eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine

HOME
QUERY
- DISEASE
- GENOTYPE
NETWORK
- PHENOTYPE
- GENE
- COMMON
- DISEASE PAIR
DOWNLOAD
SUBMIT CASE
HELP&FAQ
- HELP&FAQ
- CONTACT US


	chronic pain

Disease ID	1498
Disease	chronic pain
Definition	pain which has persisted over a long period of time; also use NTs for specific types of pain if appropriate.
Synonym	chronic pain (finding) chronic pain [disease/finding] chronic pains pain, chronic pains, chronic
UMLS	C0150055
MeSH	D059350
SNOMED-CT	SNOMEDCT_US_2016_09_01:82423001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:115) C0011570 \| depression \| 47 C0003467 \| anxiety \| 23 C0029408 \| osteoarthritis \| 15 C0016053 \| fibromyalgia \| 13 C0002766 \| analgesia \| 8 C0442874 \| neuropathy \| 7 C0037317 \| sleep disturbance \| 6 C0003864 \| arthritis \| 6 C0020619 \| hypogonadism \| 4 C0041696 \| major depressive disorder \| 4 C0003873 \| rheumatoid arthritis \| 3 C0030567 \| parkinson's disease \| 3 C0007286 \| carpal tunnel syndrome \| 3 C0019294 \| inguinal hernia \| 3 C0002895 \| sickle cell disease \| 3 C0028754 \| obesity \| 3 C0033953 \| sexual dysfunction \| 3 C0031117 \| peripheral neuropathy \| 3 C0009806 \| constipation \| 3 C0039494 \| temporomandibular disorders \| 2 C0235974 \| pancreatic cancer \| 2 C0022679 \| cystic kidney \| 2 C0011882 \| diabetic neuropathy \| 2 C0003469 \| anxiety disorder \| 2 C0015674 \| chronic fatigue syndrome \| 2 C0039494 \| temporomandibular disorder \| 2 C0002020 \| alexithymia \| 2 C0014175 \| endometriosis \| 2 C0040997 \| trigeminal neuralgia \| 2 C0042870 \| vitamin d defic \| 2 C0006012 \| borderline personality disorder \| 2 C0040188 \| tic disorders \| 2 C0041696 \| major depression \| 2 C0085413 \| autosomal dominant polycystic kidney disease \| 2 C0158266 \| disc degeneration \| 2 C0085413 \| autosomal dominant polycystic kidney \| 2 C0271680 \| diabetic polyneuropathy \| 2 C0026769 \| multiple sclerosis \| 2 C0031212 \| personality disorders \| 2 C0003864 \| inflammatory arthritis \| 2 C0022408 \| joint disease \| 2 C0003469 \| anxiety disorders \| 2 C0851578 \| sleep disorders \| 2 C0042870 \| vitamin d deficiency \| 2 C0019348 \| herpes simplex \| 2 C0149931 \| migraine \| 2 C0029456 \| osteoporosis \| 2 C0011334 \| dental caries \| 1 C0021390 \| inflammatory bowel disease \| 1 C0013502 \| hydatid cyst \| 1 C0022408 \| arthrosis \| 1 C0854776 \| unresectable pancreatic cancer \| 1 C1145670 \| respiratory failure \| 1 C0520680 \| central sleep apnea \| 1 C0019069 \| haemophilia \| 1 C0003090 \| ankylosis \| 1 C0524851 \| neurodegenerative diseases \| 1 C0476089 \| endometrial ca \| 1 C0004936 \| mental disorders \| 1 C0679466 \| cognitive deficits \| 1 C0017178 \| gastrointestinal disorders \| 1 C0037944 \| spinal stenosis \| 1 C0158266 \| intervertebral disc degeneration \| 1 C0010692 \| cystitis \| 1 C0282488 \| interstitial cystitis \| 1 C0021843 \| intestinal obstruction \| 1 C1956089 \| osteophyte \| 1 C0006142 \| breast cancer \| 1 C0011847 \| diabetes \| 1 C1510472 \| drug dependence \| 1 C0948265 \| metabolic syndrome \| 1 C0021831 \| bowel disease \| 1 C0016053 \| fibromyalgia syndrome \| 1 C0029095 \| opioid abuse \| 1 C0024198 \| lyme borreliosis \| 1 C0476089 \| endometrial carcinoma \| 1 C0024586 \| serotonin syndrome \| 1 C0037650 \| somatoform disorders \| 1 C0019158 \| hepatitis \| 1 C0149521 \| chronic pancreatitis \| 1 C0018916 \| hemangiomas \| 1 C0037650 \| somatoform disorder \| 1 C0158266 \| degenerative disc disease \| 1 C0008055 \| chikungunya fever \| 1 C0019196 \| hepatitis c \| 1 C0854778 \| resectable pancreatic cancer \| 1 C0524851 \| neurodegenerative disease \| 1 C0852949 \| arterial disease \| 1 C0029401 \| paget's disease \| 1 C0018801 \| heart failure \| 1 C0035258 \| restless legs syndrome \| 1 C0017653 \| glomus tumor \| 1 C0022658 \| renal disease \| 1 C0004096 \| asthma \| 1 C0011334 \| caries \| 1 