eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| drug-induced lupus erythematosus | ||||
| Disease ID | 1930 |
|---|---|
| Disease | drug-induced lupus erythematosus |
| Definition | An autoimmune disorder, similar to systemic lupus erythematosus, that is caused by certain drugs. |
| Synonym | drug induced lupus drug induced lupus erythematosus drug-induced lupus drug-induced lupus erythematosus (disorder) drug-induced lupus erythematosus, nos drug-induced systemic lupus erythematosus drug-induced systemic lupus erythematosus (disorder) lupus drug induced lupus drug-induced secondary lupus |
| Orphanet | |
| ICD10 | |
| UMLS | C0263591 |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:3) C0151436 | leukocytoclastic vasculitis | 1 C0001824 | granulocytopenia | 1 C0007177 | cardiac tamponade | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 1930 |
|---|---|
| Disease | drug-induced lupus erythematosus |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:23) HP:0002094 | Dyspnea HP:0025300 | Malar rash HP:0005421 | Decreased serum complement C3 HP:0001698 | Pericardial effusion HP:0002829 | Arthralgia HP:0000967 | Petechiae HP:0003326 | Myalgia HP:0003565 | Elevated erythrocyte sedimentation rate HP:0001873 | Thrombocytopenia HP:0003236 | Elevated serum creatine phosphokinase HP:0045042 | Decreased serum complement C4 HP:0000790 | Hematuria HP:0005184 | Prolonged QTc interval HP:0001903 | Anemia HP:0025343 | Lupus anticoagulant HP:0003493 | Antinuclear antibody positivity HP:0001945 | Fever HP:0025142 | Constitutional symptom HP:0030057 | Autoimmune antibody positivity HP:0001701 | Pericarditis HP:0003138 | Increased blood urea nitrogen HP:0045073 | Serositis HP:0011227 | Elevated C-reactive protein level |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:3) |
| Disease ID | 1930 |
|---|---|
| Disease | drug-induced lupus erythematosus |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:1) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:7) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0003493 | Antinuclear antibody positivity | MP:0004762 | increased anti-double stranded DNA antibody level | increase in the level of antibodies that recognize double stranded DNA |
| HP:0005184 | Prolonged QTc interval | MP:0011953 | prolonged PQ interval | increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave |
| HP:0003236 | Elevated serum creatine phosphokinase | MP:0020280 | increased creatine kinase level | increased level of the enzyme that catalyzes the reversible transfer of creatine to phosphocreatine |
| HP:0003138 | Increased blood urea nitrogen (BUN) | MP:0009642 | abnormal blood homeostasis | anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood |
| HP:0003565 | Elevated erythrocyte sedimentation rate | MP:0008770 | decreased survivor rate | a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls |
| HP:0005421 | Decreased serum complement C3 | MP:0020216 | decreased circulating complement protein level | less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes |
| HP:0011227 | Elevated C-reactive protein level | MP:0008721 | abnormal chemokine level | deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes |
Mapped by homologous gene(Total Items:17) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001698 | Pericardial effusion | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0003236 | Elevated serum creatine phosphokinase | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0000790 | Hematuria | MP:0020316 | decreased vascular endothelial cell proliferation | decrease in the expansion rate of any vascular endothelial cell population by cell division |
| HP:0002094 | Dyspnea | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0001945 | Fever | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0002829 | Arthralgia | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0003138 | Increased blood urea nitrogen (BUN) | MP:0020216 | decreased circulating complement protein level | less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes |
| HP:0001903 | Anemia | MP:0020316 | decreased vascular endothelial cell proliferation | decrease in the expansion rate of any vascular endothelial cell population by cell division |
| HP:0003493 | Antinuclear antibody positivity | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0001701 | Pericarditis | MP:0011405 | tubulointerstitial nephritis | diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease |
| HP:0005184 | Prolonged QTc interval | MP:0013578 | abnormal stomach glandular region morphology | any structural anomaly of the distinct glandular stomach area which in rodents is demarcated from the non-glandular forestomach by the limiting ridge (margo plicatus); the glandular stomach is connected to the small intestine (duodenum); the wall of the g |
| HP:0001873 | Thrombocytopenia | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0003326 | Myalgia | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0000967 | Petechiae | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0005421 | Decreased serum complement C3 | MP:0020216 | decreased circulating complement protein level | less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes |
| HP:0003565 | Elevated erythrocyte sedimentation rate | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0011227 | Elevated C-reactive protein level | MP:0008721 | abnormal chemokine level | deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes |
| Disease ID | 1930 |
|---|---|
| Disease | drug-induced lupus erythematosus |
| Case | (Waiting for update.) |