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	hellp syndrome

Disease ID	950
Disease	hellp syndrome
Definition	A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.
Synonym	haemolysis-elevated liver enzymes-low platelet count syndrome hellp hellp - syndrome of haemolysis, elevated liver enzymes and low platelet hellp - syndrome of hemolysis, elevated liver enzymes and low platelet hellp syndrome (disorder) hellp syndrome (hemolysis, elevated liver enzymes, low platelets) hellp syndrome [disease/finding] hemolysis, elevated liver enzymes, and low platelet count hemolysis, elevated liver enzymes, lowered platelets hemolysis-elevated liver enzymes-low platelet count syndrome hemolysis-elevated liver enzymes-low platelet count syndrome (disorder) syndrome hellp syndrome of haemolysis, elevated liver enzymes and low platelet syndrome of haemolysis, elevated liver enzymes and low platelet (disorder) syndrome of hemolysis, elevated liver enzymes and low platelet syndrome, hellp
DOID	DOID:13133
UMLS	C0162739
MeSH	D017359
SNOMED-CT	SNOMEDCT_US_2016_09_01:95605009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:31) C0032914 \| preeclampsia \| 17 C0013537 \| eclampsia \| 17 C0035078 \| renal failure \| 3 C0035305 \| retinal detachment \| 3 C0341950 \| severe pre-eclampsia \| 3 C0020538 \| hypertension \| 3 C0020538 \| hypertensive disorder \| 2 C0012739 \| disseminated intravascular coagulation \| 2 C0085278 \| antiphospholipid syndrome \| 2 C0011847 \| diabetes \| 2 C0022660 \| acute renal failure \| 2 C0085207 \| gestational diabetes \| 2 C0023895 \| liver disorder \| 1 C0023895 \| liver disorders \| 1 C0008370 \| cholestasis \| 1 C0035309 \| retinopathy \| 1 C0235250 \| hyperemesis \| 1 C0020450 \| hyperemesis gravidarum \| 1 C0028866 \| third nerve palsy \| 1 C0030326 \| panniculitis \| 1 C0043117 \| idiopathic thrombocytopenic purpura \| 1 C0019202 \| wilson's disease \| 1 C0155765 \| microangiopathy \| 1 C0011848 \| diabetes insipidus \| 1 C0043117 \| idiopathic thrombocytopenic purpura (itp) \| 1 C0034150 \| purpura \| 1 C0043117 \| immune thrombocytopenic purpura \| 1 C0398623 \| hypercoagulability \| 1 C0032001 \| pituitary apoplexy \| 1 C0013418 \| abnormal labor \| 1 C0000832 \| placental abruption \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:7) 355 \| FAS \| CIPHER 3030 \| HADHA \| CIPHER 3953 \| LEPR \| CIPHER 4524 \| MTHFR \| CIPHER 2908 \| NR3C1 \| CIPHER 5054 \| SERPINE1 \| CIPHER 7422 \| VEGFA \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:64) 37 \| ACADVL \| 1.206 \| DISEASES 8038 \| ADAM12 \| 2.707 \| DISEASES 11093 \| ADAMTS13 \| 3.673 \| DISEASES 174 \| AFP \| 1.375 \| DISEASES 196527 \| ANO6 \| 1.255 \| DISEASES 1028 \| CDKN1C \| 1.495 \| DISEASES 629 \| CFB \| 1.633 \| DISEASES 3075 \| CFH \| 1.487 \| DISEASES 10878 \| CFHR3 \| 1.556 \| DISEASES 3426 \| CFI \| 1.979 \| DISEASES 94027 \| CGB7 \| 1.682 \| DISEASES 94115 \| CGB8 \| 1.586 \| DISEASES 1308 \| COL17A1 \| 1.473 \| DISEASES 1325 \| CORT \| 1.934 \| DISEASES 1376 \| CPT2 \| 1.175 \| DISEASES 8804 \| CREG1 \| 1.685 \| DISEASES 115908 \| CTHRC1 \| 1.725 \| DISEASES 29119 \| CTNNA3 \| 1.567 \| DISEASES 10072 \| DPP3 \| 2.568 \| DISEASES 285193 \| DUSP28 \| 2.349 \| DISEASES 1906 \| EDN1 \| 1.91 \| DISEASES 2022 \| ENG \| 2.753 \| DISEASES 30816 \| ERVW-1 \| 1.024 \| DISEASES 2152 \| F3 \| 2.554 \| DISEASES 2153 \| F5 \| 2.417 \| DISEASES 2157 \| F8 \| 1.462 \| DISEASES 26190 \| FBXW2 \| 1.483 \| DISEASES 2268 \| FGR \| 1.235 \| DISEASES 2805 \| GOT1 \| 1.79 \| DISEASES 2875 \| GPT \| 1.434 \| DISEASES 2938 \| GSTA1 \| 2.071 \| DISEASES 2950 \| GSTP1 \| 1.312 \| DISEASES 3033 \| HADH \| 2.628 \| DISEASES 3030 \| HADHA \| 6.643 \| DISEASES 3032 \| HADHB \| 2.584 \| DISEASES 101101692 \| HELLPAR \| 4.605 \| DISEASES 3133 \| HLA-E \| 2.089 \| DISEASES 3240 \| HP \| 4.214 \| DISEASES 3586 \| IL10 \| 1.031 \| DISEASES 3821 \| KLRC1 \| 1.104 \| DISEASES 3822 \| KLRC2 \| 1.627 \| DISEASES 4065 \| LY75 \| 1.339 \| DISEASES 4318 \| MMP9 \| 1.31 \| DISEASES 4524 \| MTHFR \| 3.007 \| DISEASES 5069 \| PAPPA \| 2.655 \| DISEASES 60676 \| PAPPA2 \| 3.38 \| DISEASES 55742 \| PARVA \| 1.81 \| DISEASES 5094 \| PCBP2 \| 1.959 \| DISEASES 5228 \| PGF \| 4.306 \| DISEASES 5251 \| PHEX \| 1.078 \| DISEASES 5367 \| PMCH \| 1.339 \| DISEASES 135250 \| RAET1E \| 1.555 \| DISEASES 6129 \| RPL7 \| 2.249 \| DISEASES 6401 \| SELE \| 1.477 \| DISEASES 462 \| SERPINC1 \| 4.258 \| DISEASES 5270 \| SERPINE2 \| 1.207 \| DISEASES 5345 \| SERPINF2 \| 1.124 \| DISEASES 9467 \| SH3BP5 \| 1.225 \| DISEASES 946 \| SIGLEC6 \| 3.001 \| DISEASES 6888 \| TALDO1 \| 1.418 \| DISEASES 7056 \| THBD \| 2.102 \| DISEASES 7124 \| TNF \| 1.842 \| DISEASES 7422 \| VEGFA \| 1.168 \| DISEASES 25937 \| WWTR1 \| 1.343 \| DISEASES
Locus	Symbol \| Locus(Total Locus:4) CD46 \| 1q32.2 CFH \| 1q31.3 HELLPAR \| 12q23.2 CFI \| 4q25

