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	choriocarcinoma

Disease ID	1523
Disease	choriocarcinoma
Definition	A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
Synonym	[m]choriocarcinoma [m]chorioepithelioma chordocarcinoma chordoepithelioma chorioblastoma choriocarcinoma (disorder) choriocarcinoma (morphologic abnormality) choriocarcinoma [disease/finding] choriocarcinoma nos choriocarcinoma, malignant choriocarcinoma, no icd-o subtype choriocarcinoma, no icd-o subtype (morphologic abnormality) choriocarcinoma, no international classification of diseases for oncology subtype choriocarcinoma, no international classification of diseases for oncology subtype (morphologic abnormality) choriocarcinoma, nos choriocarcinomas chorioepithelioma chorioepithelioma nos chorionepithelioma chorionic carcinoma syncytioma
DOID	DOID:3594
UMLS	C0008497
MeSH	D002822
SNOMED-CT	SNOMEDCT_US_2016_09_01:188188009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:24) C0001418 \| adenocarcinoma \| 5 C0153676 \| lung metastasis \| 3 C0032987 \| ectopic pregnancy \| 3 C0006142 \| breast cancer \| 2 C0334523 \| teratoma with malignant transformation \| 1 C0678222 \| mammary carcinoma \| 1 C0034065 \| pulmonary embolism \| 1 C0014038 \| encephalitis \| 1 C1145670 \| respiratory failure \| 1 C0476089 \| endometrial ca \| 1 C0279651 \| gallbladder adenocarcinoma \| 1 C0035412 \| rhabdomyosarcoma \| 1 C0279672 \| cervical adenocarcinoma \| 1 C0206701 \| serous carcinoma \| 1 C0476089 \| endometrial carcinoma \| 1 C0024623 \| gastric cancer \| 1 C0684249 \| lung carcinoma \| 1 C0153676 \| lung metastases \| 1 C0279682 \| bladder adenocarcinoma \| 1 C0153676 \| pulmonary metastases \| 1 C0205696 \| anaplastic carcinoma \| 1 C0678222 \| breast carcinoma \| 1 C0494165 \| liver metastases \| 1 C0030805 \| pemphigoid \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:159) 11332 \| ACOT7 \| 1.578 \| DISEASES 103 \| ADAR \| 1.468 \| DISEASES 174 \| AFP \| 4.712 \| DISEASES 8644 \| AKR1C3 \| 1.317 \| DISEASES 250 \| ALPP \| 1.088 \| DISEASES 430 \| ASCL2 \| 2.709 \| DISEASES 23192 \| ATG4B \| 1.478 \| DISEASES 9212 \| AURKB \| 2.192 \| DISEASES 567 \| B2M \| 1.807 \| DISEASES 596 \| BCL2 \| 1.703 \| DISEASES 65250 \| C5orf42 \| 1.193 \| DISEASES 801 \| CALM1 \| 2.329 \| DISEASES 811 \| CALR \| 1.027 \| DISEASES 23607 \| CD2AP \| 2.184 \| DISEASES 960 \| CD44 \| 1.224 \| DISEASES 1028 \| CDKN1C \| 2.918 \| DISEASES 1029 \| CDKN2A \| 1.338 \| DISEASES 1045 \| CDX2 \| 1.948 \| DISEASES 1081 \| CGA \| 2.947 \| DISEASES 94027 \| CGB7 \| 2.114 \| DISEASES 94115 \| CGB8 \| 3.159 \| DISEASES 1192 \| CLIC1 \| 1.155 \| DISEASES 64084 \| CLSTN2 \| 1.147 \| DISEASES 10229 \| COQ7 \| 1.649 \| DISEASES 1368 \| CPM \| 2.907 \| DISEASES 1443 \| CSH2 \| 6.348 \| DISEASES 1486 \| CTBS \| 2.748 \| DISEASES 1499 \| CTNNB1 \| 1.232 \| DISEASES 9820 \| CUL7 \| 3.113 \| DISEASES 1735 \| DIO3 \| 1.001 \| DISEASES 1747 \| DLX3 \| 1.538 \| DISEASES 1761 \| DMRT1 \| 1.155 \| DISEASES 1791 \| DNTT \| 1.379 \| DISEASES 359787 \| DPPA3 \| 1.711 \| DISEASES 10281 \| DSCR4 \| 2.212 \| DISEASES 1832 \| DSP \| 1.239 \| DISEASES 253738 \| EBF3 \| 1.457 \| DISEASES 57593 \| EBF4 \| 2.446 \| DISEASES 1945 \| EFNA4 \| 1.679 \| DISEASES 1967 \| EIF2B1 \| 1.605 \| DISEASES 8909 \| ENDOU \| 3.021 \| DISEASES 2066 \| ERBB4 \| 1.168 \| DISEASES 2079 \| ERH \| 1.313 \| DISEASES 2086 \| ERV3-1 \| 4.112 \| DISEASES 405754 \| ERVFRD-1 \| 2.979 \| DISEASES 