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	fibrosarcoma

Disease ID	656
Disease	fibrosarcoma
Definition	A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
Synonym	[m]fibrosarcoma nos fibrosarcoma (excluding infantile fibrosarcoma) fibrosarcoma (morphologic abnormality) fibrosarcoma - not infantile fibrosarcoma [disease/finding] fibrosarcoma, malignant fibrosarcoma, nos fibrosarcomas malignant fibromatous neoplasm
Orphanet	ORPHANET:2030
DOID	DOID:3355
UMLS	C0016057
MeSH	D005354
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:17) C1261473 \| sarcoma \| 3 C0024302 \| reticulum-cell sarcoma \| 1 C1261473 \| sarcomas \| 1 C0085110 \| severe combined immunodefic \| 1 C0221348 \| yellow nail syndrome \| 1 C0153676 \| lung metastasis \| 1 C0016045 \| fibroma \| 1 C0019348 \| herpes simplex \| 1 C0014145 \| yolk sac tumor \| 1 C0015645 \| fasciitis \| 1 C0024299 \| lymphoma \| 1 C0085110 \| severe combined immunodeficiency \| 1 C0346188 \| ovarian yolk sac tumor \| 1 C0013377 \| dysgerminoma \| 1 C0042769 \| virus infection \| 1 C0008487 \| chordoma \| 1 C0153676 \| lung metastases \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 4763 \| NF1 \| CTD_human 1277 \| COL1A1 \| GHR 2120 \| ETV6 \| ORPHANET 5155 \| PDGFB \| GHR 4916 \| NTRK3 \| ORPHANET
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:194) 23527 \| ACAP2 \| 2.653 \| DISEASES 101 \| ADAM8 \| 4.794 \| DISEASES 9255 \| AIMP1 \| 2.753 \| DISEASES 238 \| ALK \| 1.75 \| DISEASES 249 \| ALPL \| 1.304 \| DISEASES 283 \| ANG \| 1.7 \| DISEASES 51378 \| ANGPT4 \| 1.16 \| DISEASES 81611 \| ANP32E \| 1.869 \| DISEASES 347 \| APOD \| 2.014 \| DISEASES 369 \| ARAF \| 1.36 \| DISEASES 27237 \| ARHGEF16 \| 2.656 \| DISEASES 170302 \| ARX \| 1.369 \| DISEASES 467 \| ATF3 \| 1.083 \| DISEASES 468 \| ATF4 \| 1.269 \| DISEASES 9529 \| BAG5 \| 1.236 \| DISEASES 8678 \| BECN1 \| 1.767 \| DISEASES 144453 \| BEST3 \| 1.102 \| DISEASES 390259 \| BSX \| 1.31 \| DISEASES 800 \| CALD1 \| 3.179 \| DISEASES 79823 \| CAMKMT \| 5.956 \| DISEASES 841 \| CASP8 \| 1.517 \| DISEASES 842 \| CASP9 \| 1.46 \| DISEASES 9332 \| CD163 \| 1.347 \| DISEASES 960 \| CD44 \| 2.228 \| DISEASES 942 \| CD86 \| 1.506 \| DISEASES 9859 \| CEP170 \| 1.987 \| DISEASES 9350 \| CER1 \| 2.447 \| DISEASES 387836 \| CLEC2A \| 1.025 \| DISEASES 100272147 \| CMC4 \| 2.153 \| DISEASES 51727 \| CMPK1 \| 1.175 \| DISEASES 8738 \| CRADD \| 1.221 \| DISEASES 90993 \| CREB3L1 \| 4.174 \| DISEASES 64764 \| CREB3L2 \| 5.256 \| DISEASES 541466 \| CT45A1 \| 