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encyclopedia of Rare Disease Annotation for Precision Medicine



   atrial septal defects
  

Disease ID 1315
Disease atrial septal defects
Definition
Developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chambers of the heart. Classification of atrial septal defects is based on location of the communication and types of incomplete fusion of atrial septa with the ENDOCARDIAL CUSHIONS in the fetal heart. They include ostium primum, ostium secundum, sinus venosus, and coronary sinus defects.
Synonym
asd - atrial septal defect
atria septal defect
atria septal defect (asd)
atrial septal defect
atrial septal defect (asd)
atrial septal defect (disorder)
atrial septal defect nos
atrial septal defect nos (disorder)
atrial septal heart defect
atrial septal heart defects
atrial septum defect
atrioseptal defect
auricular septal defect nos
auricular septal defect nos (disorder)
congenital atrial septal defect
congenital atrial septal defect (disorder)
defect artrial septum
defect in the atrial septum
defect, atrial septal
defects, atrial septal
heart septal defect atrial
heart septal defects, atrial
heart septal defects, atrial [disease/finding]
ia septal defect
interatrial septal defect
interauricular septal defect
interauricular septal defect (disorder)
septal defect interatrial
septal defect, atrial
septal defects, atrial
Orphanet
DOID
ICD10
UMLS
C0018817
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:48)
C0020538  |  hypertension  |  20
C0020542  |  pulmonary hypertension  |  12
C1619734  |  pulmonary arterial hypertension  |  11
C0026269  |  mitral stenosis  |  4
C0018818  |  ventricular septal defect  |  4
C0018799  |  heart disease  |  3
C0152021  |  congenital heart disease  |  3
C0034089  |  pulmonary valve stenosis  |  3
C0149931  |  migraine  |  2
C0040053  |  thrombosis  |  2
C0040961  |  tricuspid regurgitation  |  2
C0018801  |  heart failure  |  2
C1956257  |  pulmonary stenosis  |  2
C0011847  |  diabetes  |  2
C0878544  |  cardiomyopathy  |  2
C0014118  |  endocarditis  |  2
C1142166  |  brugada syndrome  |  1
C0020255  |  hydrocephalus  |  1
C0265237  |  blepharophimosis syndrome  |  1
C0152966  |  pneumococcal septicaemia  |  1
C0031046  |  pericarditis  |  1
C0028326  |  noonan syndrome  |  1
C0031048  |  constrictive pericarditis  |  1
C0007194  |  hypertrophic cardiomyopathy  |  1
C0026266  |  mitral regurgitation  |  1
C0014121  |  bacterial endocarditis  |  1
C0014121  |  infective endocarditis  |  1
C0018816  |  septal defects  |  1
C0005744  |  blepharophimosis  |  1
C0040053  |  thrombus  |  1
C0024164  |  lutembacher syndrome  |  1
C0007193  |  dilated cardiomyopathy  |  1
C0004245  |  atrioventricular block  |  1
C0264766  |  rheumatic mitral stenosis  |  1
C0265264  |  holt-oram syndrome  |  1
C0013069  |  double outlet right ventricle  |  1
C0034065  |  pulmonary embolism  |  1
C0003507  |  aortic stenosis  |  1
C0013080  |  trisomy 21  |  1
C1527336  |  sjogren's syndrome  |  1
C0432443  |  18q deletion syndrome  |  1
C0024236  |  lymphoedema  |  1
C0007787  |  transient ischemic attack  |  1
C0014850  |  esophageal atresia  |  1
C0153500  |  heart ca  |  1
C0349788  |  arrhythmogenic right ventricular cardiomyopathy  |  1
C0003486  |  aortic aneurysm  |  1
C0018799  |  heart diseases  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:2)
4624  |  MYH6  |  CTD_human
10084  |  PQBP1  |  CTD_human
Inferring Gene(Waiting for update.)
Text Mined Gene(Waiting for update.)
Locus(Waiting for update.)