C1704436 \| peripheral arterial disease \| 1 C0007789 \| cerebral palsy \| 1 C0029408 \| degenerative joint disease \| 1 C0038436 \| post-traumatic stress disorder \| 1 C0027765 \| neurological disorder \| 1 C0458219 \| complex regional pain syndrome \| 1 C0023895 \| liver disease \| 1 C0010674 \| cystic fibrosis \| 1 C0497327 \| dementia \| 1 C0017178 \| gastrointestinal disorder \| 1 C0022661 \| end-stage renal disease \| 1 C0037933 \| spinal disorder \| 1 C0019555 \| developmental dysplasia of the hip \| 1 C0035258 \| restless legs \| 1 C0029401 \| paget's disease of bone \| 1 C0028817 \| ochronosis \| 1 C0743332 \| focal dystonia \| 1 C0022821 \| kyphosis \| 1 C0271623 \| secondary hypogonadism \| 1 C0037315 \| sleep apnea \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 6335 \| SCN9A \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1498
Disease	chronic pain
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:86) HP:0012531 \| Pain \| 130 HP:0000716 \| Depression \| 52 HP:0000739 \| Anxiety \| 26 HP:0002758 \| Osteoarthritis \| 18 HP:0100785 \| Insomnia \| 10 HP:0003418 \| Back pain \| 9 HP:0100790 \| Hernia \| 8 HP:0000708 \| Behavioral problems \| 7 HP:0012378 \| Fatigue \| 7 HP:0003419 \| Low back pain \| 6 HP:0012533 \| Allodynia \| 6 HP:0002360 \| Sleep disturbance \| 6 HP:0001369 \| Arthritis \| 6 HP:0100543 \| Cognitive deficits \| 5 HP:0005086 \| Knee osteoarthritis \| 4 HP:0012075 \| Personality disorder \| 4 HP:0002315 \| Headaches \| 4 HP:0000135 \| Hypogonadism \| 4 HP:0001513 \| Obesity \| 3 HP:0008843 \| Hip osteoarthritis \| 3 HP:0001370 \| Rheumatoid arthritis \| 3 HP:0001249 \| Mental retardation \| 3 HP:0000023 \| Inguinal hernia \| 3 HP:0002664 \| Neoplasia \| 3 HP:0009830 \| Peripheral neuritis \| 3 HP:0002019 \| Dyschezia \| 3 HP:0002015 \| Swallowing difficulty \| 2 HP:0002354 \| Memory loss \| 2 HP:0001250 \| Seizures \| 2 HP:0002076 \| Migraine headaches \| 2 HP:0000939 \| Osteoporosis \| 2 HP:0030127 \| Endometriosis \| 2 HP:0002894 \| Neoplasia of the pancreas \| 2 HP:0100033 \| Tic disorder \| 2 HP:0012076 \| Borderline personality disorder \| 2 HP:0001382 \| Hyperextensible joints \| 2 HP:0012532 \| Chronic pain \| 2 HP:0000113 \| Polycystic kidney dysplasia \| 2 HP:0100512 \| Vitamin D deficiency \| 2 HP:0100661 \| Trigeminal neuralgia \| 2 HP:0002808 \| Gibbus deformity \| 1 HP:0012534 \| Dysesthesia \| 1 HP:0002527 \| Falls \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0030833 \| Neck pain \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0001631 \| Atria septal defect \| 1 HP:0010535 \| Sleep apnea \| 1 HP:0030834 \| Shoulder pain \| 1 HP:0012452 \| Restless legs \| 1 HP:0000670 \| Dental caries \| 1 HP:0004610 \| Narrow lumbar spinal canal \| 1 HP:0030764 \| Ochronosis \| 1 HP:0010885 \| Aseptic necrosis \| 1 HP:0003401 \| Paresthesia \| 1 HP:0002829 \| Arthralgias \| 1 HP:0002500 \| Leukoaraiosis \| 1 HP:0000726 \| Dementia \| 1 HP:0003416 \| Spinal canal stenosis \| 1 HP:0006280 \| Chronic pancreas inflammation \| 1 HP:0002180 \| Neurodegeneration \| 1 HP:0001379 \| Degenerative joint disease \| 1 HP:0012432 \| Chronic fatigue \| 1 HP:0012444 \| Brain wasting \| 1 HP:0008419 \| Degeneration of intervertebral disks \| 1 HP:0001751 \| Vestibular dysfunction \| 1 HP:0200136 \| Oral-pharyngeal dysphagia \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0001824 \| Weight loss \| 1 HP:0100021 \| Cerebral palsy \| 1 HP:0003040 \| Arthropathy \| 1 HP:0002099 \| Asthma \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0030731 \| Carcinoma \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0010536 \| Central sleep apnoea \| 1 HP:0100699 \| Scarring \| 1 HP:0012114 \| Endometrial carcinoma \| 1 HP:0000722 \| Obsessive compulsive disorder \| 1 HP:0004373 \| Focal dystonia \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0004950 \| Peripheral artery disease \| 1 HP:0002933 \| Ventral hernia \| 1

