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	brucellosis

Disease ID	545
Disease	brucellosis
Definition	Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.
Synonym	[x]brucellosis, unspecified [x]brucellosis, unspecified (disorder) brucelloses brucellosis (disorder) brucellosis [disease/finding] brucellosis due to brucella sp. brucellosis due to brucella sp. (disorder) brucellosis due to brucella species brucellosis due to brucella species (disorder) brucellosis nos brucellosis nos (disorder) brucellosis, nos brucellosis, unspecified cyprus fever cyprus fevers fever malta fever mediterranean fever, cyprus fever, gibraltar fever, malta fever, mediterranean fever, rock fever, undulant fevers, cyprus fevers, rock fevers, undulant gibraltar fever malta fever mediterranean fever melitococcosis rock fever rock fevers undulant fever undulant fevers
Orphanet	ORPHANET:1304
DOID	DOID:11077
ICD10	ICD10CM:A23.9
UMLS	C0006309
MeSH	D002006
SNOMED-CT	SNOMEDCT_US_2016_09_01:75702008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:107) C0002726 \| amyloidosis \| 17 C0003864 \| arthritis \| 9 C0030312 \| pancytopenia \| 5 C0003873 \| rheumatoid arthritis \| 4 C0014118 \| endocarditis \| 4 C0035078 \| renal failure \| 3 C0040053 \| thrombosis \| 3 C0034152 \| henoch-schonlein purpura \| 3 C0272412 \| splenic abscess \| 3 C0014733 \| erysipelas \| 3 C0031046 \| pericarditis \| 3 C0042384 \| vasculitis \| 2 C0004153 \| atherosclerosis \| 2 C0032285 \| pneumonia \| 2 C0242490 \| enthesopathy \| 2 C0023895 \| liver disease \| 2 C0027726 \| nephrotic syndrome \| 2 C0039263 \| takayasu's arteritis \| 2 C0038013 \| ankylosing spondylitis \| 2 C0038012 \| spondylitis \| 2 C0024291 \| hemophagocytic lymphohistiocytosis \| 2 C0019158 \| hepatitis \| 2 C0022661 \| end-stage renal failure \| 2 C0033687 \| proteinuria \| 2 C0017658 \| glomerulonephritis \| 2 C0270629 \| epidural abscess \| 2 C0041296 \| tuberculosis \| 2 C0011570 \| depression \| 2 C0040034 \| thrombocytopenia \| 2 C0031039 \| pericardial effusion \| 2 C0042166 \| intermediate uveitis \| 1 C0033860 \| psoriasis \| 1 C0949690 \| spondyloarthritis \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0521542 \| brain stem infarction \| 1 C0023467 \| acute myeloid leukemia \| 1 C0035021 \| recurrent fever \| 1 C0012624 \| spondylodiscitis \| 1 C0085693 \| acute appendicitis \| 1 C1275126 \| tumor necrosis factor receptor-associated periodic syndrome \| 1 C0018021 \| goiter \| 1 C0013902 \| hereditary elliptocytosis \| 1 C0042870 \| vitamin d deficiency \| 1 C0025290 \| aseptic meningitis \| 1 C0027121 \| myositis \| 1 C0013369 \| dysentery \| 1 C0023418 \| leukemia \| 1 C0017178 \| gastrointestinal disorders \| 1 C0024205 \| lymphadenitis \| 1 C0031090 \| periodontal disease \| 1 C0221239 \| rapidly progressive glomerulonephritis \| 1 C0027719 \| nephrosclerosis \| 1 C0031154 \| peritonitis \| 1 C0021390 \| inflammatory bowel disease \| 1 C0015974 \| periodic fever \| 1 C0031036 \| polyarteritis nodosa \| 1 C0747256 \| parasitic infection \| 1 C0042870 \| vitamin d defic \| 1 C0038363 \| aphthous stomatitis \| 1 C0029443 \| osteomyelitis \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C0027051 \| myocardial infarction \| 1 C0030920 \| peptic ulcer \| 1 C0271270 \| cogan's syndrome \| 1 C0035579 \| hypovitaminosis d \| 1 C0001430 \| adenoma \| 1 C0038362 \| stomatitis \| 1 C0022660 \| acute renal failure \| 1 C0036202 \| sarcoidosis \| 1 C0155765 \| microangiopathy \| 1 C0021843 \| intestinal obstruction \| 1 C0021141 \| syndrome of inappropriate secretion of antidiuretic hormone \| 1 C0004509 \| azoospermia \| 1 C1565489 \| renal insufficiency \| 1 C0409974 \| lupus erythematosus \| 1 C0021831 \| bowel disease \| 1 C0016053 \| fibromyalgia syndrome \| 1 C0036114 \| salmonellosis \| 1 C0026769 \| multiple sclerosis \| 1 C0034065 \| pulmonary embolism \| 1 C0023470 \| myeloid leukemia \| 1 C0034150 \| purpura \| 1 C0018378 \| guillain-barre syndrome \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0002871 \| anemia \| 1 C0031039 \| pericardial effusions \| 1 C0031069 \| periodic peritonitis \| 1 C0025309 \| meningoencephalitis \| 1 C0025469 \| mesenteric lymphadenitis \| 1 C0025289 \| meningitis \| 1 C0018099 \| gout \| 1 C0002986 \| fabry disease \| 1 C0026848 \| myopathy \| 1 C0031350 \| pharyngitis \| 1 C0002986 \| anderson-fabry disease \| 1 C0545047 \| nephrogenic adenoma \| 1 C0007570 \| celiac disease \| 1 C0042164 \| uveitis \| 1 C0017178 \| gastrointestinal disorder \| 1 C0022336 \| creutzfeldt-jakob disease \| 1 C0021359 \| infertile \| 1 C0030920 \| peptic ulceration \| 1 C0343084 \| capillary leak syndrome \| 1 C0521542 \| brain stem infarct \| 1 C0022658 \| nephropathy \| 1 C0027051 \| myocardial infarct \| 1 C0031069 \| familial mediterranean fever \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:20) 1234 \| CCR5 \| CIPHER 929 \| CD14 \| CIPHER 2212 \| FCGR2A \| CIPHER 3458 \| IFNG \| CIPHER 3586 \| IL10 \| CIPHER 3557 \| IL1RN \| CIPHER 3558 \| IL2 \| CIPHER 3565 \| IL4 \| CIPHER 3569 \| IL6 \| CIPHER 100507436 \| MICA \| CIPHER 5696 \| PSMB8 \| CIPHER 5698 \| PSMB9 \| CIPHER 6402 \| SELL \| CIPHER 6556 \| SLC11A1 \| CIPHER 6890 \| TAP1 \| CIPHER 6891 \| TAP2 \| CIPHER 7040 \| TGFB1 \| CIPHER 7099 \| TLR4 \| CIPHER 7124 \| TNF \| CIPHER 4210 \| MEFV \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:68) 9447 \| AIM2 \| 2.242 \| DISEASES 56899 \| ANKS1B \| 2.232 \| DISEASES 340075 \| ARSI \| 1.911 \| DISEASES 1822 \| ATN1 \| 1.592 \| DISEASES 551 \| AVP \| 1.219 \| DISEASES 63827 \| BCAN \| 1.411 \| DISEASES 57448 \| BIRC6 \| 1.45 \| DISEASES 23066 \| CAND2 \| 1.183 \| DISEASES 834 \| CASP1 \| 1.696 \| DISEASES 959 \| CD40LG \| 5.087 \| DISEASES 942 \| CD86 \| 1.121 \| DISEASES 8804 \| CREG1 \| 2.265 \| DISEASES 9547 \| CXCL14 \| 1.599 \| DISEASES 2013 \| EMP2 \| 1.392 \| DISEASES 2081 \| ERN1 \| 1.572 \| DISEASES 2098 \| ESD \| 1.285 \| DISEASES 23014 \| FBXO21 \| 2.987 \| DISEASES 84978 \| FRMD5 \| 3.191 \| DISEASES 29933 \| GPR132 \| 2.589 \| DISEASES 338442 \| HCAR2 \| 1.102 \| DISEASES 10866 \| HCP5 \| 2.117 \| DISEASES 9146 \| HGS \| 2.064 \| DISEASES 3329 \| HSPD1 \| 3.217 \| DISEASES 5654 \| HTRA1 \| 3.082 \| DISEASES 3586 \| IL10 \| 2.845 \| DISEASES 3605 \| IL17A \| 1.464 \| DISEASES 3559 \| IL2RA \| 1.762 \| DISEASES 284359 \| IZUMO1 \| 1.572 \| DISEASES 3767 \| KCNJ11 \| 1.074 \| DISEASES 8284 \| KDM5D \| 1.284 \| DISEASES 9851 \| KIAA0753 \| 1.269 \| DISEASES 3805 \| KIR2DL4 \| 1.735 \| DISEASES 10219 \| KLRG1 \| 1.456 \| DISEASES 3916 \| LAMP1 \| 3.505 \| DISEASES 4065 \| LY75 \| 1.919 \| DISEASES 23764 \| MAFF \| 1.835 \| DISEASES 4125 \| MAN2B1 \| 1.492 \| DISEASES 100507436 \| MICA \| 1.02 \| DISEASES 4318 \| MMP9 \| 1.115 \| DISEASES 4615 \| MYD88 \| 3.071 \| DISEASES 79625 \| NDNF \| 1.224 \| DISEASES 27247 \| NFU1 \| 1.909 \| DISEASES 58484 \| NLRC4 \| 1.52 \| DISEASES 114548 \| NLRP3 \| 2.847 \| DISEASES 283820 \| NOMO2 \| 1.517 \| DISEASES 408050 \| NOMO3 \| 1.52 \| DISEASES 23532 \| PRAME \| 1.704 \| DISEASES 9051 \| PSTPIP1 \| 2.536 \| DISEASES 5879 \| RAC1 \| 1.143 \| DISEASES 5888 \| RAD51 \| 2.198 \| DISEASES 6129 \| RPL7 \| 4.685 \| DISEASES 6133 \| RPL9 \| 3.463 \| DISEASES 6288 \| SAA1 \| 2.325 \| DISEASES 6337 \| SCNN1A \| 1.335 \| DISEASES 5104 \| SERPINA5 \| 1.747 \| DISEASES 55576 \| STAB2 \| 3.702 \| DISEASES 80222 \| TARS2 \| 1.89 \| DISEASES 7062 \| TCHH \| 1.691 \| DISEASES 26136 \| TES \| 1.623 \| DISEASES 284486 \| THEM5 \| 1.265 \| DISEASES 114609 \| TIRAP \| 1.187 \| DISEASES 7099 \| TLR4 \| 2.841 \| DISEASES 54106 \| TLR9 \| 2.265 \| DISEASES 7124 \| TNF \| 3.555 \| DISEASES 7133 \| TNFRSF1B \| 1.055 \| DISEASES 8725 \| URI1 \| 1.403 \| DISEASES 7417 \| VDAC2 \| 1.592 \| DISEASES 7791 \| ZYX \| 1.287 \| DISEASES
Locus	(Waiting for update.)

Disease ID	545
Disease	brucellosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:78) HP:0011034 \| Amyloid disease \| 16 HP:0001369 \| Arthritis \| 9 HP:0001945 \| Fever \| 7 HP:0001917 \| Renal amyloidosis \| 5 HP:0001876 \| Low blood cell count \| 5 HP:0000083 \| Renal insufficiency \| 4 HP:0001370 \| Rheumatoid arthritis \| 4 HP:0002633 \| Vasculitis \| 3 HP:0010783 \| Erythema \| 3 HP:0100584 \| Endocarditis \| 3 HP:0001701 \| Pericarditis \| 3 HP:0001055 \| Erysipelas \| 3 HP:0030005 \| Capillary leak \| 2 HP:0001698 \| Pericardial effusions \| 2 HP:0012531 \| Pain \| 2 HP:0012115 \| Liver inflammation \| 2 HP:0012089 \| Arteritis \| 2 HP:0000716 \| Depression \| 2 HP:0001873 \| Low platelet count \| 2 HP:0002621 \| Atherosclerosis \| 2 HP:0002090 \| Pneumonia \| 2 HP:0100796 \| Orchitis \| 2 HP:0001824 \| Weight loss \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0000093 \| Proteinuria \| 2 HP:0000099 \| Glomerular nephritis \| 2 HP:0000100 \| Nephrosis \| 2 HP:0005214 \| Bowel obstruction \| 1 HP:0001997 \| Gout \| 1 HP:0002373 \| Febrile convulsions \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0001287 \| Meningitis \| 1 HP:0012156 \| Hemophagocytosis \| 1 HP:0002045 \| Abnormally low body temperature \| 1 HP:0000112 \| Nephropathy \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0010885 \| Aseptic necrosis \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0003765 \| Psoriasis \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1 HP:0002840 \| Lymphadenitis \| 1 HP:0100512 \| Vitamin D deficiency \| 1 HP:0000027 \| Azoospermia \| 1 HP:0000853 \| Goitre \| 1 HP:0000979 \| Purpura \| 1 HP:0011877 \| Increased mean platelet volume \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0009741 \| Thickening of kidney artiries \| 1 HP:0000554 \| Uveitis \| 1 HP:0003198 \| Myopathic changes \| 1 HP:0001250 \| Seizures \| 1 HP:0002754 \| Bone infection \| 1 HP:0002664 \| Neoplasia \| 1 HP:0001903 \| Anemia \| 1 HP:0001397 \| Hepatic steatosis \| 1 HP:0030692 \| Brain tumor \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0200119 \| Acute liver inflammation \| 1 HP:0002829 \| Arthralgias \| 1 HP:0004398 \| Peptic ulcer \| 1 HP:0003326 \| Muscle pain \| 1 HP:0045073 \| Serositis \| 1 HP:0001337 \| Tremor \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0100614 \| Muscle inflammation \| 1 HP:0002608 \| Celiac disease \| 1 HP:0002586 \| Peritonitis \| 1 HP:0004808 \| Acute myelogenous leukemia \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0002625 \| Blood clot in a deep vein \| 1 HP:0003418 \| Back pain \| 1 HP:0001518 \| Small for gestational age \| 1 HP:0010280 \| Stomatitis \| 1 HP:0012124 \| Intermediate uveitis \| 1 HP:0001909 \| Leukemia \| 1

Disease ID	545
Disease	brucellosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:108) C2717961 \| thrombotic microangiopathy C2711548 \| infectious process C2364133 \| infection C2186532 \| liver disease C1963211 \| pericarditis C1963083 \| cholecystitis C1961102 \| acute lymphoblastic leukemia C1735378 \| chronic polyarthritis C1611280 \| allergy C1546654 \| granuloma C1546533 \| abscess C1449646 \| primary peritonitis C1393529 \| vascular complications C1366535 \| diabetes insipidus C1328486 \| calculous cholecystitis C1320684 \| vertebral abscess C1136085 \| monoclonal gammopathy C0878631 \| pathergy C0877378 \| sacral pain C0876991 \| hemophagocytosis C0857305 \| thrombocytopenic purpura C0796095 \| c syndrome C0752303 \| urological manifestations C0751908 \| vestibular neuronitis C0751463 \| nerve root compression C0751000 \| anterior cerebral artery aneurysm C0748159 \| pulmonary involvement C0745754 \| hepatic granuloma C0743554 \| recurrent epistaxis C0598340 \| torsion spasm C0585186 \| cutaneous hypersensitivity C0574960 \| sacroiliitis C0564778 \| obstetrical disorders C0543697 \| mixed cryoglobulinemia C0497156 \| lymphadenopathy C0452221 \| spinal osteomyelitis C0422833 \| ent symptoms C0409207 \| hip arthritis C0376293 \| stigmata C0281900 \| lumbar spondylitis C0272412 \| splenic abscess C0271355 \| abducens paralysis C0267797 \| acute hepatitis C0264551 \| exudative pleural effusion C0264097 \| calcaneal apophysitis C0240111 \| knee arthritis C0239161 \| dactylitis C0235557 \| pulmonary granuloma C0235369 \| granulomatous hepatitis C0235169 \| excitability C0235031 \| neurological symptoms C0233777 \| hallucinosis C0231230 \| fatigability C0221239 \| rapidly progressive glomerulonephritis C0155288 \| papilledema C0155223 \| dacryoadenitis C0151436 \| allergic vasculitis C0149881 \| epididymoorchitis C0149881 \| epididymo-orchitis C0149871 \| deep venous thrombosis C0085435 \| reactive arthritis C0085222 \| psoas abscess C0040053 \| thrombosis C0040034 \| thrombocytopenia C0038012 \| spondylitis C0037285 \| skin manifestations C0037285 \| skin manifestation C0037284 \| skin lesions C0035435 \| rheumatism C0035304 \| retinal degenerations C0032587 \| polyradiculoneuropathy C0032541 \| polyneuritis C0031154 \| peritonitis C0031117 \| peripheral neuropathies C0030486 \| paraplegia C0030312 \| pancytopenia C0029400 \| osteitis C0029191 \| orchitis C0027765 \| nervous system diseases C0027121 \| myositis C0025311 \| meningomyelitis C0025309 \| meningoencephalitis C0024291 \| hemophagocytic syndrome C0024205 \| lymphadenitis C0023885 \| hepatic abscess C0023355 \| leptomeningitis C0022568 \| keratitis C0021141 \| syndrome of inappropriate secretion of antidiuretic hormone C0020532 \| hypersplenism C0019080 \| hemorrhage C0017658 \| glomerulonephritis C0015397 \| ocular disease C0015230 \| exanthem C0014743 \| erythema nodosum C0014583 \| episcleritis C0014118 \| endocarditis C0014038 \| encephalitis C0013504 \| hepatic hydatidosis C0012624 \| spondylodiscitis C0012624 \| discitis C0004610 \| bacteremia C0004610 \| bacteraemia C0003864 \| arthritis C0003708 \| arachnoiditis C0002878 \| hemolytic anemia C0001621 \| adrenal gland disorders C0001403 \| addison's disease C0001339 \| acute pancreatitis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:23) C0009450 \| infection \| 14 C0000833 \| abscess \| 6 C0030312 \| pancytopenia \| 5 C0014118 \| endocarditis \| 3 C0272412 \| splenic abscess \| 3 C0031046 \| pericarditis \| 3 C0003864 \| arthritis \| 2 C0040034 \| thrombocytopenia \| 2 C0029191 \| orchitis \| 2 C0037284 \| skin lesions \| 1 C0040053 \| thrombosis \| 1 C0023895 \| liver disease \| 1 C0025309 \| meningoencephalitis \| 1 C0574960 \| sacroiliitis \| 1 C0012624 \| spondylodiscitis \| 1 C0038012 \| spondylitis \| 1 C0876991 \| hemophagocytosis \| 1 C0748159 \| pulmonary involvement \| 1 C2717961 \| thrombotic microangiopathy \| 1 C0267797 \| acute hepatitis \| 1 C0024205 \| lymphadenitis \| 1 C0796095 \| c syndrome \| 1 C0422833 \| ent symptoms \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:6)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1131498	16585636	6402	SELL	umls:C0006309	BeFree	Association between the Phe206Leu polymorphism of L-selectin and brucellosis.	0.005362824	2006	SELL	1	169707345	A	G
rs11466023	25318808	4210	MEFV	umls:C0006309	BeFree	Mediterranean fever (MEFV) variant P369S/R408Q in a patient with entero-Behçet's disease who successfully responded to treatment with colchicine.	0.008881637	2015	MEFV	16	3249586	G	T,A
rs11466024	25318808	4210	MEFV	umls:C0006309	BeFree	Mediterranean fever (MEFV) variant P369S/R408Q in a patient with entero-Behçet's disease who successfully responded to treatment with colchicine.	0.008881637	2015	MEFV	16	3249468	C	T
rs2476601	19107641	26191	PTPN22	umls:C0006309	BeFree	PTPN22 C1858T polymorphism and human brucellosis.	0.002638474	2009	PTPN22;AP4B1-AS1	1	113834946	A	G
rs3743930	21210266	4210	MEFV	umls:C0006309	BeFree	Genetic analysis was done and heterozygous mutation E148Q was detected as a disease-causing Mediterranean fever (MEFV) mutation.	0.008881637	2011	MEFV	16	3254626	C	G
rs386580517	16585636	6402	SELL	umls:C0006309	BeFree	Association between the Phe206Leu polymorphism of L-selectin and brucellosis.	0.005362824	2006	NA	NA	NA	NA	NA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	545
Disease	brucellosis
Case	(Waiting for update.)

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