Disease ID 1315
Disease atrial septal defects
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:83)
HP:0000822  |  Hypertension  |  21
HP:0002092  |  Pulmonary artery hypertension  |  14
HP:0012382  |  Left-to-right shunt  |  9
HP:0002617  |  Aneurysmal dilatation  |  8
HP:0005110  |  Atrial fibrillation  |  7
HP:0010772  |  Anomalous pulmonary venous return  |  6
HP:0001694  |  Right-to-left shunt  |  5
HP:0001642  |  Pulmonic stenosis  |  5
HP:0012383  |  Bidirectional shunt  |  4
HP:0001629  |  Ventricular septal defects  |  4
HP:0010773  |  Partial anomalous pulmonary venous return  |  4
HP:0001718  |  Mitral stenosis  |  4
HP:0001631  |  Atria septal defect  |  3
HP:0001297  |  Cerebral vascular events  |  3
HP:0011995  |  Atrial septal aneurysm  |  3
HP:0001636  |  Tetrology of fallot  |  3
HP:0011675  |  Arrhythmias  |  3
HP:0004947  |  Arteriovenous fistula  |  2
HP:0001627  |  Congenital heart defects  |  2
HP:0001651  |  Thoracic situs inversus  |  2
HP:0002076  |  Migraine headaches  |  2
HP:0010316  |  Ebstein's anomaly of the tricuspid valve  |  2
HP:0001643  |  Persistent ductus arteriosus  |  2
HP:0100584  |  Endocarditis  |  2
HP:0001638  |  Cardiomyopathy  |  2
HP:0001635  |  Congestive heart failure  |  2
HP:0002326  |  TIA  |  2
HP:0004937  |  Pulmonary artery aneurysm  |  2
HP:0005180  |  Tricuspid insufficiency  |  2
HP:0006689  |  Bacterial endocarditis  |  2
HP:0001671  |  Abnormality of the cardiac septa  |  1
HP:0001639  |  Hypertrophic cardiomyopathy  |  1
HP:0002625  |  Blood clot in a deep vein  |  1
HP:0006532  |  Pneumonia, recurrent episodes  |  1
HP:0012020  |  Right aortic arch  |  1
HP:0002094  |  Dyspnea  |  1
HP:0011604  |  Aortopulmonary window  |  1
HP:0004602  |  Fusion of cervical vertebrae c2-3  |  1
HP:0005162  |  Left ventricular impairment  |  1
HP:0002089  |  Hypoplastic lungs  |  1
HP:0001010  |  Hypopigmentation of the skin  |  1
HP:0002119  |  Ventricular dilatation  |  1
HP:0002204  |  Pulmonary embolism  |  1
HP:0000581  |  Blepharophimosis  |  1
HP:0001693  |  Cardiac shunt  |  1
HP:0001709  |  Complete heart block  |  1
HP:0001680  |  Coarctation of aorta  |  1
HP:0002032  |  Esophageal atresia  |  1
HP:0011566  |  Cor triatriatum dexter  |  1
HP:0000238  |  Nonsyndromal hydrocephalus  |  1
HP:0012722  |  Heart block  |  1
HP:0001650  |  Valvular aortic stenosis  |  1
HP:0005160  |  Total anomalous pulmonary venous return  |  1
HP:0001719  |  Double-outlet right ventricle  |  1
HP:0000961  |  Cyanosis  |  1
HP:0004890  |  Elevated pulmonary artery pressure  |  1
HP:0004942  |  Aortic aneurysm  |  1
HP:0002563  |  Constrictive pericarditis  |  1
HP:0011645  |  Aneurysm of the aortic sinus  |  1
HP:0001678  |  Atrioventricular block  |  1
HP:0030049  |  Brain abscess  |  1
HP:0001701  |  Pericarditis  |  1
HP:0001696  |  Situs inversus totalis  |  1
HP:0001510  |  Growth deficiency  |  1
HP:0001649  |  Tachycardia  |  1
HP:0004420  |  Arterial thrombosis  |  1
HP:0004415  |  Pulmonary artery stenosis  |  1
HP:0004935  |  Pulmonary atresia  |  1
HP:0040016  |  Prominent coccyx  |  1
HP:0001653  |  Mitral valve insufficiency  |  1
HP:0005182  |  Bicuspid pulmonary valve  |  1
HP:0009827  |  Amelia  |  1
HP:0001962  |  Palpitations  |  1
HP:0001644  |  Congestive cardiomyopathy  |  1
HP:0030728  |  Meromelia  |  1
HP:0004756  |  Ventricular tachycardia  |  1
HP:0004936  |  Blood clot in vein  |  1
HP:0005133  |  Right ventricular dilatation  |  1
HP:0011663  |  Cardiomyopathy, right ventricular  |  1
HP:0002015  |  Swallowing difficulty  |  1
HP:0001883  |  Talipes  |  1
HP:0007894  |  Retinal depigmentation  |  1
HP:0001004  |  Lymphatic obstruction  |  1
Disease ID 1315
Disease atrial septal defects
Manually Symptom(Waiting for update.)
