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	glomerulonephritis

Disease ID	593
Disease	glomerulonephritis
Definition	Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.
Synonym	glomerular nephritis glomerulonephritides glomerulonephritis (disorder) glomerulonephritis [disease/finding] glomerulonephritis nos glomerulonephritis, nos gn - glomerulonephritis unspecified glomerulonephritis nos unspecified glomerulonephritis nos (disorder)
DOID	DOID:2921
UMLS	C0017658
MeSH	D005921
SNOMED-CT	SNOMEDCT_US_2016_09_01:36171008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:169) C0035078 \| renal failure \| 29 C0027726 \| nephrotic syndrome \| 20 C0022658 \| nephropathy \| 18 C0022658 \| renal disease \| 16 C0033687 \| proteinuria \| 15 C0022658 \| kidney disease \| 14 C0022661 \| end-stage renal disease \| 13 C0019158 \| hepatitis \| 11 C0022661 \| chronic renal failure \| 9 C0027697 \| nephritis \| 8 C0024141 \| systemic lupus erythematosus \| 8 C0409974 \| lupus erythematosus \| 7 C0027707 \| interstitial nephritis \| 7 C0010403 \| cryoglobulinemia \| 7 C0003873 \| rheumatoid arthritis \| 6 C0019196 \| hepatitis c \| 6 C0017661 \| iga nephropathy \| 6 C1527336 \| sjogren's syndrome \| 6 C0042384 \| vasculitis \| 6 C0022660 \| acute renal failure \| 5 C1136085 \| monoclonal gammopathy \| 5 C0022661 \| chronic kidney disease \| 5 C0014118 \| endocarditis \| 5 C0024299 \| lymphoma \| 4 C0019163 \| hepatitis b \| 4 C0021053 \| immune disease \| 4 C0022661 \| end-stage kidney disease \| 4 C0035078 \| kidney failure \| 4 C0017665 \| membranous nephropathy \| 3 C0042769 \| virus infection \| 3 C0026764 \| multiple myeloma \| 3 C0020538 \| hypertension \| 3 C0003864 \| arthritis \| 3 C0041349 \| tubulointerstitial nephritis \| 3 C0085273 \| parvovirus b19 infection \| 3 C0017668 \| focal segmental glomerulosclerosis \| 3 C0031069 \| familial mediterranean fever \| 3 C0178664 \| glomerulosclerosis \| 3 C0002871 \| anemia \| 3 C0032285 \| pneumoniae \| 2 C0022679 \| cystic kidney \| 2 C1261473 \| sarcoma \| 2 C0043092 \| wegener's granulomatosis \| 2 C0036202 \| sarcoidosis \| 2 C0032285 \| pneumonia \| 2 C0042373 \| vascular disease \| 2 C0004623 \| bacterial infection \| 2 C0010403 \| cryoglobulinaemia \| 2 C0024198 \| lyme disease \| 2 C0011849 \| diabetes mellitus \| 2 C0015974 \| periodic fever \| 2 C0014122 \| subacute bacterial endocarditis \| 2 C0008728 \| churg-strauss syndrome \| 2 C0038463 \| strongyloidiasis \| 2 C0022661 \| end-stage renal failure \| 2 C0021400 \| influenza \| 2 C0014121 \| bacterial endocarditis \| 2 C0024143 \| lupus nephritis \| 2 C0011847 \| diabetes \| 2 C0034150 \| purpura \| 2 C0041296 \| tuberculosis \| 1 C0032305 \| pneumocystis jiroveci pneumonia \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0032302 \| mycoplasma pneumonia \| 1 C0032269 \| pneumococcal infection \| 1 C0036220 \| kaposi sarcoma \| 1 C0920350 \| autoimmune thyroiditis \| 1 C0004943 \| behcet's syndrome \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0007222 \| cardiovascular disease \| 1 C0019100 \| dengue haemorrhagic fever \| 1 C0018784 \| sensorineural hearing loss \| 1 C0149925 \| small cell carcinoma \| 1 C0020541 \| portal hypertension \| 1 C0034362 \| q fever \| 1 C0241910 \| autoimmune hepatitis \| 1 C0040028 \| essential thrombocytosis \| 1 C0155765 \| microangiopathy \| 1 C0155862 \| pneumococcal pneumonia \| 1 C0034152 \| henoch-schonlein