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	chronic graft versus host disease

Disease ID	1405
Disease	chronic graft versus host disease
Definition	A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, and may affect multiple organs with manifestations similar to autoimmune diseases. The onset is usually within three years of transplantation or immunologic manipulation.
Synonym	chronc graft-vs-host dis chronic graft-versus-host disease chronic graft-versus-host disease (disorder) chronic gvhd graft versus host disease, chronic gvhd, chronic
Orphanet	ORPHANET:99921
ICD10	ICD10CM:D89.811
UMLS	C0867389
SNOMED-CT	SNOMEDCT_US_2016_09_01:402356004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:49) C0314719 \| dry eye \| 10 C0027726 \| nephrotic syndrome \| 3 C0023418 \| leukemia \| 3 C0085655 \| polymyositis \| 2 C0006271 \| bronchiolitis \| 2 C0015625 \| fanconi anemia \| 2 C0878544 \| cardiomyopathy \| 2 C0006272 \| bronchiolitis obliterans \| 2 C0022658 \| nephropathy \| 2 C0013238 \| dry eye syndrome \| 2 C0019069 \| hemophilia \| 1 C0034150 \| purpura \| 1 C0041351 \| tularemia \| 1 C0017665 \| membranous nephropathy \| 1 C0020538 \| hypertension \| 1 C0037199 \| sinusitis \| 1 C0032326 \| pneumothorax \| 1 C0442874 \| neuropathy \| 1 C0021053 \| immune disease \| 1 C0346054 \| verruciform xanthoma \| 1 C0021843 \| bowel obstruction \| 1 C0026764 \| multiple myeloma \| 1 C0019163 \| hepatitis b \| 1 C0004623 \| bacterial infection \| 1 C0023473 \| chronic myelogenous leukemia \| 1 C0032285 \| pneumonitis \| 1 C0024523 \| malabsorption \| 1 C0015397 \| eye disease \| 1 C0020541 \| portal hypertension \| 1 C0030305 \| pancreatitis \| 1 C0024523 \| malabsorption syndromes \| 1 C0011991 \| diarrhea \| 1 C0026946 \| fungal disease \| 1 C0030805 \| pemphigoid \| 1 C1955861 \| t-cell large granular lymphocyte leukemia \| 1 C0011334 \| caries \| 1 C0002871 \| anemia \| 1 C0023470 \| myelogenous leukemia \| 1 C0024523 \| malabsorption syndrome \| 1 C0155765 \| microangiopathy \| 1 C0026764 \| myeloma \| 1 C0558353 \| tongue carcinoma \| 1 C0023470 \| myeloid leukemia \| 1 C0011334 \| dental caries \| 1 C0030804 \| mucous membrane pemphigoid \| 1 C0042900 \| vitiligo \| 1 C0023467 \| acute myeloid leukemia \| 1 C0162429 \| malnutrition \| 1 C0152025 \| polyneuropathy \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 3552 \| IL1A \| CIPHER 7124 \| TNF \| CIPHER
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1405
Disease	chronic graft versus host disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:45) HP:0001909 \| Leukemia \| 3 HP:0011950 \| Bronchiolitis \| 2 HP:0000100 \| Nephrosis \| 2 HP:0011946 \| Constrictive bronchiolitis \| 2 HP:0030731 \| Carcinoma \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0000112 \| Nephropathy \| 2 HP:0001638 \| Cardiomyopathy \| 2 HP:0000979 \| Purpura \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0000217 \| Dry mouth syndrome \| 1 HP:0100583 \| Corneal perforation \| 1 HP:0000670 \| Dental caries \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0004395 \| Malnutrition \| 1 HP:0045073 \| Serositis \| 1 HP:0001409 \| Portal hypertension \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0001746 \| Absent spleen \| 1 HP:0003394 \| Muscle cramps \| 1 HP:0000246 \| Sinus inflammation \| 1 HP:0001114 \| Fatty deposits on eyelids \| 1 HP:0100614 \| Muscle inflammation \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0001903 \| Anemia \| 1 HP:0004808 \| Acute myelogenous leukemia \| 1 HP:0001399 \| Liver failure \| 1 HP:0000822 \| Hypertension \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0012578 \| Membranous glomerulonephritis \| 1 HP:0001371 \| Flexion contractures of joints \| 1 HP:0002014 \| Diarrhea \| 1 HP:0007663 \| Central visual loss \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0001045 \| Blotchy loss of skin color \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0007133 \| Progressive peripheral neuropathy \| 1 HP:0012531 \| Pain \| 1 HP:0000969 \| Dropsy \| 1 HP:0002958 \| Immune dysregulation \| 1 HP:0002107 \| Collapsed lung \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0005506 \| Chronic myeloid leukemia \| 1 HP:0002024 \| Intestinal malabsorption \| 1

