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	fibromyalgia

Disease ID	73
Disease	fibromyalgia
Definition	A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
Synonym	diffuse myofascial pain syndrome fibromyalgia (disorder) fibromyalgia (finding) fibromyalgia (fm) fibromyalgia (fms) fibromyalgia -retired- fibromyalgia [ambiguous] fibromyalgia [disease/finding] fibromyalgia fibromyositis syndrome fibromyalgia syndrome fibromyalgia, nos fibromyalgia-fibromyositis syndrome fibromyalgia-fibromyositis syndromes fibromyalgias fibromyositis fibromyositis (disorder) fibromyositis fibromyalgia syndrome fibromyositis nos fibromyositis nos (disorder) fibromyositis, nos fibromyositis-fibromyalgia syndrome fibromyositis-fibromyalgia syndromes fibrositides fibrositis fibrositis (disorder) fibrositis nos fibrositis unspecified fibrositis unspecified (disorder) fibrositis, nos fms mpd syndrome mpds (myofascial pain dysfunction syndrome) mpds - myofacial pain dysfunction syndrome muscular rheumatism muscular rheumatism (disorder) myofacial pain dysfunction syndrome myofascial pain dysfunction syndrome myofascial pain syndrome myofascial pain syndrome, diffuse pain syndrome myofascial rheumatism, muscular rheumatism, tension syndrome fibromyalgia syndrome, fibromyalgia-fibromyositis syndrome, fibromyositis-fibromyalgia syndromes, fibromyalgia-fibromyositis syndromes, fibromyositis-fibromyalgia
OMIM	OMIM:164770
DOID	DOID:631 DOID:431
ICD10	ICD10CM:M79.7
UMLS	C0016053
MeSH	D005356
SNOMED-CT	SNOMEDCT_US_2016_09_01:24693007;SNOMEDCT_US_2016_09_01:56557000;SNOMEDCT_US_2016_09_01:203102006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:85) C0011570 \| depression \| 25 C0016053 \| myofascial pain syndrome \| 14 C0003873 \| rheumatoid arthritis \| 9 C0003467 \| anxiety \| 6 C0003864 \| arthritis \| 5 C0679466 \| cognitive deficits \| 3 C0041696 \| major depression \| 3 C0022104 \| irritable bowel syndrome \| 3 C0002020 \| alexithymia \| 3 C0037317 \| sleep disturbance \| 3 C0028754 \| obesity \| 3 C0851578 \| sleep disorders \| 3 C0038013 \| ankylosing spondylitis \| 3 C0149931 \| migraine \| 3 C0010068 \| coronary heart disease \| 2 C0004936 \| mental disorders \| 2 C0006142 \| breast cancer \| 2 C0018799 \| heart disease \| 2 C0035435 \| rheumatic disease \| 2 C0039494 \| temporomandibular disorder \| 2 C0035258 \| restless legs \| 2 C0035258 \| restless legs syndrome (rls) \| 2 C0035435 \| rheumatic diseases \| 2 C0039494 \| temporomandibular disorders \| 2 C0038436 \| posttraumatic stress disorder \| 2 C1527336 \| sjogren's syndrome \| 2 C0035258 \| restless legs syndrome \| 2 C0019158 \| hepatitis \| 2 C0022104 \| irritable bowel \| 2 C0029408 \| osteoarthritis \| 2 C0149931 \| migraine headache \| 1 C0006325 \| bruxism \| 1 C0037317 \| sleep disturbances \| 1 C0009241 \| cognitive disorders \| 1 C0149931 \| migraine headaches \| 1 C0003864 \| inflammatory arthritis \| 1 C0019196 \| hepatitis c infection \| 1 C0949690 \| spondyloarthritis \| 1 C0039263 \| takayasu's arteritis \| 1 C0042485 \| venous insufficiency \| 1 C0011847 \| diabetes \| 1 C0042870 \| vitamin d defic \| 1 C0029455 \| osteopoikilosis \| 1 C0041696 \| major depressive disorder \| 1 C0020502 \| hyperparathyroidism \| 1 C0042870 \| vitamin d deficiency \| 1 C0014175 \| endometriosis \| 1 C0314719 \| dry eye \| 1 C1510471 \| hypovitaminosis \| 1 C0015464 \| facial nerve palsy \| 1 C0003872 \| psoriatic arthritis \| 1 C0007222 \| cardiovascular disease \| 1 C0221757 \| alpha-1-antitrypsin deficiency \| 1 C0442874 \| neuropathy \| 1 C0015674 \| chronic fatigue syndrome \| 1 C0031069 \| familial mediterranean fever \| 1 C0003469 \| anxiety disorders \| 1 C0221002 \| primary hyperparathyroidism \| 1 C0032002 \| pituitary disorders \| 1 C0030305 \| pancreatitis \| 1 C0007570 \| celiac disease \| 1 C0026267 \| mitral valve prolapse \| 1 C0004943 \| behcet's disease \| 1 C0242490 \| enthesopathy \| 1 C0019196 \| hepatitis c \| 1 C0021053 \| immune disease \| 1 C0035579 \| hypovitaminosis d \| 1 C0013421 \| dystonia \| 1 C0700594 \| radiculopathy \| 1 C0221757 \| aat deficiency \| 1 C0016053 \| fibromyalgia \| 1 C0042769 \| virus infection \| 1 C0020676 \| hypothyroidism \| 1 C0038012 \| spondylitis \| 1 C0152078 \| pelvic pain syndrome \| 1 C0002395 \| alzheimer disease \| 1 C0002895 \| sickle cell disease \| 1 C0018916 \| angioma \| 1 C0001339 \| acute pancreatitis \| 1 C0028754 \| adiposity \| 1 C0221757 \| alpha-1-antitrypsin def \| 1 C0019163 \| hepatitis b \| 1 C0003469 \| anxiety disorder \| 1 C0042373 \| vascular disease \| 1 C0035435 \| rheumatism \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 1436 \| CSF1R \| OMIM
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:11) 1312 \| COMT \| CIPHER 3356 \| HTR2A \| CIPHER 3359 \| HTR3A \| CIPHER 9177 \| HTR3B \| CIPHER 3565 \| IL4 \| CIPHER 4128 \| MAOA \| CIPHER 4846 \| NOS3 \| CIPHER 5054 \| SERPINE1 \| CIPHER 6531 \| SLC6A3 \| CIPHER 6532 \| SLC6A4 \| CIPHER 6869 \| TACR1 \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:121) 10555 \| AGPAT2 \| 2.059 \| DISEASES 238 \| ALK \| 2.142 \| DISEASES 257 \| ALX3 \| 1.524 \| DISEASES 11273 \| ATXN2L \| 1.974 \| DISEASES 554 \| AVPR2 \| 1.394 \| DISEASES 627 \| BDNF \| 2.628 \| DISEASES 627 \| BDNF \| 2.617 \| DISEASES 388552 \| BLOC1S3 \| 2.018 \| DISEASES 26580 \| BSCL2 \| 1.855 \| DISEASES 149466 \| C1orf210 \| 2.132 \| DISEASES 778 \| CACNA1F \| 1.51 \| DISEASES 796 \| CALCA \| 1.291 \| DISEASES 820 \| CAMP \| 2.776 \| DISEASES 820 \| CAMP \| 1.111 \| DISEASES 388372 \| CCL4L1 \| 1.502 \| DISEASES 388372 \| CCL4L1 \| 1.234 \| DISEASES 914 \| CD2 \| 2.667 \| DISEASES 959 \| CD40LG \| 2.765 \| DISEASES 921 \| CD5 \| 2.424 \| DISEASES 1041 \| CDSN \| 3.418 \| DISEASES 63924 \| CIDEC \| 2.458 \| DISEASES 1312 \| COMT \| 3.818 \| DISEASES 56259 \| CTNNBL1 \| 1.233 \| DISEASES 2833 \| CXCR3 \| 1.039 \| DISEASES 50626 \| CYHR1 \| 2.267 \| DISEASES 1544 \| CYP1A2 \| 1.131 \| DISEASES 1565 \| CYP2D6 \| 1.903 \| DISEASES 9879 \| DDX46 \| 2.417 \| DISEASES 1805 \| DPT \| 1.575 \| DISEASES 1806 \| DPYD \| 1.02 \| DISEASES 23741 \| EID1 \| 1.221 \| DISEASES 954 \| ENTPD2 \| 1.092 \| DISEASES 51013 \| EXOSC1 \| 1.292 \| DISEASES 26190 \| FBXW2 \| 1.847 \| DISEASES 11153 \| FICD \| 1.402 \| DISEASES 2332 \| FMR1 \| 2.128 \| DISEASES 221937 \| FOXK1 \| 1.858 \| DISEASES 2556 \| GABRA3 \| 1.582 \| DISEASES 2624 \| GATA2 \| 2.287 \| DISEASES 2633 \| GBP1 \| 1.042 \| DISEASES 51738 \| GHRL \| 1.25 \| DISEASES 2879 \| GPX4 \| 3.022 \| DISEASES 51696 \| HECA \| 1.072 \| DISEASES 3250 \| HPR \| 1.038 \| DISEASES 3356 \| HTR2A \| 2.909 \| DISEASES 3359 \| HTR3A \| 4.159 \| DISEASES 3363 \| HTR7 \| 3.067 \| DISEASES 3620 \| IDO1 \| 1.728 \| DISEASES 3456 \| IFNB1 \| 2.451 \| DISEASES 3486 \| IGFBP3 \| 1.691 \| DISEASES 8518 \| IKBKAP \| 1.286 \| DISEASES 3586 \| IL10 \| 2.407 \| DISEASES 3563 \| IL3RA \| 1.864 \| DISEASES 50618 \| ITSN2 \| 2.972 \| DISEASES 3713 \| IVL \| 1.451 \| DISEASES 102723508 \| KANTR \| 2.93 \| DISEASES 102723508 \| KANTR \| 2.087 \| DISEASES 3776 \| KCNK2 \| 2.488 \| DISEASES 8564 \| KMO \| 1.044 \| DISEASES 348801 \| LNP1 \| 1.661 \| DISEASES 4094 \| MAF \| 1.849 \| DISEASES 4128 \| MAOA \| 1.648 \| DISEASES 5609 \| MAP2K7 \| 1.288 \| DISEASES 4191 \| MDH2 \| 1.441 \| DISEASES 79104 \| MEG8 \| 2.151 \| DISEASES 8972 \| MGAM \| 2.044 \| DISEASES 4599 \| MX1 \| 1.188 \| DISEASES 23040 \| MYT1L \| 1.67 \| DISEASES 79903 \| NAA60 \| 2.439 \| DISEASES 89796 \| NAV1 \| 1.448 \| DISEASES 89795 \| NAV3 \| 1.57 \| DISEASES 4686 \| NCBP1 \| 1.322 \| DISEASES 4803 \| NGF \| 2.165 \| DISEASES 4803 \| NGF \| 1.51 \| DISEASES 114548 \| NLRP3 \| 1.186 \| DISEASES 654364 \| NME1-NME2 \| 1.342 \| DISEASES 594857 \| NPS \| 3.673 \| DISEASES 594857 \| NPS \| 1.605 \| DISEASES 4306 \| NR3C2 \| 1.141 \| DISEASES 9369 \| NRXN3 \| 1.309 \| DISEASES 4914 \| NTRK1 \| 1.217 \| DISEASES 4988 \| OPRM1 \| 2.537 \| DISEASES 5005 \| ORM2 \| 1.596 \| DISEASES 5025 \| P2RX4 \| 1.847 \| DISEASES 10606 \| PAICS \| 1.426 \| DISEASES 55010 \| PARPBP \| 3.225 \| DISEASES 5223 \| PGAM1 \| 1.1 \| DISEASES 5406 \| PNLIP \| 2.544 \| DISEASES 5478 \| PPIA \| 1.114 \| DISEASES 5535 \| PPP3R2 \| 2.48 \| DISEASES 5550 \| PREP \| 2.486 \| DISEASES 5627 \| PROS1 \| 2.399 \| DISEASES 5696 \| PSMB8 \| 2.718 \| DISEASES 9051 \| PSTPIP1 \| 3.425 \| DISEASES 284119 \| PTRF \| 1.868 \| DISEASES 6014 \| RIT2 \| 1.065 \| DISEASES 57142 \| RTN4 \| 1.617 \| DISEASES 6336 \| SCN10A \| 1.314 \| DISEASES 6335 \| SCN9A \| 2.702 \| DISEASES 5265 \| SERPINA1 \| 4.526 \| DISEASES 59307 \| SIGIRR \| 1.161 \| DISEASES 6533 \| SLC6A6 \| 2.694 \| DISEASES 23583 \| SMUG1 \| 1.925 \| DISEASES 6633 \| SNRPD2 \| 1.529 \| DISEASES 6635 \| SNRPE \| 2.592 \| DISEASES 6635 \| SNRPE \| 1.899 \| DISEASES 6693 \| SPN \| 1.913 \| DISEASES 8676 \| STX11 \| 1.118 \| DISEASES 6863 \| TAC1 \| 4.708 \| DISEASES 6863 \| TAC1 \| 3.046 \| DISEASES 54790 \| TET2 \| 1.319 \| DISEASES 7072 \| TIA1 \| 4.339 \| DISEASES 7124 \| TNF \| 3.058 \| DISEASES 7133 \| TNFRSF1B \| 2.086 \| DISEASES 1861 \| TOR1A \| 1.266 \| DISEASES 51592 \| TRIM33 \| 1.046 \| DISEASES 7442 \| TRPV1 \| 2.319 \| DISEASES 162514 \| TRPV3 \| 1.241 \| DISEASES 706 \| TSPO \| 1.501 \| DISEASES 11169 \| WDHD1 \| 1.207 \| DISEASES 10269 \| ZMPSTE24 \| 1.791 \| DISEASES
