 1 C0022658 \| kidney disease \| 1 C0011854 \| type 1 diabetes mellitus \| 1 C0009782 \| connective tissue disease \| 1 C0039730 \| thalassemia \| 1 C0023487 \| promyelocytic leukemia \| 1 C0002874 \| aplastic anaemia \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0023903 \| hepatic tumor \| 1 C0023470 \| myeloid leukemia \| 1 C0022661 \| chronic kidney disease \| 1 C0023787 \| lipodystrophy \| 1 C0019829 \| hodgkin's lymphoma \| 1 C1619734 \| pulmonary arterial hypertension \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0023290 \| visceral leishmaniasis \| 1 C0151313 \| sensory neuropathy \| 1 C0085273 \| erythema infectiosum \| 1 C0011633 \| dermatomyositis \| 1 C0002874 \| aplastic anemia \| 1 C0003125 \| anorexia nervosa \| 1 C0376545 \| hematological malignancies \| 1 C0019163 \| hepatitis b infection \| 1 C0032587 \| polyradiculoneuropathy \| 1 C0008049 \| varicella \| 1 C0023801 \| lipomatosis \| 1 C0685938 \| gastrointestinal cancer \| 1 C0035309 \| retinopathy \| 1 C0162529 \| ischemic colitis \| 1 C0494491 \| mononeuropathy \| 1 C0002892 \| pernicious anemia \| 1 C0003864 \| arthritides \| 1 C0023281 \| leishmaniasis \| 1 C0221032 \| generalized lipodystrophy \| 1 C0011849 \| diabetes mellitus \| 1 C0022658 \| renal disease \| 1 C0023343 \| leprosy \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0268397 \| cutaneous amyloidosis \| 1 C0008325 \| cholecystitis \| 1 C0040128 \| thyroid diseases \| 1 C0009447 \| common variable immunodeficiency \| 1 C0030312 \| bone marrow failure \| 1 C0023364 \| leptospirosis \| 1 C0013371 \| shigellosis \| 1 C0026272 \| mixed connective tissue disease \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0017920 \| g6pd deficiency \| 1 C0025637 \| methemoglobinemia \| 1 C0012739 \| disseminated intravascular coagulation (dic) \| 1 C0011570 \| depression \| 1 C0040127 \| thyroid storm \| 1 C0019212 \| hepatorenal syndrome \| 1 C0001206 \| acromegaly \| 1 C0023467 \| acute myeloid leukemia \| 1 C0006309 \| brucellosis \| 1 C0267841 \| acalculous cholecystitis \| 1 C0023487 \| acute promyelocytic leukemia \| 1 C0014038 \| encephalitis \| 1 C0034212 \| pyoderma \| 1 C0042164 \| uveitis \| 1 C0079731 \| b cell lymphoma \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0027947 \| neutropenia \| 1 C0011854 \| type 1 diabetes \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 3458 \| IFNG \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:51) 316 \| AOX1 \| 1.873 \| DISEASES 916 \| CD3E \| 1.831 \| DISEASES 959 \| CD40LG \| 6.071 \| DISEASES 1066 \| CES1 \| 1.335 \| DISEASES 9074 \| CLDN6 \| 2.063 \| DISEASES 23019 \| CNOT1 \| 2.248 \| DISEASES 1660 \| DHX9 \| 1.348 \| DISEASES 22894 \| DIS3 \| 2.324 \| DISEASES 1974 \| EIF4A2 \| 1.879 \| DISEASES 1981 \| EIF4G1 \| 1.406 \| DISEASES 2053 \| EPHX2 \| 1.411 \| DISEASES 2266 \| FGG \| 1.806 \| DISEASES 50943 \| FOXP3 \| 1.258 \| DISEASES 158326 \| FREM1 \| 2.258 \| DISEASES 728441 \| GGT2 \| 1.506 \| DISEASES 3030 \| HADHA \| 3.765 \| DISEASES 3586 \| IL10 \| 1.423 \| DISEASES 3665 \| IRF7 \| 1.095 \| DISEASES 10379 \| IRF9 \| 1.835 \| DISEASES 3716 \| JAK1 \| 1.376 \| DISEASES 4149 \| MAX \| 2.141 \| DISEASES 4168 \| MCF2 \| 1.516 \| DISEASES 284424 \| MIR7-3HG \| 2.507 \| DISEASES 8569 \| MKNK1 \| 2.072 \| DISEASES 26002 \| MOXD1 \| 1.799 \| DISEASES 4514 \| MT-CO3 \| 1.12 \| DISEASES 4615 \| MYD88 \| 1.057 \| DISEASES 9436 \| NCR2 \| 1.588 \| DISEASES 259197 \| NCR3 \| 1.244 \| DISEASES 25983 \| NGDN \| 1.723 \| DISEASES 22861 \| NLRP1 \| 1.353 \| DISEASES 246734 \| NPCDR1 \| 4.697 \| DISEASES 23467 \| NPTXR \| 1.623 \| DISEASES 5034 \| P4HB \| 1.306 \| DISEASES 10846 \| PDE10A \| 1.51 \| DISEASES 10611 \| PDLIM5 \| 1.533 \| DISEASES 5455 \| POU3F3 \| 1.881 \| DISEASES 400668 \| PRSS57 \| 1.945 \| DISEASES 6218 \| RPS17 \| 2.179 \| DISEASES 10407 \| SPAG11B \| 3.56 \| DISEASES 6710 \| SPTB \| 1.632 \| DISEASES 10732 \| TCFL5 \| 1.429 \| DISEASES 7062 \| TCHH \| 1.312 \| DISEASES 7091 \| TLE4 \| 2.234 \| DISEASES 51284 \| TLR7 \| 1.336 \| DISEASES 7124 \| TNF \| 1.032 \| DISEASES 8784 \| TNFRSF18 \| 2.627 \| DISEASES 127933 \| UHMK1 \| 1.687 \| DISEASES 124997 \| WDR81 \| 2.93 \| DISEASES 56252 \| YLPM1 \| 3.794 \| DISEASES 51530 \| ZC3HC1 \| 2.557 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1295
Disease	hepatitis e
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:121) HP:0012115 \| Liver inflammation \| 39 HP:0001399 \| Liver failure \| 32 HP:0200123 \| Chronic liver inflammation \| 21 HP:0001394 \| Hepatic cirrhosis \| 21 HP:0000952 \| Yellow skin \| 14 HP:0001402 \| Hepatocellular carcinoma \| 13 HP:0030731 \| Carcinoma \| 12 HP:0006554 \| Acute hepatic failure \| 10 HP:0200119 \| Acute liver inflammation \| 10 HP:0004448 \| Fulminant hepatic failure \| 7 HP:0001396 \| Cholestasis \| 7 HP:0001919 \| Acute renal failure \| 7 HP:0001370 \| Rheumatoid arthritis \| 6 HP:0004787 \| Fulminant hepatitis \| 6 HP:0001945 \| Fever \| 6 HP:0030151 \| Cholangitis \| 6 HP:0001903 \| Anemia \| 6 HP:0001369 \| Arthritis \| 5 HP:0002608 \| Celiac disease \| 5 HP:0002910 \| Elevated transaminases \| 5 HP:0006562 \| Viral hepatitis \| 5 HP:0002613 \| Biliary cirrhosis \| 5 HP:0001873 \| Low platelet count \| 4 HP:0001909 \| Leukemia \| 4 HP:0001878 \| Haemolytic anaemia \| 4 HP:0001733 \| Pancreatic inflammation \| 4 HP:0002960 \| Autoimmune condition \| 4 HP:0001735 \| Acute pancreatitis \| 4 HP:0001271 \| Polyneuropathy \| 3 HP:0100646 \| Thyroiditis \| 3 HP:0012410 \| Pure red cell aplasia \| 3 HP:0001890 \| Autoimmune hemolytic anemia \| 3 HP:0002665 \| Lymphoma \| 3 HP:0002583 \| Colitis \| 3 HP:0000822 \| Hypertension \| 3 HP:0001397 \| Hepatic steatosis \| 3 HP:0012531 \| Pain \| 3 HP:0001395 \| Hepatic fibrosis \| 3 HP:0100033 \| Tic disorder \| 2 HP:0012578 \| Membranous glomerulonephritis \| 2 HP:0012378 \| Fatigue \| 2 HP:0100279 \| Ulcerative colitis \| 2 HP:0001409 \| Portal hypertension \| 2 HP:0002721 \| Immunodeficiency \| 2 HP:0000819 \| Diabetes mellitus \| 2 HP:0001635 \| Congestive heart failure \| 2 HP:0010628 \| Facial palsy, unilateral or bilateral \| 2 HP:0000099 \| Glomerular nephritis \| 2 HP:0001259 \| Coma \| 2 HP:0000739 \| Anxiety \| 2 HP:0001876 \| Low blood cell count \| 2 HP:0002896 \| Liver cancer \| 2 HP:0003493 \| Elevated antinuclear antibody \| 2 HP:0002725 \| Systemic lupus erythematosus \| 2 HP:0010783 \| Erythema \| 2 HP:0100522 \| Thymoma \| 2 HP:0000083 \| Renal insufficiency \| 2 HP:0003473 \| Fatigable weakness \| 2 HP:0001414 \| Microvesicular hepatic steatosis \| 2 HP:0002586 \| Peritonitis \| 2 HP:0002664 \| Neoplasia \| 2 HP:0012119 \| Methemoglobinemia \| 1 HP:0000845 \| Acromegalic growth \| 1 HP:0003256 \| Coagulopathy \| 1 HP:0001915 \| Aplastic