eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| ebola hemorrhagic fever | ||||
| Disease ID | 630 |
|---|---|
| Disease | ebola hemorrhagic fever |
| Definition | A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire. |
| Synonym | disease ebola ebola ebola fever hemorrhagic ebola haemorrhagic fever ebola infection ebola virus dis ebola virus disease ebola virus disease (disorder) ebola virus disease -retired- ebola virus infection evd - ebola virus disease hemorrhagic fever, ebola hemorrhagic fever, ebola [disease/finding] infection, ebola infection, ebola virus viral haemorrhagic fever, ebola viral hemorrhagic fever, ebola virus infection, ebola |
| Orphanet | |
| DOID | |
| ICD10 | |
| UMLS | C0282687 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:4) C0024530 | malaria | 3 C0042769 | virus infection | 1 C0042769 | viral infection | 1 C0038362 | stomatitis | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | Entrez_id | Symbol | Resource(Total Genes:17) 3802 | KIR2DL1 | CIPHER 3803 | KIR2DL2 | CIPHER 3804 | KIR2DL3 | CIPHER 3805 | KIR2DL4 | CIPHER 57292 | KIR2DL5A | CIPHER 553128 | KIR2DL5B | CIPHER 554300 | KIR2DP1 | CIPHER 3806 | KIR2DS1 | CIPHER 100132285 | KIR2DS2 | CIPHER 3808 | KIR2DS3 | CIPHER 3809 | KIR2DS4 | CIPHER 3810 | KIR2DS5 | CIPHER 3811 | KIR3DL1 | CIPHER 3812 | KIR3DL2 | CIPHER 115653 | KIR3DL3 | CIPHER 548594 | KIR3DP1 | CIPHER 3813 | KIR3DS1 | CIPHER |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:36) 79924 | ADM2 | 2.448 | DISEASES 408 | ARRB1 | 1.873 | DISEASES 65250 | C5orf42 | 2.805 | DISEASES 959 | CD40LG | 2.002 | DISEASES 1503 | CTPS1 | 2.739 | DISEASES 23586 | DDX58 | 2.903 | DISEASES 1946 | EFNA5 | 2.254 | DISEASES 26298 | EHF | 2.707 | DISEASES 2058 | EPRS | 1.403 | DISEASES 30816 | ERVW-1 | 2.557 | DISEASES 2152 | F3 | 2.247 | DISEASES 54455 | FBXO42 | 3.69 | DISEASES 2813 | GP2 | 4.028 | DISEASES 3434 | IFIT1 | 2.298 | DISEASES 3433 | IFIT2 | 2.75 | DISEASES 3437 | IFIT3 | 2.576 | DISEASES 3456 | IFNB1 | 2.457 | DISEASES 3665 | IRF7 | 1.768 | DISEASES 10379 | IRF9 | 2.508 | DISEASES 9636 | ISG15 | 1.896 | DISEASES 3712 | IVD | 1.515 | DISEASES 51520 | LARS | 1.374 | DISEASES 3965 | LGALS9 | 2.118 | DISEASES 497634 | LINC00293 | 5.785 | DISEASES 4151 | MB | 2.888 | DISEASES 284424 | MIR7-3HG | 1.574 | DISEASES 4599 | MX1 | 1.137 | DISEASES 8856 | NR1I2 | 1.218 | DISEASES 5256 | PHKA2 | 2.472 | DISEASES 139728 | PNCK | 3.161 | DISEASES 400668 | PRSS57 | 2.618 | DISEASES 6772 | STAT1 | 1.593 | DISEASES 51284 | TLR7 | 1.051 | DISEASES 79022 | TMEM106C | 3.849 | DISEASES 7306 | TYRP1 | 1.55 | DISEASES 8725 | URI1 | 3.522 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 630 |
|---|---|
| Disease | ebola hemorrhagic fever |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:27) HP:0002239 | Gastrointestinal hemorrhage HP:0012733 | Macule HP:0012378 | Fatigue HP:0002027 | Abdominal pain HP:0000093 | Proteinuria HP:0006554 | Acute hepatic failure HP:0000083 | Renal insufficiency HP:0002091 | Restrictive lung disease HP:0003326 | Myalgia HP:0001873 | Thrombocytopenia HP:0001882 | Leukopenia HP:0001254 | Lethargy HP:0002014 | Diarrhea HP:0002017 | Nausea and vomiting HP:0012375 | Chemosis HP:0100776 | Recurrent pharyngitis HP:0001250 | Seizures HP:0000225 | Gingival bleeding HP:0001259 | Coma HP:0100608 | Metrorrhagia HP:0012735 | Cough HP:0000988 | Skin rash HP:0001892 | Abnormal bleeding HP:0000421 | Epistaxis HP:0001695 | Cardiac arrest HP:0100749 | Chest pain HP:0002315 | Headache |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:4) HP:0001945 | Fever | 2 HP:0002094 | Dyspnea | 1 HP:0003201 | Rhabdomyolysis | 1 HP:0010280 | Stomatitis | 1 |
| Disease ID | 630 |
|---|---|
| Disease | ebola hemorrhagic fever |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:7) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0002239 | Gastrointestinal hemorrhage | MP:0012305 | umbilical cord hemorrhage | bleeding into or from the umbilical cord |
| HP:0000225 | Gingival bleeding | MP:0005606 | increased bleeding time | greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function |