Locus	(Waiting for update.)

Disease ID	73
Disease	fibromyalgia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:52) HP:0012531 \| Pain \| 76 HP:0000716 \| Depression \| 25 HP:0012532 \| Chronic pain \| 17 HP:0012378 \| Fatigue \| 11 HP:0001370 \| Rheumatoid arthritis \| 9 HP:0000739 \| Anxiety \| 6 HP:0100543 \| Cognitive deficits \| 5 HP:0003418 \| Back pain \| 5 HP:0001369 \| Arthritis \| 5 HP:0002076 \| Migraine headaches \| 4 HP:0002315 \| Headaches \| 4 HP:0001513 \| Obesity \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0002360 \| Sleep disturbance \| 3 HP:0003419 \| Low back pain \| 3 HP:0003326 \| Muscle pain \| 3 HP:0012452 \| Restless legs \| 2 HP:0002459 \| Dysautonomia \| 2 HP:0002758 \| Osteoarthritis \| 2 HP:0003002 \| Breast carcinoma \| 2 HP:0008200 \| Primary hyperparathyroidism \| 1 HP:0012668 \| Situational syncope \| 1 HP:0001634 \| Mitral valve prolapse \| 1 HP:0001332 \| Dystonia \| 1 HP:0003287 \| Abnormality of mitochondrial metabolism \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0003763 \| Bruxism \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0002527 \| Falls \| 1 HP:0100512 \| Vitamin D deficiency \| 1 HP:0010739 \| Osteopoikilosis \| 1 HP:0007302 \| Bipolar disorder \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0000821 \| Underactive thyroid \| 1 HP:0030016 \| Dyspareunia \| 1 HP:0012721 \| Venous malformations \| 1 HP:0005293 \| Venous insufficiency \| 1 HP:0010628 \| Facial palsy, unilateral or bilateral \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0001382 \| Hyperextensible joints \| 1 HP:0001262 \| Somnolence \| 1 HP:0000843 \| Hyperparathyroidism \| 1 HP:0002608 \| Celiac disease \| 1 HP:0002354 \| Memory loss \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0002511 \| Late-onset form of familial Alzheimer disease \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0001945 \| Fever \| 1 HP:0012329 \| Angioblastoma \| 1 HP:0100785 \| Insomnia \| 1 HP:0030127 \| Endometriosis \| 1 HP:0012089 \| Arteritis \| 1

Disease ID	73
Disease	fibromyalgia
Manually Symptom	UMLS \| Name(Total Manually Symptoms:53) C2678504 \| osteoporosis C2598155 \| pain C2364133 \| infection C2364072 \| depression C2364051 \| fatigue C2096315 \| headache C2020637 \| chronic pain C1963237 \| insomnia C1963185 \| obesity C1963064 \| anxiety C1839611 \| n syndrome C1720505 \| adult growth hormone deficiency C1718184 \| pain symptoms C1335778 \| retroperitoneal leiomyosarcoma C1269683 \| major depressive disorder C0851578 \| sleep disturbances C0851578 \| sleep disorders C0813142 \| circadian rhythm disorders C0741585 \| body pain C0717360 \| lyme disease C0700361 \| distress C0700201 \| sleep disturbance C0684239 \| tenderness C0575064 \| muscle tenderness C0559031 \| functional gastrointestinal disorders C0553844 \| keratoconjunctivitis sicca C0549622 \| sexual dysfunction