anemia \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0006580 \| Portal fibrosis \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0006573 \| Acute fatty liver \| 1 HP:0001406 \| Intrahepatic cholestasis \| 1 HP:0000999 \| Pyoderma \| 1 HP:0003613 \| Antiphospholipid antibodies \| 1 HP:0009125 \| Lipodystrophy \| 1 HP:0001082 \| Cholecystitis \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0100626 \| Chronic hepatic failure \| 1 HP:0009064 \| Generalized lipodystrophy \| 1 HP:0001880 \| Eosinophilia \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0012819 \| Myocarditis \| 1 HP:0001404 \| Hepatocellular necrosis \| 1 HP:0005528 \| Bone marrow hypoplasia \| 1 HP:0012309 \| Cutaneous amyloidosis \| 1 HP:0002480 \| Hepatic encephalopathy \| 1 HP:0200042 \| Skin ulcer \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0100754 \| Mania \| 1 HP:0001904 \| Autoimmune neutropenia \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0001894 \| Thrombocytosis \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0000716 \| Depression \| 1 HP:0000763 \| Sensory neuropathy \| 1 HP:0002383 \| Encephalitis \| 1 HP:0004836 \| Acute promyelocytic leukemia \| 1 HP:0030717 \| Meconium peritonitis \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0010702 \| Hypergammaglobulinaemia \| 1 HP:0001287 \| Meningitis \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0001973 \| Autoimmune thrombocytopenia \| 1 HP:0100806 \| Sepsis \| 1 HP:0009831 \| Single damaged nerve \| 1 HP:0004808 \| Acute myelogenous leukemia \| 1 HP:0007178 \| Motor polyneuropathy \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0002273 \| Tetraparesis \| 1 HP:0002018 \| Nausea \| 1 HP:0002039 \| Anorexia \| 1 HP:0003765 \| Psoriasis \| 1 HP:0001875 \| Neutropenia \| 1 HP:0002014 \| Diarrhea \| 1 HP:0100665 \| Angiooedema \| 1 HP:0005521 \| Disseminated intravascular coagulation \| 1 HP:0003202 \| Neurogenic muscle atrophy, especially in the lower limbs \| 1 HP:0000820 \| Thyroid abnormality \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0000554 \| Uveitis \| 1

Disease ID	1295
Disease	hepatitis e
Manually Symptom	UMLS \| Name(Total Manually Symptoms:20) C2707258 \| infections C2364133 \| infection C1963198 \| pancreatitis C1510479 \| neuralgic amyotrophy C1264606 \| persistent infection C0854537 \| zoonotic infection C0542035 \| erythroid hypoplasia C0400929 \| subacute hepatic failure C0276622 \| acute viral hepatitis C0275522 \| subclinical infection C0275518 \| acute infection C0272286 \| immune thrombocytopenia C0267797 \| acute hepatitis C0162557 \| fulminant hepatic failure C0042749 \| viremia C0038826 \| superinfection C0027613 \| giant cell hepatitis C0022660 \| acute renal failure C0008370 \| cholestasis C0007222 \| cardiovascular disorders
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:11) C0009450 \| infection \| 37 C0021311 \| infections \| 12 C0267797 \| acute hepatitis \| 8 C0276622 \| acute viral hepatitis \| 3 C0854537 \| zoonotic infection \| 2 C0022660 \| acute renal failure \| 2 C0038826 \| superinfection \| 1 C0030305 \| pancreatitis \| 1 C0162557 \| fulminant hepatic failure \| 1 C0042749 \| viremia \| 1 C0275518 \| acute infection \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1295
Disease	hepatitis e
Case	(Waiting for update.)

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