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	bile duct carcinoma

Disease ID	1669
Disease	bile duct carcinoma
Definition	Your liver makes a digestive juice called bile. Your gallbladder stores it between meals. When you eat, your gallbladder pushes the bile into tubes called bile ducts. They carry the bile to your small intestine. The bile helps break down fat. It also helps the liver get rid of toxins and wastes. Bile duct cancer is rare. It can happen in the parts of the bile ducts that are outside or inside the liver. Cancer of the bile duct outside of the liver is much more common. Risk factors include having inflammation of the bile duct, ulcerative colitis, and some liver diseases. Symptoms can include Jaundice Itchy skin Fever Abdominal pain Tests to diagnose bile duct cancer may include a physical exam, imaging tests of the liver and bile ducts, blood tests, and a biopsy. Treatments include surgery, radiation therapy, and chemotherapy. NIH: National Cancer Institute
Synonym	bile cancer duct bile duct cancers bile ducts cancer bile ducts--cancer cancer bile duct cancer of bile duct cancer of the bile duct cancer, bile duct cancers, bile duct carcinoma bile duct carcinoma of bile duct
DOID	DOID:4897
UMLS	C0740277
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:3) C0206698 \| cholangiocarcinoma \| 2 C0022354 \| obstructive jaundice \| 1 C0334121 \| inflammatory myofibroblastic tumor \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 5774 \| PTPN3 \| ORPHANET
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:217) 1244 \| ABCC2 \| 2.025 \| DISEASES 84740 \| AFAP1-AS1 \| 2.04 \| DISEASES 174 \| AFP \| 4.653 \| DISEASES 10768 \| AHCYL1 \| 1.456 \| DISEASES 150209 \| AIFM3 \| 2.362 \| DISEASES 210 \| ALAD \| 1.893 \| DISEASES 11199 \| ANXA10 \| 1.934 \| DISEASES 307 \| ANXA4 \| 1.779 \| DISEASES 653145 \| ANXA8 \| 1.9 \| DISEASES 728113 \| ANXA8L1 \| 1.884 \| DISEASES 8289 \| ARID1A \| 2.959 \| DISEASES 444 \| ASPH \| 2.93 \| DISEASES 8314 \| BAP1 \| 1.809 \| DISEASES 80114 \| BICC1 \| 1.845 \| DISEASES 648 \| BMI1 \| 1.731 \| DISEASES 91653 \| BOC \| 1.544 \| DISEASES 682 \| BSG \| 1.258 \| DISEASES 685 \| BTC \| 3.068 \| DISEASES 128864 \| C20orf144 \| 1.767 \| DISEASES 801 \| CALM1 \| 1.784 \| DISEASES 841 \| CASP8 \| 1.647 \| DISEASES 842 \| CASP9 \| 1.865 \| DISEASES 1233 \| CCR4 \| 1.619 \| DISEASES 9332 \| CD163 \| 1.455 \| DISEASES 29126 \| CD274 \| 1.844 \| DISEASES 960 \| CD44 \| 2.16 \| DISEASES 1029 \| CDKN2A \| 3.083 \| DISEASES 1045 \| CDX2 \| 3.065 \| DISEASES 55743 \| CHFR \| 1.108 \| DISEASES 10164 \| CHST4 \| 2.037 \| DISEASES 26097 \| CHTOP \| 1.934 \| DISEASES 10970 \| CKAP4 \| 1.249 \| DISEASES 1364 \| CLDN4 \| 1.781 \| DISEASES 1366 \| CLDN7 \| 1.49 \| DISEASES 29034 \| CPS1-IT1 \| 2.218 \| DISEASES 9586 \| CREB5 \| 1.322 \| DISEASES 1490 \| CTGF \| 1.368 \| DISEASES 1499 \| CTNNB1 \| 3.601 \| DISEASES 8451 \| CUL4A \| 1.966 \| DISEASES 6387 \| CXCL12 \| 1.426 \| DISEASES 7852 \| CXCR4 \| 1.93 \| DISEASES 30827 \| CXXC1 \| 1.441 \| DISEASES 1543 \| CYP1A1 \| 1.299 \| DISEASES 1544 \| CYP1A2 \| 2.184 \| DISEASES 1612 \| DAPK1 \| 1.334 \| DISEASES 25853 \| DCAF12 \| 2.401 \| DISEASES 1630 \| DCC \| 1.212 \| DISEASES 25981 \| DNAH1 \| 1.619 \| DISEASES 1786 \| DNMT1 \| 1.663 \| DISEASES 9166 \| EBAG9 \| 2.061 \| DISEASES 8661 \| EIF3A \| 1.268 \| DISEASES 1977 \| EIF4E \| 1.49 \| DISEASES 1978 \| EIF4EBP1 \| 1.038 \| DISEASES 339221 \| ENPP7 \| 1.17 \| DISEASES 284656 \| EPHA10 \| 1.276 \| DISEASES 2042 \| EPHA3 \| 1.965 \| DISEASES 83481 \| EPPK1 \| 1.423 \| DISEASES 7430 \| EZR \| 1.42 \| DISEASES 25817 \| FAM19A5 \| 2.657 \| DISEASES 356 \| FASLG \| 1.75 \| DISEASES 2260 \| FGFR1 \| 1.395 \| DISEASES 2263 \| FGFR2 \| 3.094 \| DISEASES 2272 \| FHIT \| 1.606 \| DISEASES 11259 \| FILIP1L \| 1.231 \| DISEASES 51661 \| FKBP7 \| 1.63 \| DISEASES 6624 \| FSCN1 \| 2.549 \| DISEASES 5349 \| FXYD3 \| 1.528 \| DISEASES 728441 \| GGT2 \| 2.643 \| DISEASES 152007 \| GLIPR2 \| 1.6 \| DISEASES 2778 \| GNAS \| 1.945 \| DISEASES 346562 \| GNAT3 \| 1.634 \| DISEASES 51280 \| GOLM1 \| 1.936 \| DISEASES 57120 \| GOPC \| 2.49 \| DISEASES 151306 \| GPBAR1 \| 1.947 \| DISEASES 2719 \| GPC3 \| 3.705 \| DISEASES 2950 \| GSTP1 \| 1.135 \| DISEASES 3039 \| HBA1 \| 1.092 \| DISEASES 3045 \| HBD \| 1.441 \| DISEASES 3068 \| HDGF \| 2.776 \| DISEASES 3091 \| HIF1A \| 1.293 \| DISEASES 84072 \| HORMAD1 \| 1.037 \| DISEASES 3316 \| HSPB2 \| 1.113 \| DISEASES 3418 \| IDH2 \| 3.775 \| DISEASES 3481 \| IGF2 \| 1.23 \| DISEASES 3638 \| INSIG1 \| 2.651 \| DISEASES 55756 \| INTS9 \| 2.221 \| DISEASES 79831 \| KDM8 \| 1.146 \| DISEASES 3838 \| KPNA2 \| 1.402 \| DISEASES 3875 \| KRT18 \| 2.179 \| DISEASES 3880 \| KRT19 \| 5.307 \| DISEASES 3855 \| KRT7 \| 4.851 \| DISEASES 55353 \| LAPTM4B \| 1.402 \| DISEASES 90632 \| LINC00473 \| 1.985 \| DISEASES 8513 \| LIPF \| 1.224 \| DISEASES 4017 \| LOXL2 \| 1.532 \| DISEASES 121227 \| LRIG3 \| 1.162 \| DISEASES 4097 \| MAFG \| 1.548 \| DISEASES 81557 \| MAGED4B \| 1.904 \| DISEASES 28986 \| MAGEH1 \| 1.82 \| DISEASES 5609 \| MAP2K7 \| 2.69 \| DISEASES 4216 \| MAP3K4 \| 1.082 \| DISEASES 5599 \| MAPK8 \| 1.222 \| DISEASES 4082 \| MARCKS \| 1.58 \| DISEASES 4170 \| MCL1 \| 3.115 \| DISEASES 4192 \| MDK \| 1.049 \| DISEASES 4193 \| MDM2 \| 1.97 \| DISEASES 8076 \| MFAP5 \| 1.069 \| DISEASES 84864 \| MINA \| 1.114 \| DISEASES 284424 \| MIR7-3HG \| 1.405 \| DISEASES 4311 \| MME \| 2.423 \| DISEASES 4318 \| MMP9 \| 3.259 \| DISEASES 10232 \| MSLN \| 1.94 \| DISEASES 2475 \| MTOR \| 1.872 \| DISEASES 9788 \| MTSS1 \| 1.206 \| DISEASES 4582 \| MUC1 \| 4.321 \| DISEASES 4583 \| MUC2 \| 4.251 \| DISEASES 4585 \| MUC4 \| 2.782 \| DISEASES 4586 \| MUC5AC \| 4.395 \| DISEASES 4588 \| MUC6 \| 3.463 \| DISEASES 4595 \| MUTYH \| 1.216 \| DISEASES 4609 \| MYC \| 2.41 \| DISEASES 9 \| NAT1 \| 1.66 \| DISEASES 4751 \| NEK2 \| 2.223 \| DISEASES 4886 \| NPY1R \| 1.086 \| DISEASES 9971 \| NR1H4 \| 1.754 \| DISEASES 