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	cholesteatoma

Disease ID	1266
Disease	cholesteatoma
Definition	A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL.
Synonym	cholesteatoma (disorder) cholesteatoma (morphologic abnormality) cholesteatoma [disease/finding] cholesteatoma nos cholesteatoma, nos cholesteatoma, unspecified cholesteatomas epidermoid cholesteatoma unspecified cholesteatoma unspecified cholesteatoma (morphologic abnormality)
DOID	DOID:869 DOID:10964
UMLS	C0008373
MeSH	D002781
SNOMED-CT	SNOMEDCT_US_2016_09_01:363668000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:15) C0029882 \| otitis media \| 43 C0271454 \| chronic suppurative otitis media \| 5 C0008925 \| cleft palate \| 3 C0021874 \| intracranial abscess \| 2 C0024904 \| mastoiditis \| 1 C0155478 \| adhesive otitis media \| 1 C0015469 \| facial paralysis \| 1 C0011649 \| dermoid cyst \| 1 C0035078 \| renal failure \| 1 C0022661 \| chronic renal failure \| 1 C0016045 \| fibromas \| 1 C0018784 \| sensorineural hearing loss \| 1 C0008924 \| cleft lip \| 1 C0011334 \| cavities \| 1 C0015469 \| facial nerve paralysis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 2706 \| GJB2 \| CIPHER 10804 \| GJB6 \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:78) 257 \| ALX3 \| 1.037 \| DISEASES 650 \| BMP2 \| 1.519 \| DISEASES 799 \| CALCR \| 1.721 \| DISEASES 820 \| CAMP \| 1.05 \| DISEASES 1041 \| CDSN \| 1.05 \| DISEASES 160364 \| CLEC12A \| 2.279 \| DISEASES 387837 \| CLEC12B \| 3.716 \| DISEASES 170482 \| CLEC4C \| 1.207 \| DISEASES 23601 \| CLEC5A \| 2.419 \| DISEASES 93978 \| CLEC6A \| 2.456 \| DISEASES 9244 \| CRLF1 \| 2.416 \| DISEASES 1499 \| CTNNB1 \| 1.063 \| DISEASES 414325 \| DEFB103A \| 1.083 \| DISEASES 55894 \| DEFB103B \| 1.083 \| DISEASES 100289462 \| DEFB4B \| 1.426 \| DISEASES 646480 \| FABP9 \| 1.942 \| DISEASES 2258 \| FGF13 \| 1.102 \| DISEASES 2263 \| FGFR2 \| 3.139 \| DISEASES 2312 \| FLG \| 2.853 \| DISEASES 27023 \| FOXB1 \| 2.868 \| DISEASES 27022 \| FOXD3 \| 1.171 \| DISEASES 2706 \| GJB2 \| 1.551 \| DISEASES 3039 \| HBA1 \| 1.083 \| DISEASES 3091 \| HIF1A \| 1.093 \| DISEASES 3384 \| ICAM2 \| 1.194 \| DISEASES 3397 \| ID1 \| 2.133 \| DISEASES 3683 \| ITGAL \| 1.109 \| DISEASES 3713 \| IVL \| 3.329 \| DISEASES 102723508 \| KANTR \| 2.036 \| DISEASES 9851 \| KIAA0753 \| 2.526 \| DISEASES 25818 \| KLK5 \| 1.272 \| DISEASES 5650 \| KLK7 \| 1.068 \| DISEASES 3875 \| KRT18 \| 1.472 \| DISEASES 3880 \| KRT19 \| 2.095 \| DISEASES 3851 \| KRT4 \| 3.63 \| DISEASES 3909 \| LAMA3 \| 1.012 \| DISEASES 4065 \| LY75 \| 2.263 \| DISEASES 153562 \| MARVELD2 \| 1.81 \| DISEASES 79104 \| MEG8 \| 1.84 \| DISEASES 4312 \| MMP1 \| 1.735 \| DISEASES 4318 \| MMP9 \| 2.996 \| DISEASES 4513 \| MT-CO2 \| 1.05 \| DISEASES 727897 \| MUC5B \| 1.005 \| DISEASES 100129528 \| MUC8 \| 2.09 \| DISEASES 4609 \| MYC \| 1.434 \| DISEASES 54892 \| NCAPG2 \| 2.661 \| DISEASES 64332 \| NFKBIZ \| 1.666 \| DISEASES 4942 \| OAT \| 1.399 \| DISEASES 126014 \| OSCAR \| 1.216 \| DISEASES 26578 \| OSTF1 \| 