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	bacterial meningitis

Disease ID	1118
Disease	bacterial meningitis
Definition	Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.
Synonym	bact meningitides bact meningitis bacterial meningitides bacterial meningitis (disorder) bacterial meningitis nos bacterial meningitis nos (disorder) bacterial meningitis, nos bm - bacterial meningitis meningitides bact meningitides, bacterial meningitis bact meningitis due to unspecified bacterium meningitis, bacterial meningitis, bacterial [disease/finding] meningitis, bacterial nos
DOID	DOID:9470
UMLS	C0085437
MeSH	D016920
SNOMED-CT	SNOMEDCT_US_2016_09_01:95883001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:38) C0025289 \| meningitis \| 5 C0038539 \| subdural empyema \| 3 C0007785 \| cerebral infarct \| 2 C0025297 \| viral meningitis \| 2 C0014118 \| endocarditis \| 2 C0020255 \| hydrocephalus \| 2 C0007785 \| cerebral infarction \| 2 C0038463 \| strongyloidiasis \| 2 C0029882 \| otitis media \| 2 C0023890 \| liver cirrhosis \| 2 C0038220 \| status epilepticus \| 1 C0025295 \| pneumococcal meningitis \| 1 C0014070 \| encephalomyelitis \| 1 C0276430 \| enteroviral meningitis \| 1 C0267917 \| acute cholangitis \| 1 C0032285 \| pneumoniae \| 1 C0018784 \| sensorineural hearing loss \| 1 C0042164 \| uveitis \| 1 C0024530 \| malaria \| 1 C0025303 \| meningococcal disease \| 1 C0008049 \| chickenpox \| 1 C0026764 \| myeloma \| 1 C0023890 \| cirrhosis \| 1 C0037198 \| sinus thrombosis \| 1 C0014059 \| acute disseminated encephalomyelitis \| 1 C0026764 \| multiple myeloma \| 1 C0041318 \| tuberculous meningitis \| 1 C0271429 \| acute otitis media \| 1 C0008311 \| cholangitis \| 1 C0004623 \| bacterial infection \| 1 C0042165 \| anterior uveitis \| 1 C0014236 \| endophthalmitis \| 1 C0021400 \| influenzae \| 1 C0022116 \| ischemia \| 1 C0041296 \| tuberculosis \| 1 C0040053 \| thrombosis \| 1 C0007785 \| cerebral infarctions \| 1 C0023860 \| listeriosis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 720 \| C4A \| CIPHER 721 \| C4B \| CIPHER 4179 \| CD46 \| CIPHER 4153 \| MBL2 \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:84) 2 \| A2M \| 2.203 \| DISEASES 361 \| AQP4 \| 2.2 \| DISEASES 1822 \| ATN1 \| 1.438 \| DISEASES 551 \| AVP \| 3.209 \| DISEASES 567 \| B2M \| 1.247 \| DISEASES 2683 \| B4GALT1 \| 1.993 \| DISEASES 25805 \| BAMBI \| 4.222 \| DISEASES 627 \| BDNF \| 2.557 \| DISEASES 721 \| C4B \| 2.192 \| DISEASES 728 \| C5AR1 \| 1.968 \| DISEASES 730 \| C7 \| 2.518 \| DISEASES 820 \| CAMP \| 2.175 \| DISEASES 22900 \| CARD8 \| 2.053 \| DISEASES 834 \| CASP1 \| 2.27 \| DISEASES 388372 \| CCL4L1 \| 1.761 \| DISEASES 959 \| CD40LG \| 2.99 \| DISEASES 942 \| CD86 \| 1.549 \| DISEASES 1052 \| CEBPD \| 1.485 \| DISEASES 7122 \| CLDN5 \| 1.137 \| DISEASES 1270 \| CNTF \| 1.671 \| DISEASES 1435 \| CSF1 \| 1.398 \| DISEASES 2919 \| CXCL1 \| 2.233 \| DISEASES 2920 \| CXCL2 \| 2.061 \| DISEASES 51164 \| DCTN4 \| 2.632 \| DISEASES 1805 \| DPT \| 1.503 \| DISEASES 1809 \| DPYSL3 \| 1.206 \| DISEASES 83658 \| DYNLRB1 \| 1.145 \| DISEASES 1859 \| DYRK1A \| 1.914 \| DISEASES 124454 \| EARS2 \| 1.125 \| DISEASES 1906 \| EDN1 \| 1.162 \| DISEASES 2152 \| F3 \| 1.342 \| DISEASES 23017 \| FAIM2 \| 2.705 \| DISEASES 355 \| FAS \| 1.323 \| DISEASES 2214 \| FCGR3A \| 1.074 \| DISEASES 2582 \| GALE \| 1.656 \| DISEASES 2633 \| GBP1 \| 2.195 \| DISEASES 2668 \| GDNF \| 1.011 \| DISEASES 26061 \| HACL1 \| 1.963 \| DISEASES 3045 \| HBD \| 1.152 \| DISEASES 3146 \| HMGB1 \| 1.077 \| DISEASES 3586 \| IL10 \| 2.814 \| DISEASES 3605 \| IL17A \| 1.57 \| DISEASES 3664 \| IRF6 \| 3.059 \| DISEASES 9261 \| MAPKAPK2 \| 1.034 \| DISEASES 4153 \| MBL2 \| 2.159 \| DISEASES 50488 \| MINK1 \| 1.152 \| DISEASES 4318 \| MMP9 \| 