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encyclopedia of Rare Disease Annotation for Precision Medicine

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	complex regional pain syndrome

Disease ID	1284
Disease	complex regional pain syndrome
Definition	Conditions characterized by pain involving an extremity or other body region, HYPERESTHESIA, and localized autonomic dysfunction following injury to soft tissue or nerve. The pain is usually associated with ERYTHEMA; SKIN TEMPERATURE changes, abnormal sudomotor activity (i.e., changes in sweating due to altered sympathetic innervation) or edema. The degree of pain and other manifestations is out of proportion to that expected from the inciting event. Two subtypes of this condition have been described: type I; (REFLEX SYMPATHETIC DYSTROPHY) and type II; (CAUSALGIA). (From Pain 1995 Oct;63(1):127-33)
Synonym	complex pain regional syndrome complex regional pain syndrome (crps) complex regional pain syndrome (disorder) complex regional pain syndrome nos complex regional pain syndromes complex regional pain syndromes (disorder) complex regional pain syndromes [disease/finding] complexed pain regional syndrome crps crps (complex regional pain syndromes) pain regional complex syndrome pain syndromes, regional complex regional complex pain syndrome
Orphanet	ORPHANET:83452
DOID	DOID:3223
UMLS	C0458219
MeSH	D020918
SNOMED-CT	SNOMEDCT_US_2016_09_01:128200000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:25) C0013421 \| dystonia \| 12 C0011570 \| depression \| 2 C0017653 \| glomus tumor \| 2 C0038013 \| ankylosing spondylitis \| 2 C0006142 \| breast cancer \| 1 C0024408 \| machado-joseph disease \| 1 C0023343 \| leprosy \| 1 C0743332 \| focal dystonia \| 1 C0018099 \| gout \| 1 C0029456 \| osteoporosis \| 1 C0035920 \| rubella \| 1 C0021053 \| immune disease \| 1 C0038012 \| spondylitis \| 1 C0024408 \| joseph disease \| 1 C0003467 \| anxiety \| 1 C0026850 \| muscular dystrophy \| 1 C0019158 \| hepatitis \| 1 C0085253 \| adult onset still's disease \| 1 C0149931 \| migraine \| 1 C0007286 \| carpal tunnel syndrome \| 1 C0002766 \| analgesia \| 1 C0019163 \| hepatitis b \| 1 C0001418 \| adenocarcinoma \| 1 C0010068 \| coronary artery disease \| 1 C0034734 \| raynaud's disease \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:58) 23141 \| ANKLE2 \| 3.05 \| DISEASES 632 \| BGLAP \| 1.386 \| DISEASES 796 \| CALCA \| 5.176 \| DISEASES 799 \| CALCR \| 1.009 \| DISEASES 10203 \| CALCRL \| 1.382 \| DISEASES 834 \| CASP1 \| 1.491 \| DISEASES 388372 \| CCL4L1 \| 2.01 \| DISEASES 9560 \| CCL4L2 \| 1.245 \| DISEASES 959 \| CD40LG \| 1.039 \| DISEASES 1269 \| CNR2 \| 1.469 \| DISEASES 1441 \| CSF3R \| 1.067 \| DISEASES 1813 \| DRD2 \| 1.229 \| DISEASES 1906 \| EDN1 \| 2.414 \| DISEASES 1910 \| EDNRB \| 1.249 \| DISEASES 1915 \| EEF1A1 \| 1.225 \| DISEASES 10938 \| EHD1 \| 1.175 \| DISEASES 2027 \| ENO3 \| 1.68 \| DISEASES 53827 \| FXYD5 \| 1.052 \| DISEASES 2556 \| GABRA3 \| 2.298 \| DISEASES 2719 \| GPC3 \| 3.119 \| DISEASES 2821 \| GPI \| 1.283 \| DISEASES 164045 \| HFM1 \| 2.508 \| DISEASES 3105 \| HLA-A \| 1.396 \| DISEASES 3106 \| HLA-B \| 1.279 \| DISEASES 81502 \| HM13 \| 1.877 \| DISEASES 3586 \| IL10 \| 1.3 \| DISEASES 102723508 \| KANTR \| 2.826 \| DISEASES 