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:23)
C0020542  |  pulmonary hypertension  |  12
C1619734  |  pulmonary arterial hypertension  |  11
C0009814  |  stenosis  |  8
C0002940  |  aneurysm  |  8
C0232197  |  fibrillation  |  7
C0016169  |  fistula  |  4
C0013922  |  embolism  |  4
C0521533  |  atrial septal aneurysm  |  3
C0232605  |  regurgitation  |  2
C0018801  |  heart failure  |  2
C1956257  |  pulmonary stenosis  |  2
C0040961  |  tricuspid regurgitation  |  1
C0006105  |  brain abscess  |  1
C0014121  |  bacterial endocarditis  |  1
C0151517  |  complete atrioventricular block  |  1
C0007194  |  hypertrophic cardiomyopathy  |  1
C0039231  |  tachycardia  |  1
C0034065  |  pulmonary embolism  |  1
C0023212  |  left ventricular failure  |  1
C0427008  |  stiffness  |  1
C0028326  |  noonan syndrome  |  1
C0010520  |  cyanosis  |  1
C0026266  |  mitral regurgitation  |  1
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:42)
snpId pubmedId geneId geneSymbol diseaseId sourceId sentence score Year geneSymbol_dbSNP CHROMOSOME POS REF ALT
rs10951154223593393198HOXA1umls:C0018817BeFreeIn line with this notion, a nonsynonymous single nucleotide polymorphism within a highly conserved domain of HOXA1--A218G (rs10951154)--has been linked to both ASD risk, and cross-sectional differences in superior posterior lobar cerebellar anatomy in late adulthood.0.0005428842012HOXA1;HOTAIRM1727095695CT
rs1219178932136465354413NLGN3umls:C0018817BeFreeBoth mutated CADM1 and neuroligin 3(R451C) induced upregulation of C/EBP-homologous protein (CHOP), an ER stress marker, suggesting that in addition to the trafficking impairment, this CHOP upregulation may also be involved in ASD pathogenesis.0.0008143262010NLGN3X71167508CT
rs1219178932136465323705CADM1umls:C0018817BeFreeBoth mutated CADM1 and neuroligin 3(R451C) induced upregulation of C/EBP-homologous protein (CHOP), an ER stress marker, suggesting that in addition to the trafficking impairment, this CHOP upregulation may also be involved in ASD pathogenesis.0.0008143262010NLGN3X71167508CT
rs121917893213646531649DDIT3umls:C0018817BeFreeBoth mutated CADM1 and neuroligin 3(R451C) induced upregulation of C/EBP-homologous protein (CHOP), an ER stress marker, suggesting that in addition to the trafficking impairment, this CHOP upregulation may also be involved in ASD pathogenesis.0.0002714422010NLGN3X71167508CT
rs12498533248185972332FMR1umls:C0018817BeFreeThe predicted impact on transcription through the ASD associated EIF4E variants rs4699369T and rs12498533G as well as the association of the EIF4E interaction partners FMRP and CYFIP1 with ASD point to an mRNA mediated pathomechanism for ASD.0.0032573022014EIF4E498897682AC
rs12498533248185971977EIF4Eumls:C0018817BeFreeThe predicted impact on transcription through the ASD associated EIF4E variants rs4699369T and rs12498533G as well as the association of the EIF4E interaction partners FMRP and CYFIP1 with ASD point to an mRNA mediated pathomechanism for ASD.0.0005428842014EIF4E498897682AC
rs124985332481859723191CYFIP1umls:C0018817BeFreeThe predicted impact on transcription through the ASD associated EIF4E variants rs4699369T and rs12498533G as well as the association of the EIF4E interaction partners FMRP and CYFIP1 with ASD point to an mRNA mediated pathomechanism for ASD.0.0005428842014EIF4E498897682AC
