eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| dermatitis herpetiformis | ||||
| Disease ID | 332 |
|---|---|
| Disease | dermatitis herpetiformis |
| Definition | Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis. |
| Synonym | dermatitis herpetiformis (disorder) dermatitis herpetiformis [disease/finding] dermatitis herpetiformis [dup] (disorder) dermatitis, herpetiformis dermatosis herpetiformis dh - dermatitis herpetiformis disease duhring's disease, duhring disease, duhring's duhring dis duhring disease duhring's disease duhring-brocq disease duhrings dis duhrings disease herpetiformis dermatitis |
| Orphanet | |
| DOID | |
| ICD10 | |
| UMLS | C0011608 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:23) C0024299 | lymphoma | 2 C0007570 | gluten-sensitive enteropathy | 2 C0206180 | anaplastic large cell lymphoma | 1 C0242379 | lung cancer | 1 C0013595 | eczema | 1 C0007570 | coeliac disease | 1 C0010068 | coronary heart disease | 1 C0015230 | rash | 1 C0007570 | celiac disease | 1 C0004096 | asthma | 1 C0024302 | large cell lymphoma | 1 C0021831 | enteropathy | 1 C0409974 | lupus erythematosus | 1 C0018799 | heart disease | 1 C0042900 | vitiligo | 1 C0017152 | gastritis | 1 C0024305 | non-hodgkin lymphoma | 1 C0263398 | erythema elevatum diutinum | 1 C0024141 | systemic lupus erythematosus | 1 C0004096 | bronchial asthma | 1 C0151436 | leukocytoclastic vasculitis | 1 C0027873 | neuromyelitis optica | 1 C0019829 | hodgkin lymphoma | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:41) 8754 | ADAM9 | 1.095 | DISEASES 29994 | BAZ2B | 1.978 | DISEASES 680 | BRS3 | 1.275 | DISEASES 720 | C4A | 1.343 | DISEASES 721 | C4B | 1.801 | DISEASES 959 | CD40LG | 3.4 | DISEASES 10669 | CGREF1 | 3.18 | DISEASES 1308 | COL17A1 | 3.192 | DISEASES 85301 | COL27A1 | 2.122 | DISEASES 1665 | DHX15 | 2.218 | DISEASES 2204 | FCAR | 1.432 | DISEASES 23150 | FRMD4B | 2.948 | DISEASES 2524 | FUT2 | 1.649 | DISEASES 2520 | GAST | 1.473 | DISEASES 9464 | HAND2 | 2.193 | DISEASES 51696 | HECA | 1.636 | DISEASES 3105 | HLA-A | 1.59 | DISEASES 3115 | HLA-DPB1 | 2.183 | DISEASES 3117 | HLA-DQA1 | 2.091 | DISEASES 3118 | HLA-DQA2 | 1.814 | DISEASES 3119 | HLA-DQB1 | 1.784 | DISEASES 3120 | HLA-DQB2 | 1.898 | DISEASES 3240 | HP | 1.498 | DISEASES 3320 | HSP90AA1 | 1.075 | DISEASES 219844 | HYLS1 | 1.074 | DISEASES 3428 | IFI16 | 1.426 | DISEASES 4312 | MMP1 | 1.023 | DISEASES 4650 | MYO9B | 1.829 | DISEASES 4976 | OPA1 | 2.101 | DISEASES 5178 | PEG3 | 1.484 | DISEASES 5339 | PLEC | 1.789 | DISEASES 5625 | PRODH | 1.101 | DISEASES 5737 | PTGFR | 1.957 | DISEASES 9467 | SH3BP5 | 1.107 | DISEASES 10011 | SRA1 | 1.085 | DISEASES 7052 | TGM2 | 5.428 | DISEASES 7053 | TGM3 | 3.975 | DISEASES 284486 | THEM5 | 1.525 | DISEASES 8718 | TNFRSF25 | 4.763 | DISEASES 1861 | TOR1A | 4.47 | DISEASES 7177 | TPSAB1 | 2.171 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 332 |
|---|---|
| Disease | dermatitis herpetiformis |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:14) HP:0010783 | Erythema HP:0001025 | Urticaria HP:0012733 | Macule HP:0200037 | Skin vesicle HP:0002653 | Bone pain HP:0002757 | Recurrent fractures HP:0002960 | Autoimmunity HP:0000989 | Pruritus HP:0000964 | Eczema HP:0100725 | Lichenification HP:0008066 | Abnormal blistering of the skin HP:0002024 | Malabsorption HP:0001935 | Microcytic anemia HP:0000969 | Edema |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:15) HP:0002665 | Lymphoma | 2 HP:0200037 | Skin vesicle | 1 HP:0002608 | Celiac disease | 1 HP:0001045 | Blotchy loss of skin color | 1 HP:0012189 | Hodgkin disease | 1 HP:0012539 | Non-Hodgkin lymphoma | 1 HP:0000964 | Eczema | 1 HP:0000961 | Cyanosis | 1 HP:0005231 | Chronic gastritis | 1 HP:0002242 | Enteropathy | 1 HP:0010783 | Erythema | 1 HP:0000967 | Petechiae | 1 HP:0005263 | Gastritis | 1 HP:0002725 | Systemic lupus erythematosus | 1 HP:0002099 | Asthma | 1 |
| Disease ID | 332 |
|---|---|