Disease ID	1405
Disease	chronic graft versus host disease
Manually Symptom	UMLS \| Name(Total Manually Symptoms:6) C0600502 \| hemostatic disorders C0314719 \| dry eye C0043352 \| xerostomia C0027121 \| myositis C0023895 \| liver disorders C0002170 \| alopecia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0314719 \| dry eye \| 10 C0027726 \| nephrotic syndrome \| 2 C0029166 \| oral manifestations \| 2 C0037284 \| skin lesions \| 2 C0006272 \| bronchiolitis obliterans \| 2 C0085655 \| polymyositis \| 2 C0027121 \| myositis \| 1 C0152025 \| polyneuropathy \| 1 C0009450 \| infection \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:9)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1131012	22646485	5175	PECAM1	umls:C0867389	BeFree	We evaluated the association of 4 SNPs in ICAM1 (rs5498), PECAM1 (rs668 and rs1131012) and SELL (rs2229569) genes with acute and chronic graft-versus-host disease (GvHD) and those experiencing transplant-related mortality (TRM) within 1 year among 425 allogeneic HCT recipient-donor pairs.	0.001085767	2013	PECAM1	17	64350416	T	C
rs12428930	21628416	10673	TNFSF13B	umls:C0867389	BeFree	In multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.	0.000542884	2011	TNFSF13B;LOC102724347	13	108287357	A	C
rs16972217	21628416	10673	TNFSF13B	umls:C0867389	BeFree	In multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.	0.000542884	2011	TNFSF13B;LOC102724347	13	108283099	C	T
rs1805410	20574454	142	PARP1	umls:C0867389	BeFree	One SNP in PARP1 gene (rs1805410) was associated with a higher risk of chronic GVHD (RR: 1.81, 95% CI: 1.29-2.54, P=0.001).	0.000271442	2010	PARP1	1	226380964	T	C
rs2229569	22646485	5175	PECAM1	umls:C0867389	BeFree	We evaluated the association of 4 SNPs in ICAM1 (rs5498), PECAM1 (rs668 and rs1131012) and SELL (rs2229569) genes with acute and chronic graft-versus-host disease (GvHD) and those experiencing transplant-related mortality (TRM) within 1 year among 425 allogeneic HCT recipient-donor pairs.	0.001085767	2013	SELL	1	169704697	G	T,A
rs2893321	21628416	10673	TNFSF13B	umls:C0867389	BeFree	In multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.	0.000542884	2011	TNFSF13B;LOC102724347	13	108290686	A	G
rs5498	22646485	5175	PECAM1	umls:C0867389	BeFree	We evaluated the association of 4 SNPs in ICAM1 (rs5498), PECAM1 (rs668 and rs1131012) and SELL (rs2229569) genes with acute and chronic graft-versus-host disease (GvHD) and those experiencing transplant-related mortality (TRM) within 1 year among 425 allogeneic HCT recipient-donor pairs.	0.001085767	2013	ICAM1;ICAM4;LOC105372272	19	10285007	A	G
rs668	22646485	5175	PECAM1	umls:C0867389	BeFree	We evaluated the association of 4 SNPs in ICAM1 (rs5498), PECAM1 (rs668 and rs1131012) and SELL (rs2229569) genes with acute and chronic graft-versus-host disease (GvHD) and those experiencing transplant-related mortality (TRM) within 1 year among 425 allogeneic HCT recipient-donor pairs.	0.001085767	2013	NA	NA	NA	NA	NA
rs7993590	21628416	10673	TNFSF13B	umls:C0867389	BeFree	In multivariate analyses, 4 recipient BAFF SNPs (rs16972217 [odds ratio = 2.72, P = .004], rs7993590 [odds ratio = 2.35, P = .011], rs12428930 [odds ratio2.53, P = .008], and rs2893321 [odds ratio = 2.48, P = .009]) were independent predictors of GVHD subtypes, adjusted for conventional predictors of cGVHD.	0.000542884	2011	TNFSF13B;LOC102724347	13	108283554	A	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1405
Disease	chronic graft versus host disease
Case	(Waiting for update.)

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