eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| dextrocardia | ||||
| Disease ID | 943 |
|---|---|
| Disease | dextrocardia |
| Definition | A congenital defect in which the heart is located on the right side of the THORAX instead of on the left side (levocardia, the normal position). When dextrocardia is accompanied with inverted HEART ATRIA, a right-sided STOMACH, and a left-sided LIVER, the combination is called dextrocardia with SITUS INVERSUS. Dextrocardia may adversely affect other thoracic organs. |
| Synonym | dextrocardia (disorder) dextrocardia [disease/finding] dextrocardias heart dextroposition heart in right chest heart predominantly in right hemithorax heart predominantly in right hemithorax (disorder) right sided heart thoracic situs inversus |
| Orphanet | |
| DOID | |
| ICD10 | |
| UMLS | C0011813 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:20) C0032357 | poland syndrome | 9 C0027051 | myocardial infarct | 4 C0027051 | myocardial infarction | 4 C0018799 | heart disease | 3 C0152021 | congenital heart disease | 2 C0018818 | ventricular septal defect | 2 C0026269 | mitral stenosis | 2 C0155626 | acute myocardial infarction | 1 C0026266 | mitral regurgitation | 1 C0152101 | hypoplastic left heart | 1 C0003507 | aortic stenosis | 1 C0175703 | tar syndrome | 1 C0038379 | strabismus | 1 C0022521 | kartagener syndrome | 1 C0018824 | valvular heart disease | 1 C0152101 | hypoplastic left heart syndrome | 1 C0005411 | biliary atresia | 1 C0264766 | rheumatic mitral stenosis | 1 C0024164 | lutembacher's syndrome | 1 C0008925 | cleft palate | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:22) 93 | ACVR2B | 2.164 | DISEASES 10533 | ATG7 | 1.389 | DISEASES 54880 | BCOR | 2.89 | DISEASES 10370 | CITED2 | 2.214 | DISEASES 79827 | CLMP | 3.584 | DISEASES 78987 | CRELD1 | 4.57 | DISEASES 5476 | CTSA | 1.48 | DISEASES 2081 | ERN1 | 1.756 | DISEASES 2318 | FLNC | 1.005 | DISEASES 2626 | GATA4 | 2.192 | DISEASES 84667 | HES7 | 4.103 | DISEASES 3339 | HSPG2 | 1.082 | DISEASES 11009 | IL24 | 1.439 | DISEASES 7044 | LEFTY2 | 2.566 | DISEASES 4535 | MT-ND1 | 2.08 | DISEASES 1482 | NKX2-5 | 1.389 | DISEASES 261734 | NPHP4 | 2.357 | DISEASES 51715 | RAB23 | 2.616 | DISEASES 7955 | RNF217-AS1 | 2.237 | DISEASES 221421 | RSPH9 | 3.849 | DISEASES 5270 | SERPINE2 | 1.882 | DISEASES 347734 | SLC35B2 | 3.445 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 943 |
|---|---|
| Disease | dextrocardia |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:12) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001743 | Abnormality of the spleen | MP:0004485 | increased response of heart to induced stress | increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding |
| HP:0001627 | Abnormal heart morphology | MP:0004251 | failure of heart looping | failure of the primitive heart tube to loop asymmetrically during early development |
| HP:0000384 | Preauricular skin tag | MP:0001786 | skin edema | accumulation of an excessive amount of fluid in the skin layers or just underneath the skin |
| HP:0001696 | Situs inversus totalis | MP:0011252 | situs inversus totalis | the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia) |
| HP:0000772 | Abnormality of the ribs | MP:0020010 | decreased bone mineral density of femur | reduction in the quatitative measurment value of mineral content of bone in the long bone of the thigh |
| HP:0004414 | Abnormality of the pulmonary artery | MP:0011665 | d-loop transposition of the great arteries | complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and th |
| HP:0001263 | Global developmental delay | MP:0002084 | abnormal developmental patterning | abnormal systematic arrangement of the developing body along an axis |
| HP:0002594 | Pancreatic hypoplasia | MP:0009111 | pancreas hypoplasia | underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells |
| HP:0002101 | Abnormal lung lobation | MP:0010975 | abnormal lung lobe morphology | any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls |
| HP:0000069 | Abnormality of the ureter | MP:0011665 | d-loop transposition of the great arteries | complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and th |
| HP:0001760 | Abnormality of the foot | MP:0011665 | d-loop transposition of the great arteries | complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and th |
| HP:0012210 | Abnormal renal morphology | MP:0004505 | decreased renal glomerulus number | reduced number of the capillary loops of the kidney that normally function as a filtration unit |
Mapped by homologous gene(Total Items:20) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0000772 | Abnormality of the ribs | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0001263 | Global developmental delay | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0003115 | Abnormal EKG | MP:0013504 | increased embryonic tissue cell apoptosis | increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death |
| HP:0002245 | Meckel diverticulum | MP:0014051 | abnormal maxillary-premaxillary suture morphology | any structural anomaly of the line of union of the two portions of the maxilla (pre- and postmaxilla) |
| HP:0004414 | Abnormality of the pulmonary artery | MP:0013696 | increased granulocyte monocyte progenitor cell number | increase in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1 |
| HP:0003006 | Neuroblastoma | MP:0014130 | thymus cysts | presence of fluid-filled spaces lined by epithelium within the thymus; thymic cysts are rare mediastinal lesions and are thought to result from the congenital persistence of thymopharyngeal tracts and acquired, progressive cystic degeneration of thymic (H |
| HP:0001743 | Abnormality of the spleen | MP:0013696 | increased granulocyte monocyte progenitor cell number | increase in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1 |
| HP:0002594 | Pancreatic hypoplasia | MP:0014125 | decreased amylin secretion | reduction in the production or release of the polypeptide hormone that is normally co-secreted with insulin by the beta cells of the pancreatic islets of Langerhans and is known to inhibit glucagon secretion, delay gastric emptying, and act as a satiety a |
| HP:0001760 | Abnormality of the foot | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0000384 | Preauricular skin tag | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0001374 | Congenital hip dislocation | MP:0020214 | susceptible to malignant hyperthermia | increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine |
| HP:0001627 | Abnormal heart morphology | MP:0012159 | absent anterior visceral endoderm | absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue |
| HP:0000465 | Webbed neck | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0000069 | Abnormality of the ureter | MP:0014171 | increased fatty acid oxidation | increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydr |
| HP:0002101 | Abnormal lung lobation | MP:0013785 | abnormal mammary gland bud morphology | any structural anomaly of the morphologically distinct bulb of epithelial cells formed once each mammary placode expands and invaginates into the underlying mesenchyme; in mouse embryos at E12.5, each epithelial bud with its contiguous mesenchyme is eleva |
| HP:0012210 | Abnormal renal morphology | MP:0014152 | absent exorbital lacrimal gland | absence of the large extra-orbital lacrimal gland that, in mice, is normally located subcutaneously at the anteroventral base of the ear adjacent to the parotid gland |
| HP:0002566 | Intestinal malrotation | MP:0014155 | absent olfactory epithelium | absence of the epithelial cells that line the interior of the nose |
| HP:0001651 | Dextrocardia | MP:0012739 | abnormal anterior primitive streak morphology | any structural anomaly of the anterior region of the vertebrate primitive streak which gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node |
| HP:0000238 | Hydrocephalus | MP:0020080 | increased bone mineralization | increase in the rate at which minerals are deposited into bone |
| HP:0001696 | Situs inversus totalis | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| Disease ID | 943 |
|---|---|
| Disease | dextrocardia |
| Case | (Waiting for update.) |