3.208 \| DISEASES 26002 \| MOXD1 \| 1.112 \| DISEASES 219972 \| MPEG1 \| 2.464 \| DISEASES 4615 \| MYD88 \| 2.1 \| DISEASES 79625 \| NDNF \| 1.116 \| DISEASES 64332 \| NFKBIZ \| 1.302 \| DISEASES 100506658 \| OCLN \| 1.546 \| DISEASES 5284 \| PIGR \| 1.847 \| DISEASES 5294 \| PIK3CG \| 1.202 \| DISEASES 5329 \| PLAUR \| 1.231 \| DISEASES 56342 \| PPAN \| 1.178 \| DISEASES 5730 \| PTGDS \| 3.182 \| DISEASES 135250 \| RAET1E \| 1.069 \| DISEASES 2889 \| RAPGEF1 \| 2.236 \| DISEASES 222546 \| RFX6 \| 1.213 \| DISEASES 8986 \| RPS6KA4 \| 2.534 \| DISEASES 25813 \| SAMM50 \| 3.375 \| DISEASES 6401 \| SELE \| 1.308 \| DISEASES 5265 \| SERPINA1 \| 1.154 \| DISEASES 6565 \| SLC15A2 \| 1.614 \| DISEASES 57154 \| SMURF1 \| 1.182 \| DISEASES 25870 \| SUMF2 \| 1.369 \| DISEASES 50945 \| TBX22 \| 1.109 \| DISEASES 7018 \| TF \| 2.179 \| DISEASES 51270 \| TFDP3 \| 1.059 \| DISEASES 93643 \| TJAP1 \| 2.588 \| DISEASES 7096 \| TLR1 \| 2.466 \| DISEASES 7099 \| TLR4 \| 2.624 \| DISEASES 7100 \| TLR5 \| 1.044 \| DISEASES 10333 \| TLR6 \| 1.534 \| DISEASES 54106 \| TLR9 \| 2.928 \| DISEASES 7124 \| TNF \| 4.446 \| DISEASES 8771 \| TNFRSF6B \| 1.685 \| DISEASES 127262 \| TPRG1L \| 1.351 \| DISEASES 7177 \| TPSAB1 \| 1.802 \| DISEASES 7247 \| TSN \| 1.162 \| DISEASES 55432 \| YOD1 \| 1.868 \| DISEASES 7709 \| ZBTB17 \| 1.73 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1118
Disease	bacterial meningitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:31) HP:0001287 \| Meningitis \| 5 HP:0002315 \| Headaches \| 5 HP:0000238 \| Nonsyndromal hydrocephalus \| 2 HP:0001297 \| Cerebral vascular events \| 2 HP:0100584 \| Endocarditis \| 2 HP:0002045 \| Abnormally low body temperature \| 2 HP:0001945 \| Fever \| 2 HP:0000388 \| Otitis media \| 2 HP:0001250 \| Seizures \| 1 HP:0002170 \| Intracranial hemorrhage \| 1 HP:0000371 \| Acute middle ear infection \| 1 HP:0000407 \| sensorineural hearing loss \| 1 HP:0012683 \| Pineal cyst \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0002133 \| Status epilepticus \| 1 HP:0006702 \| Spontaneous coronary artery dissection \| 1 HP:0005305 \| Cerebral vein thrombosis \| 1 HP:0004326 \| Cachexia \| 1 HP:0100806 \| Sepsis \| 1 HP:0012122 \| Anterior uveitis \| 1 HP:0000554 \| Uveitis \| 1 HP:0030151 \| Cholangitis \| 1 HP:0001342 \| Intracerebral hemorrhage \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0002090 \| Pneumonia \| 1 HP:0001988 \| hypoglycemia, recurrent \| 1 HP:0000969 \| Dropsy \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0002181 \| Cerebral edema \| 1 HP:0000010 \| Frequent urinary tract infections \| 1 HP:0000365 \| Hearing impairment \| 1

Disease ID	1118
Disease	bacterial meningitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:46) C2712035 \| hyperglycaemia C2711548 \| infectious process C2364133 \| infection C2096315 \| headache C2029884 \| hearing loss C1963178 \| myelitis C1963137 \| hydrocephalus C1550639 \| fistula C1546533 \| abscess C1522136 \| hypernatremia C1393529 \| vascular complications C1282231 \| endogenous endophthalmitis C1135207 \| ataxia C1000483 \| anemia C0917798 \| cerebral ischaemia C0751401 \| ophthalmoparesis C0748903 \| spinal cord involvement C0581883 \| deafness C0457506 \| reactive thrombocytosis C0424755 \| fever C0392548 \| cauda equina syndrome C0272242 \| complement deficiency C0238051 \| cerebral vasculitis C0151740 \| intracranial hypertension C0043046 \| wasting syndrome C0038454 \| cerebral infarction C0038220 \| status epilepticus C0036572 \| seizures C0032285 \| pneumoniae C0032268 \| pneumocephalus C0031039 \| pericardial effusions C0029089 \| oculomotor paralysis C0026650 \| movement disorders C0022893 \| labyrinthitis C0021933 \| intussusception C0021308 \| infarction C0020456 \| hyperglycemia C0019270 \| herniation C0018784 \| sensorineural hearing loss C0018775 \| bilateral hearing loss C0016397 \| focal infections C0014544 \| epilepsy C0014236 \| endophthalmitis C0013447 \| otologic diseases C0007766 \| intracranial aneurysms C0001125 \| lactic acidosis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:18) C0009450 \| infection \| 7 C0018681 \| headache \| 5 C1384666 \| hearing loss \| 4 C0032285 \| pneumoniae \| 3 C0020255 \| hydrocephalus \| 2 C0015967 \| fever \| 2 C1393529 \| vascular complications \| 2 C0021308 \| infarction \| 2 C0032268 \| pneumocephalus \| 2 C0011053 \| deafness \| 1 C0007785 \| cerebral infarction \| 1 C0038220 \| status epilepticus \| 1 C0018784 \| sensorineural hearing loss \| 1 C0036572 \| seizures \| 1 C0000833 \| abscess \| 1 C0043046 \| wasting syndrome \| 1 C0016397 \| focal infections \| 1 C0016169 \| fistula \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:9)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1042714	22624056	127617	OR14L1P	umls:C0085437	BeFree	We identified a functional polymorphism in ADRB2 (rs1042714) to be associated with an increased risk for bacterial meningitis (Odds ratio [OR] 1.35, 95% confidence interval [CI] 1.04-1.76; p = 0.026).	0.000271442	2012	ADRB2	5	148826910	G	C,T
rs1047286	23068452	718	C3	umls:C0085437	BeFree	Rs1047286 (Pro314Leu) in complement component 3 was associated with reduced susceptibility to bacterial meningitis after correction for multiple testing: the protective Leu/Leu genotype was found in 5 of 435 patients (1%) compared to 15 of 302 controls (5%; odds ratio [OR] 4.50, 95% confidence interval [CI] 1.62-12.50, p = 0.0017).	0.000271442	2013	C3	19	6713251	G	A
rs1052133	26316174	4968	OGG1	umls:C0085437	BeFree	In recent papers published by our group, we described the associations between the single nucleotide polymorphisms (SNPs) AADAT +401C > T, APEX1 Asn148Glu, OGG1 Ser326Cys and PARP1 Val762Ala and BM.	0.000542884	2015	OGG1;CAMK1	3	9757089	C	G
rs1052133	26316174	142	PARP1	umls:C0085437	BeFree	In recent papers published by our group, we described the associations between the single nucleotide polymorphisms (SNPs) AADAT +401C > T, APEX1 Asn148Glu, OGG1 Ser326Cys and PARP1 Val762Ala and BM.	0.000271442	2015	OGG1;CAMK1	3	9757089	C	G
rs1052133	26316174	328	APEX1	umls:C0085437	BeFree	In recent papers published by our group, we described the associations between the single nucleotide polymorphisms (SNPs) AADAT +401C > T, APEX1 Asn148Glu, OGG1 Ser326Cys and PARP1 Val762Ala and BM.	0.000542884	2015	OGG1;CAMK1	3	9757089	C	G
rs1052133	21651918	4968	OGG1	umls:C0085437	BeFree	For the SNP OGG1 Ser326Cys, the genotype Cys/Cys was more frequent (P<0.05) in BM group.	0.000542884	2011	OGG1;CAMK1	3	9757089	C	G
rs1136410	26316174	142	PARP1	umls:C0085437	BeFree	In recent papers published by our group, we described the associations between the single nucleotide polymorphisms (SNPs) AADAT +401C > T, APEX1 Asn148Glu, OGG1 Ser326Cys and PARP1 Val762Ala and BM.	0.000271442	2015	PARP1	1	226367601	A	G
rs1136410	26316174	4968	OGG1	umls:C0085437	BeFree	In recent papers published by our group, we described the associations between the single nucleotide polymorphisms (SNPs) AADAT +401C > T, APEX1 Asn148Glu, OGG1 Ser326Cys and PARP1 Val762Ala and BM.	0.000542884	2015	PARP1	1	226367601	A	G
rs1136410	26316174	328	APEX1	umls:C0085437	BeFree	In recent papers published by our group, we described the associations between the single nucleotide polymorphisms (SNPs) AADAT +401C > T, APEX1 Asn148Glu, OGG1 Ser326Cys and PARP1 Val762Ala and BM.	0.000542884	2015	PARP1	1	226367601	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1118
Disease	bacterial meningitis
Case	(Waiting for update.)

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