purpura \| 1 C0456909 \| blindness \| 1 C0019061 \| hemolytic uremic syndrome \| 1 C0403529 \| goodpasture's syndrome \| 1 C0684249 \| carcinoma of the lung \| 1 C0034065 \| pulmonary embolism \| 1 C0009782 \| connective tissue disease \| 1 C0282193 \| iron overload \| 1 C0033626 \| protein deficiency \| 1 C0007102 \| colon cancer \| 1 C0078911 \| hiv-associated nephropathy \| 1 C0028754 \| obesity \| 1 C0024535 \| plasmodium falciparum malaria \| 1 C0393819 \| chronic inflammatory demyelinating polyneuropathy \| 1 C0949690 \| spondyloarthritis \| 1 C0034155 \| thrombotic thrombocytopenic purpura \| 1 C0036421 \| systemic sclerosis \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0007939 \| chancre \| 1 C0011644 \| scleroderma \| 1 C0010346 \| crohn's disease \| 1 C0035436 \| rheumatic fever \| 1 C0008049 \| varicella \| 1 C0023343 \| leprosy \| 1 C0032285 \| pneumonitis \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0040053 \| thrombosis \| 1 C0022658 \| nephropathies \| 1 C1136084 \| plasma cell dyscrasia \| 1 C0019360 \| zoster \| 1 C0009324 \| ulcerative colitis \| 1 C0010414 \| cryptococcosis \| 1 C0043194 \| wiskott-aldrich syndrome \| 1 C0085413 \| autosomal dominant polycystic kidney disease \| 1 C0748540 \| limited scleroderma \| 1 C0149925 \| small cell carcinoma of the lung \| 1 C0014122 \| infectious endocarditis \| 1 C0349632 \| splenic marginal zone lymphoma \| 1 C0155320 \| cortical blindness \| 1 C0032533 \| polymyalgia rheumatica \| 1 C0017665 \| membranous glomerulopathy \| 1 C0022658 \| kidney diseases \| 1 C0024198 \| borrelia burgdorferi infection \| 1 C0019829 \| hodgkin lymphoma \| 1 C0001339 \| acute pancreatitis \| 1 C0011633 \| dermatomyositis \| 1 C0242379 \| lung cancer \| 1 C0014121 \| infective endocarditis \| 1 C0031090 \| periodontal disease \| 1 C0019061 \| hemolytic-uremic syndrome \| 1 C0030305 \| pancreatitis \| 1 C0036205 \| pulmonary sarcoidosis \| 1 C0036319 \| schistosoma mansoni \| 1 C1565489 \| renal insufficiency \| 1 C0796004 \| kabuki syndrome \| 1 C0042769 \| viral infection \| 1 C0155550 \| neural deafness \| 1 C0007131 \| non-small cell carcinoma of the lung \| 1 C0042721 \| viral hepatitis \| 1 C0403416 \| crescentic glomerulonephritis \| 1 C0017662 \| membranoproliferative glomerulonephritis \| 1 C0019829 \| hodgkin's disease \| 1 C0007222 \| cardiovascular diseases \| 1 C0026272 \| mixed connective tissue disease \| 1 C0042373 \| vascular diseases \| 1 C0002878 \| hemolytic anemia \| 1 C0033838 \| kimura's disease \| 1 C0600327 \| toxic shock syndrome \| 1 C0235618 \| proliferative glomerulonephritis \| 1 C0748540 \| limited cutaneous systemic sclerosis \| 1 C0042769 \| viral diseases \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0041349 \| tubulo-interstitial nephritis \| 1 C0042769 \| viral disease \| 1 C0018799 \| heart disease \| 1 C0018784 \| sensorineural deafness \| 1 C0041948 \| uremia \| 1 C0038160 \| staphylococcal infection \| 1 C0036323 \| schistosomiasis \| 1 C0032302 \| mycoplasma pneumoniae pneumonia \| 1 C0271270 \| cogan syndrome \| 1 C0334634 \| mantle cell lymphoma \| 1 C0017668 \| focal sclerosing glomerulonephritis \| 1 C0403447 \| chronic renal insufficiency \| 1 C0020676 \| hypothyroidism \| 1 C0085413 \| autosomal dominant polycystic kidney \| 1 C0019163 \| hepatitis b infection \| 1 C0038160 \| staphylococcus infection \| 1 C0026934 \| mycoplasma \| 1 C0022661 \| chronic kidney