Disease ID	1498
Disease	chronic pain
Manually Symptom	UMLS \| Name(Total Manually Symptoms:50) C2364108 \| stigma C2364074 \| drug abuse C2364072 \| depression C2364051 \| fatigue C2364045 \| activity intolerance C1963237 \| insomnia C1963138 \| hypertension C1963087 \| constipation C1963064 \| anxiety C1842981 \| neuroticism C1839611 \| n syndrome C1660219 \| analgesia C1568272 \| tendinopathy C1546654 \| granuloma C1269683 \| major depressive disorder C1269683 \| major depression C1135120 \| breakthrough pain C0947622 \| gallstones C0853946 \| exacerbation of pain C0851578 \| sleep problem C0851578 \| sleep disturbances C0851578 \| sleep disorders C0751188 \| postdural puncture headache C0700361 \| distress C0700201 \| sleep disturbance C0679466 \| cognitive deficits C0575031 \| cervical facet joint pain C0549622 \| sexual dysfunction C0522224 \| palsy C0520680 \| central sleep apnea C0278139 \| moderate pain C0269106 \| endosalpingiosis C0262471 \| ent problem C0262405 \| brain dysfunction C0240735 \| personality changes C0233470 \| constricted affect C0086439 \| reduced activity C0086132 \| emotional depression C0086132 \| depressive symptoms C0038436 \| posttraumatic stress disorder C0038436 \| post-traumatic stress disorder C0038220 \| status epilepticus C0037650 \| somatoform disorders C0031212 \| personality disorders C0029095 \| opioid abuse C0020604 \| hypochondriasis C0004936 \| mental disorders C0003469 \| anxiety disorders C0002962 \| angina pectoris C0002020 \| alexithymia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:27) C0011570 \| depression \| 53 C0003467 \| anxiety \| 26 C0231303 \| distress \| 15 C0002766 \| analgesia \| 10 C0917801 \| insomnia \| 10 C0015672 \| fatigue \| 7 C0086132 \| depressive symptoms \| 6 C0037317 \| sleep disturbance \| 6 C1839611 \| n syndrome \| 4 C0041696 \| major depressive disorder \| 4 C0009806 \| constipation \| 3 C0033953 \| sexual dysfunction \| 3 C0041696 \| major depression \| 2 C0700201 \| sleep problem \| 2 C0031212 \| personality disorders \| 2 C0002020 \| alexithymia \| 2 C0851578 \| sleep disorders \| 2 C0003469 \| anxiety disorders \| 2 C0679466 \| cognitive deficits \| 1 C0004936 \| mental disorders \| 1 C0029095 \| opioid abuse \| 1 C0038436 \| post-traumatic stress disorder \| 1 C0013146 \| drug abuse \| 1 C0522224 \| palsy \| 1 C0037650 \| somatoform disorders \| 1 C1135120 \| breakthrough pain \| 1 C0520680 \| central sleep apnea \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:9)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1045642	23803057	4988	OPRM1	umls:C0150055	BeFree	Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain.	0.001357209	2015	ABCB1	7	87509329	A	T,G
rs1045642	23803057	5243	ABCB1	umls:C0150055	BeFree	Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain.	0.000542884	2015	ABCB1	7	87509329	A	T,G
rs1799971	23803057	4988	OPRM1	umls:C0150055	BeFree	Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain.	0.001357209	2015	OPRM1	6	154039662	A	G
rs1799971	17000822	4988	OPRM1	umls:C0150055	BeFree	A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gene in patients with acute and chronic pain.	0.001357209	2006	OPRM1	6	154039662	A	G
rs1799971	23803057	5243	ABCB1	umls:C0150055	BeFree	Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain.	0.000542884	2015	OPRM1	6	154039662	A	G
rs386602118	21049025	1312	COMT	umls:C0150055	BeFree	However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain.	0.002171535	2010	NA	NA	NA	NA	NA
rs4680	22722321	1312	COMT	umls:C0150055	BeFree	The meta-analyses showed that fibromyalgia or chronic widespread pain is the only type of chronic pain that could be associated with the COMT single nucleotide polymorphism rs4680 (Val158Met).	0.002171535	2012	COMT;MIR4761	22	19963748	G	A
rs4680	21049025	1312	COMT	umls:C0150055	BeFree	However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain.	0.002171535	2010	COMT;MIR4761	22	19963748	G	A
rs4680	23773341	1312	COMT	umls:C0150055	BeFree	This study highlights the importance of COMT rs4680 in influencing the clinical response to drugs used for chronic pain, including opioid analgesics and triptans.	0.002171535	2013	COMT;MIR4761	22	19963748	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1498
Disease	chronic pain
Case	(Waiting for update.)

Web Analytics Made Easy - StatCounter