rs13000344217505755013OTX1umls:C0018817BeFreeSimilarly, in OTX1, rs2018650 and rs13000344 were associated with autism in ASD-CARC cohorts (P(FDR)=8.65 × 10(-7) and 6.07 × 10(5), respectively), AGRE cohort (P(FDR)=0.0034 and 0.015, respectively) and the combined families (P(FDR)=2.34 × 10(-9) and 0.00017, respectively); associations were marginal or insignificant in the New York and SIRFA cohorts.0.0002714422011NA263062599TG
rs147405081187067116910TBX5umls:C0018817BeFreeA novel TBX5 missense mutation (V263M) in a family with atrial septal defects and postaxial hexodactyly.0.0013572092008TBX512114366360CT
rs15052804124752249783CACNB2umls:C0018817BeFreeHere, we present three rare missense mutations of CACNB2 (G167S, S197F, and F240L) found in ASD-affected families, two of them described here for the first time (G167S and F240L).0.0002714422014CACNB21018500945CT
rs167771223976331814DRD3umls:C0018817BeFreeHowever, the rs167771 marker in DRD3, associated with ASD in a previous study, displayed a nominal association in our analysis (P = 0.023).0.0013572092014DRD33114157428GA
rs1858830241502254204MECP2umls:C0018817BeFreeMeCP2 binds to a region of the MET promoter containing the ASD-risk SNV, and displays rs1858830 genotype-specific binding in human neural progenitor cells derived from the olfactory neuroepithelium.0.0016286512013MET7116672385CG
rs1858830193606638731RNMTumls:C0018817BeFreeReplicating our initial findings, family-based association test (FBAT) analyses demonstrated that the MET promoter variant rs1858830 C allele was associated with ASD in 101 new families (P=0.033).0.0021715352008MET7116672385CG
rs2018650217505755013OTX1umls:C0018817BeFreeSimilarly, in OTX1, rs2018650 and rs13000344 were associated with autism in ASD-CARC cohorts (P(FDR)=8.65 × 10(-7) and 6.07 × 10(5), respectively), AGRE cohort (P(FDR)=0.0034 and 0.015, respectively) and the combined families (P(FDR)=2.34 × 10(-9) and 0.00017, respectively); associations were marginal or insignificant in the New York and SIRFA cohorts.0.0002714422011EHBP1;LOC100132215263045589TC
rs2056202178944128604SLC25A12umls:C0018817BeFreeEvidence for a genetic association between autism and two single nucleotide polymorphisms (SNPs), rs2056202 and rs2292813, in the mitochondrial aspartate/glutamate carrier (SLC25A12) gene led us to ask whether any of the four previously identified familial traits in autism spectrum disorders (ASD) varied by these SNPs.0.0008143262008SLC25A122171855970TC
rs2056202259213258604SLC25A12umls:C0018817BeFreeOur meta-analysis suggests that rs2056202 and rs2292813 in SLC25A12 may contribute significantly to ASD risk.0.0008143262015SLC25A122171855970TC
rs2228638245945444745NELL1umls:C0018817BeFreeWe found that rs2228638 in NRP1 on 10p11 was significantly increased the risk of TOF (OR = 1.52, 95% CI = 1.13-2.04, P = 0.006), but not in other subgroups including ASD and VSD.0.0002714422014NRP11033186354CT
rs2292813178944128604SLC25A12umls:C0018817BeFreeEvidence for a genetic association between autism and two single nucleotide polymorphisms (SNPs), rs2056202 and rs2292813, in the mitochondrial aspartate/glutamate carrier (SLC25A12) gene led us to ask whether any of the four previously identified familial traits in autism spectrum disorders (ASD) varied by these SNPs.0.0008143262008SLC25A12;LOC1053737382171787719TC
rs2292813259213258604SLC25A12umls:C0018817BeFreeOur meta-analysis suggests that rs2056202 and rs2292813 in SLC25A12 may contribute significantly to ASD risk.0.0008143262015SLC25A12;LOC1053737382171787719TC