Disease ID	950
Disease	hellp syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:27) HP:0100602 \| Pre-eclampsia \| 14 HP:0100601 \| Eclampsia \| 14 HP:0001397 \| Hepatic steatosis \| 4 HP:0006573 \| Acute fatty liver \| 4 HP:0000822 \| Hypertension \| 3 HP:0000083 \| Renal insufficiency \| 3 HP:0000541 \| Detached retina \| 3 HP:0001298 \| Encephalopathy \| 2 HP:0002910 \| Elevated transaminases \| 2 HP:0009800 \| gestational diabetes \| 2 HP:0001410 \| Decreased liver function \| 2 HP:0012231 \| Exudative retinal detachment \| 2 HP:0100603 \| Toxemia of pregnancy \| 1 HP:0000873 \| Diabetes insipidus \| 1 HP:0005521 \| Disseminated intravascular coagulation \| 1 HP:0001981 \| Schistocytosis \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0100724 \| Hypercoagulability \| 1 HP:0001342 \| Intracerebral hemorrhage \| 1 HP:0012188 \| Hyperemesis gravidarum \| 1 HP:0000952 \| Yellow skin \| 1 HP:0001873 \| Low platelet count \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0012490 \| Inflammation of fat tissue \| 1 HP:0001541 \| Ascites \| 1 HP:0001396 \| Cholestasis \| 1 HP:0000979 \| Purpura \| 1

Disease ID	950
Disease	hellp syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:22) C2717961 \| thrombotic microangiopathy C1962966 \| retinopathy C1962958 \| hematoma C1565662 \| acute renal insufficiency C1504439 \| reversible posterior leukoencephalopathy syndrome C1366535 \| diabetes insipidus C0473120 \| peritoneal hematoma C0409980 \| primary antiphospholipid syndrome C0347630 \| liver hematoma C0347630 \| hepatic hematoma C0340708 \| deep vein thrombosis C0268379 \| pseudocholinesterase deficiency C0235574 \| intravascular hemolysis C0232492 \| upper abdominal pain C0221238 \| mesangial proliferative glomerulonephritis C0085616 \| vasospasm C0085278 \| antiphospholipid syndrome C0031190 \| fetal circulation C0022660 \| acute renal failure C0020615 \| hypoglycemia C0019080 \| hemorrhage C0011854 \| type 1 diabetes
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:8) C0018944 \| hematoma \| 8 C0347630 \| liver hematoma \| 4 C0085278 \| antiphospholipid syndrome \| 2 C0347630 \| hepatic hematoma \| 1 C0022660 \| acute renal failure \| 1 C0019080 \| hemorrhage \| 1 C0035309 \| retinopathy \| 1 C0011848 \| diabetes insipidus \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	950
Disease	hellp syndrome
Case	(Waiting for update.)

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