286826 \| LIN9 \| 3.063 \| DISEASES 9968 \| MED12 \| 1.264 \| DISEASES 8972 \| MGAM \| 1.193 \| DISEASES 4311 \| MME \| 1.672 \| DISEASES 4791 \| NFKB2 \| 1.151 \| DISEASES 4803 \| NGF \| 3.614 \| DISEASES 22861 \| NLRP1 \| 2.277 \| DISEASES 594857 \| NPS \| 4.499 \| DISEASES 4914 \| NTRK1 \| 1.754 \| DISEASES 4988 \| OPRM1 \| 1.691 \| DISEASES 55010 \| PARPBP \| 2.245 \| DISEASES 25859 \| PART1 \| 1.003 \| DISEASES 5179 \| PENK \| 1.053 \| DISEASES 5333 \| PLCD1 \| 2.267 \| DISEASES 5535 \| PPP3R2 \| 3.196 \| DISEASES 51334 \| PRR16 \| 1.89 \| DISEASES 29122 \| PRSS50 \| 2.13 \| DISEASES 146713 \| RBFOX3 \| 1.29 \| DISEASES 7905 \| REEP5 \| 1.16 \| DISEASES 6050 \| RNH1 \| 1.228 \| DISEASES 6164 \| RPL34 \| 1.011 \| DISEASES 6336 \| SCN10A \| 1.455 \| DISEASES 6335 \| SCN9A \| 2.161 \| DISEASES 8910 \| SGCE \| 1.186 \| DISEASES 9467 \| SH3BP5 \| 1.259 \| DISEASES 6863 \| TAC1 \| 4.895 \| DISEASES 7124 \| TNF \| 2.61 \| DISEASES 1861 \| TOR1A \| 1.562 \| DISEASES 7316 \| UBC \| 1.061 \| DISEASES 9218 \| VAPA \| 1.224 \| DISEASES 7694 \| ZNF135 \| 1.821 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1284
Disease	complex regional pain syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:30) HP:0012531 \| Pain \| 43 HP:0001332 \| Dystonia \| 13 HP:0012532 \| Chronic pain \| 5 HP:0012533 \| Allodynia \| 4 HP:0100022 \| Movement disorder \| 4 HP:0001297 \| Cerebral vascular events \| 3 HP:0002664 \| Neoplasia \| 3 HP:0000969 \| Dropsy \| 3 HP:0000716 \| Depression \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0010834 \| Trophic changes \| 2 HP:0000734 \| Disinhibition \| 2 HP:0001997 \| Gout \| 1 HP:0004373 \| Focal dystonia \| 1 HP:0003419 \| Low back pain \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0002076 \| Migraine headaches \| 1 HP:0200037 \| Skin vesicle \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0002607 \| Anal incontinence \| 1 HP:0002459 \| Dysautonomia \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0000739 \| Anxiety \| 1 HP:0002533 \| Abnormal posturing \| 1 HP:0000938 \| Decreased bone mineral density \| 1 HP:0010524 \| Agnosia \| 1 HP:0001279 \| Syncope \| 1 HP:0003418 \| Back pain \| 1 HP:0003560 \| Muscular dystrophy \| 1

Disease ID	1284
Disease	complex regional pain syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:20) C2189399 \| hyperacusis C1660219 \| analgesia C1389037 \| bone atrophy C0751188 \| postdural puncture headache C0497552 \| nervous system abnormalities C0426980 \| motor symptoms C0423716 \| neuropathic pain C0393911 \| autonomic failure C0393593 \| dystonia C0239377 \| upper extremity pain C0184567 \| acute pain C0042769 \| viral infection C0040822 \| tremors C0030200 \| refractory pain C0030196 \| limb pain C0027066 \| myoclonus C0026650 \| movement disorders C0013384 \| abnormal movements C0008489 \| chorea C0007286 \| carpal tunnel syndrome
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0013421 \| dystonia \| 2 C0030200 \| refractory pain \| 1 C0007286 \| carpal tunnel syndrome \| 1 C0423716 \| neuropathic pain \| 1 C0026650 \| movement disorders \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1284
Disease	complex regional pain syndrome
Case	(Waiting for update.)

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