8856 \| NR1I2 \| 1.613 \| DISEASES 2494 \| NR5A2 \| 1.066 \| DISEASES 55968 \| NSFL1C \| 1.105 \| DISEASES 4978 \| OPCML \| 2.149 \| DISEASES 5005 \| ORM2 \| 2.014 \| DISEASES 142 \| PARP1 \| 2.029 \| DISEASES 55193 \| PBRM1 \| 2.862 \| DISEASES 5095 \| PCCA \| 4.298 \| DISEASES 5154 \| PDGFA \| 1.97 \| DISEASES 80310 \| PDGFD \| 1.223 \| DISEASES 5178 \| PEG3 \| 1.338 \| DISEASES 5223 \| PGAM1 \| 1.429 \| DISEASES 1263 \| PLK3 \| 1.485 \| DISEASES 10631 \| POSTN \| 1.776 \| DISEASES 51535 \| PPHLN1 \| 2.22 \| DISEASES 5478 \| PPIA \| 1.106 \| DISEASES 5567 \| PRKACB \| 1.352 \| DISEASES 5573 \| PRKAR1A \| 1.559 \| DISEASES 8842 \| PROM1 \| 3.204 \| DISEASES 112476 \| PRRT2 \| 5.165 \| DISEASES 5706 \| PSMC6 \| 1.223 \| DISEASES 55269 \| PSPC1 \| 1.505 \| DISEASES 5728 \| PTEN \| 2.774 \| DISEASES 5743 \| PTGS2 \| 3.379 \| DISEASES 5744 \| PTHLH \| 1.393 \| DISEASES 5784 \| PTPN14 \| 2.125 \| DISEASES 5774 \| PTPN3 \| 2.053 \| DISEASES 221002 \| RASGEF1A \| 1.729 \| DISEASES 11186 \| RASSF1 \| 2.005 \| DISEASES 55758 \| RCOR3 \| 2.197 \| DISEASES 8434 \| RECK \| 2.315 \| DISEASES 54894 \| RNF43 \| 1.897 \| DISEASES 6091 \| ROBO1 \| 1.006 \| DISEASES 6092 \| ROBO2 \| 2.244 \| DISEASES 6098 \| ROS1 \| 3.315 \| DISEASES 6171 \| RPL41 \| 1.152 \| DISEASES 3921 \| RPSA \| 1.448 \| DISEASES 55680 \| RUFY2 \| 2.233 \| DISEASES 864 \| RUNX3 \| 1.703 \| DISEASES 6273 \| S100A2 \| 1.161 \| DISEASES 6275 \| S100A4 \| 2.799 \| DISEASES 6277 \| S100A6 \| 1.479 \| DISEASES 6280 \| S100A9 \| 1.254 \| DISEASES 9294 \| S1PR2 \| 1.988 \| DISEASES 389432 \| SAMD5 \| 1.839 \| DISEASES 60485 \| SAV1 \| 1.635 \| DISEASES 27111 \| SDCBP2 \| 1.872 \| DISEASES 5265 \| SERPINA1 \| 2.016 \| DISEASES 2810 \| SFN \| 2.503 \| DISEASES 53358 \| SHC3 \| 3.225 \| DISEASES 6497 \| SKI \| 1.234 \| DISEASES 6564 \| SLC15A1 \| 1.754 \| DISEASES 6580 \| SLC22A1 \| 1.698 \| DISEASES 2030 \| SLC29A1 \| 2.523 \| DISEASES 6513 \| SLC2A1 \| 1.615 \| DISEASES 10568 \| SLC34A2 \| 1.353 \| DISEASES 81539 \| SLC38A1 \| 2.335 \| DISEASES 4089 \| SMAD4 \| 2.982 \| DISEASES 23583 \| SMUG1 \| 3.366 \| DISEASES 64754 \| SMYD3 \| 1.964 \| DISEASES 6696 \| SPP1 \| 1.55 \| DISEASES 6700 \| SPRR2A \| 2.402 \| DISEASES 6714 \| SRC \| 1.196 \| DISEASES 222183 \| SRRM3 \| 2.267 \| DISEASES 6794 \| STK11 \| 1.664 \| DISEASES 10460 \| TACC3 \| 2.246 \| DISEASES 4070 \| TACSTD2 \| 1.425 \| DISEASES 6925 \| TCF4 \| 1.138 \| DISEASES 10732 \| TCFL5 \| 5.238 \| DISEASES 163589 \| TDRD5 \| 2.566 \| DISEASES 7033 \| TFF3 \| 1.443 \| DISEASES 7048 \| TGFBR2 \| 1.297 \| DISEASES 9874 \| TLK1 \| 1.929 \| DISEASES 79838 \| TMC5 \| 2.037 \| DISEASES 7124 \| TNF \| 2.002 \| DISEASES 10766 \| TOB2 \| 1.769 \| DISEASES 7164 \| TPD52L1 \| 1.311 \| DISEASES 10612 \| TRIM3 \| 1.321 \| DISEASES 89122 \| TRIM4 \| 1.723 \| DISEASES 10100 \| TSPAN2 \| 1.174 \| DISEASES 284076 \| TTLL6 \| 2.028 \| DISEASES 9039 \| UBA3 \| 1.41 \| DISEASES 10720 \| UGT2B11 \| 1.962 \| DISEASES 7422 \| VEGFA \| 2.625 \| DISEASES 11326 \| VSIG4 \| 1.947 \| DISEASES 7477 \| WNT7B \| 2.024 \| DISEASES 9589 \| WTAP \| 2.052 \| DISEASES 51741 \| WWOX \| 1.292 \| DISEASES 331 \| XIAP \| 1.983 \| DISEASES 6935 \| ZEB1 \| 1.897 \| DISEASES 80139 \| ZNF703 \| 1.081 \| DISEASES 65982 \| ZSCAN18 \| 3.257 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1669