failure \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:30) 213 \| ALB \| CTD_human 1675 \| CFD \| CTD_human 7124 \| TNF \| CTD_human 3553 \| IL1B \| CTD_human 5443 \| POMC \| CTD_human 3458 \| IFNG \| CTD_human 1674 \| DES \| CTD_human 3569 \| IL6 \| CTD_human 5468 \| PPARG \| CTD_human 3558 \| IL2 \| CTD_human 3559 \| IL2RA \| CTD_human 183 \| AGT \| CTD_human 7490 \| WT1 \| CTD_human 3586 \| IL10 \| CTD_human 3576 \| CXCL8 \| CTD_human 4803 \| NGF \| CTD_human 6347 \| CCL2 \| CTD_human 2099 \| ESR1 \| CTD_human 3727 \| JUND \| CTD_human 3606 \| IL18 \| CTD_human 4868 \| NPHS1 \| CTD_human 6354 \| CCL7 \| CTD_human 6351 \| CCL4 \| CTD_human 6352 \| CCL5 \| CTD_human 6348 \| CCL3 \| CTD_human 6346 \| CCL1 \| CTD_human 2833 \| CXCR3 \| CTD_human 133 \| ADM \| CTD_human 406892 \| MIR100 \| CTD_human 406903 \| MIR10B \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:37) 1636 \| ACE \| CIPHER 183 \| AGT \| CIPHER;CTD_human 185 \| AGTR1 \| CIPHER 929 \| CD14 \| CIPHER 3075 \| CFH \| CIPHER 81494 \| CFHR5 \| CIPHER 142 \| PARP1 \| CIPHER 5444 \| PON1 \| CIPHER 3576 \| CXCL8 \| CTD_human 5468 \| PPARG \| CTD_human 7490 \| WT1 \| CTD_human 3586 \| IL10 \| CTD_human 3606 \| IL18 \| CTD_human 3558 \| IL2 \| CTD_human 3569 \| IL6 \| CTD_human 6354 \| CCL7 \| CTD_human 6351 \| CCL4 \| CTD_human 6352 \| CCL5 \| CTD_human 6347 \| CCL2 \| CTD_human 6348 \| CCL3 \| CTD_human 6346 \| CCL1 \| CTD_human 1674 \| DES \| CTD_human 2833 \| CXCR3 \| CTD_human 7124 \| TNF \| CTD_human 3727 \| JUND \| CTD_human 4868 \| NPHS1 \| CTD_human 5443 \| POMC \| CTD_human 133 \| ADM \| CTD_human 2099 \| ESR1 \| CTD_human 3458 \| IFNG \| CTD_human 4803 \| NGF \| CTD_human 406892 \| MIR100 \| CTD_human 406903 \| MIR10B \| CTD_human 213 \| ALB \| CTD_human 3559 \| IL2RA \| CTD_human 1675 \| CFD \| CTD_human 3553 \| IL1B \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:336) 2 \| A2M \| 2.145 \| DISEASES 54988 \| ACSM5 \| 1.516 \| DISEASES 60 \| ACTB \| 2.334 \| DISEASES 10881 \| ACTL7A \| 1.264 \| DISEASES 10880 \| ACTL7B \| 1.019 \| DISEASES 87 \| ACTN1 \| 2.404 \| DISEASES 11093 \| ADAMTS13 \| 2.251 \| DISEASES 55811 \| ADCY10 \| 1.397 \| DISEASES 9370 \| ADIPOQ \| 1.448 \| DISEASES 2334 \| AFF2 \| 2.005 \| DISEASES 375790 \| AGRN \| 1.215 \| DISEASES 183 \| AGT \| 3.674 \| DISEASES 186 \| AGTR2 \| 1.485 \| DISEASES 79868 \| ALG13 \| 1.586 \| DISEASES 240 \| ALOX5 \| 1.998 \| DISEASES 57182 \| ANKRD50 \| 1.416 \| DISEASES 302 \| ANXA2 \| 1.599 \| DISEASES 55082 \| ARGLU1 \| 2.281 \| DISEASES 551 \| AVP \| 1.336 \| DISEASES 567 \| B2M \| 4.037 \| DISEASES 8702 \| B4GALT4 \| 1.616 \| DISEASES 29086 \| BABAM1 \| 2.3 \| DISEASES 596 \| BCL2 \| 1.293 \| DISEASES 633 \| BGN \| 2.417 \| DISEASES 390259 \| BSX \| 1.315 \| DISEASES 714 \| C1QC \| 1.134 \| DISEASES 716 \| C1S \| 3.364 \| DISEASES 720 \| C4A \| 3.344 \| DISEASES 721 \| C4B \| 3.736 \| DISEASES 728 \| C5AR1 \| 2.168 \| DISEASES 153571 \| C5orf38 \| 1.164 \| DISEASES 79886 \| CAAP1 \| 1.477 \| DISEASES 11094 \| CACFD1 \| 2.374 \| DISEASES 834 \| CASP1 \| 2.286 \| DISEASES 841 \| CASP8 \| 1.461 \| DISEASES 6364 \| CCL20 \| 2.017 \| DISEASES 388372 \| CCL4L1 \| 2.137 \| DISEASES 6354 \| CCL7 \| 1.372 \| DISEASES 9332 \| CD163 \| 1.851 \| DISEASES 930 \| CD19 \| 3.176 \| DISEASES 911 \| CD1C \| 1.87 \| DISEASES 912 \| CD1D \| 1.45 \| DISEASES 29126 \| CD274 \| 1.484 \| DISEASES 23607 \| CD2AP \| 3.697 \| DISEASES 342510 \| CD300E \| 1.314 \| DISEASES 146894 \| CD300LG \| 2.198 \| DISEASES 958 \| CD40 \| 3.167 \| DISEASES 959 \| CD40LG \| 6.177 \| DISEASES 960 \| CD44 \| 3.343 \| DISEASES 921 \| CD5 \| 2.595 \| DISEASES 966 \| CD59 \| 2.848 \| DISEASES 942 \| CD86 \| 2.31 \| DISEASES 55561 \| CDC42BPG \| 1.858 \| DISEASES 1029 \| CDKN2A \| 2.057 \| DISEASES 1041 \| CDSN \| 1.824 \| DISEASES 629 \| CFB \| 3.438 \| DISEASES 3075 \| CFH \| 4.248 \| DISEASES 3080 \| CFHR2 \| 1.552 \| DISEASES 10878 \| CFHR3 \| 3.247 \| DISEASES 10877 \| CFHR4 \| 1.516 \| DISEASES 3426 \| CFI \| 3.094 \| DISEASES 1184 \| CLCN5 \| 2.024 \| DISEASES 170482 \| CLEC4C \| 1.758 \| DISEASES 80790 \| CMIP \| 1.177 \| DISEASES 1285 \| COL4A3 \| 4.763 \| DISEASES 1286 \| COL4A4 \| 3.874 \| DISEASES 1287 \| COL4A5 \| 3.811 \| DISEASES 51004 \| COQ6 \| 1.435 \| DISEASES 1363 \| CPE \| 1.123 \| DISEASES 1369 \| CPN1 \| 2.423 \| DISEASES 1378 \| CR1 \| 3.619 \| DISEASES 1380 \| CR2 \| 1.913 \| DISEASES 286204 \| CRB2 \| 2.308 \| DISEASES 155051 \| CRYGN \| 2.924 \| DISEASES 1435 \| CSF1 \| 2.55 \| DISEASES 1471 \| CST3 \| 2.903 \| DISEASES 1490 \| CTGF \| 3.311 \| DISEASES 1499 \| CTNNB1 \| 1.082 \| DISEASES 8029 \| CUBN \| 1.35 \| DISEASES 1524 \| CX3CR1 \| 2.679 \| DISEASES 2919 \| CXCL1 \| 2.343 \| DISEASES 6387 \| CXCL12 \| 1.485 \| DISEASES 2920 \| CXCL2 \| 1.361 \| DISEASES 4283 \| CXCL9 \| 1.856 \| DISEASES 2833 \| CXCR3 \| 2.508 \| DISEASES 7852 \| CXCR4 \| 1.561 \| DISEASES 1585 \| CYP11B2 \| 2.362 \| DISEASES 1555 \| CYP2B6 \| 1.026 \| DISEASES 85443 \| DCLK3 \| 1.896 \| DISEASES 23109 \| DDN \| 1.823 \| DISEASES 51428 \| DDX41 \| 4.304 \| DISEASES 23586 \| DDX58 \| 2.009 \| DISEASES 1791 \| DNTT \| 1.732 \| DISEASES 1803 \| DPP4 \| 1.356 \| DISEASES 6993 \| DYNLT1 \| 1.247 \| DISEASES 1896 \| EDA \| 4.52 \| DISEASES 1906 \| EDN1 \| 3.475 \| DISEASES 1908 \| EDN3 \| 1.383 \| DISEASES 1910 \| EDNRB \| 1.91 \| DISEASES 954 \| ENTPD2 \| 1.649 \| DISEASES 3266 \| ERAS \| 1.202 \| DISEASES 30816 \| ERVW-1 \| 1.849 \| DISEASES 2113 \| ETS1 \| 1.352 \| DISEASES 7430 \| EZR \| 2.25 \| DISEASES 2159 \| F10 \| 1.428 \| DISEASES 2152 \| F3 \| 3.062 \| DISEASES 2187 \| FANCB \| 1.813 \| DISEASES 356 \| FASLG \| 2.105 \| DISEASES 64319 \| FBRS \| 2.244 \| DISEASES 2204 \| FCAR \| 5.064 \| DISEASES 2209 \| FCGR1A \| 1.972 \| DISEASES 2213 \| FCGR2B \| 3.545 \| DISEASES 2214 \| FCGR3A \| 2.632 \| DISEASES 2258 \| FGF13 \| 1.244 \| DISEASES 342184 \| FMN1 \| 3.142 \| DISEASES 2335 \| FN1 \| 2.029 \| DISEASES 2290 \| FOXG1 \| 2.288 \| DISEASES 50943 \| FOXP3 \| 3.38 \| DISEASES 2526 \| FUT4 \| 1.249 \| DISEASES 2534 \| FYN \| 1.597 \| DISEASES 2585 \| GALK2 \| 2.242 \| DISEASES 2590 \| GALNT2 \| 2.038 \| DISEASES 60674 \| GAS5 \| 1.12 \| DISEASES 2621 \| GAS6 \| 1.221 \| DISEASES 2625 \| GATA3 \| 1.537 \| DISEASES 2638 \| GC \| 1.402 \| DISEASES 11146 \| GLMN \| 1.149 \| DISEASES 29933 \| GPR132 \| 1.302 \| DISEASES 8908 \| GYG2 \| 2.179 \| DISEASES 64412 \| GZF1 \| 1.453 \| DISEASES 3005 \| H1F0 \| 1.776 \| DISEASES 3029 \| HAGH \| 1.536 \| DISEASES 26762 \| HAVCR1 \| 3.408 \| DISEASES 3039 \| HBA1 \| 1.646 \| DISEASES 3052 \| HCCS \| 1.75 \| DISEASES 51020 \| HDDC2 \| 1.899 \| DISEASES 28996 \| HIPK2 \| 1.112 \| DISEASES 8341 \| HIST1H2BN \| 2.72 \| DISEASES 8337 \| HIST2H2AA3 \| 2.635 \| DISEASES 8338 \| HIST2H2AC \| 2.635 \| DISEASES 8349 \| HIST2H2BE \| 3.058 \| DISEASES 3105 \| HLA-A \| 3.431 \| DISEASES 3106 \| HLA-B \| 2.429 \| DISEASES 3115 \| HLA-DPB1 \| 1.461 \| DISEASES 3117 \| HLA-DQA1 \| 2.872 \| DISEASES 3118 \| HLA-DQA2 \| 3.134 \| DISEASES 3119 \| HLA-DQB1 \| 2.152 \| DISEASES 3120 \| HLA-DQB2 \| 1.675 \| DISEASES 3123 \| HLA-DRB1 \| 2.09 \| DISEASES 3127 \| HLA-DRB5 \| 1.096 \| DISEASES 8091 \| HMGA2 \| 1.535 \| DISEASES 3146 \| HMGB1 \| 2.365 \| DISEASES 150280 \| HORMAD2 \| 1.799 \| DISEASES 3240 \| HP \| 2.103 \| DISEASES 3320 \| HSP90AA1 \| 1.609 \| DISEASES 3309 \| HSPA5 \| 1.282 \| DISEASES 3339 \| HSPG2 \| 1.916 \| DISEASES 23308 \| ICOSLG \| 1.112 \| DISEASES 3440 \| IFNA2 \| 1.908 \| DISEASES 3456 \| IFNB1 \| 2.24 \| DISEASES 3476 \| IGBP1 \| 1.17 \| DISEASES 3543 \| IGLL1 \| 1.044 \| DISEASES 3321 \| IGSF3 \| 1.669 \| DISEASES 150084 \| IGSF5 \| 1.324 \| DISEASES 22806 \| IKZF3 \| 1.032 \| DISEASES 3586 \| IL10 \| 3.957 \| DISEASES 3594 \| IL12RB1 \| 1.131 \| DISEASES 3605 \| IL17A \| 3.833 \| DISEASES 112744 \| IL17F \| 1.04 \| DISEASES 23765 \| IL17RA \| 1.438 \| DISEASES 3559 \| IL2RA \| 1.825 \| DISEASES 64423 \| INF2 \| 4.476 \| DISEASES 3654 \| IRAK1 \| 1.318 \| DISEASES 51135 \| IRAK4 \| 1.23 \| DISEASES 3663 \| IRF5 \| 1.962 \| DISEASES 3665 \| IRF7 \| 1.426 \| DISEASES 3683 \| ITGAL \| 2.072 \| DISEASES 3684 \| ITGAM \| 2.828 \| DISEASES 3725 \| JUN \| 2.362 \| DISEASES 55083 \| KIF26B \| 1.636 \| DISEASES 55243 \| KIRREL \| 1.824 \| DISEASES 84063 \| KIRREL2 \| 1.819 \| DISEASES 9365 \| KL \| 1.857 \| DISEASES 9622 \| KLK4 \| 3.14 \| DISEASES 284217 \| LAMA1 \| 1.516 \| DISEASES 3920 \| LAMP2 \| 2.111 \| DISEASES 143903 \| LAYN \| 1.056 \| DISEASES 4010 \| LMX1B \| 1.686 \| DISEASES 4018 \| LPA \| 1.387 \| DISEASES 4049 \| LTA \| 1.368 \| DISEASES 4067 \| LYN \| 3.007 \| DISEASES 5599 \| MAPK8 \| 2.203 \| DISEASES 10747 \| MASP2 \| 1.451 \| DISEASES 4153 \| MBL2 \| 3.24 \| DISEASES 4192 \| MDK \| 1.211 \| DISEASES 8972 \| MGAM \| 1.244 \| DISEASES 10724 \| MGEA5 \| 4.125 \| DISEASES 4311 \| MME \| 2.716 \| DISEASES 4318 \| MMP9 \| 2.525 \| DISEASES 4478 \| MSN \| 1.239 \| DISEASES 4485 \| MST1 \| 1.158 \| DISEASES 92170 \| MTG1 \| 1.818 \| DISEASES 8897 \| MTMR3 \| 2.141 \| DISEASES 2475 \| MTOR \| 2.035 \| DISEASES 200958 \| MUC20 \| 2.537 \| DISEASES 4599 \| MX1 \| 1.197 \| DISEASES 4615 \| MYD88 \| 2.338 \| DISEASES 4668 \| NAGA \| 1.577 \| DISEASES 10763 \| NES \| 1.462 \| DISEASES 4772 \| NFATC1 \| 1.22 \| DISEASES 4780 \| NFE2L2 \| 1.048 \| DISEASES 387921 \| NHLRC3 \| 1.82 \| DISEASES 55922 \| NKRF \| 1.008 \| DISEASES 57486 \| NLN \| 1.165 \| DISEASES 114548 \| NLRP3 \| 2.152 \| DISEASES 4842 \| NOS1 \| 1.475 \| DISEASES 4843 \| NOS2 \| 2.738 \| DISEASES 344022 \| NOTO \| 1.294 \| DISEASES 256933 \| NPB \| 1.169 \| DISEASES 4868 \| NPHS1 \| 5.674 \| DISEASES 7827 \| NPHS2 \| 5.852 \| DISEASES 255743 \| NPNT \| 1.49 \| DISEASES 4306 \| NR3C2 \| 1.139 \| DISEASES 51559 \| NT5DC3 \| 2.361 \| DISEASES 4942 \| OAT \| 1.636 \| DISEASES 4948 \| OCA2 \| 1.476 \| DISEASES 26578 \| OSTF1 \| 1.678 \| DISEASES 340990 \| OTOG \| 1.928 \| DISEASES 5076 \| PAX2 \| 2.181 \| DISEASES 5133 \| PDCD1 \| 1.027 \| DISEASES 5154 \| PDGFA \| 2.936 \| DISEASES 5155 \| PDGFB \| 3.556 \| DISEASES 56034 \| PDGFC \| 1.273 \| DISEASES 80310 \| PDGFD \| 2.563 \| DISEASES 57107 \| PDSS2 \| 1.787 \| DISEASES 57162 \| PELI1 \| 1.502 \| DISEASES 5236 \| PGM1 \| 1.568 \| DISEASES 5251 \| PHEX \| 1.284 \| DISEASES 9063 \| PIAS2 \| 1.203 \| DISEASES 5277 \| PIGA \| 3.731 \| DISEASES 23556 \| PIGN \| 4.991 \| DISEASES 5284 \| PIGR \| 2.253 \| DISEASES 5294 \| PIK3CG \| 1.018 \| DISEASES 5321 \| PLA2G4A \| 1.111 \| DISEASES 5328 \| PLAU \| 1.274 \| DISEASES 5329 \| PLAUR \| 2.456 \| DISEASES 59339 \| PLEKHA2 \| 1.22 \| DISEASES 5420 \| PODXL \| 4.63 \| DISEASES 9989 \| PPP4R1 \| 1.143 \| DISEASES 56980 \| PRDM10 \| 1.493 \| DISEASES 5587 \| PRKD1 \| 1.63 \| DISEASES 5698 \| PSMB9 \| 1.41 \| DISEASES 5730 \| PTGDS \| 1.696 \| DISEASES 5743 \| PTGS2 \| 1.924 \| DISEASES 5777 \| PTPN6 \| 1.045 \| DISEASES 5788 \| PTPRC \| 2.548 \| DISEASES 2889 \| RAPGEF1 \| 3.757 \| DISEASES 5962 \| RDX \| 1.401 \| DISEASES 387 \| RHOA \| 1.838 \| DISEASES 6014 \| RIT2 \| 1.218 \| DISEASES 55328 \| RNLS \| 1.469 \| DISEASES 6139 \| RPL17 \| 1.399 \| DISEASES 6187 \| RPS2 \| 4.17 \| DISEASES 23168 \| RTF1 \| 1.17 \| DISEASES 6280 \| S100A9 \| 1.172 \| DISEASES 22908 \| SACM1L \| 1.225 \| DISEASES 22904 \| SBNO2 \| 1.118 \| DISEASES 6401 \| SELE \| 2.936 \| DISEASES 10507 \| SEMA4D \| 1.07 \| DISEASES 5265 \| SERPINA1 \| 2.964 \| DISEASES 1992 \| SERPINB1 \| 1.593 \| DISEASES 8710 \| SERPINB7 \| 4.027 \| DISEASES 5271 \| SERPINB8 \| 2.033 \| DISEASES 5272 \| SERPINB9 \| 1.104 \| DISEASES 462 \| SERPINC1 \| 2.563 \| DISEASES 5345 \| SERPINF2 \| 2.246 \| DISEASES 871 \| SERPINH1 \| 1.499 \| DISEASES 51460 \| SFMBT1 \| 1.148 \| DISEASES 6446 \| SGK1 \| 1.303 \| DISEASES 6614 \| SIGLEC1 \| 1.985 \| DISEASES 348235 \| SKA2 \| 1.529 \| DISEASES 9748 \| SLK \| 4.127 \| DISEASES 4088 \| SMAD3 \| 2.277 \| DISEASES 50485 \| SMARCAL1 \| 2.71 \| DISEASES 27293 \| SMPDL3B \| 2.359 \| DISEASES 27099 \| SND1-IT1 \| 1.455 \| DISEASES 677807 \| SNORA22 \| 2.256 \| DISEASES 6625 \| SNRNP70 \| 2.86 \| DISEASES 8651 \| SOCS1 \| 1.178 \| DISEASES 6693 \| SPN \| 1.758 \| DISEASES 6696 \| SPP1 \| 3.561 \| DISEASES 10253 \| SPRY2 \| 1.172 \| DISEASES 144108 \| SPTY2D1 \| 1.86 \| DISEASES 6714 \| SRC \| 1.762 \| DISEASES 6772 \| STAT1 \| 2.151 \| DISEASES 6775 \| STAT4 \| 1.846 \| DISEASES 6850 \| SYK \| 2.629 \| DISEASES 11346 \| SYNPO \| 5.269 \| DISEASES 7062 \| TCHH \| 1.009 \| DISEASES 7018 \| TF \| 2.936 \| DISEASES 7037 \| TFRC \| 2.602 \| DISEASES 7041 \| TGFB1I1 \| 2.068 \| DISEASES 7042 \| TGFB2 \| 1.81 \| DISEASES 7052 \| TGM2 \| 1.977 \| DISEASES 7056 \| THBD \| 2.604 \| DISEASES 102659353 \| THRIL \| 1.158 \| DISEASES 221981 \| THSD7A \| 4.42 \| DISEASES 7096 \| TLR1 \| 1.822 \| DISEASES 7099 \| TLR4 \| 2.663 \| DISEASES 7100 \| TLR5 \| 3.478 \| DISEASES 51284 \| TLR7 \| 3.87 \| DISEASES 54106 \| TLR9 \| 3.887 \| DISEASES 7124 \| TNF \| 4.712 \| DISEASES 51330 \| TNFRSF12A \| 3.349 \| DISEASES 7133 \| TNFRSF1B \| 2.656 \| DISEASES 8718 \| TNFRSF25 \| 3.641 \| DISEASES 7293 \| TNFRSF4 \| 1.945 \| DISEASES 8742 \| TNFSF12 \| 3.964 \| DISEASES 8741 \| TNFSF13 \| 3.031 \| DISEASES 10673 \| TNFSF13B \| 4.263 \| DISEASES 7189 \| TRAF6 \| 1.503 \| DISEASES 51499 \| TRIAP1 \| 5.265 \| DISEASES 7222 \| TRPC3 \| 1.271 \| DISEASES 7225 \| TRPC6 \| 4.562 \| DISEASES 10194 \| TSHZ1 \| 1.345 \| DISEASES 85480 \| TSLP \| 1.91 \| DISEASES 55284 \| UBE2W \| 1.239 \| DISEASES 7422 \| VEGFA \| 2.886 \| DISEASES 11326 \| VSIG4 \| 1.241 \| DISEASES 7454 \| WAS \| 1.008 \| DISEASES 23038 \| WDTC1 \| 1.199 \| DISEASES 7490 \| WT1 \| 4.145 \| DISEASES 23051 \| ZHX3 \| 1.355 \| DISEASES 57178 \| ZMIZ1 \| 1.059 \| DISEASES 125919 \| ZNF543 \| 2.326 \| DISEASES 100128252 \| ZNF667-AS1 \| 1.299 \| DISEASES
Locus	(Waiting for update.)