2.571 \| DISEASES 27445 \| PCLO \| 1.21 \| DISEASES 5332 \| PLCB4 \| 2.238 \| DISEASES 139728 \| PNCK \| 1.208 \| DISEASES 5456 \| POU3F4 \| 1.354 \| DISEASES 5728 \| PTEN \| 1.259 \| DISEASES 5744 \| PTHLH \| 1.261 \| DISEASES 5879 \| RAC1 \| 1.487 \| DISEASES 83695 \| RHNO1 \| 1.285 \| DISEASES 6278 \| S100A7 \| 2.467 \| DISEASES 338324 \| S100A7A \| 2.838 \| DISEASES 6279 \| S100A8 \| 1.216 \| DISEASES 6280 \| S100A9 \| 1.418 \| DISEASES 5265 \| SERPINA1 \| 1.464 \| DISEASES 6318 \| SERPINB4 \| 1.358 \| DISEASES 6520 \| SLC3A2 \| 2.232 \| DISEASES 4184 \| SMCP \| 1.853 \| DISEASES 4070 \| TACSTD2 \| 1.036 \| DISEASES 7099 \| TLR4 \| 2.075 \| DISEASES 55858 \| TMEM165 \| 2.394 \| DISEASES 7110 \| TMF1 \| 1.616 \| DISEASES 7124 \| TNF \| 2.691 \| DISEASES 131405 \| TRIM71 \| 3.456 \| DISEASES 162514 \| TRPV3 \| 1.712 \| DISEASES 55503 \| TRPV6 \| 1.137 \| DISEASES 9875 \| URB1 \| 3.582 \| DISEASES 10090 \| UST \| 1.666 \| DISEASES 7422 \| VEGFA \| 1.553 \| DISEASES 7716 \| VEZF1 \| 2.942 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1266
Disease	cholesteatoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:19) HP:0000388 \| Otitis media \| 48 HP:0000389 \| Chronic otitis media \| 43 HP:0100246 \| Osteoma \| 4 HP:0000175 \| Palatoschisis \| 3 HP:0000651 \| Diplopia \| 2 HP:0003774 \| End-stage renal failure \| 1 HP:0030049 \| Brain abscess \| 1 HP:0000718 \| Aggressive behaviour \| 1 HP:0000265 \| Mastoiditis \| 1 HP:0200040 \| Epidermal inclusion cyst \| 1 HP:0000405 \| Conductive hearing loss \| 1 HP:0000365 \| Hearing impairment \| 1 HP:0000407 \| sensorineural hearing loss \| 1 HP:0004439 \| Crouzon syndrome \| 1 HP:0010628 \| Facial palsy, unilateral or bilateral \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0002315 \| Headaches \| 1 HP:0009795 \| Branchial cleft fistula \| 1 HP:0002006 \| Tessier facial cleft \| 1

Disease ID	1266
Disease	cholesteatoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:22) C2707258 \| infections C2029884 \| hearing loss C1550639 \| fistula C1510420 \| cavities C1333646 \| epidermoid carcinoma of the frontal sinus C1263876 \| chronic ear disease C0339774 \| bezold's abscess C0271441 \| chronic otitis media C0270639 \| lateral sinus thrombosis C0270628 \| cerebellar abscess C0238792 \| bone lesion C0238790 \| bone destruction C0155842 \| parapharyngeal abscess C0155509 \| labyrinthine fistula C0040997 \| trigeminal neuralgia C0032285 \| pneumoniae C0029882 \| middle ear infection C0018777 \| conductive hearing loss C0015469 \| facial paralysis C0015469 \| facial palsy C0010201 \| chronic cough C0007137 \| squamous cell carcinoma
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:6) C0271441 \| chronic otitis media \| 43 C0155509 \| labyrinthine fistula \| 3 C1384666 \| hearing loss \| 2 C0021311 \| infections \| 2 C0011334 \| cavities \| 1 C0339774 \| bezold's abscess \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1266
Disease	cholesteatoma
Case	(Waiting for update.)

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