C0521991 \| stress symptoms C0497552 \| nervous system abnormalities C0427008 \| stiffness C0426576 \| gastrointestinal symptoms C0278140 \| severe pain C0262405 \| cerebral dysfunction C0235704 \| adynamia C0235169 \| excitability C0234244 \| somatic pain C0231528 \| muscular pain C0151825 \| skeletal pain C0151293 \| chronic headache C0149645 \| cervical myelopathy C0086132 \| depressive symptoms C0085616 \| vasospasm C0039494 \| temporomandibular disorders C0039494 \| temporomandibular disorder C0035258 \| restless legs syndrome (rls) C0034735 \| raynaud's syndrome C0034735 \| raynaud phenomenon C0025322 \| early menopause C0022104 \| irritable bowel syndrome C0013363 \| dysautonomia C0007384 \| cataplexy C0007286 \| carpal tunnel syndrome C0004364 \| autoimmune diseases
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:24) C0030193 \| pain \| 73 C0011570 \| depression \| 25 C0150055 \| chronic pain \| 16 C0015672 \| fatigue \| 11 C0086132 \| depressive symptoms \| 6 C0003467 \| anxiety \| 6 C1839611 \| n syndrome \| 3 C0028754 \| obesity \| 3 C0851578 \| sleep disorders \| 3 C0018681 \| headache \| 3 C0022104 \| irritable bowel syndrome \| 3 C0035258 \| restless legs syndrome (rls) \| 2 C0037317 \| sleep disturbance \| 2 C0039494 \| temporomandibular disorders \| 2 C0234233 \| tenderness \| 1 C0741585 \| body pain \| 1 C0427008 \| stiffness \| 1 C0004364 \| autoimmune diseases \| 1 C0231303 \| distress \| 1 C0917801 \| insomnia \| 1 C0024198 \| lyme disease \| 1 C0037317 \| sleep disturbances \| 1 C0041696 \| major depressive disorder \| 1 C0235169 \| excitability \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:22)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1799971	24671502	4988	OPRM1	umls:C0016053	BeFree	Assessment of opioid receptor μ1 gene A118G polymorphism and its association with pain intensity in patients with fibromyalgia.	0.005634266	2014	OPRM1	6	154039662	A	G
rs1799983	16951945	4846	NOS3	umls:C0016053	BeFree	No evidence for an association between the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and fibromyalgia syndrome.	0.002995792	2007	NOS3	7	150999023	T	G
rs3771863	25786041	6869	TACR1	umls:C0016053	BeFree	The rs3771863 single nucleotide polymorphism of the TACR1 gene is associated to a lower risk of sicca syndrome in fibromyalgia patients.	0.002638474	2014	TACR1;LOC105374811	2	75192588	C	T
rs386602118	21773883	627	BDNF	umls:C0016053	BeFree	A brain-derived neurotrophic factor polymorphism Val66Met identifies fibromyalgia syndrome subgroup with higher body mass index and C-reactive protein.	0.002995792	2012	NA	NA	NA	NA	NA
rs386602276	21120487	3356	HTR2A	umls:C0016053	BeFree	This meta-analysis demonstrates that the 5-HT2A receptor 102T/C polymorphism confers susceptibility to fibromyalgia.	0.003995683	2012	NA	NA	NA	NA	NA
rs386602276	11732859	3356	HTR2A	umls:C0016053	BeFree	Association of T102C polymorphism of the 5-HT2A receptor gene with psychiatric status in fibromyalgia syndrome.	0.003995683	2001	NA	NA	NA	NA	NA
