eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| dengue fever | ||||
| Disease ID | 248 |
|---|---|
| Disease | dengue fever |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:24) C2364133 | infection C2118460 | acute colitis C1963101 | encephalopathy C0752303 | urological manifestations C0730362 | maculopathy C0547030 | visual disturbances C0270790 | quadriparesis C0267842 | acute acalculous cholecystitis C0267841 | acalculous cholecystitis C0267797 | acute hepatitis C0267373 | intestinal bleeding C0154946 | acute angle closure glaucoma C0154874 | neuroretinitis C0042749 | viraemia C0040034 | thrombocytopenia C0037284 | skin lesions C0029132 | optic neuropathy C0023530 | leukopenia C0022660 | acute renal failure C0019080 | hemorrhage C0015230 | rash C0015230 | exanthem C0007177 | cardiac tamponade C0000727 | acute abdomen |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:11) C0009450 | infection | 14 C0040034 | thrombocytopenia | 8 C0270790 | quadriparesis | 6 C0752303 | urological manifestations | 5 C0019080 | hemorrhage | 3 C0015230 | rash | 2 C0730362 | maculopathy | 2 C0007177 | cardiac tamponade | 1 C0022660 | acute renal failure | 1 C0000727 | acute abdomen | 1 C0085584 | encephalopathy | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:28) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs1131454 | 24819159 | 4938 | OAS1 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | OAS1 | 12 | 112911065 | G | A,C |
| rs1131454 | 24819159 | 4940 | OAS3 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | OAS1 | 12 | 112911065 | G | A,C |
| rs1285933 | 24016730 | 30835 | CD209 | umls:C0011311 | BeFree | We demonstrated that the TT genotype of CLEC5A SNP (rs1285933 C>T) is associated with dengue severity (OR=2.25; p=0.03) and that GG genotype of -336G>A DCSIGN (CD209) SNP is associated with protection to severe dengue (OR=0.12; p=0.04). | 0.122985861 | 2013 | CLEC5A;OR9A4 | 7 | 141927349 | G | A |
| rs1293762 | 24819159 | 4938 | OAS1 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | OAS2 | 12 | 112993031 | T | G |
| rs1293762 | 24819159 | 4940 | OAS3 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | OAS2 | 12 | 112993031 | T | G |
| rs15895 | 24819159 | 4940 | OAS3 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | OAS2 | 12 | 113010483 | A | G |
| rs15895 | 24819159 | 4938 | OAS1 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | OAS2 | 12 | 113010483 | A | G |
| rs1732778 | 24819159 | 4940 | OAS3 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | NA | 12 | 113019120 | G | A |
| rs1732778 | 24819159 | 4938 | OAS1 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | NA | 12 | 113019120 | G | A |
| rs1799964 | 23380141 | 3123 | HLA-DRB1 | umls:C0011311 | BeFree | Presence of combination of HLA-DRB1*07/*15 with either rs1799964 'C/C' genotype or rs1800629 'G/A' genotype or both was present in 17.2% of DHF cases and 1.2% in HCs while this combination was not observed in DF cases. | 0.006634157 | 2013 | LTA;TNF;LOC100287329 | 6 | 31574531 | T | C |
| rs1800629 | 23380141 | 3123 | HLA-DRB1 | umls:C0011311 | BeFree | Presence of combination of HLA-DRB1*07/*15 with either rs1799964 'C/C' genotype or rs1800629 'G/A' genotype or both was present in 17.2% of DHF cases and 1.2% in HCs while this combination was not observed in DF cases. | 0.006634157 | 2013 | TNF | 6 | 31575254 | G | A |
| rs2072136 | 24819159 | 4940 | OAS3 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | OAS3 | 12 | 112961114 | G | C,A |
| rs2072136 | 24819159 | 4938 | OAS1 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | OAS3 | 12 | 112961114 | G | C,A |
| rs2285932 | 24819159 | 4938 | OAS1 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | OAS3 | 12 | 112949145 | T | C |
| rs2285932 | 24819159 | 4940 | OAS3 | umls:C0011311 | BeFree | Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. | 0.000542884 | 2014 | OAS3 | 12 | 112949145 | T | C |
| rs3132468 | 23536857 | 4277 | MICB | umls:C0011311 | BeFree | This study confirms that the MICB rs3132468 and PLCE1 rs3740360 risk genotypes are not only associated with DSS, but are also associated with less severe clinical phenotypes of dengue, as well as with dengue in infants. | 0.000542884 | 2013 | MICB | 6 | 31507709 | C | T |
| rs3132468 | 23536857 | 51196 | PLCE1 | umls:C0011311 | BeFree | This study confirms that the MICB rs3132468 and PLCE1 rs3740360 risk genotypes are not only associated with DSS, but are also associated with less severe clinical phenotypes of dengue, as well as with dengue in infants. | 0.000271442 | 2013 | MICB | 6 | 31507709 | C | T |
| rs3205166 | 25850761 | 23586 | DDX58 | umls:C0011311 | BeFree | The results revealed a lower carrier frequency of the DDX58 rs3205166 G allele in DEN than in HCs and a higher frequency of the DDX58 rs669260 T/C genotype in DHF than in DF cases (P = 0.043, OR with 95 % CI 3.358 [1.038-10.861]). | 0.001357209 | 2015 | DDX58;LOC101060445 | 9 | 32459452 | T | G |
| rs3740360 | 23536857 | 51196 | PLCE1 | umls:C0011311 | BeFree | This study confirms that the MICB rs3132468 and PLCE1 rs3740360 risk genotypes are not only associated with DSS, but are also associated with less severe clinical phenotypes of dengue, as well as with dengue in infants. | 0.000271442 | 2013 | PLCE1 | 10 | 94265734 | A | C |