| Disease | dermatitis herpetiformis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:41) C1963165 | malabsorption C1368041 | pancreatic somatostatinoma C0848454 | uterine carcinoma C0679408 | gastric lesion C0679407 | gastrointestinal dysfunction C0409977 | bullous systemic lupus erythematosus C0340987 | splenic atrophy C0272132 | drug-induced haemolytic anaemia C0263367 | koebner phenomenon C0156084 | gastric dysfunction C0152025 | polyneuropathies C0151744 | ischaemic heart disease C0151313 | sensory neuropathy C0079746 | immunoblastic sarcoma C0037285 | skin manifestations C0037284 | skin lesions C0037274 | skin diseases C0034150 | purpura C0033680 | protein-losing enteropathy C0031256 | petechiae C0031117 | peripheral neuropathy C0029166 | oral manifestations C0025637 | methaemoglobinaemia C0024299 | lymphoma C0021831 | intestinal disease C0021831 | enteropathy C0017658 | glomerulonephritis C0017657 | glomerulitis C0017152 | gastritis C0015230 | skin rash C0015230 | rash C0013720 | ehlers-danlos syndrome C0011854 | type 1 diabetes C0011854 | insulin-dependent diabetes mellitus C0011633 | polymyositis/dermatomyositis C0007570 | gluten-sensitive enteropathy C0007570 | gluten sensitive enteropathy C0007570 | gluten enteropathy C0007570 | coeliac syndrome C0002886 | macrocytic anaemia C0002871 | anaemia |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:8) C0024299 | lymphoma | 2 C0007570 | gluten-sensitive enteropathy | 2 C0021831 | enteropathy | 1 C0409977 | bullous systemic lupus erythematosus | 1 C0015230 | rash | 1 C0031256 | petechiae | 1 C0037284 | skin lesions | 1 C0017152 | gastritis | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:3) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001935 | Microcytic anemia | MP:0001577 | anemia | less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs |
| HP:0002757 | Recurrent fractures | MP:0004675 | rib fractures | a crack or break in the bones forming the bony wall of the chest |
| HP:0008066 | Abnormal blistering of the skin | MP:0009536 | abnormal interstitial cell of Cajal morphology | any structural anomaly in the type of cell found in the gastrointestinal tract and serving as a pacemaker that triggers gut contraction; ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which |
Mapped by homologous gene(Total Items:13) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0000969 | Edema | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0002653 | Bone pain | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0001935 | Microcytic anemia | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0002960 | Autoimmunity | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0100725 | Lichenification | MP:0011939 | increased food intake | increase in the total number of calories/food amount taken in over time when compared to the normal state |
| HP:0000989 | Pruritus | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0000964 | Eczema | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0010783 | Erythema | MP:0013781 | abnormal mammary gland luminal epithelium morphology | any structural anomaly of the inner cell layer of the mammary epithelium bilayer that lines the luminal surface of mammary gland ducts and alveoli; luminal cells have only limited contact with the underlying basement membrane and surrounding connective ti |
| HP:0001025 | Urticaria | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0008066 | Abnormal blistering of the skin | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0002024 | Malabsorption | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0200037 | Skin vesicle | MP:0011094 | embryonic lethality before implantation, complete penetrance | death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5) |
| HP:0002757 | Recurrent fractures | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| Disease ID | 332 |
|---|---|
| Disease | dermatitis herpetiformis |
| Case | (Waiting for update.) |