rs386602276	22124593	3356	HTR2A	umls:C0016053	BeFree	Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility.	0.003995683	2011	NA	NA	NA	NA	NA
rs386602276	10527809	3356	HTR2A	umls:C0016053	BeFree	The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia.	0.003995683	1999	NA	NA	NA	NA	NA
rs4680	23025981	1312	COMT	umls:C0016053	BeFree	Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome.	0.023451079	2012	COMT;MIR4761	22	19963748	G	A
rs4680	24762091	1312	COMT	umls:C0016053	BeFree	Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism.	0.023451079	2015	COMT;MIR4761	22	19963748	G	A
rs4680	21120493	1312	COMT	umls:C0016053	BeFree	These results suggest that SNPs rs4680 and rs4818 of the COMT gene may be associated with fibromyalgia and pain sensitivity in FS Brazilian patients.	0.023451079	2012	COMT;MIR4761	22	19963748	G	A
rs4680	20074440	1312	COMT	umls:C0016053	BeFree	The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia.	0.023451079	2009	COMT;MIR4761	22	19963748	G	A
rs4680	24503977	1312	COMT	umls:C0016053	BeFree	Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome?	0.023451079	2014	COMT;MIR4761	22	19963748	G	A
rs4680	18196244	3356	HTR2A	umls:C0016053	BeFree	The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS.	0.003995683	2008	COMT;MIR4761	22	19963748	G	A
rs4680	24951880	1312	COMT	umls:C0016053	BeFree	Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia impact questionnaire score: a meta-analysis.	0.023451079	2014	COMT;MIR4761	22	19963748	G	A
rs4818	21120493	1312	COMT	umls:C0016053	BeFree	These results suggest that SNPs rs4680 and rs4818 of the COMT gene may be associated with fibromyalgia and pain sensitivity in FS Brazilian patients.	0.023451079	2012	COMT;MIR4761	22	19963684	C	G,T
rs6311	18196244	3356	HTR2A	umls:C0016053	BeFree	The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS.	0.003995683	2008	HTR2A	13	46897343	C	T
rs6313	18196244	3356	HTR2A	umls:C0016053	BeFree	The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS.	0.003995683	2008	HTR2A	13	46895805	G	A
rs6313	22124593	3356	HTR2A	umls:C0016053	BeFree	Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility.	0.003995683	2011	HTR2A	13	46895805	G	A
rs6313	11732859	3356	HTR2A	umls:C0016053	BeFree	Association of T102C polymorphism of the 5-HT2A receptor gene with psychiatric status in fibromyalgia syndrome.	0.003995683	2001	HTR2A	13	46895805	G	A
rs6313	21120487	3356	HTR2A	umls:C0016053	BeFree	This meta-analysis demonstrates that the 5-HT2A receptor 102T/C polymorphism confers susceptibility to fibromyalgia.	0.003995683	2012	HTR2A	13	46895805	G	A
rs6313	10527809	3356	HTR2A	umls:C0016053	BeFree	The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia.	0.003995683	1999	HTR2A	13	46895805	G	A

GWASdb Annotation(Total Genotypes:13)
Chr	Pos	SNP_Id	RefGene	EnsemblGene	ENCODE_Factor	ENCODE_TFBS	Chromosome_interaction	GTEx_eQTL	SNP_TFBS_affinity_GWAS3D	SNP_miRNA_target_affinity_PolymiRTS	SNP_splicing_effect_Skippy	SNP_splicing_effect_MutPred_Splice	SNP_ns_protein_effect_dbNSFP	SNP_syn_effect_Silva	SNP_phosphorylation_effect_PhosSNP	PhastCons_score	PhyloP_score	GERP++_RS	Segway_state	Ancestral_allele	ESP_AF	ESP_AFR	ESP_AFR	ESP_EUR	TG_ASN	TG_AMR	TG_AFR	TG_EUR	Type	Consequence	bStatistic	EncH3K27Ac	EncH3K4Me1	EncH3K4Me3	EncNucleo	OMIM	Clinvar