rs25531231233606532SLC6A4umls:C0018817BeFreeThe 5-HTTLPR/rs25531 polymorphism or its correlates may modulate severity of ADHD and ASD symptoms in children with ASD, but in different ways.0.0027144192013SLC6A4;LOC1053717201730237328TC
rs28364997253319036531SLC6A3umls:C0018817BeFreeRecently, we identified a rare, nonsynonymous Slc6a3 variant that produces the DAT substitution Ala559Val in two male siblings who share a diagnosis of attention-deficit hyperactivity disorder (ADHD), with other studies identifying the variant in subjects with bipolar disorder (BPD) and autism spectrum disorder (ASD).0.0008143262015SLC6A351403013GA
rs2857766210841213105HLA-Aumls:C0018817BeFreePolymorphism haplotype analysis demonstrated that two haplotypes comprising the TNF-238(G)-TNF-308(G)-MIB*332-HLA-B*38-HLA-Cw*12 and the D6S265*218-HLA-A*23-MOGc*131-rs2857766(G) alleles are more frequently transmitted to ASD.0.0002714422011MOG629666226GC
rs2857766210841213106HLA-Bumls:C0018817BeFreePolymorphism haplotype analysis demonstrated that two haplotypes comprising the TNF-238(G)-TNF-308(G)-MIB*332-HLA-B*38-HLA-Cw*12 and the D6S265*218-HLA-A*23-MOGc*131-rs2857766(G) alleles are more frequently transmitted to ASD.0.0002714422011MOG629666226GC
rs2857766210841217124TNFumls:C0018817BeFreePolymorphism haplotype analysis demonstrated that two haplotypes comprising the TNF-238(G)-TNF-308(G)-MIB*332-HLA-B*38-HLA-Cw*12 and the D6S265*218-HLA-A*23-MOGc*131-rs2857766(G) alleles are more frequently transmitted to ASD.0.0005428842011MOG629666226GC
rs344781193606635329PLAURumls:C0018817BeFreeIn addition, the PLAUR promoter variant rs344781 T allele was associated with ASD by both FBAT (P=0.006) and case-control analyses (P=0.007).0.0002714422008PLAUR1943670636CT
rs35753505258588003084NRG1umls:C0018817BeFreeTo determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 and rs6994992 SNPs in NRG1 revealed a statistically significant family-based association with three quantitative traits for sociality.0.0005428842015NA831616625TC
rs3626912445313879017GGCTumls:C0018817BeFreeOur meta-analysis revealed that the RELN rs362691, rather than rs736707 or GGC repeat variant, might contribute significantly to ASD risk.0.0002714422013RELN7103610714GA,C
rs37583259424752249783CACNB2umls:C0018817BeFreeHere, we present three rare missense mutations of CACNB2 (G167S, S197F, and F240L) found in ASD-affected families, two of them described here for the first time (G167S and F240L).0.0002714422014CACNB2;LOC1053764391018514299CT
rs3879067722034709926227PHGDHumls:C0018817BeFreeWe identified a novel M310V mutation in GATA4 gene that is located in the NLS region and leads to hereditary ASD in a Chinese family.0.0002714422010GATA4811755064AG
rs444690923349736438ASMTumls:C0018817BeFreeA previous study reported an association between ASD and single nucleotide polymorphisms (SNPs) rs4446909 and rs5989681 located in the promoter of ASMT.0.0008143262013ASMTY;X1614890;1614890GA
rs4680208683726532SLC6A4umls:C0018817BeFreeWe studied the association of the catechol O-methyltransferase (COMT) Val158Met polymorphism and the serotonin transporter (SLC6A4/SERT/5-HTT) 5-HTTLPR insertion/deletion polymorphism with ASD symptoms in children with ADHD, and whether these polymorphisms would interact with pre- and perinatal risk factors, i.e., maternal smoking during pregnancy and low birth weight.0.0027144192010COMT;MIR47612219963748GA