| HP:0006554 | Acute hepatic failure | MP:0002628 | hepatic steatosis | an accumulation of fat deposits in the liver |
| HP:0000083 | Renal insufficiency | MP:0003335 | exocrine pancreatic insufficiency | inadequate synthesis and/or secretion of digestive enzymes by the exocrine portion of the pancreas, usually due to loss of acinar tissue from idiopathic atrophy or acute or chronic inflammation, causing maldigestion and malabsorption of nutrients |
| HP:0002091 | Restrictive lung disease | MP:0008714 | increased lung carcinoma incidence | greater than the expected number of a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous, occurring in a specific population in a given time period |
| HP:0001892 | Abnormal bleeding | MP:0005606 | increased bleeding time | greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function |
| HP:0002017 | Nausea and vomiting | MP:0010426 | abnormal heart and great artery attachment | any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta |
Mapped by homologous gene(Total Items:25) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0012735 | Cough | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0006554 | Acute hepatic failure | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0012375 | Chemosis | MP:0012732 | abnormal perineural vascular plexus morphology | any structural anomaly of the capillary bed that initially surrounds the relative avascular brain and spinal cord; the perineural vascular plexus (PNVP) is the precursor to the blood brain barrier formed by angioblasts which migrate away from somites and |
| HP:0002315 | Headache | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0001250 | Seizures | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0001259 | Coma | MP:0020216 | decreased circulating complement protein level | less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes |
| HP:0000093 | Proteinuria | MP:0020216 | decreased circulating complement protein level | less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes |
| HP:0001892 | Abnormal bleeding | MP:0020138 | delayed bone mineralization | late onset of the process by which minerals are deposited into bone |
| HP:0002239 | Gastrointestinal hemorrhage | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0002017 | Nausea and vomiting | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0001873 | Thrombocytopenia | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0002014 | Diarrhea | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0001695 | Cardiac arrest | MP:0013578 | abnormal stomach glandular region morphology | any structural anomaly of the distinct glandular stomach area which in rodents is demarcated from the non-glandular forestomach by the limiting ridge (margo plicatus); the glandular stomach is connected to the small intestine (duodenum); the wall of the g |
| HP:0012378 | Fatigue | MP:0013659 | abnormal erythroid lineage cell morphology | any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes |
| HP:0001882 | Leukopenia | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0000083 | Renal insufficiency | MP:0020316 | decreased vascular endothelial cell proliferation | decrease in the expansion rate of any vascular endothelial cell population by cell division |
| HP:0002027 | Abdominal pain | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0001254 | Lethargy | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0003326 | Myalgia | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0000421 | Epistaxis | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0100749 | Chest pain | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0100776 | Recurrent pharyngitis | MP:0013716 | hypolactation | partial failure, or reduced ability to produce or secrete milk from the mammary gland |
| HP:0000225 | Gingival bleeding | MP:0020186 | altered susceptibility to bacterial infection | a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria |
| HP:0002091 | Restrictive lung disease | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0000988 | Skin rash | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| Disease ID | 630 |
|---|---|
| Disease | ebola hemorrhagic fever |
| Case | (Waiting for update.) |