5	149440045	rs12516676	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000504875,ENSG00000182578	ENST00000394307,ENSG00000182578	ENST00000515068,ENSG00000182578	ENST00000513609,ENSG00000182578	ENST00000515239,ENSG00000182578	NA	NA	NA	NA	Asg1-DBD-primary,7.9738	Asg1-DBD-primary,1.3568	Asg1-DBD-primary,24.186	Asg1-DBD-primary,66.5157	Asg1-DBD-primary,4.0317	NA	NA	NA	NA	NA	NA	0.000	-0.741	-3.87	R3	C	NA	NA	NA	NA	NA	NA	NA	NA
5	149443298	rs216140	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000504875,ENSG00000182578	ENST00000394307,ENSG00000182578	ENST00000513609,ENSG00000182578	ENST00000515239,ENSG00000182578	NA	NA	NA	NA	Gat1-primary,8.3728	Gzf3-primary,10.1043	Rdr1-DBD-primary,1.6969	Tbf1-DBD-primary,7.3762	Tec1-primary,5.0564	NA	NA	NA	NA	NA	NA	0.000	-1.885	-8.27	R3	T	NA	NA	NA	NA	NA	NA	NA	NA	Transcript
5	149445595	rs216145	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000504875,ENSG00000182578	ENST00000394307,ENSG00000182578	ENST00000513609,ENSG00000182578	ENST00000515239,ENSG00000182578	TFP.MAX	NA	NA	NA	Aro80-primary,1.7456	Ecm22-primary,2.4161	Gal4-primary,1.6751	Gal4-primary,1.3214	Gsm1-FL-primary,1.5537	NA	NA	NA	NA	NA	NA	0.000	-0.207	-1.11	R5	G	NA	NA	NA	NA	NA	NA	NA	NA	RegulatoryFeature
5	149445921	rs216146	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000504875,ENSG00000182578	ENST00000394307,ENSG00000182578	ENST00000513609,ENSG00000182578	ENST00000515239,ENSG00000182578	TFP.MAX	MCV-3	NA	NA	NA	Gat1-primary,1.6676	Gzf3-primary,1.6616	Pbf1-primary,3.7868	Skn7-primary,1.4239	Skn7-primary,1.609	NA	NA	NA	NA	NA	NA	0.003	0.737	2.25	R1	T	NA	NA	NA	NA	NA	NA	NA	NA
5	149446487	rs216148	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000504875,ENSG00000182578	ENST00000394307,ENSG00000182578	ENST00000513609,ENSG00000182578	ENST00000515239,ENSG00000182578	TFP.MAX	TFP.MYC	NA	NA	NA	LM152,2.1818	LM152,2.2438	LM197,2.7663	Pax5,1.4035	PPARG-RXRA,3.2188	NA	NA	NA	NA	NA	NA	0.001	0.368	1.16	TF0	A	NA	NA	NA	0.290	0.440	0.250	0.470	0.090
5	149447628	rs216150	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000504875,ENSG00000182578	ENST00000394307,ENSG00000182578	ENST00000513609,ENSG00000182578	ENST00000515239,ENSG00000182578	MCV-2	NA	NA	NA	LM7,9.6604	LM14,5.7656	LM23,9.2765	LM46,1.7805	LM46,1.7393	NA	NA	NA	NA	NA	NA	0.000	-0.398	-1.47	R3	G	NA	NA	NA	NA	NA	NA	NA	NA	Transcript
5	149450132	rs10079250	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000504875,ENSG00000182578	ENST00000394307,ENSG00000182578	TFP.CTCF	TFP.RAD21	NA	NA	NA	Cgd2_3490,3.652	Cgd2_3490,10.0422	Cha4-primary,59.2578	Leu3-primary,2.8451	Pdr1-DBD-primary,3.4557	NA	NA	NA	CSF1R,T,G,H,P,0.589,0.97,0.983215,0.264712	CSF1R,T,C,H,R,0.442,0.95,0.983215,0.090019	CSF1R,T,A,H,L,0.006,0.96,0.983215,0.316504	NA	NM_005211,TypeII+,CAC->CGC,H->R,3.25	NM_005211,TypeII+,CAC->CGC,H->R,2.75	NM_005211,TypeII+,CAC->CGC,H->R,4.226	NM_005211,TypeII+,CAC->CGC,H->R,3.316	NM_005211,TypeII-,CAC->CGC,H->R,2.364	NM_005211,TypeIII+,CAC->CGC,H->R,3.76	NM_005211,TypeIII+,CAC->CGC,H->R,3.967	NM_005211,TypeIII+,CAC->CGC,H->R,5.411	NM_005211,TypeIII+,CAC->CGC,H->R,2.273	NM_005211,TypeIII+,CAC->CGC,H->R,4.462	NM_005211,TypeIII+,CAC->CGC,H->R,6	NM_005211,TypeIII+,CAC->CGC,H->R,2.593	NM_005211,TypeIII+,CAC->CGC,H->R,3.526	NM_005211,TypeIII-,CAC->CGC,H->R,2.923