rs4680236135041312COMTumls:C0018817BeFreeThe COMT gene Val158Met polymorphism may be a biomarker for phenotypic variation in ASD, but these preliminary findings remain tentative, pending replication in larger, independent samples.0.0010857672013COMT;MIR47612219963748GA
rs4699369248185971977EIF4Eumls:C0018817BeFreeThe predicted impact on transcription through the ASD associated EIF4E variants rs4699369T and rs12498533G as well as the association of the EIF4E interaction partners FMRP and CYFIP1 with ASD point to an mRNA mediated pathomechanism for ASD.0.0005428842014EIF4E498888271GA
rs4699369248185972332FMR1umls:C0018817BeFreeThe predicted impact on transcription through the ASD associated EIF4E variants rs4699369T and rs12498533G as well as the association of the EIF4E interaction partners FMRP and CYFIP1 with ASD point to an mRNA mediated pathomechanism for ASD.0.0032573022014EIF4E498888271GA
rs46993692481859723191CYFIP1umls:C0018817BeFreeThe predicted impact on transcription through the ASD associated EIF4E variants rs4699369T and rs12498533G as well as the association of the EIF4E interaction partners FMRP and CYFIP1 with ASD point to an mRNA mediated pathomechanism for ASD.0.0005428842014EIF4E498888271GA
rs4746252012842739GLO1umls:C0018817BeFreeWe previously found the rs4746 A332 (Glu111) allele of the GLO1 gene, which encodes for glyoxalase I, associated with unaffected sibling status in families with one or more children affected by Autism Spectrum Disorder (ASD).0.0005428842014GLO1638682852TG
rs561077206576429248GPR50umls:C0018817BeFreeConcerning GPR50, we detected a significant association between ASD and two variations, Delta502-505 and T532A, in affected males, but it did not hold up after Bonferonni correction for multiple testing.0.0005428842010GPR50X151181177AG
rs598968123349736438ASMTumls:C0018817BeFreeA previous study reported an association between ASD and single nucleotide polymorphisms (SNPs) rs4446909 and rs5989681 located in the promoter of ASMT.0.0008143262013ASMTY;X1614999;1614999GC
rs6311247533163356HTR2Aumls:C0018817BeFreeConsistent with our previous findings in the dorsolateral prefrontal cortex of unaffected individuals, rs6311/A decreases expression of HTR2A mRNA with an extended 5' untranslated region (UTR) in the frontopolar cortex in brain samples from 54 ASD patients and controls.0.0013572092014HTR2A1346897343CT
rs644918221528155952CD38umls:C0018817BeFreeIn addition, analysis of the role of genetic polymorphisms in the dynamics of the molecule revealed that the genotype of a single-nucleotide polymorphism (rs6449182; C>G variation) in the CpG island of intron 1, harboring the retinoic-acid response element, exerts differential roles in CD38 expression in ASD and in parental LBC.0.0016286512011CD38415778830CG
rs6994992258588003084NRG1umls:C0018817BeFreeTo determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 and rs6994992 SNPs in NRG1 revealed a statistically significant family-based association with three quantitative traits for sociality.0.0005428842015NRG1831638065CT
rs7367072445313879017GGCTumls:C0018817BeFreeOur meta-analysis revealed that the RELN rs362691, rather than rs736707 or GGC repeat variant, might contribute significantly to ASD risk.0.0002714422013RELN;LOC1019278707103489956AG
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Disease ID 1315
Disease atrial septal defects
Case(Waiting for update.)