1.147 \| DISEASES 1490 \| CTGF \| 1.003 \| DISEASES 1499 \| CTNNB1 \| 1.709 \| DISEASES 1508 \| CTSB \| 2.185 \| DISEASES 1520 \| CTSS \| 1.056 \| DISEASES 2017 \| CTTN \| 1.605 \| DISEASES 1649 \| DDIT3 \| 1.739 \| DISEASES 8528 \| DDO \| 2.451 \| DISEASES 4921 \| DDR2 \| 1.149 \| DISEASES 168400 \| DDX53 \| 2.902 \| DISEASES 26052 \| DNM3 \| 1.048 \| DISEASES 55715 \| DOK4 \| 1.538 \| DISEASES 11266 \| DUSP12 \| 1.246 \| DISEASES 2009 \| EML1 \| 1.112 \| DISEASES 64772 \| ENGASE \| 1.925 \| DISEASES 30816 \| ERVW-1 \| 2.557 \| DISEASES 2120 \| ETV6 \| 4.889 \| DISEASES 51513 \| ETV7 \| 1.385 \| DISEASES 2130 \| EWSR1 \| 3.582 \| DISEASES 2152 \| F3 \| 2.295 \| DISEASES 2197 \| FAU \| 1.803 \| DISEASES 2192 \| FBLN1 \| 1.295 \| DISEASES 2242 \| FES \| 1.058 \| DISEASES 2246 \| FGF1 \| 1.554 \| DISEASES 2258 \| FGF13 \| 1.677 \| DISEASES 2272 \| FHIT \| 1.425 \| DISEASES 2274 \| FHL2 \| 1.294 \| DISEASES 2308 \| FOXO1 \| 1.861 \| DISEASES 4303 \| FOXO4 \| 3.986 \| DISEASES 2526 \| FUT4 \| 1.034 \| DISEASES 2800 \| GOLGA1 \| 2.095 \| DISEASES 257202 \| GPX6 \| 1.029 \| DISEASES 23560 \| GTPBP4 \| 1.093 \| DISEASES 3039 \| HBA1 \| 1.929 \| DISEASES 3052 \| HCCS \| 2 \| DISEASES 3091 \| HIF1A \| 1.554 \| DISEASES 8349 \| HIST2H2BE \| 2.803 \| DISEASES 10362 \| HMG20B \| 1.954 \| DISEASES 8091 \| HMGA2 \| 1.94 \| DISEASES 3161 \| HMMR \| 1.65 \| DISEASES 3320 \| HSP90AA1 \| 1.784 \| DISEASES 3326 \| HSP90AB1 \| 1.71 \| DISEASES 3309 \| HSPA5 \| 1.916 \| DISEASES 3440 \| IFNA2 \| 1.924 \| DISEASES 3456 \| IFNB1 \| 1.671 \| DISEASES 3481 \| IGF2 \| 1.362 \| DISEASES 3586 \| IL10 \| 1.516 \| DISEASES 246778 \| IL27 \| 1.697 \| DISEASES 3638 \| INSIG1 \| 1.216 \| DISEASES 3716 \| JAK1 \| 1.386 \| DISEASES 83700 \| JAM3 \| 1.574 \| DISEASES 84502 \| JPH4 \| 1.884 \| DISEASES 3725 \| JUN \| 2.684 \| DISEASES 3755 \| KCNG1 \| 1.042 \| DISEASES 80333 \| KCNIP4 \| 1.109 \| DISEASES 11004 \| KIF2C \| 3.191 \| DISEASES 9314 \| KLF4 \| 1.15 \| DISEASES 11202 \| KLK8 \| 1.227 \| DISEASES 3932 \| LCK \| 1.277 \| DISEASES 11155 \| LDB3 \| 1.164 \| DISEASES 1902 \| LPAR1 \| 1.092 \| DISEASES 23566 \| LPAR3 \| 1.507 \| DISEASES 57121 \| LPAR5 \| 1.467 \| DISEASES 23499 \| MACF1 \| 1.089 \| DISEASES 4094 \| MAF \| 5.159 \| DISEASES 9935 \| MAFB \| 3.491 \| DISEASES 23764 \| MAFF \| 3.326 \| DISEASES 4097 \| MAFG \| 1.704 \| DISEASES 7975 \| MAFK \| 1.94 \| DISEASES 5609 \| MAP2K7 \| 2.767 \| DISEASES 5599 \| MAPK8 \| 2.606 \| DISEASES 4151 \| MB \| 2.806 \| DISEASES 4193 \| MDM2 \| 2.733 \| DISEASES 4222 \| MEOX1 \| 1.547 \| DISEASES 2315 \| MLANA \| 1.654 \| DISEASES 4311 \| MME \| 1.751 \| DISEASES 4312 \| MMP1 \| 2.065 \| DISEASES 4318 \| MMP9 \| 3.631 \| DISEASES 10198 \| MPHOSPH9 \| 1.465 \| DISEASES 2475 \| MTOR \| 1.484 \| DISEASES 4585 \| MUC4 \| 3.171 \| DISEASES 4599 \| MX1 \| 1.395 \| DISEASES 4609 \| MYC \| 2.244 \| DISEASES 4637 \| MYL6 \| 1.06 \| DISEASES 10763 \| NES \| 1.932 \| DISEASES 4780 \| NFE2L2 \| 1.736 \| DISEASES 22861 \| NLRP1 \| 1.045 \| DISEASES 4831 \| NME2 \| 1.286 \| DISEASES 135935 \| NOBOX \| 1.263 \| DISEASES 10360 \| NPM3 \| 1.609 \| DISEASES 8131 \| NPRL3 \| 1.635 \| DISEASES 7182 \| NR2C2 \| 1.183 \| DISEASES 4893 \| NRAS \| 2.446 \| DISEASES 4908 \| NTF3 \| 2.197 \| DISEASES 4916 \| NTRK3 \| 5.115 \| DISEASES 116150 \| NUS1 \| 1.692 \| DISEASES 142 \| PARP1 \| 1.205 \| DISEASES 5081 \| PAX7 \| 1.71 \| DISEASES 5155 \| PDGFB \| 5.742 \| DISEASES 3651 \| PDX1 \| 3.386 \| DISEASES 5230 \| PGK1 \| 1.328 \| DISEASES 5320 \| PLA2G2A \| 1.088 \| DISEASES 5321 \| PLA2G4A \| 1.888 \| DISEASES 5325 \| PLAGL1 \| 1.185 \| DISEASES 5328 \| PLAU \| 2.095 \| DISEASES 11243 \| PMF1 \| 2.031 \| DISEASES 5447 \| POR \| 1.359 \| DISEASES 5456 \| POU3F4 \| 1.826 \| DISEASES 11281 \| POU6F2 \| 1.408 \| DISEASES 11105 \| PRDM7 \| 2.497 \| DISEASES 5578 \| PRKCA \| 1.457 \| DISEASES 5738 \| PTGFRN \| 1.603 \| DISEASES 5747 \| PTK2 \| 1.079 \| DISEASES 5788 \| PTPRC \| 1.775 \| DISEASES 5900 \| RALGDS \| 1.602 \| DISEASES 399 \| RHOH \| 1.736 \| DISEASES 6016 \| RIT1 \| 1.865 \| DISEASES 6041 \| RNASEL \| 2.029 \| DISEASES 6091 \| ROBO1 \| 1.073 \| DISEASES 6188 \| RPS3 \| 1.13 \| DISEASES 349667 \| RTN4RL2 \| 2.569 \| DISEASES 9853 \| RUSC2 \| 2.133 \| DISEASES 5265 \| SERPINA1 \| 2.414 \| DISEASES 12 \| SERPINA3 \| 2.592 \| DISEASES 5270 \| SERPINE2 \| 1.526 \| DISEASES 871 \| SERPINH1 \| 1.24 \| DISEASES 27244 \| SESN1 \| 1.193 \| DISEASES 153769 \| SH3RF2 \| 2.396 \| DISEASES 55186 \| SLC25A36 \| 1.951 \| DISEASES 6514 \| SLC2A2 \| 1.102 \| DISEASES 9351 \| SLC9A3R2 \| 1.019 \| DISEASES 6609 \| SMPD1 \| 1.022 \| DISEASES 23583 \| SMUG1 \| 1.644 \| DISEASES 6663 \| SOX10 \| 1.988 \| DISEASES 6657 \| SOX2 \| 1.675 \| DISEASES 11166 \| SOX21 \| 1.594 \| DISEASES 6714 \| SRC \| 2.463 \| DISEASES 6736 \| SRY \| 1.35 \| DISEASES 6760 \| SS18 \| 1.261 \| DISEASES 6756 \| SSX1 \| 2.401 \| DISEASES 727837 \| SSX2B \| 2.595 \| DISEASES 10274 \| STAG1 \| 4.192 \| DISEASES 10492 \| SYNCRIP \| 1.281 \| DISEASES 7018 \| TF \| 1.05 \| DISEASES 10618 \| TGOLN2 \| 1.228 \| DISEASES 9967 \| THRAP3 \| 1.695 \| DISEASES 7088 \| TLE1 \| 1.834 \| DISEASES 7124 \| TNF \| 3.477 \| DISEASES 8784 \| TNFRSF18 \| 1.347 \| DISEASES 7150 \| TOP1 \| 1.095 \| DISEASES 7170 \| TPM3 \| 1.61 \| DISEASES 80128 \| TRIM46 \| 1.407 \| DISEASES 706 \| TSPO \| 1.316 \| DISEASES 7329 \| UBE2I \| 1.631 \| DISEASES 7371 \| UCK2 \| 1.209 \| DISEASES 7422 \| VEGFA \| 2.935 \| DISEASES 7490 \| WT1 \| 2.231 \| DISEASES 4904 \| YBX1 \| 1.24 \| DISEASES 7525 \| YES1 \| 1.473 \| DISEASES 285525 \| YIPF7 \| 1.825 \| DISEASES 346171 \| ZFP57 \| 1.042 \| DISEASES
Locus	Symbol \| Locus(Total Locus:2) ETV6 \| 12p13.2 NTRK3 \| 15q25.3

Disease ID	656
Disease	fibrosarcoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:10) HP:0002664 \| Neoplasia \| 12 HP:0100242 \| Sarcoma \| 3 HP:0005387 \| Combined immunodeficiency \| 1 HP:0100537 \| Inflammation of the fascia \| 1 HP:0010614 \| Fibroma \| 1 HP:0004430 \| Severe combined immunodeficiency \| 1 HP:0010762 \| Chordoma \| 1 HP:0100621 \| Dysgerminoma \| 1 HP:0002665 \| Lymphoma \| 1 HP:0002721 \| Immunodeficiency \| 1

Disease ID	656
Disease	fibrosarcoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:13) C1962974 \| chylothorax C0856747 \| ascending aortic aneurysm C0748355 \| acute respiratory distress C0426768 \| o sign C0153676 \| pulmonary metastasis C0153676 \| pulmonary metastases C0153676 \| lung metastases C0022408 \| arthropathy C0020473 \| hyperlipidemia C0020305 \| hydrops fetalis C0014145 \| yolk sac tumor C0002874 \| aplastic anaemia C0002793 \| anaplasia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0153676 \| lung metastases \| 1 C0014145 \| yolk sac tumor \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs113488022	14500344	673	BRAF	umls:C0016057	BeFree	Similar targeting of BRAF(V599E) or wild-type BRAF in human fibrosarcoma cells that lack the BRAF(V599E) mutation does not recapitulate these effects.	0.000271442	2003	BRAF	7	140753336	A	T,G,C
rs121913499	22885298	3417	IDH1	umls:C0016057	BeFree	Here, using a genetically engineered inducible system, we report that selective suppression of endogenous mutant IDH1 expression in HT1080, a fibrosarcoma cell line with a native IDH1(R132C) heterozygous mutation, significantly inhibits cell proliferation and decreases clonogenic potential.	0.000271442	2012	IDH1	2	208248389	G	T,A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	656
Disease	fibrosarcoma
Case	(Waiting for update.)

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