5	149454918	rs12651699	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000504875,ENSG00000182578	ENST00000394307,ENSG00000182578	NA	NA	NA	NA	LM35,5.1226	LM52,2.3039	LM77,5.0038	LM85,3.3137	LM145,10.0665	NA	NA	NA	NA	NA	NA	0.006	0.000	0	R1	C	NA	NA	NA	NA	NA	NA	NA	NA	Transcript	INTRONIC	667
5	149459574	rs13188584	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000504875,ENSG00000182578	ENST00000394307,ENSG00000182578	ENST00000502660,ENSG00000182578	ENST00000511344,ENSG00000182578	MCV-3	NA	NA	NA	Asg1-DBD-primary,23.1567	Gal4-primary,1.5472	Hal9-primary,6.5637	Hal9-primary,6.5637	Mbp1-primary,1.5609	NA	NA	NA	NA	NA	NA	0.000	-0.742	-5.46	R5	C	NA	NA	NA	NA	NA	NA	NA	NA	Transcript
5	149481535	rs1465692	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000511344,ENSG00000182578	NA	NA	chr5,149480001,149490000,chr5,149460001,149470000,27,Hi-C	chr5,149480001,149490000,chr5,177340001,177350000,38,Hi-C	chr5,149480001,149490000,chr7,102150001,102160000,194,Hi-C	chr5,149480001,149490000,chr5,154190001,154200000,5,Hi-C	NA	Fhl1-DBD-primary,2.456	LM33,2.4677	LM44,1.8498	LM46,1.3889	LM59,1.5167	NA	NA	NA	NA	NA	NA	0.004	1.214	1.97	R2	T	NA	NA	NA	NA	NA	NA	NA	NA	Intergenic
5	149485772	rs6865659	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000511344,ENSG00000182578	MCV-3	NA	chr5,149480001,149490000,chr5,149460001,149470000,27,Hi-C	chr5,149480001,149490000,chr5,177340001,177350000,38,Hi-C	chr5,149480001,149490000,chr7,102150001,102160000,194,Hi-C	chr5,149480001,149490000,chr5,154190001,154200000,5,Hi-C	NA	LM58,5.9133	LM165,4.6582	LM174,7.3932	dl_1,2.3765	Gfi,1.3755	NA	NA	NA	NA	NA	NA	0.004	0.713	2.4	R5	A	NA	NA	NA	NA	NA	NA	NA	NA	Transcript
5	149489110	rs1010101	NM_005211,CSF1R	ENST00000286301,ENSG00000182578	ENST00000511344,ENSG00000182578	MCV-6	NA	chr5,149480001,149490000,chr5,149460001,149470000,27,Hi-C	chr5,149480001,149490000,chr5,177340001,177350000,38,Hi-C	chr5,149480001,149490000,chr7,102150001,102160000,194,Hi-C	chr5,149480001,149490000,chr5,154190001,154200000,5,Hi-C	NA	LM12,1.8026	LM31,1.6547	LM44,1.3206	LM54,1938.45	LM117,2.1234	NA	NA	NA	NA	NA	NA	0.001	0.013	0.133	R4	C	NA	NA	NA	NA	NA	NA	NA	NA	Intergenic
5	149492455	rs11740298	NM_005211,CSF1R	NM_002609,PDGFRB	ENST00000286301,ENSG00000182578	ENST00000511344,ENSG00000182578	ENST00000261799,ENSG00000113721	ENST00000520851,ENSG00000113721	TFP.TFAP2A	TFP.TFAP2C	TFP.SMARCC1	TFP.STAT3	NA	NA	NA	Aft1-primary,2.824	Ceh-22,1.3236	Cgd2_3490,1.341	Cha4-primary,3.4829	Rap1-FL-primary,1.6087	NA	NA	NA	NA	NA	NA	0.000	-0.119	-0.622	TF1	C	NA	NA	NA	NA	NA	NA

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	73
Disease	fibromyalgia
Case	(Waiting for update.)