30816 \| ERVW-1 \| 3.252 \| DISEASES 2103 \| ESRRB \| 1.033 \| DISEASES 2114 \| ETS2 \| 2.813 \| DISEASES 2274 \| FHL2 \| 2.864 \| DISEASES 2524 \| FUT2 \| 1.072 \| DISEASES 85569 \| GALP \| 1.164 \| DISEASES 2624 \| GATA2 \| 1.549 \| DISEASES 2625 \| GATA3 \| 1.803 \| DISEASES 2643 \| GCH1 \| 2.55 \| DISEASES 9573 \| GDF3 \| 1.081 \| DISEASES 2689 \| GH2 \| 3.95 \| DISEASES 114814 \| GNRHR2 \| 2.254 \| DISEASES 2719 \| GPC3 \| 2.85 \| DISEASES 414778 \| HCG17 \| 3.201 \| DISEASES 8925 \| HERC1 \| 1.973 \| DISEASES 3105 \| HLA-A \| 2.674 \| DISEASES 3135 \| HLA-G \| 4.186 \| DISEASES 9324 \| HMGN3 \| 2.35 \| DISEASES 374875 \| HSD11B1L \| 3.109 \| DISEASES 3283 \| HSD3B1 \| 2.96 \| DISEASES 3481 \| IGF2 \| 2.315 \| DISEASES 3550 \| IK \| 1.457 \| DISEASES 3725 \| JUN \| 1.801 \| DISEASES 11104 \| KATNA1 \| 2.533 \| DISEASES 374654 \| KIF7 \| 1.476 \| DISEASES 3875 \| KRT18 \| 2.726 \| DISEASES 3855 \| KRT7 \| 2.273 \| DISEASES 284217 \| LAMA1 \| 1.381 \| DISEASES 3908 \| LAMA2 \| 1.113 \| DISEASES 3927 \| LASP1 \| 1.016 \| DISEASES 3953 \| LEPR \| 1.211 \| DISEASES 3963 \| LGALS7 \| 1.717 \| DISEASES 286826 \| LIN9 \| 1.334 \| DISEASES 140828 \| LINC00261 \| 2.626 \| DISEASES 100506757 \| LINC00629 \| 3.478 \| DISEASES 4097 \| MAFG \| 1.515 \| DISEASES 5609 \| MAP2K7 \| 1.202 \| DISEASES 5599 \| MAPK8 \| 1.175 \| DISEASES 84515 \| MCM8 \| 1.718 \| DISEASES 196410 \| METTL7B \| 1.363 \| DISEASES 84879 \| MFSD2A \| 2.106 \| DISEASES 11282 \| MGAT4B \| 2.28 \| DISEASES 84848 \| MIR503HG \| 3.45 \| DISEASES 4311 \| MME \| 1.58 \| DISEASES 4326 \| MMP17 \| 1.382 \| DISEASES 4318 \| MMP9 \| 1.363 \| DISEASES 4496 \| MT1H \| 1.437 \| DISEASES 57504 \| MTA3 \| 1.492 \| DISEASES 143662 \| MUC15 \| 1.698 \| DISEASES 4609 \| MYC \| 2.034 \| DISEASES 100132406 \| NBPF10 \| 1.99 \| DISEASES 9436 \| NCR2 \| 1.606 \| DISEASES 259197 \| NCR3 \| 1.942 \| DISEASES 4751 \| NEK2 \| 1.748 \| DISEASES 199713 \| NLRP7 \| 1.202 \| DISEASES 190 \| NR0B1 \| 3.336 \| DISEASES 2516 \| NR5A1 \| 1.07 \| DISEASES 2649 \| NR6A1 \| 1.863 \| DISEASES 5155 \| PDGFB \| 1.446 \| DISEASES 5209 \| PFKFB3 \| 1.712 \| DISEASES 5228 \| PGF \| 2.462 \| DISEASES 5328 \| PLAU \| 1.483 \| DISEASES 10687 \| PNMA2 \| 1.141 \| DISEASES 5494 \| PPM1A \| 1.641 \| DISEASES 51400 \| PPME1 \| 1.626 \| DISEASES 5764 \| PTN \| 2.133 \| DISEASES 5802 \| PTPRS \| 1.391 \| DISEASES 9232 \| PTTG1 \| 1.291 \| DISEASES 5893 \| RAD52 \| 1.609 \| DISEASES 221002 \| RASGEF1A \| 2.212 \| DISEASES 100526737 \| RBM14-RBM4 \| 1.726 \| DISEASES 1104 \| RCC1 \| 1.021 \| DISEASES 54101 \| RIPK4 \| 1.429 \| DISEASES 6195 \| RPS6KA1 \| 1.61 \| DISEASES 6241 \| RRM2 \| 1.688 \| DISEASES 6256 \| RXRA \| 1.388 \| DISEASES 9672 \| SDC3 \| 1.244 \| DISEASES 26168 \| SENP3 \| 1.779 \| DISEASES 946 \| SIGLEC6 \| 2.352 \| DISEASES 6510 \| SLC1A5 \| 1.446 \| DISEASES 6582 \| SLC22A2 \| 1.013 \| DISEASES 9962 \| SLC23A2 \| 1.248 \| DISEASES 292 \| SLC25A5 \| 1.152 \| DISEASES 64078 \| SLC28A3 \| 1.15 \| DISEASES 2030 \| SLC29A1 \| 1.169 \| DISEASES 3177 \| SLC29A2 \| 1.941 \| DISEASES 144195 \| SLC2A14 \| 1.614 \| DISEASES 9152 \| SLC6A5 \| 2.229 \| DISEASES 6533 \| SLC6A6 \| 2.49 \| DISEASES 4088 \| SMAD3 \| 1.955 \| DISEASES 4089 \| SMAD4 \| 1.152 \| DISEASES 23583 \| SMUG1 \| 1.937 \| DISEASES 54212 \| SNTG1 \| 2.283 \| DISEASES 6657 \| SOX2 \| 2.573 \| DISEASES 6667 \| SP1 \| 1.671 \| DISEASES 6714 \| SRC \| 1.261 \| DISEASES 10948 \| STARD3 \| 1.419 \| DISEASES 56910 \| STARD7 \| 4.146 \| DISEASES 6776 \| STAT5A \| 1.492 \| DISEASES 85360 \| SYDE1 \| 2.289 \| DISEASES 8407 \| TAGLN2 \| 1.138 \| DISEASES 6925 \| TCF4 \| 1.12 \| DISEASES 6949 \| TCOF1 \| 2.765 \| DISEASES 7005 \| TEAD3 \| 2.331 \| DISEASES 7004 \| TEAD4 \| 2.465 \| DISEASES 7018 \| TF \| 1.653 \| DISEASES 7020 \| TFAP2A \| 1.434 \| DISEASES 7037 \| TFRC \| 1.148 \| DISEASES 7046 \| TGFBR1 \| 1.275 \| DISEASES 7159 \| TP53BP2 \| 1.098 \| DISEASES 11074 \| TRIM31 \| 1.379 \| DISEASES 7422 \| VEGFA \| 1.587 \| DISEASES 54059 \| YBEY \| 2.542 \| DISEASES 53349 \| ZFYVE1 \| 1.632 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1523
Disease	choriocarcinoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:17) HP:0030731 \| Carcinoma \| 7 HP:0002664 \| Neoplasia \| 6 HP:0012531 \| Pain \| 2 HP:0003002 \| Breast carcinoma \| 2 HP:0002383 \| Encephalitis \| 1 HP:0030157 \| Flank pain \| 1 HP:0000790 \| Hematuria \| 1 HP:0004947 \| Arteriovenous fistula \| 1 HP:0012114 \| Endometrial carcinoma \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0100758 \| Gangrene \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0002170 \| Intracranial hemorrhage \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0100718 \| Uterine rupture \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0002859 \| Rhabdomyosarcoma \| 1

Disease ID	1523
Disease	choriocarcinoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:39) C2364133 \| infection C1517567 \| intravascular metastasis C1393529 \| vascular complications C1145670 \| respiratory failure C0948265 \| metabolic syndrome C0752303 \| urological manifestation C0686377 \| cns metastases C0686377 \| central nervous system metastasis C0686377 \| central nervous system metastases C0555278 \| cerebral metastasis C0555278 \| cerebral metastases C0494165 \| liver metastasis C0494165 \| hepatic metastasis C0494165 \| hepatic metastases C0334520 \| immature teratoma C0220650 \| brain metastasis C0220650 \| brain metastases C0153687 \| skin metastasis C0153687 \| skin metastases C0153687 \| cutaneous metastasis C0153685 \| renal metastasis C0153685 \| renal metastases C0153676 \| pulmonary metastasis C0153676 \| pulmonary metastases C0153676 \| lung metastasis C0042755 \| virilization C0042143 \| uterine rupture C0042139 \| uterine perforation C0040156 \| thyrotoxicosis C0030472 \| paraneoplastic syndrome C0020550 \| hyperthyroidism C0019693 \| hiv infection C0019343 \| herpes gestationis C0019080 \| hemorrhage C0017665 \| membranous glomerulonephritis C0017181 \| gastrointestinal hemorrhage C0013930 \| tumor embolus C0002940 \| aneurysms C0002940 \| aneurysm
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0153676 \| lung metastasis \| 3 C0555278 \| cerebral metastasis \| 2 C0019080 \| hemorrhage \| 2 C0153676 \| pulmonary metastases \| 1 C0042143 \| uterine rupture \| 1 C1145670 \| respiratory failure \| 1 C0220650 \| brain metastases \| 1 C0334520 \| immature teratoma \| 1 C0555278 \| cerebral metastases \| 1

Manually Genotype(Total Text Mining Genotypes:0)
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Text Mining Genotype(Total Genotypes:0)
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All Snps(Total Genotypes:0)
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GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Disease ID	1523
Disease	choriocarcinoma
Case	(Waiting for update.)

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