Disease	bile duct carcinoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:4) HP:0000952 \| Yellow skin \| 2 HP:0030731 \| Carcinoma \| 2 HP:0002664 \| Neoplasia \| 2 HP:0030153 \| Cholangiocarcinoma \| 2

Disease ID	1669
Disease	bile duct carcinoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:5) C0400979 \| biliary obstruction C0333577 \| cholesterosis C0153687 \| cutaneous metastasis C0022354 \| obstructive jaundice C0008370 \| cholestasis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0022354 \| obstructive jaundice \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:7)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1003723	18296645	3949	LDLR	umls:C0740277	BeFree	Male and female carriers of the T allele of LDLR IVS9-30C>T (rs1003723) had a 1.5-fold risk of bile duct cancer.	0.000271442	2008	LDLR;MIR6886	19	11113505	C	T
rs1126579	18676870	3579	CXCR2	umls:C0740277	BeFree	Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.	0.000271442	2008	CXCR2	2	218136011	T	C
rs1126580	18676870	3579	CXCR2	umls:C0740277	BeFree	Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.	0.000271442	2008	CXCR2	2	218136243	G	A
rs11887534	21062971	64241	ABCG8	umls:C0740277	BeFree	Carriers of the CG genotype of ABCG8 rs11887534 had higher risk of biliary stones [odds ratio (OR) = 2.3, 95% confidence interval (CI) 0.82-6.5), gallbladder cancer (OR = 4.3, 95% CI 1.7-10.4) and bile duct cancer (OR = 1.94, 95% CI 0.64-5.91), compared with carriers of the GG genotype.	0.000271442	2011	ABCG5;ABCG8	2	43839108	G	A,C
rs2230054	18676870	3579	CXCR2	umls:C0740277	BeFree	Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, and rs1126580), was associated with the risk of bile duct cancer (P = 0.003) and biliary stones (P = 0.02), relative to the most frequent haplotype.	0.000271442	2008	CXCR2	2	218135587	C	T
rs4986938	20172949	6817	SULT1A1	umls:C0740277	BeFree	Also, the ESR2 rs4986938 (38 bp 3' of STP) GG genotype was associated with a higher risk of bile duct cancer (OR = 3.3, 95% CI 1.3-8.7) compared with the AA genotype, although this estimate was based on a small number of subjects.	0.000271442	2010	ESR2	14	64233098	C	T
rs4986938	20172949	2100	ESR2	umls:C0740277	BeFree	Also, the ESR2 rs4986938 (38 bp 3' of STP) GG genotype was associated with a higher risk of bile duct cancer (OR = 3.3, 95% CI 1.3-8.7) compared with the AA genotype, although this estimate was based on a small number of subjects.	0.000271442	2010	ESR2	14	64233098	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1669
Disease	bile duct carcinoma
Case	(Waiting for update.)

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