| rs3740360 | 23536857 | 4277 | MICB | umls:C0011311 | BeFree | This study confirms that the MICB rs3132468 and PLCE1 rs3740360 risk genotypes are not only associated with DSS, but are also associated with less severe clinical phenotypes of dengue, as well as with dengue in infants. | 0.000542884 | 2013 | PLCE1 | 10 | 94265734 | A | C |
| rs3764879 | 25446400 | 51311 | TLR8 | umls:C0011311 | BeFree | Higher frequency of TLR8 rs3764879–rs3764880 haplotype C-A was observed in male DF cases compared to male HC [P = 0.025 OR with 95% CI 2.185 (1.101–4.336)]. | 0.000271442 | 2014 | TLR8;TLR8-AS1 | X | 12906578 | C | G |
| rs3764880 | 25446400 | 51311 | TLR8 | umls:C0011311 | BeFree | Higher frequency of TLR8 rs3764879–rs3764880 haplotype C-A was observed in male DF cases compared to male HC [P = 0.025 OR with 95% CI 2.185 (1.101–4.336)]. | 0.000271442 | 2014 | TLR8;TLR8-AS1 | X | 12906707 | A | G |
| rs3775291 | 25446400 | 7098 | TLR3 | umls:C0011311 | BeFree | Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF. | 0.000542884 | 2014 | TLR3 | 4 | 186082920 | C | T,G |
| rs4804803 | 20470843 | 30835 | CD209 | umls:C0011311 | BeFree | A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is associated with the severity of tuberculosis and dengue fever. | 0.122985861 | 2010 | CD209 | 19 | 7747847 | A | G |
| rs4804803 | 21245921 | 30835 | CD209 | umls:C0011311 | BeFree | the rs4804803 SNP in the CD209 promoter contributed to susceptibility to dengue infection and complication of DHF. | 0.122985861 | 2011 | CD209 | 19 | 7747847 | A | G |
| rs4804803 | 22061615 | 30835 | CD209 | umls:C0011311 | BeFree | Previously the severity and outcome of dengue fever and hepatitis C (diseases caused by viruses from the family Flaviviridae) were associated with the rs4804803 single nucleotide polymorphism (SNP) located in the promoter region of the human CD209 gene. | 0.122985861 | 2012 | CD209 | 19 | 7747847 | A | G |
| rs669260 | 25850761 | 23586 | DDX58 | umls:C0011311 | BeFree | The results revealed a lower carrier frequency of the DDX58 rs3205166 G allele in DEN than in HCs and a higher frequency of the DDX58 rs669260 T/C genotype in DHF than in DF cases (P = 0.043, OR with 95 % CI 3.358 [1.038-10.861]). | 0.001357209 | 2015 | DDX58 | 9 | 32503442 | T | C |
| rs8177374 | 25446400 | 7098 | TLR3 | umls:C0011311 | BeFree | Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF. | 0.000542884 | 2014 | TIRAP | 11 | 126292948 | C | T |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:5) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0000225 | Gingival bleeding | MP:0005606 | increased bleeding time | greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function |
| HP:0002017 | Nausea and vomiting | MP:0010426 | abnormal heart and great artery attachment | any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta |
| HP:0002239 | Gastrointestinal hemorrhage | MP:0012305 | umbilical cord hemorrhage | bleeding into or from the umbilical cord |
| HP:0001342 | Cerebral hemorrhage | MP:0001914 | hemorrhage | loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels |
| HP:0000978 | Bruising susceptibility | MP:0005596 | increased susceptibility to type I hypersensitivity reaction | greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation a |
Mapped by homologous gene(Total Items:22) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001945 | Fever | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0002315 | Headache | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0000978 | Bruising susceptibility | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0003075 | Hypoproteinemia | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0002240 | Hepatomegaly | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0002239 | Gastrointestinal hemorrhage | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0001541 | Ascites | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0001873 | Thrombocytopenia | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0002014 | Diarrhea | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0000967 | Petechiae | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0002017 | Nausea and vomiting | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0001342 | Cerebral hemorrhage | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0001882 | Leukopenia | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0002829 | Arthralgia | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0002027 | Abdominal pain | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0001254 | Lethargy | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0000421 | Epistaxis | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0002615 | Hypotension | MP:0020214 | susceptible to malignant hyperthermia | increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine |
| HP:0000989 | Pruritus | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0000225 | Gingival bleeding | MP:0020186 | altered susceptibility to bacterial infection | a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria |
| HP:0006543 | Cardiorespiratory arrest | MP:0011100 | preweaning lethality, complete penetrance | death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age) |
| HP:0000988 | Skin rash | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| Disease ID | 248 |
|---|---|
| Disease | dengue fever |
| Case | (Waiting for update.) |