Disease ID	593
Disease	glomerulonephritis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:87) HP:0000083 \| Renal insufficiency \| 33 HP:0003774 \| End-stage renal failure \| 26 HP:0000100 \| Nephrosis \| 21 HP:0000093 \| Proteinuria \| 18 HP:0000112 \| Nephropathy \| 17 HP:0012115 \| Liver inflammation \| 12 HP:0002725 \| Systemic lupus erythematosus \| 10 HP:0000123 \| Nephritis \| 9 HP:0002633 \| Vasculitis \| 8 HP:0001919 \| Acute renal failure \| 8 HP:0001945 \| Fever \| 7 HP:0001970 \| Interstitial nephritis \| 7 HP:0100778 \| Cryoglobulinemia \| 7 HP:0002960 \| Autoimmune condition \| 6 HP:0001370 \| Rheumatoid arthritis \| 6 HP:0012622 \| Chronic kidney disease \| 5 HP:0000096 \| Glomerulosclerosis \| 4 HP:0002665 \| Lymphoma \| 4 HP:0100584 \| Endocarditis \| 4 HP:0001903 \| Anemia \| 4 HP:0012574 \| Mesangial hypercellularity \| 3 HP:0001369 \| Arthritis \| 3 HP:0000822 \| Hypertension \| 3 HP:0012578 \| Membranous glomerulonephritis \| 3 HP:0000097 \| focal glomerulosclerosis \| 3 HP:0006689 \| Bacterial endocarditis \| 3 HP:0006775 \| Multiple myeloma \| 3 HP:0100820 \| Glomerulopathy \| 3 HP:0002090 \| Pneumonia \| 2 HP:0003003 \| Colon cancer \| 2 HP:0012587 \| Gross hematuria \| 2 HP:0000790 \| Hematuria \| 2 HP:0000113 \| Polycystic kidney dysplasia \| 2 HP:0100242 \| Sarcoma \| 2 HP:0005575 \| Hemolytic-uremic syndrome \| 2 HP:0000979 \| Purpura \| 2 HP:0000819 \| Diabetes mellitus \| 2 HP:0011034 \| Amyloid disease \| 2 HP:0000407 \| sensorineural hearing loss \| 2 HP:0012189 \| Hodgkin disease \| 2 HP:0002955 \| Granulomatosis \| 2 HP:0002584 \| Intestinal hemorrhage \| 2 HP:0200123 \| Chronic liver inflammation \| 2 HP:0001395 \| Hepatic fibrosis \| 1 HP:0000821 \| Underactive thyroid \| 1 HP:0012531 \| Pain \| 1 HP:0200120 \| Chronic active hepatitis \| 1 HP:0100699 \| Scarring \| 1 HP:0003073 \| Hypoalbuminaemia \| 1 HP:0004722 \| Thickening of the glomerular basement membrane \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0000127 \| Salt wasting \| 1 HP:0008653 \| Crescentic glomerulonephritis \| 1 HP:0000365 \| Hearing impairment \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0004313 \| Decreased immunoglobulin level \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0100806 \| Sepsis \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0004737 \| Global glomerulosclerosis \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0030731 \| Carcinoma \| 1 HP:0100704 \| Cortical visual impairment \| 1 HP:0030150 \| Plasmacytosis \| 1 HP:0001917 \| Renal amyloidosis \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0001513 \| Obesity \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0006532 \| Pneumonia, recurrent episodes \| 1 HP:0006562 \| Viral hepatitis \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0000618 \| Blindness \| 1 HP:0100279 \| Ulcerative colitis \| 1 HP:0000078 \| Genital abnormalities \| 1 HP:0001744 \| Splenomegaly \| 1 HP:0001409 \| Portal hypertension \| 1 HP:0000793 \| Membranoproliferative glomerulonephritis \| 1 HP:0000572 \| Visual loss \| 1 HP:0012597 \| Heavy proteinuria \| 1 HP:0100324 \| Progressive systemic scleroderma \| 1 HP:0002170 \| Intracranial hemorrhage \| 1 HP:0000969 \| Dropsy \| 1 HP:0001581 \| Recurrent skin infections \| 1 HP:0004729 \| Acute tubulointerstitial nephritis \| 1

Disease ID	593
Disease	glomerulonephritis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:79) C2697310 \| sarcoidosis C2364133 \| infection C1963274 \| vasculitis C1963154 \| renal failure C1963138 \| hypertension C1962972 \| proteinuria C1881236 \| interstitial disease C1839611 \| n syndrome C1827745 \| disseminated mycobacterium gordonae infection C1579029 \| chronic uremia C1565489 \| renal insufficiency C1417247 \| glomerulosclerosis C1373218 \| immunosuppression C0948347 \| nephroangiosclerosis C0948265 \| metabolic syndrome C0748159 \| pulmonary involvement C0746556 \| metabolic disturbance C0730345 \| microalbuminuria C0728936 \| circulatory disorders C0426359 \| urinary symptoms C0403447 \| chronic renal insufficiency C0403447 \| chronic renal disease C0343208 \| essential mixed cryoglobulinemia C0334054 \| cystic disease C0265050 \| vena cava thrombosis C0235989 \| renal interstitial fibrosis C0206061 \| interstitial pneumonitis C0178664 \| glomerular sclerosis C0162538 \| selective iga deficiency C0155862 \| pneumococcal pneumonia C0155616 \| secondary hypertension C0154251 \| lipid metabolism disorders C0151620 \| hypertensive encephalopathy C0149746 \| orthostasis C0086981 \| sicca syndrome C0042384 \| vasculitides C0041349 \| tubulointerstitial nephritis C0040188 \| tic disorders C0039263 \| takayasu's arteritis C0038395 \| streptococcal infection C0037140 \| b virus infection C0036416 \| scleritis C0034186 \| pyelonephritis C0034150 \| purpura C0034063 \| pulmonary edema C0033117 \| priapism C0032962 \| pregnancy complications C0032285 \| pneumonia C0032227 \| pleural effusions C0027726 \| nephrotic syndromes C0027726 \| nephrotic syndrome C0027707 \| interstitial nephritis C0025517 \| metabolic disorders C0025517 \| metabolic disorder C0024141 \| systemic lupus erythematosus C0022661 \| end-stage renal disease C0022661 \| chronic renal failure C0022661 \| chronic kidney failure C0022660 \| acute renal failure C0022660 \| acute kidney failure C0022658 \| renal disease C0022521 \| kartagener syndrome C0021053 \| immune disorders C0020807 \| pulmonary hemosiderosis C0020639 \| hypoproteinaemia C0020538 \| systemic hypertension C0020488 \| sodium retention C0019163 \| hepatitis b infection C0019158 \| hepatitis C0019080 \| hemorrhage C0014378 \| enterovirus infections C0014118 \| endocarditis C0010403 \| cryoglobulinemia C0010403 \| cryoglobulinaemia C0007134 \| renal adenocarcinoma C0005940 \| bone diseases C0005779 \| blood coagulation disorders C0004364 \| autoimmune disease C0004153 \| atherosclerosis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:33) C0035078 \| renal failure \| 32 C0022658 \| renal disease \| 18 C0033687 \| proteinuria \| 18 C0027726 \| nephrotic syndrome \| 18 C0009450 \| infection \| 15 C0022661 \| end-stage renal disease \| 14 C0019158 \| hepatitis \| 12 C0022661 \| chronic renal failure \| 10 C0024141 \| systemic lupus erythematosus \| 10 C0042384 \| vasculitis \| 8 C0010403 \| cryoglobulinemia \| 7 C0027707 \| interstitial nephritis \| 7 C0019080 \| hemorrhage \| 6 C0022660 \| acute renal failure \| 5 C0178664 \| glomerulosclerosis \| 4 C0004364 \| autoimmune disease \| 4 C0014118 \| endocarditis \| 4 C0020538 \| hypertension \| 3 C0038395 \| streptococcal infection \| 3 C0041349 \| tubulointerstitial nephritis \| 3 C0021079 \| immunosuppression \| 3 C0010403 \| cryoglobulinaemia \| 2 C0032285 \| pneumonia \| 2 C0034150 \| purpura \| 2 C0343208 \| essential mixed cryoglobulinemia \| 1 C0022661 \| chronic kidney failure \| 1 C0155862 \| pneumococcal pneumonia \| 1 C0019163 \| hepatitis b infection \| 1 C1565489 \| renal insufficiency \| 1 C1839611 \| n syndrome \| 1 C0042384 \| vasculitides \| 1 C0403447 \| chronic renal insufficiency \| 1 C0036202 \| sarcoidosis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1045642	22380717	5243	ABCB1	umls:C0017658	BeFree	The CYP2B6*9 and ABCB1 C3435T polymorphisms alter the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide in glomerulonephritis.	0.000271442	2012	ABCB1	7	87509329	A	T,G
rs1045642	22380717	1555	CYP2B6	umls:C0017658	BeFree	The CYP2B6*9 and ABCB1 C3435T polymorphisms alter the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide in glomerulonephritis.	0.000271442	2012	ABCB1	7	87509329	A	T,G
rs1570360	24673399	7422	VEGFA	umls:C0017658	BeFree	The association between therapeutic outcomes and VEGF G-1154A and C-936T gene polymorphisms in patients with glomerulonephritis.	0.001628651	2015	VEGFA	6	43770093	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:1)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
22	36661330	rs2239785	G	A	rs2239785	20668430	5.00E-13	AA	NA	NA	56 African American cases; 61 European descent cases	European(61)	African American(56)	ALL(117)	AFR(56)	EUR(61)	ALL(117)	Glomerulosclerosis	HPOID:0000096	Glomerulosclerosis	DOID:2921	glomerulonephritis	D005923	Glomerulosclerosis, Focal Segmental	EFOID:0004236	focal segmental glomerulosclerosis	Glomerulonephritis	rs2239785-G	Research Support, N.I.H., Extramural

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	593
Disease	glomerulonephritis
Case	(Waiting for update.)

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