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encyclopedia of Rare Disease Annotation for Precision Medicine

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	eosinophilic gastroenteritis

Disease ID	702
Disease	eosinophilic gastroenteritis
Definition	Gastroenteritis that is characterized by eosinophilic infiltration.
Synonym	eosinophilic gastroent eosinophilic gastroenteritis (disorder) eosinophilic gastroenteropathy eosinophilic gastroenteropathy (disorder) eosinophilic gastroenteropathy, nos gastroenteritis eosinophilic
Orphanet	ORPHANET:2070
DOID	DOID:4031
UMLS	C1262481
SNOMED-CT	SNOMEDCT_US_2016_09_01:359804008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:16) C0002871 \| anemia \| 1 C0024623 \| gastric cancer \| 1 C0004096 \| asthma \| 1 C0015645 \| fasciitis \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0019196 \| hepatitis c \| 1 C0019158 \| hepatitis \| 1 C0155877 \| allergic asthma \| 1 C0023890 \| cirrhosis \| 1 C0006277 \| bronchitis \| 1 C0206141 \| hypereosinophilic syndrome \| 1 C0409974 \| lupus erythematosus \| 1 C0008728 \| churg-strauss syndrome \| 1 C0023890 \| liver cirrhosis \| 1 C0003873 \| rheumatoid arthritis \| 1 C0013292 \| duodenal obstruction \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:11) 58 \| ACTA1 \| 1.641 \| DISEASES 1232 \| CCR3 \| 1.496 \| DISEASES 1103 \| CHAT \| 1.167 \| DISEASES 81608 \| FIP1L1 \| 3.229 \| DISEASES 388698 \| FLG2 \| 2.686 \| DISEASES 55340 \| GIMAP5 \| 2.797 \| DISEASES 2875 \| GPT \| 2.359 \| DISEASES 90865 \| IL33 \| 1.27 \| DISEASES 5265 \| SERPINA1 \| 1.246 \| DISEASES 7052 \| TGM2 \| 1.81 \| DISEASES 85480 \| TSLP \| 2.261 \| DISEASES
Locus	(Waiting for update.)

Disease ID	702
Disease	eosinophilic gastroenteritis
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:19) HP:0002243 \| Protein-losing enteropathy HP:0001974 \| Leukocytosis HP:0003565 \| Elevated erythrocyte sedimentation rate HP:0002570 \| Steatorrhea HP:0002013 \| Vomiting HP:0001047 \| Atopic dermatitis HP:0002014 \| Diarrhea HP:0002015 \| Dysphagia HP:0003193 \| Allergic rhinitis HP:0002027 \| Abdominal pain HP:0001824 \| Weight loss HP:0011227 \| Elevated C-reactive protein level HP:0002573 \| Hematochezia HP:0001541 \| Ascites HP:0002099 \| Asthma HP:0003073 \| Hypoalbuminemia HP:0001903 \| Anemia HP:0002024 \| Malabsorption HP:0000969 \| Edema
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:14) HP:0001541 \| Ascites \| 4 HP:0001903 \| Anemia \| 1 HP:0005240 \| Esophageal obstruction \| 1 HP:0002099 \| Asthma \| 1 HP:0002240 \| Enlarged liver \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0005202 \| Helicobacter pylori infection \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0012387 \| Bronchitis \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0100537 \| Inflammation of the fascia \| 1

Disease ID	702
Disease	eosinophilic gastroenteritis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:14) C2632116 \| stenosis C1699656 \| jejunal obstruction C1527407 \| eosinophilic pneumonia C1443924 \| severe diarrhea C0744421 \| immune complex glomerulonephritis C0742965 \| eosinophilic cystitis C0400979 \| biliary obstruction C0348024 \| thyroid dysfunction C0267937 \| recurrent acute pancreatitis C0267448 \| eosinophilic colitis C0034194 \| pyloric stenosis C0021845 \| intestinal perforation C0013395 \| dyspepsia C0000727 \| acute abdomen
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0742965 \| eosinophilic cystitis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:4)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0011227	Elevated C-reactive protein level	MP:0008721	abnormal chemokine level	deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes
HP:0003565	Elevated erythrocyte sedimentation rate	MP:0008770	decreased survivor rate	a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls
HP:0001047	Atopic dermatitis	MP:0001194	dermatitis	inflammation of the skin (redness and itching) caused by an allergic reaction or contact with an irritant
HP:0001824	Weight loss	MP:0005114	premature hair loss	release of fur at an earlier than expected time

Mapped by homologous gene(Total Items:19)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0002099	Asthma	MP:0020254	decreased collagen level	decreased level of the main structural protein of the various connective tissues in animals
HP:0003193	Allergic rhinitis	MP:0012080	chylous ascites	the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms
HP:0001824	Weight loss	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0000969	Edema	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0002013	Vomiting	MP:0020316	decreased vascular endothelial cell proliferation	decrease in the expansion rate of any vascular endothelial cell population by cell division
HP:0002027	Abdominal pain	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0001047	Atopic dermatitis	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0001974	Leukocytosis	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0002570	Steatorrhea	MP:0020137	decreased bone mineralization	decrease in the rate at which minerals are deposited into bone
HP:0002015	Dysphagia	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0003073	Hypoalbuminemia	MP:0020215	impaired blood coagulation	impaired ability of the blood to clot
HP:0002243	Protein-losing enteropathy	MP:0013504	increased embryonic tissue cell apoptosis	increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death
HP:0002014	Diarrhea	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0001541	Ascites	MP:0020137	decreased bone mineralization	decrease in the rate at which minerals are deposited into bone
HP:0002024	Malabsorption	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0002573	Hematochezia	MP:0013745	abnormal eyelid margin morphology	any structural anomaly of the confluence of the mucosal surface of the conjunctiva, the edge of the orbicularis, and the cutaneous epithelium
HP:0001903	Anemia	MP:0020316	decreased vascular endothelial cell proliferation	decrease in the expansion rate of any vascular endothelial cell population by cell division
HP:0003565	Elevated erythrocyte sedimentation rate	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0011227	Elevated C-reactive protein level	MP:0008721	abnormal chemokine level	deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes

Disease ID	702
Disease	eosinophilic gastroenteritis
Case	(Waiting for update.)